indomethacin has been researched along with Renal Artery Obstruction in 14 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Renal Artery Obstruction: Narrowing or occlusion of the RENAL ARTERY or arteries. It is due usually to ATHEROSCLEROSIS; FIBROMUSCULAR DYSPLASIA; THROMBOSIS; EMBOLISM, or external pressure. The reduced renal perfusion can lead to renovascular hypertension (HYPERTENSION, RENOVASCULAR).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The prostaglandin excretion decreased significantly after indomethacin administration both in RAS and in essential hypertension patients." | 5.08 | Prostaglandins and renal function in hypertensive patients with unilateral renal artery stenosis and patients with essential hypertension. ( Cusson, JR; Lambert, R; Larochelle, P; Lebel, M; Milot, A, 1996) |
| " In an attempt to improve the detection rate, indomethacin was administered orally to nine patients with renal artery stenosis (proven by arteriography and by divided ureteric function studies) before rapid-series intravenous urography." | 3.66 | Does inhibition of prostaglandin synthesis increase the diagnostic accuracy of the intravenous urogram in renal artery stenosis? ( Atkinson, AB; Carr, D; Mackay, A, 1981) |
| "To evaluate the effect of prostaglandin inhibition on the renal blood flow of the ischemic kidney, we administered indomethacin to 10 anesthetized dogs with renal artery stenosis and contralateral nephrectomy." | 3.66 | Paradoxical increase of renal blood flow in anesthetized hypertensive dog treated with indomethacin. ( Kedar, A; Moore, R; Murphy, GP; Wajsman, Z; Williams, P, 1979) |
| "The effect of meclofenamate and indomethacin on renal blood flow and renal vascular resistance was determined under basal experimental conditions and during renal ischemia in pentobarbital-anesthetized dogs." | 3.65 | Influence of the renin-angiotensin system on the effect of prostaglandin synthesis inhibitors in the renal vasculature. ( Satoh, S; Zimmerman, BG, 1975) |
| "Renal artery stenosis was produced with a Goldblatt clamp on one renal artery." | 1.26 | The importance of renal prostaglandin synthesis in maintaining renal blood flow and glomerular filtration after renal artery stenosis in the conscious dog. ( Cruze, J; Frölich, JC; Nies, AS; Oates, JA; Rawl, J, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (92.86) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ichikawa, S | 1 |
| Kogure, M | 1 |
| Murata, K | 1 |
| Carr, D | 1 |
| Mackay, A | 1 |
| Atkinson, AB | 1 |
| Milot, A | 1 |
| Lambert, R | 1 |
| Lebel, M | 1 |
| Cusson, JR | 1 |
| Larochelle, P | 1 |
| Kedar, A | 1 |
| Wajsman, Z | 1 |
| Williams, P | 1 |
| Moore, R | 1 |
| Murphy, GP | 1 |
| Nies, AS | 1 |
| Rawl, J | 1 |
| Cruze, J | 1 |
| Oates, JA | 1 |
| Frölich, JC | 1 |
| Spielman, WS | 1 |
| Osswald, H | 1 |
| Altsheler, P | 1 |
| Klahr, S | 1 |
| Rosenbaum, R | 1 |
| Slatopolsky, E | 1 |
| Satoh, S | 1 |
| Zimmerman, BG | 1 |
| Galvez, OG | 1 |
| Roberts, BW | 1 |
| Mishkind, MH | 1 |
| Bay, WH | 1 |
| Ferris, TF | 1 |
| Pamnani, MB | 1 |
| Simon, G | 1 |
| Overbeck, HW | 1 |
| Muirhead, EE | 1 |
| Germain, GS | 1 |
| Armstrong, FB | 1 |
| Brooks, B | 1 |
| Leach, BE | 1 |
| Byers, LW | 1 |
| Pitcock, JA | 1 |
| Brown, P | 1 |
| Pugsley, DJ | 1 |
| Beilin, LJ | 1 |
| Peto, R | 1 |
| Swain, JA | 1 |
| Heyndrickx, GR | 1 |
| Boettcher, DH | 1 |
| Vatner, SF | 1 |
| Herbaczynska-Cedro, K | 1 |
| Vane, JR | 1 |
1 trial available for indomethacin and Renal Artery Obstruction
| Article | Year |
|---|---|
Prostaglandins and renal function in hypertensive patients with unilateral renal artery stenosis and patients with essential hypertension.
Topics: Blood Pressure; Glomerular Filtration Rate; Humans; Hypertension; Indomethacin; Kidney; Kidney Glome | 1996 |
13 other studies available for indomethacin and Renal Artery Obstruction
| Article | Year |
|---|---|
Pressor responses to norepinephrine in rabbits with 3-day renal artery stenosis--the role of prostaglandins.
Topics: Animals; Blood Pressure; Epoprostenol; Indomethacin; Male; Norepinephrine; Prostaglandins E; Rabbits | 1984 |
Does inhibition of prostaglandin synthesis increase the diagnostic accuracy of the intravenous urogram in renal artery stenosis?
Topics: Adolescent; Adult; Humans; Indomethacin; Kidney; Middle Aged; Pilot Projects; Prostaglandins; Radiog | 1981 |
Paradoxical increase of renal blood flow in anesthetized hypertensive dog treated with indomethacin.
Topics: Animals; Blood Pressure; Dogs; Erythropoietin; Female; Hypertension; Indomethacin; Ischemia; Kidney; | 1979 |
The importance of renal prostaglandin synthesis in maintaining renal blood flow and glomerular filtration after renal artery stenosis in the conscious dog.
Topics: Animals; Creatinine; Dogs; Female; Glomerular Filtration Rate; Indomethacin; Kidney; p-Aminohippuric | 1978 |
Characterization of the postocclusive response of renal blood flow in the cat.
Topics: Adenosine; Angiotensin II; Animals; Blood Flow Velocity; Cats; Indomethacin; Ischemia; Kidney; Meclo | 1978 |
Effects of inhibitors of prostaglandin synthesis on renal sodium excretion in normal dogs and dogs with decreased renal mass.
Topics: Administration, Oral; Animals; Diuresis; Dogs; Female; Indomethacin; Meclofenamic Acid; Natriuresis; | 1978 |
Influence of the renin-angiotensin system on the effect of prostaglandin synthesis inhibitors in the renal vasculature.
Topics: Angiotensin II; Animals; Cyclooxygenase Inhibitors; Dogs; Female; Indomethacin; Injections, Intra-Ar | 1975 |
Studies of the mechanism of contralateral polyuria after renal artery stenosis.
Topics: Animals; Blood Pressure; Dogs; Glomerular Filtration Rate; Indomethacin; Polyuria; Prostaglandins E; | 1977 |
Bioassay in vivo for circulating vasoactive agents after renal artery constriction in dogs.
Topics: Animals; Aorta, Abdominal; Blood Gas Analysis; Blood Pressure; Dogs; Electrolytes; Hypertension, Ren | 1976 |
Endocrine-type antihypertensive function of renomedullary interstitial cells.
Topics: Angiotensin II; Animals; Blood Pressure; Cells, Cultured; Connective Tissue; Connective Tissue Cells | 1975 |
Renal prostaglandin synthesis in the Goldblatt hypertensive rat.
Topics: Animals; Blood Pressure; Body Weight; Chromatography, Gas; Drinking; Hypertension, Renal; Indomethac | 1975 |
Prostaglandin control of renal circulation in the unanesthetized dog and baboon.
Topics: Angiotensin II; Animals; Blood Flow Velocity; Blood Pressure; Dogs; Heart Rate; Indomethacin; Kidney | 1975 |
Prostaglandins as mediators of reactive hyperaemia in kidney.
Topics: Animals; Blood Flow Velocity; Dogs; Female; Indomethacin; Kidney; Male; Regional Blood Flow; Renal A | 1974 |