indomethacin has been researched along with Pyloric Stenosis in 2 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Pyloric Stenosis: Narrowing of the pyloric canal with varied etiology. A common form is due to muscle hypertrophy (PYLORIC STENOSIS, HYPERTROPHIC) seen in infants.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Early postnatal steroids and indomethacin in combination have been shown to increase the risk of spontaneous intestinal perforation (SIP) in infants with extremely low birth weight (ELBW), but the mechanism behind this synergistic effect is unknown." | 7.74 | A neonatal mouse model of intestinal perforation: investigating the harmful synergism between glucocorticoids and indomethacin. ( Aschner, JL; Gaston, BM; Gordon, PV; Herman, AC; Laubach, VE; Marcinkiewicz, M, 2007) |
| "The effects of 4-week indomethacin administration (1mg/kg/day, orally) on gastrin cell (G-cell), somatostatin cell (D-cell) and prostaglandin E2 (PGE2) of gastric mucosa were examined in pyloric stenosis rats." | 7.68 | [Effect of indomethacin on endocrine kinetics of the stomach in experimental pyloric stenosis model]. ( Omura, N, 1993) |
| "Early postnatal steroids and indomethacin in combination have been shown to increase the risk of spontaneous intestinal perforation (SIP) in infants with extremely low birth weight (ELBW), but the mechanism behind this synergistic effect is unknown." | 3.74 | A neonatal mouse model of intestinal perforation: investigating the harmful synergism between glucocorticoids and indomethacin. ( Aschner, JL; Gaston, BM; Gordon, PV; Herman, AC; Laubach, VE; Marcinkiewicz, M, 2007) |
| "The effects of 4-week indomethacin administration (1mg/kg/day, orally) on gastrin cell (G-cell), somatostatin cell (D-cell) and prostaglandin E2 (PGE2) of gastric mucosa were examined in pyloric stenosis rats." | 3.68 | [Effect of indomethacin on endocrine kinetics of the stomach in experimental pyloric stenosis model]. ( Omura, N, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gordon, PV | 1 |
| Herman, AC | 1 |
| Marcinkiewicz, M | 1 |
| Gaston, BM | 1 |
| Laubach, VE | 1 |
| Aschner, JL | 1 |
| Omura, N | 1 |
2 other studies available for indomethacin and Pyloric Stenosis
| Article | Year |
|---|---|
A neonatal mouse model of intestinal perforation: investigating the harmful synergism between glucocorticoids and indomethacin.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Dexamethasone | 2007 |
[Effect of indomethacin on endocrine kinetics of the stomach in experimental pyloric stenosis model].
Topics: Administration, Oral; Animals; Disease Models, Animal; Gastric Mucosa; Gastrins; Indomethacin; Male; | 1993 |