indomethacin has been researched along with Pulmonary Fibrosis in 18 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Pulmonary Fibrosis: A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have shown in a previous study that indomethacin reduced breathlessness in normal subjects during exercise." | 9.06 | The effect of indomethacin on breathlessness in patients with diffuse parenchymal disease of the lung. ( Ellis, SH; O'Neill, PA; Stark, RD; Stretton, TB, 1986) |
| "The purpose of this study was to examine whether development of pulmonary fibrosis in mice could be influenced by indomethacin, prednisolone or a proline analog." | 7.66 | The effect of indomethacin, prednisolone and cis-4-hydroxyproline on pulmonary fibrosis produced by butylated hydroxytoluene and oxygen. ( Kehrer, JP; Witschi, H, 1981) |
| "A model for pulmonary fibrosis in the rat has been developed using intratracheal administration of bleomycin." | 5.26 | Bleomycin-induced pulmonary fibrosis in the rat: inhibition by indomethacin. ( Jack, RM; McCormick, JR; McReynolds, RA; Thrall, RS; Ward, PA, 1979) |
| "We have shown in a previous study that indomethacin reduced breathlessness in normal subjects during exercise." | 5.06 | The effect of indomethacin on breathlessness in patients with diffuse parenchymal disease of the lung. ( Ellis, SH; O'Neill, PA; Stark, RD; Stretton, TB, 1986) |
| "The purpose of this study was to examine whether development of pulmonary fibrosis in mice could be influenced by indomethacin, prednisolone or a proline analog." | 3.66 | The effect of indomethacin, prednisolone and cis-4-hydroxyproline on pulmonary fibrosis produced by butylated hydroxytoluene and oxygen. ( Kehrer, JP; Witschi, H, 1981) |
| "To characterize the role of GM-CSF in pulmonary fibrosis, we have studied bleomycin-induced fibrosis in wild-type mice vs mice with a targeted deletion of the GM-CSF gene (GM-CSF-/- mice)." | 1.31 | GM-CSF regulates bleomycin-induced pulmonary fibrosis via a prostaglandin-dependent mechanism. ( Christensen, P; Coffey, MJ; McDonald, R; Moore, BB; Ngan, R; Paine, R; Peters-Golden, M; Phare, SM; Sitterding, S; Toews, GB; Wilke, CA, 2000) |
| "However, in patients with pulmonary fibrosis, PGE(2) levels are decreased." | 1.31 | Cyclooxygenase-2 deficiency results in a loss of the anti-proliferative response to transforming growth factor-beta in human fibrotic lung fibroblasts and promotes bleomycin-induced pulmonary fibrosis in mice. ( Booth, H; Foster, ML; Harrison, NK; Hart, SL; Hernandez-Rodriguez, NA; Jenkins, RG; Keerthisingam, CB; Laurent, GJ; McAnulty, RJ, 2001) |
| "In order to clarify the mechanism of pulmonary fibrosis, we examined the functional changes of lung fibroblasts in bleomycin (BLM)-induced pulmonary fibrosis." | 1.30 | Decreased prostaglandin E2 synthesis by lung fibroblasts isolated from rats with bleomycin-induced lung fibrosis. ( Asada, K; Endo, T; Kawano, T; Maniwa, K; Ogushi, F; Sone, S; Tada, H; Tani, K, 1999) |
| "Histological examination revealed fibrosing alveolitis in the BLM-treated group which was markedly suppressed in the combination group." | 1.28 | Prevention of bleomycin-induced fibrosing alveolitis with indomethacin: stereological studies on rat lungs. ( Burkhardt, A; Mall, G; Otto, HF; Siemens, I; Zimmermann, P, 1991) |
| "Pulmonary fibrosis is characterized by an alteration in lung collagen synthesis and deposition, as well as by increased fibroblast proliferation." | 1.27 | Alveolar macrophage/peripheral blood monocyte-derived factors modulate proliferation of primary lines of human lung fibroblasts. ( Gauldie, J; Jordana, M; Newhouse, MT, 1987) |
| "A model for pulmonary fibrosis in the rat has been developed using intratracheal administration of bleomycin." | 1.26 | Bleomycin-induced pulmonary fibrosis in the rat: inhibition by indomethacin. ( Jack, RM; McCormick, JR; McReynolds, RA; Thrall, RS; Ward, PA, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (55.56) | 18.7374 |
| 1990's | 5 (27.78) | 18.2507 |
| 2000's | 3 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hakkinen, PJ | 1 |
| Schmoyer, RL | 1 |
| Witschi, HP | 1 |
| Auletta, M | 1 |
| Usberti, M | 1 |
| Antoniello, S | 1 |
| Stanziale, P | 1 |
| Kehrer, JP | 1 |
| Witschi, H | 1 |
| Marrakchi, H | 1 |
| Fazaa, B | 1 |
| Gorgi, Y | 1 |
| Jellouli, A | 1 |
| Mokhtar, I | 1 |
| Kamoun, MR | 1 |
| Ogushi, F | 1 |
| Endo, T | 1 |
| Tani, K | 1 |
| Asada, K | 1 |
| Kawano, T | 1 |
| Tada, H | 1 |
| Maniwa, K | 1 |
| Sone, S | 1 |
| Moore, BB | 1 |
| Coffey, MJ | 1 |
| Christensen, P | 1 |
| Sitterding, S | 1 |
| Ngan, R | 1 |
| Wilke, CA | 1 |
| McDonald, R | 1 |
| Phare, SM | 1 |
| Peters-Golden, M | 1 |
| Paine, R | 1 |
| Toews, GB | 1 |
| Keerthisingam, CB | 1 |
| Jenkins, RG | 1 |
| Harrison, NK | 1 |
| Hernandez-Rodriguez, NA | 1 |
| Booth, H | 1 |
| Laurent, GJ | 1 |
| Hart, SL | 1 |
| Foster, ML | 1 |
| McAnulty, RJ | 1 |
| Vancheri, C | 1 |
| Mastruzzo, C | 1 |
| Tomaselli, V | 1 |
| Sortino, MA | 1 |
| D'Amico, L | 1 |
| Bellistrí, G | 1 |
| Pistorio, MP | 1 |
| Salinaro, ET | 1 |
| Palermo, F | 1 |
| Mistretta, A | 1 |
| Crimi, N | 1 |
| Thrall, RS | 1 |
| McCormick, JR | 1 |
| Jack, RM | 1 |
| McReynolds, RA | 1 |
| Ward, PA | 1 |
| Meier-Sydow, J | 1 |
| Mitrou, PS | 1 |
| Mall, G | 1 |
| Zimmermann, P | 1 |
| Siemens, I | 1 |
| Burkhardt, A | 1 |
| Otto, HF | 1 |
| Taganovich, AD | 1 |
| Ozaki, T | 1 |
| Moriguchi, H | 1 |
| Nakamura, Y | 1 |
| Kamei, T | 1 |
| Yasuoka, S | 1 |
| Ogura, T | 1 |
| Clark, JG | 1 |
| Greenberg, J | 1 |
| Fireman, E | 1 |
| Ben Efraim, S | 1 |
| Greif, J | 1 |
| Alguetti, A | 1 |
| Ayalon, D | 1 |
| Topilsky, M | 1 |
| Heppleston, AG | 1 |
| Jordana, M | 1 |
| Newhouse, MT | 1 |
| Gauldie, J | 1 |
| O'Neill, PA | 1 |
| Stretton, TB | 1 |
| Stark, RD | 1 |
| Ellis, SH | 1 |
2 reviews available for indomethacin and Pulmonary Fibrosis
| Article | Year |
|---|---|
[Antiphospholipid antibodies and systemic scleroderma. Apropos of a case with review of the literature].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Antiphospholipid; Antiphospholipid Syndrome; Ar | 1995 |
[Treatment of auto-immune diseases with special reference to their pulmonary manifestations (author's transl)].
Topics: Adrenal Cortex Hormones; Anti-Glomerular Basement Membrane Disease; Anti-Inflammatory Agents; Antine | 1979 |
1 trial available for indomethacin and Pulmonary Fibrosis
| Article | Year |
|---|---|
The effect of indomethacin on breathlessness in patients with diffuse parenchymal disease of the lung.
Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Dyspnea; Exercise Test; Female; Forced E | 1986 |
15 other studies available for indomethacin and Pulmonary Fibrosis
| Article | Year |
|---|---|
Potentiation of butylated-hydroxytoluene-induced acute lung damage by oxygen. Effects of prednisolone and indomethacin.
Topics: Animals; Butylated Hydroxytoluene; Hydroxyproline; Indomethacin; Lung; Male; Mice; Mice, Inbred BALB | 1983 |
[Membranoproliferative glomerulonephritis as an unusual initial manifestation in a case of plasmacytoma].
Topics: Bence Jones Protein; Glomerulonephritis; Humans; Indomethacin; Male; Middle Aged; Plasmacytoma; Pulm | 1984 |
The effect of indomethacin, prednisolone and cis-4-hydroxyproline on pulmonary fibrosis produced by butylated hydroxytoluene and oxygen.
Topics: Animals; Butylated Hydroxytoluene; Collagen; Hydroxyproline; Indomethacin; Male; Mice; Mice, Inbred | 1981 |
Decreased prostaglandin E2 synthesis by lung fibroblasts isolated from rats with bleomycin-induced lung fibrosis.
Topics: Animals; Bleomycin; Cell Culture Techniques; Cell Division; Cyclooxygenase 2; Dinoprostone; Fibrobla | 1999 |
GM-CSF regulates bleomycin-induced pulmonary fibrosis via a prostaglandin-dependent mechanism.
Topics: Animals; Bleomycin; Cell Division; Dinoprostone; Drug Administration Schedule; Granulocyte-Macrophag | 2000 |
Cyclooxygenase-2 deficiency results in a loss of the anti-proliferative response to transforming growth factor-beta in human fibrotic lung fibroblasts and promotes bleomycin-induced pulmonary fibrosis in mice.
Topics: Bleomycin; Cell Division; Cell Line; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors | 2001 |
Normal human lung fibroblasts differently modulate interleukin-10 and interleukin-12 production by monocytes: implications for an altered immune response in pulmonary chronic inflammation.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; CD40 Antigens; Cell Communication; Cells, Cultured; | 2001 |
Bleomycin-induced pulmonary fibrosis in the rat: inhibition by indomethacin.
Topics: Animals; Bleomycin; Capillary Permeability; Collagen; Cricetinae; Eosinophils; Indomethacin; Leukocy | 1979 |
Prevention of bleomycin-induced fibrosing alveolitis with indomethacin: stereological studies on rat lungs.
Topics: Animals; Bleomycin; Female; Indomethacin; Lung; Pulmonary Fibrosis; Rats | 1991 |
[Surfactant-inducted suppressive action on fibroblasts of pulmonary macrophages from rats with fibrosis after intratracheal administration of bleomycin].
Topics: Animals; Bleomycin; Cell Division; Cells, Cultured; Fibroblasts; Indomethacin; Macrophages, Alveolar | 1991 |
Regulatory effect of prostaglandin E2 on fibronectin release from human alveolar macrophages.
Topics: Adult; Bronchoalveolar Lavage Fluid; Cell Count; Cells, Cultured; Dinoprostone; Female; Fibronectins | 1990 |
Modulation of the effects of alveolar macrophages on lung fibroblast collagen production rate.
Topics: Animals; Bleomycin; Cells, Cultured; Collagen; Cricetinae; Dinoprostone; Fibroblasts; Humans; Hydrox | 1987 |
Suppressive activity of alveolar macrophages and blood monocytes from interstitial lung diseases: role of released soluble factors.
Topics: Adult; Dinoprostone; Female; Humans; Immune Tolerance; Indomethacin; Interleukins; Lymphocyte Activa | 1989 |
Determinants of pulmonary fibrosis and lipidosis in the silica model.
Topics: Animals; Cell Membrane; Diphenylacetic Acids; Dose-Response Relationship, Drug; Guinea Pigs; Indomet | 1986 |
Alveolar macrophage/peripheral blood monocyte-derived factors modulate proliferation of primary lines of human lung fibroblasts.
Topics: Biological Products; Cell Division; Cell Line; Cytokines; Dinoprostone; Fibroblasts; Humans; Indomet | 1987 |