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indomethacin and Renal Artery Obstruction

indomethacin has been researched along with Renal Artery Obstruction in 14 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Renal Artery Obstruction: Narrowing or occlusion of the RENAL ARTERY or arteries. It is due usually to ATHEROSCLEROSIS; FIBROMUSCULAR DYSPLASIA; THROMBOSIS; EMBOLISM, or external pressure. The reduced renal perfusion can lead to renovascular hypertension (HYPERTENSION, RENOVASCULAR).

Research Excerpts

ExcerptRelevanceReference
"The prostaglandin excretion decreased significantly after indomethacin administration both in RAS and in essential hypertension patients."5.08Prostaglandins and renal function in hypertensive patients with unilateral renal artery stenosis and patients with essential hypertension. ( Cusson, JR; Lambert, R; Larochelle, P; Lebel, M; Milot, A, 1996)
" In an attempt to improve the detection rate, indomethacin was administered orally to nine patients with renal artery stenosis (proven by arteriography and by divided ureteric function studies) before rapid-series intravenous urography."3.66Does inhibition of prostaglandin synthesis increase the diagnostic accuracy of the intravenous urogram in renal artery stenosis? ( Atkinson, AB; Carr, D; Mackay, A, 1981)
"To evaluate the effect of prostaglandin inhibition on the renal blood flow of the ischemic kidney, we administered indomethacin to 10 anesthetized dogs with renal artery stenosis and contralateral nephrectomy."3.66Paradoxical increase of renal blood flow in anesthetized hypertensive dog treated with indomethacin. ( Kedar, A; Moore, R; Murphy, GP; Wajsman, Z; Williams, P, 1979)
"The effect of meclofenamate and indomethacin on renal blood flow and renal vascular resistance was determined under basal experimental conditions and during renal ischemia in pentobarbital-anesthetized dogs."3.65Influence of the renin-angiotensin system on the effect of prostaglandin synthesis inhibitors in the renal vasculature. ( Satoh, S; Zimmerman, BG, 1975)
"Renal artery stenosis was produced with a Goldblatt clamp on one renal artery."1.26The importance of renal prostaglandin synthesis in maintaining renal blood flow and glomerular filtration after renal artery stenosis in the conscious dog. ( Cruze, J; Frölich, JC; Nies, AS; Oates, JA; Rawl, J, 1978)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-199013 (92.86)18.7374
1990's1 (7.14)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ichikawa, S1
Kogure, M1
Murata, K1
Carr, D1
Mackay, A1
Atkinson, AB1
Milot, A1
Lambert, R1
Lebel, M1
Cusson, JR1
Larochelle, P1
Kedar, A1
Wajsman, Z1
Williams, P1
Moore, R1
Murphy, GP1
Nies, AS1
Rawl, J1
Cruze, J1
Oates, JA1
Frölich, JC1
Spielman, WS1
Osswald, H1
Altsheler, P1
Klahr, S1
Rosenbaum, R1
Slatopolsky, E1
Satoh, S1
Zimmerman, BG1
Galvez, OG1
Roberts, BW1
Mishkind, MH1
Bay, WH1
Ferris, TF1
Pamnani, MB1
Simon, G1
Overbeck, HW1
Muirhead, EE1
Germain, GS1
Armstrong, FB1
Brooks, B1
Leach, BE1
Byers, LW1
Pitcock, JA1
Brown, P1
Pugsley, DJ1
Beilin, LJ1
Peto, R1
Swain, JA1
Heyndrickx, GR1
Boettcher, DH1
Vatner, SF1
Herbaczynska-Cedro, K1
Vane, JR1

Trials

1 trial available for indomethacin and Renal Artery Obstruction

ArticleYear
Prostaglandins and renal function in hypertensive patients with unilateral renal artery stenosis and patients with essential hypertension.
    Journal of hypertension, 1996, Volume: 14, Issue:6

    Topics: Blood Pressure; Glomerular Filtration Rate; Humans; Hypertension; Indomethacin; Kidney; Kidney Glome

1996

Other Studies

13 other studies available for indomethacin and Renal Artery Obstruction

ArticleYear
Pressor responses to norepinephrine in rabbits with 3-day renal artery stenosis--the role of prostaglandins.
    Japanese circulation journal, 1984, Volume: 48, Issue:11

    Topics: Animals; Blood Pressure; Epoprostenol; Indomethacin; Male; Norepinephrine; Prostaglandins E; Rabbits

1984
Does inhibition of prostaglandin synthesis increase the diagnostic accuracy of the intravenous urogram in renal artery stenosis?
    Clinical radiology, 1981, Volume: 32, Issue:4

    Topics: Adolescent; Adult; Humans; Indomethacin; Kidney; Middle Aged; Pilot Projects; Prostaglandins; Radiog

1981
Paradoxical increase of renal blood flow in anesthetized hypertensive dog treated with indomethacin.
    Urology, 1979, Volume: 14, Issue:3

    Topics: Animals; Blood Pressure; Dogs; Erythropoietin; Female; Hypertension; Indomethacin; Ischemia; Kidney;

1979
The importance of renal prostaglandin synthesis in maintaining renal blood flow and glomerular filtration after renal artery stenosis in the conscious dog.
    Investigative urology, 1978, Volume: 16, Issue:1

    Topics: Animals; Creatinine; Dogs; Female; Glomerular Filtration Rate; Indomethacin; Kidney; p-Aminohippuric

1978
Characterization of the postocclusive response of renal blood flow in the cat.
    The American journal of physiology, 1978, Volume: 235, Issue:4

    Topics: Adenosine; Angiotensin II; Animals; Blood Flow Velocity; Cats; Indomethacin; Ischemia; Kidney; Meclo

1978
Effects of inhibitors of prostaglandin synthesis on renal sodium excretion in normal dogs and dogs with decreased renal mass.
    The American journal of physiology, 1978, Volume: 235, Issue:4

    Topics: Administration, Oral; Animals; Diuresis; Dogs; Female; Indomethacin; Meclofenamic Acid; Natriuresis;

1978
Influence of the renin-angiotensin system on the effect of prostaglandin synthesis inhibitors in the renal vasculature.
    Circulation research, 1975, Volume: 36, Issue:6 Suppl 1

    Topics: Angiotensin II; Animals; Cyclooxygenase Inhibitors; Dogs; Female; Indomethacin; Injections, Intra-Ar

1975
Studies of the mechanism of contralateral polyuria after renal artery stenosis.
    The Journal of clinical investigation, 1977, Volume: 59, Issue:4

    Topics: Animals; Blood Pressure; Dogs; Glomerular Filtration Rate; Indomethacin; Polyuria; Prostaglandins E;

1977
Bioassay in vivo for circulating vasoactive agents after renal artery constriction in dogs.
    Circulation research, 1976, Volume: 39, Issue:4

    Topics: Animals; Aorta, Abdominal; Blood Gas Analysis; Blood Pressure; Dogs; Electrolytes; Hypertension, Ren

1976
Endocrine-type antihypertensive function of renomedullary interstitial cells.
    Kidney international. Supplement, 1975

    Topics: Angiotensin II; Animals; Blood Pressure; Cells, Cultured; Connective Tissue; Connective Tissue Cells

1975
Renal prostaglandin synthesis in the Goldblatt hypertensive rat.
    Circulation research, 1975, Volume: 36, Issue:6 Suppl 1

    Topics: Animals; Blood Pressure; Body Weight; Chromatography, Gas; Drinking; Hypertension, Renal; Indomethac

1975
Prostaglandin control of renal circulation in the unanesthetized dog and baboon.
    The American journal of physiology, 1975, Volume: 229, Issue:3

    Topics: Angiotensin II; Animals; Blood Flow Velocity; Blood Pressure; Dogs; Heart Rate; Indomethacin; Kidney

1975
Prostaglandins as mediators of reactive hyperaemia in kidney.
    Nature, 1974, Feb-15, Volume: 247, Issue:5441

    Topics: Animals; Blood Flow Velocity; Dogs; Female; Indomethacin; Kidney; Male; Regional Blood Flow; Renal A

1974