Page last updated: 2024-10-29

indomethacin and Renal Insufficiency

indomethacin has been researched along with Renal Insufficiency in 20 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Renal Insufficiency: Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLOMERULAR FILTRATION RATE.

Research Excerpts

ExcerptRelevanceReference
"Long-term indomethacin treatment during pregnancy may lead to the development of renal failure and irreversible renal damage with cystic dilatation of developing nephrons in an exposed fetus."7.69Persistent anuria, neonatal death, and renal microcystic lesions after prenatal exposure to indomethacin. ( Bavoux, F; Carlus, C; Delezoide, AL; Gubler, MC; Narcy, F; van der Heijden, BJ, 1994)
"Eighteen pregnant women were given indomethacin during the year 1989 for treatment of premature labor (n = 16) or polyhydramnios (n = 2)."7.68[Maternal and neonatal effects of indomethacin administrated during pregnancy. Apropos of 18 cases]. ( Bavoux, F; Blot, P; Boissinot, C; Guillonneau, M; Hartmann, JF; Jacqz-Aigrain, E, 1993)
" Oral ibuprofen is associated with lower instance of necrotizing enterocolitis."4.95Patent Ductus Arteriosus in the Preterm Infant: Diagnostic and Treatment Options. ( Keim-Malpass, J; Prescott, S, 2017)
" Up to the present day, several cases of severe and sometimes irreversible renal insufficiency have been described in neonates exposed to indomethacin prenatally or in the first days of life for treatment of patent ductus arteriosus (PDA)."4.81NSAID-induced nephrotoxicity from the fetus to the child. ( Cuzzolin, L; Dal Cerè, M; Fanos, V, 2001)
"To compare the incidence of medical closure of patent ductus arteriosus (PDA) and adverse events (acute renal dysfunction, necrotizing enterocolitis, spontaneous intestinal perforation, and gastrointestinal bleeding) between preterm infants who received indomethacin and ibuprofen for the treatment of PDA."3.79Effectiveness and safety of indomethacin versus ibuprofen for the treatment of patent ductus arteriosus in preterm infants. ( Bali, V; Harabor, A; Kamaluddeen, M; Sivanandan, S; Soraisham, AS, 2013)
"Long-term indomethacin treatment during pregnancy may lead to the development of renal failure and irreversible renal damage with cystic dilatation of developing nephrons in an exposed fetus."3.69Persistent anuria, neonatal death, and renal microcystic lesions after prenatal exposure to indomethacin. ( Bavoux, F; Carlus, C; Delezoide, AL; Gubler, MC; Narcy, F; van der Heijden, BJ, 1994)
"Three cases of neonatal renal insufficiency in very low birthweight (VLBW) infants following repeated antenatal administration of indomethacin to prevent premature labor are reported."3.69Renal impairment in very low birthweight infants following antenatal indomethacin administration. ( Ichijo, M; Kawaguchi, C; Nakagawa, Y; Nakajima, M; Nishikubo, T; Takahashi, Y; Yoshioka, A, 1994)
"Indomethacin has been shown to have adverse effects on renal function in patients with well-compensated alcoholic cirrhosis."3.69The effect of misoprostol on indomethacin-induced renal dysfunction in well-compensated cirrhosis. ( Dudley, F; Hsu, P; Massie, D; Wong, F, 1995)
"Eighteen pregnant women were given indomethacin during the year 1989 for treatment of premature labor (n = 16) or polyhydramnios (n = 2)."3.68[Maternal and neonatal effects of indomethacin administrated during pregnancy. Apropos of 18 cases]. ( Bavoux, F; Blot, P; Boissinot, C; Guillonneau, M; Hartmann, JF; Jacqz-Aigrain, E, 1993)
"Increasing indomethacin concentrations above the levels achieved with a conventional dosing regimen had little effect on the rate of PDA closure but was associated with higher rates of moderate/severe ROP and renal compromise."2.73Increased indomethacin dosing for persistent patent ductus arteriosus in preterm infants: a multicenter, randomized, controlled trial. ( Buchh, B; Chorne, N; Clyman, R; Ewig, A; Fields, S; Ianus, V; Jegatheesan, P; Lin, E; Milstein, J; Moon-Grady, A; Padbury, J; Schreiber, M; Tacy, T; Yoon, G, 2008)
"Ibuprofen appears to be a better choice for PDA closure, with a better side effect profile and efficacy that equals that of indomethacin."2.53Pharmacological Closure of Patent Ductus Arteriosus: Selecting the Agent and Route of Administration. ( Agarwal, R; Sivanandan, S, 2016)
"Indomethacin is a non-steroidal anti-inflammatory drug that is a potent inhibitor of prostaglandin E(2) synthesis."2.49Clinical pharmacology of indomethacin in preterm infants: implications in patent ductus arteriosus closure. ( Pacifici, GM, 2013)
"Indomethacin therapy for closure of patent ductus arteriosus frequently causes oliguria, and occasionally more serious renal dysfunction."2.41Dopamine versus no treatment to prevent renal dysfunction in indomethacin-treated preterm newborn infants. ( Barrington, K; Brion, LP, 2002)
"The symptomatic patent ductus arteriosus (sPDA) is common in extremely premature infants (EPI)."1.46[Digestive and Kidney Complications by indomethacin and ibuprofen in extreme preterm infants with patent ductus arteriosus]. ( Lavín, P; López, M; Miranda, J; Rincón, Y; Salas, R, 2017)
"Kidney failure is associated with changes in renal vascular responses to angiotensin (Ang) II."1.31Angiotensin II type AT(2) receptor mRNA expression and renal vasodilatation are increased in renal failure. ( Bautista, R; Escalante, B; Hernández, J; Oyekan, A; Sánchez, A, 2001)
"Kidney failure is the common end of hypertension and renal diseases."1.30Effect of cyclooxygenase-2 inhibition on renal function after renal ablation. ( Escalante, B; Ferreri, NR; Salgado, LM; Sanchez, PL, 1999)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's7 (35.00)18.2507
2000's6 (30.00)29.6817
2010's7 (35.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Salas, R1
Lavín, P1
Rincón, Y1
Miranda, J1
López, M1
Pacifici, GM1
Waeckel, L1
Bertin, F1
Clavreul, N1
Damery, T1
Köhler, R1
Paysant, J1
Sansilvestri-Morel, P1
Simonet, S1
Vayssettes-Courchay, C1
Wulff, H1
Verbeuren, TJ1
Félétou, M1
Sivanandan, S2
Agarwal, R1
Prescott, S1
Keim-Malpass, J1
Jegatheesan, P1
Ianus, V1
Buchh, B1
Yoon, G1
Chorne, N1
Ewig, A1
Lin, E1
Fields, S1
Moon-Grady, A1
Tacy, T1
Milstein, J1
Schreiber, M1
Padbury, J1
Clyman, R1
Heo, MJ1
Lee, OS1
Lim, SC1
Bali, V1
Soraisham, AS1
Harabor, A1
Kamaluddeen, M1
Barrington, K1
Brion, LP1
Kömhoff, M1
Tekesin, I1
Peters, M1
Leonhard, A1
Seyberth, HW1
van der Heijden, BJ1
Carlus, C1
Narcy, F1
Bavoux, F3
Delezoide, AL1
Gubler, MC1
Nishikubo, T1
Takahashi, Y1
Nakagawa, Y1
Kawaguchi, C1
Nakajima, M1
Ichijo, M1
Yoshioka, A1
Agnoli, GC1
Borgatti, R1
Cacciari, M1
Ikonomu, E1
Lenzi, P1
Marinelli, M1
Jacqz-Aigrain, E1
Guillonneau, M1
Boissinot, C1
Hartmann, JF1
Blot, P1
Wong, F1
Massie, D1
Hsu, P1
Dudley, F1
Sanchez, PL1
Salgado, LM1
Ferreri, NR1
Escalante, B2
Cuzzolin, L1
Dal Cerè, M1
Fanos, V1
Bautista, R1
Sánchez, A1
Hernández, J1
Oyekan, A1
Monasterolo, LA1
Ochoa, JE1
Elías, MM1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Combination of Acetaminophen and Ibuprofen in the Management of Patent Ductus Arteriosus in Premature Infants: A Pilot Study[NCT03103022]Phase 120 participants (Actual)Interventional2017-06-12Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

6 reviews available for indomethacin and Renal Insufficiency

ArticleYear
Clinical pharmacology of indomethacin in preterm infants: implications in patent ductus arteriosus closure.
    Paediatric drugs, 2013, Volume: 15, Issue:5

    Topics: Age Factors; Anti-Inflammatory Agents, Non-Steroidal; Blood Flow Velocity; Ductus Arteriosus, Patent

2013
Pharmacological Closure of Patent Ductus Arteriosus: Selecting the Agent and Route of Administration.
    Paediatric drugs, 2016, Volume: 18, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Decision Making; Drug Administra

2016
Patent Ductus Arteriosus in the Preterm Infant: Diagnostic and Treatment Options.
    Advances in neonatal care : official journal of the National Association of Neonatal Nurses, 2017, Volume: 17, Issue:1

    Topics: Biomarkers; Cardiac Catheterization; Conservative Treatment; Cyclooxygenase Inhibitors; Ductus Arter

2017
Dopamine versus no treatment to prevent renal dysfunction in indomethacin-treated preterm newborn infants.
    The Cochrane database of systematic reviews, 2002, Issue:3

    Topics: Cardiovascular Agents; Dopamine; Ductus Arteriosus, Patent; Humans; Indomethacin; Infant, Newborn; I

2002
NSAID-induced nephrotoxicity from the fetus to the child.
    Drug safety, 2001, Volume: 24, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Ductus Arteriosus, Patent; Female;

2001
[Fetal toxicity of non-steroidal anti-inflammatory agents].
    Presse medicale (Paris, France : 1983), 1992, Nov-28, Volume: 21, Issue:40

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Fetal Diseases; Heart Failure; Humans; Indomethacin

1992

Trials

1 trial available for indomethacin and Renal Insufficiency

ArticleYear
Increased indomethacin dosing for persistent patent ductus arteriosus in preterm infants: a multicenter, randomized, controlled trial.
    The Journal of pediatrics, 2008, Volume: 153, Issue:2

    Topics: Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Ductus Arteriosus, Patent; Echocardiogr

2008

Other Studies

13 other studies available for indomethacin and Renal Insufficiency

ArticleYear
[Digestive and Kidney Complications by indomethacin and ibuprofen in extreme preterm infants with patent ductus arteriosus].
    Revista chilena de pediatria, 2017, Volume: 88, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Ductus Arteriosus, Patent; Enterocolitis; Female; Humans; I

2017
Preserved regulation of renal perfusion pressure by small and intermediate conductance KCa channels in hypertensive mice with or without renal failure.
    Pflugers Archiv : European journal of physiology, 2015, Volume: 467, Issue:4

    Topics: Angiotensinogen; Animals; Endothelium, Vascular; Female; Humans; Hypertension, Renovascular; Indomet

2015
Comparative evaluation for the use of oral ibuprofen and intravenous indomethacin in Korean infants with patent ductus.
    Archives of pharmacal research, 2012, Volume: 35, Issue:9

    Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Comorbidity; Ductus Arteriosus, Paten

2012
Effectiveness and safety of indomethacin versus ibuprofen for the treatment of patent ductus arteriosus in preterm infants.
    American journal of perinatology, 2013, Volume: 30, Issue:9

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Ductus Arteriosus, Patent; Enterocolitis, Necrotizing; Fema

2013
Perinatal management of a preterm neonate affected by hyperprostaglandin E2 syndrome (HPS).
    Acta paediatrica (Oslo, Norway : 1992), 2005, Volume: 94, Issue:11

    Topics: Bartter Syndrome; Cyclooxygenase Inhibitors; Female; Humans; Indomethacin; Infant, Newborn; Perinata

2005
Persistent anuria, neonatal death, and renal microcystic lesions after prenatal exposure to indomethacin.
    American journal of obstetrics and gynecology, 1994, Volume: 171, Issue:3

    Topics: Adult; Anuria; Dilatation, Pathologic; Female; Fetal Death; Humans; Immunohistochemistry; Indomethac

1994
Renal impairment in very low birthweight infants following antenatal indomethacin administration.
    Acta paediatrica Japonica : Overseas edition, 1994, Volume: 36, Issue:2

    Topics: Adult; Female; Humans; Indomethacin; Infant, Low Birth Weight; Infant, Newborn; Male; Maternal-Fetal

1994
Effects of angiotensin-converting enzyme inhibition on renal dysfunction induced by moderate potassium depletion in healthy women.
    Clinical physiology (Oxford, England), 1994, Volume: 14, Issue:2

    Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Enalapril; Female; Humans; Indomethacin; Kidney Fun

1994
[Maternal and neonatal effects of indomethacin administrated during pregnancy. Apropos of 18 cases].
    Archives francaises de pediatrie, 1993, Volume: 50, Issue:4

    Topics: Adult; Female; Humans; Indomethacin; Infant, Newborn; Male; Obstetric Labor, Premature; Polyhydramni

1993
The effect of misoprostol on indomethacin-induced renal dysfunction in well-compensated cirrhosis.
    Journal of hepatology, 1995, Volume: 23, Issue:1

    Topics: Administration, Oral; Aged; Anti-Inflammatory Agents, Non-Steroidal; Drug Interactions; Drug Therapy

1995
Effect of cyclooxygenase-2 inhibition on renal function after renal ablation.
    Hypertension (Dallas, Tex. : 1979), 1999, Volume: 34, Issue:4 Pt 2

    Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors;

1999
Angiotensin II type AT(2) receptor mRNA expression and renal vasodilatation are increased in renal failure.
    Hypertension (Dallas, Tex. : 1979), 2001, Volume: 38, Issue:3 Pt 2

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 5,8,11,14-Eicosatetraynoic Acid;

2001
Rat renal function four days after bile-duct ligation: effects of indomethacin and vasoactive agents.
    Renal failure, 2002, Volume: 24, Issue:2

    Topics: Animals; Bile Ducts; Cyclooxygenase Inhibitors; Disease Models, Animal; Glomerular Filtration Rate;

2002