indomethacin has been researched along with Primary Ovarian Insufficiency in 1 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Primary Ovarian Insufficiency: Cessation of ovarian function after MENARCHE but before the age of 40, without or with OVARIAN FOLLICLE depletion. It is characterized by the presence of OLIGOMENORRHEA or AMENORRHEA, elevated GONADOTROPINS, and low ESTRADIOL levels. It is a state of female HYPERGONADOTROPIC HYPOGONADISM. Etiologies include genetic defects, autoimmune processes, chemotherapy, radiation, and infections. The most commonly known genetic cause is the expansion of a CGG repeat to 55 to 199 copies in the 5' untranslated region in the X-linked FMR1 gene.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Menopause is the permanent cessation of menstruation that results from depletion of ovarian germ cells and follicles." | 1.39 | Cyclooxygenase-1 inhibition prolongs postnatal ovarian follicle lifespan in mice. ( Cai, KQ; Smedberg, J; Smith, ER; Xu, XX; Yang, WL; Yeasky, T, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Smith, ER | 1 |
| Yang, WL | 1 |
| Yeasky, T | 1 |
| Smedberg, J | 1 |
| Cai, KQ | 1 |
| Xu, XX | 1 |
1 other study available for indomethacin and Primary Ovarian Insufficiency
| Article | Year |
|---|---|
Cyclooxygenase-1 inhibition prolongs postnatal ovarian follicle lifespan in mice.
Topics: Aging; Animals; Celecoxib; Crosses, Genetic; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 In | 2013 |