Page last updated: 2024-10-29

indomethacin and Pulmonary Arterial Remodeling

indomethacin has been researched along with Pulmonary Arterial Remodeling in 4 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Research Excerpts

ExcerptRelevanceReference
" In this study, PVR was induced in pups in utero by exposure of pregnant dams to indomethacin and hypoxia and cardiac lipids, echocardiographic function and cardiomyocyte mitochondrial function were subsequently examined."4.12Altered cardiolipin metabolism is associated with cardiac mitochondrial dysfunction in pulmonary vascular remodeled perinatal rat pups. ( Cole, LK; Dolinsky, VW; Hatch, GM; Sparagna, GC, 2022)
"CSA hypertension was associated with renal perivascular fibrosis and divergent changes in immunohistochemical signals of renal arteriolar ETA (increases) and ETB (decreases) receptors."1.42Celecoxib, but not indomethacin, ameliorates the hypertensive and perivascular fibrotic actions of cyclosporine in rats: role of endothelin signaling. ( Ali, RM; El-Gowelli, HM; El-Mas, MM; Helmy, MW, 2015)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (75.00)24.3611
2020's1 (25.00)2.80

Authors

AuthorsStudies
Cole, LK1
Sparagna, GC1
Dolinsky, VW1
Hatch, GM1
Westergren-Thorsson, G1
Bagher, M1
Andersson-Sjöland, A1
Thiman, L1
Löfdahl, CG1
Hallgren, O1
Bjermer, L1
Larsson-Callerfelt, AK1
El-Mas, MM1
Helmy, MW1
Ali, RM1
El-Gowelli, HM1
Perez-Ternero, C1
Rodriguez-Rodriguez, R1
Herrera, MD1
Alvarez de Sotomayor, M1

Other Studies

4 other studies available for indomethacin and Pulmonary Arterial Remodeling

ArticleYear
Altered cardiolipin metabolism is associated with cardiac mitochondrial dysfunction in pulmonary vascular remodeled perinatal rat pups.
    PloS one, 2022, Volume: 17, Issue:2

    Topics: Animals; Animals, Newborn; Cardiolipins; Disease Models, Animal; Female; Hypoxia; Indomethacin; Mito

2022
VEGF synthesis is induced by prostacyclin and TGF-β in distal lung fibroblasts from COPD patients and control subjects: Implications for pulmonary vascular remodelling.
    Respirology (Carlton, Vic.), 2018, Volume: 23, Issue:1

    Topics: Aged; Biglycan; Cell Movement; Cell Proliferation; Cells, Cultured; Cyclooxygenase Inhibitors; Fibro

2018
Celecoxib, but not indomethacin, ameliorates the hypertensive and perivascular fibrotic actions of cyclosporine in rats: role of endothelin signaling.
    Toxicology and applied pharmacology, 2015, Apr-01, Volume: 284, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Celecoxib; Cyclosporine; Cytoprote

2015
Diet supplementation with rice bran enzymatic extract restores endothelial impairment and wall remodelling of ApoE(-/-) mice microvessels.
    Atherosclerosis, 2016, Volume: 250

    Topics: Animals; Apamin; Arteries; Charybdotoxin; Collagen; Dietary Supplements; Elastin; Endothelium, Vascu

2016