indomethacin has been researched along with Reperfusion Injury in 75 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Reperfusion Injury: Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The anthocyanidin effects were examined in gastric ulcer mouse models induced by ethanol, non-steroidal anti-inflammatory drugs (NSAIDs), ischemia-reperfusion (IR), acetic acid and duodenal ulcer induced by polypharmacy." | 8.02 | Malvidin Protects against and Repairs Peptic Ulcers in Mice by Alleviating Oxidative Stress and Inflammation. ( Dos Santos, RC; Fagundes, FL; Pereira, QC; Zarricueta, ML, 2021) |
| "To evaluate the renoprotection effects of non-steroidal anti-inflammatory drugs (NSAIDs) in renal ischemia-reperfusion injury (IRI) and the cyclooxygenase (COX)-1/2 blockade association by indomethacin (IMT) in the mice model." | 7.80 | Protective effect of indomethacin in renal ischemia-reperfusion injury in mice. ( Chen, JH; Chen, RJ; Feng, S; Jiang, H; Jin, J; Lin, C; Wu, JY; Zhou, LJ; Zhu, SH, 2014) |
| "Indomethacin-sensitive mechanisms involved in inducible heat shock protein 70 (iHSP 70) synthesis were investigated at 6 h after global cerebral ischemia in parietal cortex and hippocampus." | 7.70 | Indomethacin attenuates early increases in inducible heat shock protein 70 after cerebral ischemia/reperfusion in piglets. ( Bari, F; Beasley, TC; Busija, D; Louis, T; Thore, C; Thrikawala, N, 1998) |
| "Indomethacin induces ulceration in the rat jejunum with sparing of the ileum." | 7.69 | Vascular anatomy defines sites of indomethacin induced jejunal ulceration along the mesenteric margin. ( Anthony, A; Dhillon, AP; Pounder, RE; Wakefield, AJ, 1997) |
| " The anthocyanidin effects were examined in gastric ulcer mouse models induced by ethanol, non-steroidal anti-inflammatory drugs (NSAIDs), ischemia-reperfusion (IR), acetic acid and duodenal ulcer induced by polypharmacy." | 4.02 | Malvidin Protects against and Repairs Peptic Ulcers in Mice by Alleviating Oxidative Stress and Inflammation. ( Dos Santos, RC; Fagundes, FL; Pereira, QC; Zarricueta, ML, 2021) |
| "To evaluate the renoprotection effects of non-steroidal anti-inflammatory drugs (NSAIDs) in renal ischemia-reperfusion injury (IRI) and the cyclooxygenase (COX)-1/2 blockade association by indomethacin (IMT) in the mice model." | 3.80 | Protective effect of indomethacin in renal ischemia-reperfusion injury in mice. ( Chen, JH; Chen, RJ; Feng, S; Jiang, H; Jin, J; Lin, C; Wu, JY; Zhou, LJ; Zhu, SH, 2014) |
| "Indomethacin diminished cell death by necrosis and apoptosis, release of prostaglandin E2, induction of I/R-induced protein, dedifferentiation or induction of inducible nitric oxide synthase." | 3.76 | Indomethacin corrects alterations associated with ischemia/reperfusion in an in vitro proximal tubular model. ( Gekle, M; Holzinger, H; Renker, S; Sauvant, C; Schneider, R; Wanner, C, 2010) |
| "The effect of peroxisome proliferator-activated receptor-alpha (PPAR-alpha) on gastric secretion and gastric cytoprotection was evaluated using five different models of gastric ulcers: acetic acid-induced chronic gastric ulcers, pylorus ligation, ethanol-induced, indomethacin-induced and ischemia-reperfusion-induced gastric ulcers." | 3.74 | Effect of peroxisome proliferator-activated receptor-alpha agonist (bezafibrate) on gastric secretion and gastric cytoprotection in rats. ( Asad, M; Hrishikeshavan, HJ; Pathak, R; Prasad, S, 2007) |
| " Celecoxib (10, 20 and 40 mg/kg(-l)) was significantly more potent at aggravating ischemia-reperfusion injury as compared to nimesulide." | 3.73 | Comparative gastrointestinal toxicity of selective cyclooxygenase (COX-2) inhibitors. ( Malhotra, S; Nada, R; Pandhi, P; Shafiq, N, 2005) |
| "Indomethacin-sensitive mechanisms involved in inducible heat shock protein 70 (iHSP 70) synthesis were investigated at 6 h after global cerebral ischemia in parietal cortex and hippocampus." | 3.70 | Indomethacin attenuates early increases in inducible heat shock protein 70 after cerebral ischemia/reperfusion in piglets. ( Bari, F; Beasley, TC; Busija, D; Louis, T; Thore, C; Thrikawala, N, 1998) |
| " We tested whether pretreatment with the kinin receptor antagonist Hoe 140, the nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester, or the cyclooxygenase inhibitor indomethacin blocked the effect of ramiprilat on infarct size and reperfusion arrhythmias." | 3.69 | Paracrine systems in the cardioprotective effect of angiotensin-converting enzyme inhibitors on myocardial ischemia/reperfusion injury in rats. ( Carretero, OA; Liu, YH; Sabbath, HN; Sharov, VG; Sigmon, DH; Yang, XP, 1996) |
| "The role of eicosanoids as one of the main shock mediators was demonstrated in experiments anesthetized dogs with modeled postischemic shock using premedication with indometacin and/or quercetin." | 3.69 | [The role of the eicosanoids in the development of a postischemic shock reaction]. ( Sahach, VF; Zhukova, AV, 1996) |
| "Indomethacin induces ulceration in the rat jejunum with sparing of the ileum." | 3.69 | Vascular anatomy defines sites of indomethacin induced jejunal ulceration along the mesenteric margin. ( Anthony, A; Dhillon, AP; Pounder, RE; Wakefield, AJ, 1997) |
| " In 10-day-old rats, mucosal permeability to 51Cr EDTA was measured after subjecting the animals to 10-minute ischemia-reperfusion injury, 30 minutes of hypoxia (14% oxygen), cold stress (4 degree C for 4 minutes), and intraperitoneal indomethacin (0." | 3.68 | Mucosal permeability in the immature rat intestine: effects of ischemia-reperfusion, cold stress, hypoxia, and drugs. ( Langer, JC; Mumford, DA; Sohal, SS, 1993) |
| "The effects of platelet-activating factor (PAF) on prostanoid release during mesenteric ischemia-reperfusion-induced shock were investigated in anesthesized dogs 1) by measuring plasma levels of prostaglandin (PG)F2 alpha, 6-keto-PGF1 alpha and thromboxane (TX)B2 in the superior mesenteric vein during reperfusion following 2 hr occlusion of the superior mesenteric artery; 2) by monitoring the effects of BN 52021, a specific PAF receptor antagonist and indomethacin on hemodynamic parameters and prostanoid levels; and 3) by studying circulatory responses to PAF and PGF2 alpha injected into the superior mesenteric vein in the presence of BN 52021 or indomethacin." | 3.68 | Interactions between platelet-activating factor and prostanoids during mesenteric ischemia-reperfusion-induced shock in the anesthetized dog. ( Braquet, P; Filep, JG; Mózes, T, 1991) |
| "Ischemia/reperfusion injury was induced by clamping left renal pedicle for 60 min, two weeks after right nephrectomy." | 1.38 | Protective effects of acute lithium preconditioning against renal ischemia/reperfusion injury in rat: role of nitric oxide and cyclooxygenase systems. ( Assa, S; Dehpour, AR; Elmi, A; Emami, H; Ghasemi, M; Nezami, BG; Talab, SS; Tavangar, SM, 2012) |
| "Pretreatment with capsazepine, CGRP(8-37), indomethacin, and denervation of primary sensory nerves significantly increased blood urea nitrogen and serum creatinine levels, renal vascular permeability, renal tissue levels of myeloperoxidase activity, cytokine-induced neutrophil chemoattractant, and tumor necrosis factor-alpha, and decreased renal tissue blood flow." | 1.35 | Activation of sensory neurons reduces ischemia/reperfusion-induced acute renal injury in rats. ( Kadoi, Y; Kudo, K; Mizutani, A; Mizutani, S; Murakami, K; Noguchi, T; Okajima, K; Uchino, T, 2009) |
| "Indomethacin (1 mg/kg) was given intraperitoneally as soon as reperfusion started." | 1.35 | Low-dose indomethacin after ischemic acute kidney injury prevents downregulation of Oat1/3 and improves renal outcome. ( Bauer, C; Gekle, M; Holzinger, H; Meusel, M; Renker, S; Roeder, M; Sauvant, C; Schneider, R; Wanner, C, 2009) |
| "Indomethacin treatment induced a better renal function (serum urea) when compared to control animals at 24, 48 and 72 h (219+/-54." | 1.33 | Cyclooxygenase 1 and/or 2 blockade ameliorates the renal tissue damage triggered by ischemia and reperfusion injury. ( Câmara, NO; Cenedeze, MA; Feitoza, CQ; Gonçalves, GM; Pacheco-Silva, A; Pinheiro, HS; Santos, OF, 2005) |
| "Endothelial dysfunction in ischemic acute renal failure (IARF) has been attributed to both direct endothelial injury and to altered endothelial nitric oxide synthase (eNOS) activity, with either maximal upregulation of eNOS or inhibition of eNOS by excess nitric oxide (NO) derived from iNOS." | 1.33 | Renal endothelial dysfunction and impaired autoregulation after ischemia-reperfusion injury result from excess nitric oxide. ( Endre, ZH; Gobé, G; Guan, Z; Willgoss, D, 2006) |
| "Pretreatment with indomethacin completely reversed both of the therapeutic effects of dalteparin, whereas pretreatment with NS-398, a selective inhibitor of cyclooxygenase-2, did not." | 1.33 | Dalteparin, a low molecular weight heparin, attenuates inflammatory responses and reduces ischemia-reperfusion-induced liver injury in rats. ( Harada, N; Okajima, K; Uchiba, M, 2006) |
| "Pretreatment with indomethacin was not effective." | 1.31 | Gut barrier permeability, reticuloendothelial system function and protease inhibitor levels following intestinal ischaemia and reperfusion--effects of pretreatment with N-acetyl-L-cysteine and indomethacin. ( Andersson, R; Deng, X; Lasson, A; Olanders, K; Sun, Z, 2002) |
| "Reducing reperfusion injury is effective in reducing flap loss after prolonged ischemia." | 1.29 | Reducing ischemia-reperfusion injury in rat island groin flaps using dexamethasone. ( Arena, S; Dolan, RW; Kerr, D; Schneiderman, T, 1995) |
| "Allopurinol may prevent reperfusion injury by inhibiting formation of xanthine oxidase generated, oxygen-derived free radicals and may be valuable in pretreating premature infants with patent ductus arteriosus who have had an ischemic episode in whom INDO use is contemplated." | 1.29 | Allopurinol protects the bowel from necrosis caused by indomethacin and temporary intestinal ischemia in mice. ( Krasna, IH; Lee, RT, 1993) |
| "The role of reperfusion injury in the progression to necrosis in pulmonary embolism was evaluated." | 1.28 | Reperfusion after a two-hour period of pulmonary artery occlusion causes pulmonary necrosis. ( Mori, I; Murata, T; Nakazawa, H; Ohta, Y; Yamabayashi, H, 1992) |
| "Pretreatment with indomethacin did not attenuate the neutrophil sequestration within the pulmonary parenchyma." | 1.28 | Acute lung injury following reperfusion after ischemia in the hind limbs of rats. ( Cashmer, B; Oldham, K; Punch, J; Rees, R; Smith, DJ; Wilkins, E, 1991) |
| "Indomethacin treatment abolished the reduction of infarct size seen with defibrotide alone." | 1.28 | Defibrotide reduces infarct size in a rabbit model of experimental myocardial ischaemia and reperfusion. ( Thiemermann, C; Thomas, GR; Vane, JR, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (2.67) | 18.7374 |
| 1990's | 33 (44.00) | 18.2507 |
| 2000's | 27 (36.00) | 29.6817 |
| 2010's | 12 (16.00) | 24.3611 |
| 2020's | 1 (1.33) | 2.80 |
| Authors | Studies |
|---|---|
| Bi, W | 1 |
| Bi, Y | 1 |
| Xue, P | 1 |
| Zhang, Y | 1 |
| Gao, X | 1 |
| Wang, Z | 1 |
| Li, M | 1 |
| Baudy-Floc'h, M | 1 |
| Ngerebara, N | 1 |
| Gibson, KM | 1 |
| Bi, L | 1 |
| Fagundes, FL | 1 |
| Pereira, QC | 1 |
| Zarricueta, ML | 1 |
| Dos Santos, RC | 1 |
| Venkatesh, M | 1 |
| Mukherjee, S | 1 |
| Wang, H | 1 |
| Li, H | 1 |
| Sun, K | 1 |
| Benechet, AP | 1 |
| Qiu, Z | 1 |
| Maher, L | 1 |
| Redinbo, MR | 1 |
| Phillips, RS | 1 |
| Fleet, JC | 1 |
| Kortagere, S | 1 |
| Mukherjee, P | 1 |
| Fasano, A | 1 |
| Le Ven, J | 1 |
| Nicholson, JK | 1 |
| Dumas, ME | 1 |
| Khanna, KM | 1 |
| Mani, S | 1 |
| Zhu, SH | 1 |
| Zhou, LJ | 1 |
| Jiang, H | 1 |
| Chen, RJ | 1 |
| Lin, C | 1 |
| Feng, S | 1 |
| Jin, J | 1 |
| Chen, JH | 1 |
| Wu, JY | 1 |
| Schneider, R | 3 |
| Meusel, M | 2 |
| Betz, B | 1 |
| Held, C | 1 |
| Möller-Ehrlich, K | 1 |
| Büttner-Herold, M | 1 |
| Wanner, C | 3 |
| Gekle, M | 3 |
| Sauvant, C | 3 |
| Abdel-Gaber, SA | 1 |
| Ibrahim, MA | 1 |
| Amin, EF | 1 |
| Ibrahim, SA | 1 |
| Mohammed, RK | 1 |
| Abdelrahman, AM | 1 |
| Mizutani, A | 2 |
| Okajima, K | 8 |
| Murakami, K | 1 |
| Mizutani, S | 2 |
| Kudo, K | 1 |
| Uchino, T | 1 |
| Kadoi, Y | 1 |
| Noguchi, T | 2 |
| Feitoza, CQ | 3 |
| Semedo, P | 1 |
| Gonçalves, GM | 2 |
| Cenedeze, MA | 2 |
| Pinheiro, HS | 2 |
| Dos Santos, OF | 1 |
| Landgraf, RG | 1 |
| Pacheco-Silva, A | 3 |
| Câmara, NO | 3 |
| Yusifzade, K | 1 |
| Akin, M | 1 |
| Isikgonul, I | 1 |
| Gulbahar, O | 1 |
| Anadol, AZ | 1 |
| Kurukahvecioglu, O | 1 |
| Ercan, S | 2 |
| Sare, M | 2 |
| Renker, S | 2 |
| Bauer, C | 1 |
| Holzinger, H | 2 |
| Roeder, M | 1 |
| Peskar, BM | 2 |
| Ehrlich, K | 2 |
| Schuligoi, R | 2 |
| Peskar, BA | 1 |
| Nakagiri, A | 1 |
| Murakami, M | 1 |
| Nakamori, Y | 1 |
| Komatsu, Y | 1 |
| Kotani, T | 1 |
| Kojima, S | 1 |
| Takeuchi, K | 1 |
| Kawai, M | 1 |
| Harada, N | 7 |
| Takeyama, H | 1 |
| Bobryshev, PIu | 1 |
| Bagaeva, TR | 1 |
| Filaretova, LP | 1 |
| Freitas, FF | 1 |
| Fernandes, HB | 1 |
| Piauilino, CA | 1 |
| Pereira, SS | 1 |
| Carvalho, KI | 1 |
| Chaves, MH | 1 |
| Soares, PM | 1 |
| Miura, LM | 1 |
| Leite, JR | 1 |
| Oliveira, RC | 1 |
| Oliveira, FA | 1 |
| Talab, SS | 1 |
| Elmi, A | 1 |
| Emami, H | 1 |
| Nezami, BG | 1 |
| Assa, S | 1 |
| Ghasemi, M | 1 |
| Tavangar, SM | 1 |
| Dehpour, AR | 1 |
| Ballabeni, V | 1 |
| Barocelli, E | 1 |
| Bertoni, S | 1 |
| Impicciatore, M | 1 |
| Sanders, H | 1 |
| Cenedeze, M | 1 |
| Uchiba, M | 4 |
| Isobe, H | 2 |
| Sun, Z | 1 |
| Lasson, A | 1 |
| Olanders, K | 1 |
| Deng, X | 1 |
| Andersson, R | 1 |
| Mori, M | 1 |
| Brzozowski, T | 3 |
| Konturek, PC | 3 |
| Konturek, SJ | 3 |
| Pajdo, R | 3 |
| Kwiecien, S | 2 |
| Pawlik, M | 2 |
| Drozdowicz, D | 3 |
| Sliwowski, Z | 3 |
| Pawlik, WW | 1 |
| Santos, OF | 1 |
| Xiao, L | 1 |
| Zhao, FL | 1 |
| Zhu, XZ | 1 |
| Shafiq, N | 1 |
| Malhotra, S | 1 |
| Pandhi, P | 1 |
| Nada, R | 1 |
| Guan, Z | 1 |
| Gobé, G | 1 |
| Willgoss, D | 1 |
| Endre, ZH | 1 |
| Pathak, R | 1 |
| Asad, M | 1 |
| Hrishikeshavan, HJ | 1 |
| Prasad, S | 1 |
| Nakayama, T | 1 |
| Asano, M | 1 |
| Nomura, N | 1 |
| Saito, T | 1 |
| Mishima, A | 1 |
| Birkenmeier, K | 1 |
| Staudt, A | 1 |
| Schunck, WH | 1 |
| Janke, I | 1 |
| Labitzke, C | 1 |
| Prange, T | 1 |
| Trimpert, C | 1 |
| Krieg, T | 1 |
| Landsberger, M | 1 |
| Stangl, V | 1 |
| Felix, SB | 1 |
| Joviliano, EE | 1 |
| Piccinato, CE | 1 |
| Cherri, J | 1 |
| Viaro, F | 1 |
| Moryia, T | 1 |
| Celotto, AC | 1 |
| Bonaventura, D | 1 |
| Evora, PR | 1 |
| Lozano, H | 2 |
| Wu, D | 2 |
| Bassuk, J | 1 |
| Aria, J | 1 |
| Kurlansky, P | 2 |
| Lamas, GA | 2 |
| Adams, JA | 2 |
| Fromm, RE | 1 |
| Varon, J | 1 |
| Bassuk, JA | 1 |
| Arias, J | 1 |
| Dolan, RW | 2 |
| Kerr, D | 2 |
| Schneiderman, T | 1 |
| Arena, S | 2 |
| Piana, RN | 1 |
| Shafique, T | 1 |
| Dai, HB | 1 |
| Sellke, FW | 1 |
| Hotter, G | 1 |
| Closa, D | 1 |
| Gelpí, E | 1 |
| Prats, N | 1 |
| Roselló-Catafau, J | 1 |
| Cristol, JP | 1 |
| Thiemermann, C | 2 |
| Mitchell, JA | 1 |
| Walder, C | 1 |
| Vane, JR | 2 |
| Tasdemiroglu, E | 1 |
| Christenberry, PD | 1 |
| Ardell, JL | 1 |
| Chronister, RB | 1 |
| Taylor, AE | 1 |
| Sakurai, T | 1 |
| Sugawara, H | 1 |
| Saito, K | 1 |
| Kano, Y | 1 |
| Langer, JC | 1 |
| Sohal, SS | 1 |
| Mumford, DA | 1 |
| Krasna, IH | 1 |
| Lee, RT | 1 |
| Louis, TM | 2 |
| Meng, W | 1 |
| Bari, F | 4 |
| Errico, RA | 1 |
| Busija, DW | 2 |
| Liu, YH | 1 |
| Yang, XP | 1 |
| Sharov, VG | 1 |
| Sigmon, DH | 1 |
| Sabbath, HN | 1 |
| Carretero, OA | 1 |
| Zhukova, AV | 1 |
| Sahach, VF | 1 |
| Bozkurt, S | 1 |
| Onuk, E | 1 |
| Oguz, M | 1 |
| Gurel, M | 1 |
| Sonnino, RE | 1 |
| Pigatt, L | 1 |
| Schrama, A | 1 |
| Burchett, S | 1 |
| Franson, R | 1 |
| Blikslager, AT | 1 |
| Roberts, MC | 1 |
| Rhoads, JM | 1 |
| Argenzio, RA | 1 |
| Beasley, TC | 2 |
| Thore, C | 2 |
| Thrikawala, N | 2 |
| Louis, T | 2 |
| Busija, D | 2 |
| Anthony, A | 1 |
| Pounder, RE | 1 |
| Dhillon, AP | 1 |
| Wakefield, AJ | 1 |
| Jiang, XW | 1 |
| Kambara, K | 1 |
| Gotoh, N | 1 |
| Nishigaki, K | 1 |
| Fujiwara, H | 1 |
| Kushimoto, S | 1 |
| Tanaka, K | 1 |
| Criniti, A | 1 |
| Picard, S | 1 |
| Monti, F | 1 |
| Dawodu, AA | 1 |
| Ruvolo, G | 1 |
| Puddu, PE | 1 |
| Campa, PP | 1 |
| Maricic, N | 1 |
| Gretzer, B | 1 |
| Respondek, M | 1 |
| Stachura, J | 1 |
| Hahn, EG | 2 |
| Ptak, A | 1 |
| Mojzis, J | 1 |
| Hviscová, K | 1 |
| Germanova, D | 1 |
| Bukovicová, D | 1 |
| Mirossay, L | 1 |
| Salvatierra, A | 1 |
| Guerrero, R | 1 |
| Rodriguez, M | 1 |
| Alvarez, A | 1 |
| Soriano, F | 1 |
| Lopez-Pedrera, R | 1 |
| Ramirez, R | 1 |
| Carracedo, J | 1 |
| Lopez-Rubio, F | 1 |
| Lopez-Pujol, J | 1 |
| Velasco, F | 1 |
| Katsuragi, T | 1 |
| Sicard, GA | 1 |
| Etheredge, EE | 1 |
| Anderson, CB | 1 |
| Manner, M | 2 |
| Roy, K | 2 |
| Hofheinz, H | 1 |
| Post, S | 1 |
| Senninger, N | 1 |
| Otto, G | 2 |
| Murata, T | 1 |
| Nakazawa, H | 1 |
| Mori, I | 1 |
| Ohta, Y | 1 |
| Yamabayashi, H | 1 |
| Punch, J | 1 |
| Rees, R | 1 |
| Cashmer, B | 1 |
| Oldham, K | 1 |
| Wilkins, E | 1 |
| Smith, DJ | 1 |
| Filep, JG | 1 |
| Braquet, P | 1 |
| Mózes, T | 1 |
| Pittet, JF | 1 |
| Morel, DR | 1 |
| Mentha, G | 1 |
| Le Coultre, C | 1 |
| Suter, PM | 1 |
| Rohner, A | 1 |
| Ljungman, AG | 1 |
| Grum, CM | 1 |
| Deeb, GM | 1 |
| Bolling, SF | 1 |
| Morganroth, ML | 1 |
| Seelos, R | 1 |
| Runkel, N | 1 |
| Murthy, SN | 1 |
| Cooney, CG | 1 |
| Clearfield, HR | 1 |
| Ting, P | 1 |
| Thomas, GR | 1 |
75 other studies available for indomethacin and Reperfusion Injury
| Article | Year |
|---|---|
Synthesis and characterization of novel indole derivatives reveal improved therapeutic agents for treatment of ischemia/reperfusion (I/R) injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Capillary Permeability; Free Radical | 2010 |
Malvidin Protects against and Repairs Peptic Ulcers in Mice by Alleviating Oxidative Stress and Inflammation.
Topics: Acetic Acid; Animals; Anthocyanins; Antioxidants; Biomarkers; Cyclooxygenase 1; Disease Models, Anim | 2021 |
Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4.
Topics: Adherens Junctions; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies; Caco-2 Cells; CD3 | 2014 |
Protective effect of indomethacin in renal ischemia-reperfusion injury in mice.
Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents, Non-Steroidal; Creatinine; Cyclooxygenase 1; | 2014 |
Oat1/3 restoration protects against renal damage after ischemic AKI.
Topics: Acute Kidney Injury; Animals; Disease Models, Animal; Female; Glomerular Filtration Rate; Indomethac | 2015 |
Effect of selective versus non-selective cyclooxygenase inhibitors on ischemia-reperfusion-induced hepatic injury in rats.
Topics: Alanine Transaminase; Animals; Caspase 3; Celecoxib; Cyclooxygenase 2 Inhibitors; Gene Expression Re | 2015 |
Activation of sensory neurons reduces ischemia/reperfusion-induced acute renal injury in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Calci | 2009 |
Modulation of inflammatory response by selective inhibition of cyclooxygenase-1 and cyclooxygenase-2 in acute kidney injury.
Topics: Acute Kidney Injury; Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Cytokin | 2010 |
The protective role of anandamide in mesenteric ischemia reperfusion injury in guinea pig.
Topics: Acute Disease; Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Endocannabinoids; Enzyme | 2009 |
Low-dose indomethacin after ischemic acute kidney injury prevents downregulation of Oat1/3 and improves renal outcome.
Topics: Acute Disease; Animals; Biological Transport; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response | 2009 |
Role of lipoxygenases and the lipoxin A(4)/annexin 1 receptor in ischemia-reperfusion-induced gastric mucosal damage in rats.
Topics: 16,16-Dimethylprostaglandin E2; Acetamides; Animals; Annexins; Anti-Ulcer Agents; Celecoxib; Cycloox | 2009 |
Roles of NADPH oxidase in occurrence of gastric damage and expression of cyclooxygenase-2 during ischemia/reperfusion in rat stomachs.
Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Gastric M | 2009 |
Pathogenic importance of cysteinyl leukotrienes in development of gastric lesions induced by ischemia/reperfusion in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Chromones; Gastric Ac | 2010 |
Neutrophil elastase contributes to the development of ischemia/reperfusion-induced liver injury by decreasing the production of insulin-like growth factor-I in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Calcitonin Gene-Related Peptide; Cephalo | 2010 |
Indomethacin corrects alterations associated with ischemia/reperfusion in an in vitro proximal tubular model.
Topics: Animals; Apoptosis; Biomarkers; Cardiovascular Agents; Cells, Cultured; Chemokine CCL2; Dinoprostone | 2010 |
[Contribution of glucocorticoid hormones to gastroprotective effect of ischemic preconditioning in rats with normal and deficient prostaglandin production].
Topics: Adrenalectomy; Animals; Corticosterone; Gastric Mucosa; Glucocorticoids; Indomethacin; Ischemic Prec | 2010 |
Gastroprotective activity of Zanthoxylum rhoifolium Lam. in animal models.
Topics: Animals; Anti-Ulcer Agents; Catalase; Cytoprotection; Disease Models, Animal; Enzyme Inhibitors; Eth | 2011 |
Protective effects of acute lithium preconditioning against renal ischemia/reperfusion injury in rat: role of nitric oxide and cyclooxygenase systems.
Topics: Animals; Antimanic Agents; Disease Models, Animal; Indomethacin; Ischemic Preconditioning; Kidney; L | 2012 |
Alterations of intestinal motor responsiveness in a model of mild mesenteric ischemia/reperfusion in rats.
Topics: Acetylcholine; Animals; Chymotrypsin; Disease Models, Animal; Dose-Response Relationship, Drug; Elec | 2002 |
Pretreatment with indomethacin protects from acute renal failure following ischemia-reperfusion injury.
Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Indom | 2002 |
Antithrombin reduces ischemia/reperfusion-induced renal injury in rats by inhibiting leukocyte activation through promotion of prostacyclin production.
Topics: 6-Ketoprostaglandin F1 alpha; Amino Acid Chloromethyl Ketones; Animals; Anti-Inflammatory Agents, No | 2003 |
Gut barrier permeability, reticuloendothelial system function and protease inhibitor levels following intestinal ischaemia and reperfusion--effects of pretreatment with N-acetyl-L-cysteine and indomethacin.
Topics: Acetylcysteine; Animals; Cyclooxygenase Inhibitors; Endothelium; Epithelium; Free Radical Scavengers | 2002 |
Neutrophil elastase contributes to the development of ischemia-reperfusion-induced liver injury by decreasing endothelial production of prostacyclin in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Capillary Permeability; Cephalosporins; Chemokines, CXC; Cycl | 2004 |
Ischemic preconditioning of remote organs attenuates gastric ischemia-reperfusion injury through involvement of prostaglandins and sensory nerves.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygen | 2004 |
Cyclooxygenase 1 and/or 2 blockade ameliorates the renal tissue damage triggered by ischemia and reperfusion injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase | 2005 |
Down regulation of cyclooxygenase-2 is involved in delayed neuroprotection by ischemic preconditioning in rats.
Topics: Animals; Brain; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Down-Regul | 2005 |
Comparative gastrointestinal toxicity of selective cyclooxygenase (COX-2) inhibitors.
Topics: Animals; Celecoxib; Colitis; Cyclooxygenase Inhibitors; Gastric Mucosa; Gastrointestinal Tract; Indo | 2005 |
Renal endothelial dysfunction and impaired autoregulation after ischemia-reperfusion injury result from excess nitric oxide.
Topics: Acute Kidney Injury; Angiotensin II; Animals; Endothelium; Homeostasis; In Vitro Techniques; Indomet | 2006 |
Dalteparin, a low molecular weight heparin, attenuates inflammatory responses and reduces ischemia-reperfusion-induced liver injury in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anticoagulants; Calcium; Cyclooxygenase 2 Inhibitors; Daltepa | 2006 |
Effect of peroxisome proliferator-activated receptor-alpha agonist (bezafibrate) on gastric secretion and gastric cytoprotection in rats.
Topics: Acetic Acid; Animals; Anti-Ulcer Agents; Bezafibrate; Ethanol; Gastric Acid; Gastric Mucosa; Indomet | 2007 |
Atrial natriuretic peptide reduces ischemia/reperfusion-induced spinal cord injury in rats by enhancing sensory neuron activation.
Topics: 6-Ketoprostaglandin F1 alpha; Anilides; Animals; Atrial Natriuretic Factor; Calcitonin Gene-Related | 2007 |
COX-2-dependent and potentially cardioprotective effects of negative inotropic substances released after ischemia.
Topics: Adenosine Triphosphate; Animals; Calcium Signaling; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenas | 2007 |
In vitro pharmacological study of femoral artery vascular reactivity after inferior canine hindlimb ischemia/reperfusion: effects of in vivo nitric oxide blocker infusion.
Topics: Animals; Cyclooxygenase Inhibitors; Dogs; Endothelium-Dependent Relaxing Factors; Endothelium, Vascu | 2007 |
The effects of prostaglandin inhibition on whole-body ischemia-reperfusion in swine.
Topics: Animals; Cardiopulmonary Resuscitation; Celecoxib; Cyclooxygenase Inhibitors; Dinoprostone; Disease | 2008 |
Prostaglandin inhibition and ischemia: where are the data?
Topics: Animals; Cardiopulmonary Resuscitation; Celecoxib; Cyclooxygenase Inhibitors; Disease Models, Animal | 2008 |
Non-selective cyclooxygenase inhibition before periodic acceleration (pGz) cardiopulmonary resuscitation (CPR) in a porcine model of ventricular fibrillation.
Topics: Analysis of Variance; Animals; Biomarkers; Blood Gas Analysis; Cardiopulmonary Resuscitation; Creati | 2008 |
Reducing ischemia-reperfusion injury in rat island groin flaps using dexamethasone.
Topics: Animals; Dexamethasone; Groin; Indomethacin; Male; Random Allocation; Rats; Rats, Sprague-Dawley; Re | 1995 |
Epicardial and endocardial coronary microvascular responses: effects of ischemia-reperfusion.
Topics: Adenosine; Animals; Arginine; Bradykinin; Calcimycin; Coronary Circulation; Endocardium; Endothelium | 1994 |
Role of xanthine oxidase and eicosanoids in development of pancreatic ischemia-reperfusion injury.
Topics: 6-Ketoprostaglandin F1 alpha; Allopurinol; Animals; Biomarkers; Cyclooxygenase Inhibitors; Dinoprost | 1995 |
Support of renal blood flow after ischaemic-reperfusion injury by endogenous formation of nitric oxide and of cyclo-oxygenase vasodilator metabolites.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Calcium; Dexamethasone; Endothelium, Vascular; Enzyme | 1993 |
Effects of antioxidants on the blood-brain barrier and postischemic hyperemia.
Topics: Animals; Antioxidants; Blood Flow Velocity; Blood-Brain Barrier; Brain; Brain Ischemia; Capillary Pe | 1994 |
Effects of the acetylene compound from Atractylodes rhizome on experimental gastric ulcers induced by active oxygen species.
Topics: Acetylene; Administration, Oral; Alkynes; Animals; Anti-Ulcer Agents; Disease Models, Animal; Diynes | 1994 |
Mucosal permeability in the immature rat intestine: effects of ischemia-reperfusion, cold stress, hypoxia, and drugs.
Topics: Animals; Animals, Newborn; Cell Membrane Permeability; Cold Temperature; Dose-Response Relationship, | 1993 |
Allopurinol protects the bowel from necrosis caused by indomethacin and temporary intestinal ischemia in mice.
Topics: Allopurinol; Animals; Ductus Arteriosus, Patent; Enterocolitis, Pseudomembranous; Gastric Lavage; In | 1993 |
Reducing ischemia-reperfusion injury in rat island groin flaps by dexamethasone and BW755C.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents; Ant | 1995 |
Ischemia reduces CGRP-induced cerebral vascular dilation in piglets.
Topics: Animals; Animals, Newborn; Antioxidants; Arterioles; Calcitonin Gene-Related Peptide; Cerebral Arter | 1996 |
Paracrine systems in the cardioprotective effect of angiotensin-converting enzyme inhibitors on myocardial ischemia/reperfusion injury in rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine | 1996 |
[The role of the eicosanoids in the development of a postischemic shock reaction].
Topics: Animals; Cyclooxygenase Inhibitors; Dogs; Eicosanoids; Hemodynamics; Hindlimb; Indomethacin; Ischemi | 1996 |
The effects of indomethacin, NDGA, allopurinol and superoxide dismutase on prostaglandin E2 and leukotriene C4 levels after mesenteric ischemia-reperfusion injury.
Topics: Alkaline Phosphatase; Allopurinol; Animals; Antioxidants; Creatine Kinase; Cyclooxygenase Inhibitors | 1996 |
Phospholipase A2 secretion during intestinal graft ischemia.
Topics: Alkanesulfonates; Animals; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Indomethacin; Intestinal Mu | 1997 |
Kainate-induced cerebrovascular dilation is resistant to ischemia in piglets.
Topics: Animals; Animals, Newborn; Arterioles; Brain Ischemia; Cerebral Arteries; Dizocilpine Maleate; Excit | 1997 |
Prostaglandins I2 and E2 have a synergistic role in rescuing epithelial barrier function in porcine ileum.
Topics: Animals; Cytoprotection; Dinoprostone; Drug Synergism; Electric Impedance; Epithelium; Epoprostenol; | 1997 |
Cerebral ischemia/reperfusion increases endothelial nitric oxide synthase levels by an indomethacin-sensitive mechanism.
Topics: Animals; Animals, Newborn; Brain Ischemia; Cyclooxygenase Inhibitors; Indomethacin; Nitric Oxide Syn | 1998 |
Vascular anatomy defines sites of indomethacin induced jejunal ulceration along the mesenteric margin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Ileum; Indomethacin; Intestinal Mucosa; Ischemia; | 1997 |
Indomethacin attenuates early increases in inducible heat shock protein 70 after cerebral ischemia/reperfusion in piglets.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Brain Ischemia; Female; Heat-Sho | 1998 |
Effects of low-dose Beraprost sodium, a stable prostaglandin I2 analogue, on reperfusion injury to rabbit lungs.
Topics: 6-Ketoprostaglandin F1 alpha; Analysis of Variance; Animals; Anti-Inflammatory Agents; Anti-Inflamma | 1998 |
Antithrombin reduces ischemia/reperfusion injury of rat liver by increasing the hepatic level of prostacyclin.
Topics: 6-Ketoprostaglandin F1 alpha; Amino Acid Chloromethyl Ketones; Animals; Antithrombin III; Disease Mo | 1999 |
Cicletanine prevents the excitation-conduction blocks induced by terfenadine in ischemic myocardium.
Topics: Animals; Anti-Arrhythmia Agents; Dimethyl Sulfoxide; Drug Interactions; Epoprostenol; Female; Guinea | 1999 |
Selective cyclo-oxygenase-2 inhibitors aggravate ischaemia-reperfusion injury in the rat stomach.
Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; | 1999 |
Role of prostaglandins generated by cyclooxygenase-1 and cyclooxygenase-2 in healing of ischemia-reperfusion-induced gastric lesions.
Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; | 1999 |
Ischemic preconditioning, the most effective gastroprotective intervention: involvement of prostaglandins, nitric oxide, adenosine and sensory nerves.
Topics: Adenosine; Animals; Blotting, Western; Calcitonin Gene-Related Peptide; Capsaicin; Cyclooxygenase 1; | 2001 |
Protective effect of quercetin on ischemia/reperfusion-induced gastric mucosal injury in rats.
Topics: Animals; Antioxidants; Celiac Artery; Constriction; Gastric Mucosa; Indomethacin; Male; Prostaglandi | 2001 |
Antithrombin III prevents early pulmonary dysfunction after lung transplantation in the dog.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Antithrombin III; Cell Adhesion Molecules; Dogs; Epoprostenol | 2001 |
Ischemia/reperfusion-induced increase in the hepatic level of prostacyclin is mainly mediated by activation of capsaicin-sensitive sensory neurons in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cyclooxygenase 1; | 2002 |
Modification of ischemic renal injury by prostaglandin inhibition.
Topics: Animals; Dogs; Indomethacin; Kidney; Prostaglandins; Reperfusion Injury; Vascular Resistance | 1978 |
Reperfusion injury after liver transplantation: the role of eicosanoids.
Topics: Animals; Eicosanoids; Endothelium, Vascular; Epoprostenol; Iloprost; Indoles; Indomethacin; Leukotri | 1992 |
Reperfusion after a two-hour period of pulmonary artery occlusion causes pulmonary necrosis.
Topics: Animals; Constriction; Indomethacin; Lung; Male; Pulmonary Alveoli; Pulmonary Artery; Pulmonary Embo | 1992 |
Acute lung injury following reperfusion after ischemia in the hind limbs of rats.
Topics: Allopurinol; Animals; Capillary Permeability; Catalase; Dimethyl Sulfoxide; Free Radicals; Hindlimb; | 1991 |
Interactions between platelet-activating factor and prostanoids during mesenteric ischemia-reperfusion-induced shock in the anesthetized dog.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Dinoprost; Diterpenes; Dogs; Ginkgolides; Hemodynamics; Indom | 1991 |
Protective effect of indomethacin in the development of the postreperfusion syndrome during liver transplantation in pigs.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Cell Count; Blood Pressure; Cardiac Output; Heart Rate; | 1991 |
Inhibition of cyclooxygenase metabolite production attenuates ischemia-reperfusion lung injury.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Benzofurans; Blood Pressure; Cyclooxygenase Inhibitors; Dinop | 1991 |
The role of prostaglandins in reperfusion injury after liver transplantation in pigs.
Topics: Animals; Graft Survival; Indomethacin; Liver Function Tests; Liver Transplantation; Prostaglandins; | 1991 |
Hydrogen peroxide-induced alterations in prostaglandin secretion in the rat colon in vitro.
Topics: 6-Ketoprostaglandin F1 alpha; Adrenal Cortex Hormones; Animals; Antioxidants; Calcimycin; Colon; Epi | 1990 |
Indomethacin attenuates early postischemic vasogenic edema and cerebral injury.
Topics: Animals; Blood-Brain Barrier; Brain Edema; Brain Ischemia; Cats; Cerebral Cortex; Cerebrovascular Ci | 1990 |
Defibrotide reduces infarct size in a rabbit model of experimental myocardial ischaemia and reperfusion.
Topics: Animals; Blood Pressure; Coronary Circulation; Coronary Disease; Electrocardiography; Heart Rate; He | 1989 |