Page last updated: 2024-10-29

indomethacin and Preterm Birth

indomethacin has been researched along with Preterm Birth in 44 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Research Excerpts

ExcerptRelevanceReference
"Our aim was to estimate if indomethacin therapy prevents preterm birth (PTB) in women with a short cervical length (CL) on transvaginal ultrasound (TVU)."8.83Short cervix on ultrasound: does indomethacin prevent preterm birth? ( Althuisius, SM; Berghella, V; Rust, OA, 2006)
"To evaluate the efficacy of long-term indomethacin therapy (LIT) in prolonging pregnancy and reducing spontaneous preterm birth (PTB) in patients undergoing fetoscopic laser surgery (FLS) for the management of twin-to-twin transfusion syndrome (TTTS)."8.12Efficacy of long-term indomethacin therapy in prolonging pregnancy after fetoscopic laser surgery for twin-to-twin transfusion syndrome: a collaborative cohort study. ( Belfort, MA; Cortes, MS; Donepudi, R; Espinoza, J; Harman, C; Krispin, E; Mustafa, HJ; Nassr, AA; Pederson, N; Shamshirsaz, AA; Tadbiri, H; Turan, OM, 2022)
"We sought to estimate the effect of indomethacin on duration of pregnancy in women with dilated cervix between 14 (0)/ (7) to 25 (6)/ (7) weeks."7.75Does indomethacin prevent preterm birth in women with cervical dilatation in the second trimester? ( Berghella, V; Chaithongwongwatthana, S; Cotter, A; Gomez, R; Kearney, E; Mittal, S; Pereira, L; Prasertcharoensuk, W; Rasanen, J; Tolosa, JE, 2009)
"The purpose of this study was to estimate the effect of indomethacin on the prevention of preterm birth (PTB) in women with an ultrasound-indicated cerclage."7.74Indomethacin administration at the time of ultrasound-indicated cerclage: is there an association with a reduction in spontaneous preterm birth? ( Airoldi, J; Berghella, V; Visintine, J, 2008)
"Preterm birth is the most common cause of neonatal morbidity and mortality."7.01The effectiveness of nifedipine/indomethacin combination therapy and nifedipine monotherapy for postponing preterm birth (25-34 weeks of gestation) in Sudanese women: a randomized clinical trial study protocol. ( Abdelrahiem, SK; Adam, I; Elfaki, T; Elhassan, EM; Ibrahim, MH, 2021)
"In women with twin pregnancies and asymptomatic cervical dilation before 24 weeks of gestation, a combination of physical examination-indicated cerclage, indomethacin, and antibiotics significantly decreased preterm birth at all evaluated gestational ages."5.34Physical examination-indicated cerclage in twin pregnancy: a randomized controlled trial. ( Berghella, V; Colihan, S; Gimovsky, AC; Haeri, S; Roman, A; Saccone, G; Schoen, CN; Seligman, NS; Zelig, C; Zork, N; Zullo, F, 2020)
"Nifedipine may be better for delayed delivery and less likely to produce adverse pregnancy outcomes, followed by indomethacin."5.22Four kinds of tocolytic therapy for preterm delivery: Systematic review and network meta-analysis. ( Pei, S; Xiong, Z; Zhu, Z, 2022)
" Moderate certainty evidence showed a reduction in NEC following administration of a combination of species of probiotics, probiotics (any), antenatal corticosteroids in pregnant women at risk of preterm birth, and ibuprofen versus indomethacin for treatment of patent ductus arteriosus (PDA)."5.05An Overview of Systematic Reviews of Randomized-Controlled Trials for Preventing Necrotizing Enterocolitis in Preterm Infants. ( Ei-Saie, A; Maheshwari, A; Neu, J; Pammi, M; Xiong, T, 2020)
"Our aim was to estimate if indomethacin therapy prevents preterm birth (PTB) in women with a short cervical length (CL) on transvaginal ultrasound (TVU)."4.83Short cervix on ultrasound: does indomethacin prevent preterm birth? ( Althuisius, SM; Berghella, V; Rust, OA, 2006)
"This study aimed to estimate whether a combination of ultrasound-indicated cerclage, indomethacin, and antibiotics in twin pregnancies between 18 and 26 weeks' gestation could extend the pregnancy, reduce the risk for spontaneous preterm birth, and improve perinatal and neonatal outcomes."4.31Efficacy of ultrasound-indicated cerclage in twin pregnancies: a retrospective case-control study matched by cervical length. ( Chen, C; Li, J; Luo, Q; Lv, M; Qiu, L; Zhao, B, 2023)
"To evaluate the efficacy of long-term indomethacin therapy (LIT) in prolonging pregnancy and reducing spontaneous preterm birth (PTB) in patients undergoing fetoscopic laser surgery (FLS) for the management of twin-to-twin transfusion syndrome (TTTS)."4.12Efficacy of long-term indomethacin therapy in prolonging pregnancy after fetoscopic laser surgery for twin-to-twin transfusion syndrome: a collaborative cohort study. ( Belfort, MA; Cortes, MS; Donepudi, R; Espinoza, J; Harman, C; Krispin, E; Mustafa, HJ; Nassr, AA; Pederson, N; Shamshirsaz, AA; Tadbiri, H; Turan, OM, 2022)
" We evaluated the ability of oxytocin receptor-targeted liposomes to localize to uterine tissue in vivo, and assessed if targeted liposomes loaded with indomethacin were capable of preventing lipopolysaccharide-induced preterm birth in mice."3.85Drug delivery to the human and mouse uterus using immunoliposomes targeted to the oxytocin receptor. ( Butler, T; Hua, S; Ilicic, M; Paul, JW; Robertson, S; Smith, R; Tolosa, JM, 2017)
" Magnesium sulfate administration, steroid administration, maternal diabetes mellitus, gestational age at delivery, indomethacin exposure, birthweight, and chorioamnionitis were all considered as possible covariates in the multivariable regression models."3.83Effect of obesity on neonatal outcomes in pregnancies with preterm premature rupture of membranes. ( DeWitt, PE; Faucett, AM; Gibbs, RS; Metz, TD, 2016)
"In the present study, we evaluated the therapeutic value of indomethacin (IDM) and dexamethasone (DXS) on reducing the preterm birth rate in experimental goats after IUBAV."3.78Protective effects of indomethacin and dexamethasone in a goat model with intrauterine balloon aortic valvuloplasty. ( Hua, Y; Huang, X; Li, Y; Mu, D; Wu, G; Zhao, L; Zhou, K; Zhou, R; Zhu, Q, 2012)
"We sought to estimate the effect of indomethacin on duration of pregnancy in women with dilated cervix between 14 (0)/ (7) to 25 (6)/ (7) weeks."3.75Does indomethacin prevent preterm birth in women with cervical dilatation in the second trimester? ( Berghella, V; Chaithongwongwatthana, S; Cotter, A; Gomez, R; Kearney, E; Mittal, S; Pereira, L; Prasertcharoensuk, W; Rasanen, J; Tolosa, JE, 2009)
"The purpose of this study was to estimate the effect of indomethacin on the prevention of preterm birth (PTB) in women with an ultrasound-indicated cerclage."3.74Indomethacin administration at the time of ultrasound-indicated cerclage: is there an association with a reduction in spontaneous preterm birth? ( Airoldi, J; Berghella, V; Visintine, J, 2008)
"Preterm birth is the most common cause of neonatal morbidity and mortality."3.01The effectiveness of nifedipine/indomethacin combination therapy and nifedipine monotherapy for postponing preterm birth (25-34 weeks of gestation) in Sudanese women: a randomized clinical trial study protocol. ( Abdelrahiem, SK; Adam, I; Elfaki, T; Elhassan, EM; Ibrahim, MH, 2021)
"Indomethacin was less effective than nifedipine for the fast treatment of preterm labor."2.76Comparison of the efficacy and adverse effects of nifedipine and indomethacin for the treatment of preterm labor. ( Bahasadri, S; Kashanian, M; Zolali, B, 2011)
" In an attempt to prevent PTB in singleton pregnancies, cervical cerclage, in combination with other treatments, has been advocated."2.66Cervical stitch (cerclage) in combination with other treatments for preventing spontaneous preterm birth in singleton pregnancies. ( Eke, AC; Eleje, GU; Ezebialu, IU; Ikechebelu, JI; Ilika, CP; Okam, PC, 2020)
"Preterm birth is a major cause of perinatal mortality and morbidity."2.52Cyclo-oxygenase (COX) inhibitors for treating preterm labour. ( Dos Santos, RA; Flenady, V; Kumar, S; Pileggi-Castro, C; Reinebrant, HE; Romero, CL; Souza, JP, 2015)
"Preterm birth is associated with increased mortality and morbidity."1.62The relationship between antenatal indomethacin as a tocolytic drug and neonatal outcomes: a retrospective cohort study. ( Dieleman, JP; Janssen, LCE; Lingius, S; Niemarkt, HJ; Rovers, JFJ; Thomissen, IJC; van Runnard Heimel, PJ; Wieland, BV, 2021)
"Indomethacin has been administered for longer durations to prolong gestation in extreme prematurity."1.43Perinatal Outcomes after Short versus Prolonged Indomethacin for Tocolysis in Women with Preterm Labor. ( Behnia, F; Costantine, M; Dutta, EH; Harirah, H; Saade, G, 2016)
"Treatment with ibuprofen is safer, decreasing the risk of renal failure, thrombocytopenia, and hyponatremia."1.36Treatment of patent ductus arteriosus: indomethacin or ibuprofen? ( Bello, R; Birk, E; Hernandez, A; Klinger, G; Linder, N; Pushkov, Y; Rosen, C; Sirota, L, 2010)
"Chorioamnionitis was positively correlated with the risk, but did not reach statistical significance."1.33Possible antenatal and perinatal related factors in development of cystic periventricular leukomalacia. ( Itakura, A; Matsuzawa, K; Mizutani, S; Murata, Y; Okumura, A; Wakai, K, 2005)

Research

Studies (44)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's7 (15.91)29.6817
2010's20 (45.45)24.3611
2020's17 (38.64)2.80

Authors

AuthorsStudies
Mustafa, HJ1
Krispin, E1
Tadbiri, H1
Espinoza, J1
Shamshirsaz, AA1
Nassr, AA1
Donepudi, R1
Belfort, MA1
Cortes, MS1
Pederson, N1
Harman, C1
Turan, OM1
Avci, S1
Kuscu, N1
Kilinc, L1
Ustunel, I1
Xiong, Z1
Pei, S1
Zhu, Z1
Mohammad, K1
Momin, S1
Murthy, P1
Zein, H1
Scott, JN1
Mehrem, AA1
Ghosh, A1
Javadyan, A1
Awad, EA1
Venkata, SKRG1
Paul, R1
Rombough, B1
Bolderheij, L1
Dossani, S1
Montpetit, J1
Eshemokhai, P1
Fiedrich, E1
Thomas, S1
Hossain, MR1
Tolosa, JM2
Young, RC1
Smith, R2
Paul, JW2
Qiu, L1
Lv, M1
Chen, C1
Li, J1
Zhao, B1
Luo, Q1
Utsumi, M1
Motoki, N1
Yokota, S1
Kobayashi, H1
Yamazaki, S1
Miyosawa, Y1
Villamor, E1
Borges-Luján, M1
González-Luis, G1
Rovers, JFJ1
Thomissen, IJC1
Janssen, LCE1
Lingius, S1
Wieland, BV1
Dieleman, JP1
Niemarkt, HJ1
van Runnard Heimel, PJ1
Xiong, T1
Maheshwari, A1
Neu, J1
Ei-Saie, A1
Pammi, M1
Roman, A1
Zork, N1
Haeri, S1
Schoen, CN1
Saccone, G1
Colihan, S1
Zelig, C1
Gimovsky, AC1
Seligman, NS1
Zullo, F1
Berghella, V4
Eleje, GU1
Eke, AC1
Ikechebelu, JI1
Ezebialu, IU1
Okam, PC1
Ilika, CP1
Emeruwa, UN1
Krenitsky, NM1
Sheen, JJ1
Faim, DRO1
Tiago, JAM1
Castelo, RJS1
Francisco, ASS1
Alves, RR1
Pires, AMGS1
Brichta, C1
Hoppe, KK1
Lasarev, MR1
Harer, MW1
Ibrahim, MH1
Elfaki, T1
Elhassan, EM1
Abdelrahiem, SK1
Adam, I1
Govindaswami, B1
Jegatheesan, P1
Nudelman, M1
Narasimhan, SR1
Kashanian, M2
Shirvani, S1
Sheikhansari, N1
Javanmanesh, F1
Zanardini, C1
Pagani, G1
Fichera, A1
Prefumo, F1
Frusca, T1
Roos, C1
Borowiack, E1
Kowalska, M1
Zapalska, A1
Mol, B1
Mignini, L1
Meads, C1
Walczak, J1
Khan, K1
Martinez de Tejada, B1
Karolinski, A1
Ocampo, MC1
Laterra, C1
Hösli, I1
Fernández, D1
Surbek, D1
Huespe, M1
Drack, G1
Bunader, A1
Rouillier, S1
López de Degani, G1
Seidenstein, E1
Prentl, E1
Antón, J1
Krähenmann, F1
Nowacki, D1
Poncelas, M1
Nassif, JC1
Papera, R1
Tuma, C1
Espoile, R1
Tiberio, O1
Breccia, G1
Messina, A1
Peker, B1
Schinner, E1
Mol, BW1
Kanterewicz, L1
Wainer, V1
Boulvain, M1
Othenin-Girard, V1
Bertolino, MV1
Irion, O1
Smith, J1
DeFranco, EA1
Reinebrant, HE1
Pileggi-Castro, C1
Romero, CL1
Dos Santos, RA1
Kumar, S1
Souza, JP1
Flenady, V1
Faucett, AM1
Metz, TD1
DeWitt, PE1
Gibbs, RS1
Dutta, EH1
Behnia, F1
Harirah, H1
Costantine, M1
Saade, G1
Hua, S1
Ilicic, M1
Butler, T1
Robertson, S1
Refuerzo, JS1
Leonard, F1
Bulayeva, N1
Gorenstein, D1
Chiossi, G1
Ontiveros, A1
Longo, M1
Godin, B1
Prasertcharoensuk, W1
Cotter, A1
Rasanen, J1
Mittal, S1
Chaithongwongwatthana, S1
Gomez, R1
Kearney, E1
Tolosa, JE1
Pereira, L1
Linder, N1
Bello, R1
Hernandez, A1
Rosen, C1
Birk, E1
Sirota, L1
Pushkov, Y1
Klinger, G1
Ziyan, J1
Huaibin, R1
Xiaotian, M1
Guangtong, S1
Xiaoqing, C1
Zijiang, D1
Ziyue, J1
We, D1
Lizhou, S1
Soraisham, AS1
Dalgleish, S1
Singhal, N1
Ehsanipoor, RM1
Shrivastava, VK1
Lee, RM1
Chan, K1
Galyean, AM1
Garite, TJ1
Rumney, PJ1
Wing, DA1
Bahasadri, S1
Zolali, B1
Marinov, B2
Andreeva, A1
Cankova, M1
Museva, A1
Dimitrov, A1
Shopova, E1
Zhou, K1
Wu, G1
Li, Y1
Zhao, L1
Zhou, R1
Zhu, Q1
Huang, X1
Mu, D1
Hua, Y1
Grigsby, PL1
Novy, MJ1
Sadowsky, DW1
Morgan, TK1
Long, M1
Acosta, E1
Duffy, LB1
Waites, KB1
Perron, N1
Tremblay, E1
Ferretti, E1
Babakissa, C1
Seidman, EG1
Levy, E1
Ménard, D1
Beaulieu, JF1
Murata, Y1
Itakura, A1
Matsuzawa, K1
Okumura, A1
Wakai, K1
Mizutani, S1
Tsvetkov, K1
Kozovski, G1
Petkova, U1
Rushing, S1
Ment, LR1
Rust, OA1
Althuisius, SM1
Fortson, W1
Beharry, KD1
Nageotte, S1
Sills, JH1
Stavitsky, Y1
Asrat, T1
Modanlou, HD1
Visintine, J1
Airoldi, J1

Clinical Trials (10)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Randomized Control Trial Physical Exam Indicated Cerclage in Twin Gestations[NCT02490384]30 participants (Actual)Interventional2015-06-30Terminated (stopped due to due to significant decrease of perinatal mortality in the cerclage group)
Effect of Oral N-Acetyl Cysteine on Pregnancy Outcome After Cervical Cerclage: a Randomized Controlled Trial[NCT00787813]100 participants (Anticipated)Interventional2008-06-30Completed
The Effect of Adjunctive Use of Vaginal Progesterone After Cerclage on Prevention of 2nd Trimester Miscarriage[NCT02846909]Phase 2242 participants (Actual)Interventional2017-04-01Completed
Cervical Cerclage for Singleton Pregnant on Vaginal Progesterone With Progressive Cervical Length Shortening[NCT03837288]60 participants (Anticipated)Interventional2019-04-22Recruiting
Pessary as Adjunctive Therapy to Cerclage for the Prevention of Preterm Birth[NCT02678026]Phase 30 participants (Actual)Interventional2016-01-01Withdrawn (stopped due to no enrollment)
Prevention of Preterm Delivery With Vaginal Progesterone in Women With Preterm Labor[NCT00536003]Phase 3384 participants (Actual)Interventional2006-07-31Terminated
Vaginal Progesterone Supplementation in the Management of Preterm Labor: A Randomized, Double Blind, Controlled Trial[NCT03202836]90 participants (Actual)Interventional2017-06-29Completed
Vaginal Indomethacin Versus Oral Nifedipine for Preterm Labor; a Randomized Controlled Trial[NCT04404686]Phase 2/Phase 3300 participants (Anticipated)Interventional2020-10-31Not yet recruiting
Comparison of Two Antibiotic Prophylactic Protocols in Preterm Premature Rupture of the Membranes. A Randomized Prospective, Open Trial[NCT02819570]Phase 4400 participants (Anticipated)Interventional2015-11-30Recruiting
Physiological Disturbances Associated With Neonatal Intraventricular Hemorrhage[NCT00665769]103 participants (Actual)Interventional2008-06-30Terminated (stopped due to Recruitment was proceeding too slowly)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

10 reviews available for indomethacin and Preterm Birth

ArticleYear
Four kinds of tocolytic therapy for preterm delivery: Systematic review and network meta-analysis.
    Journal of clinical pharmacy and therapeutics, 2022, Volume: 47, Issue:7

    Topics: Female; Humans; Indomethacin; Infant; Infant, Newborn; Network Meta-Analysis; Nifedipine; Obstetric

2022
Association of patent ductus arteriosus with fetal factors and endotypes of prematurity.
    Seminars in perinatology, 2023, Volume: 47, Issue:2

    Topics: Ductus Arteriosus, Patent; Female; Fetal Growth Retardation; Humans; Ibuprofen; Indomethacin; Infant

2023
An Overview of Systematic Reviews of Randomized-Controlled Trials for Preventing Necrotizing Enterocolitis in Preterm Infants.
    Neonatology, 2020, Volume: 117, Issue:1

    Topics: Administration, Oral; Adrenal Cortex Hormones; Ductus Arteriosus, Patent; Enterocolitis, Necrotizing

2020
Cervical stitch (cerclage) in combination with other treatments for preventing spontaneous preterm birth in singleton pregnancies.
    The Cochrane database of systematic reviews, 2020, 09-24, Volume: 9

    Topics: Albuterol; Analgesics, Opioid; Anti-Bacterial Agents; Bias; Cefazolin; Cerclage, Cervical; Clindamyc

2020
Cervical stitch (cerclage) in combination with other treatments for preventing spontaneous preterm birth in singleton pregnancies.
    The Cochrane database of systematic reviews, 2020, 09-24, Volume: 9

    Topics: Albuterol; Analgesics, Opioid; Anti-Bacterial Agents; Bias; Cefazolin; Cerclage, Cervical; Clindamyc

2020
Cervical stitch (cerclage) in combination with other treatments for preventing spontaneous preterm birth in singleton pregnancies.
    The Cochrane database of systematic reviews, 2020, 09-24, Volume: 9

    Topics: Albuterol; Analgesics, Opioid; Anti-Bacterial Agents; Bias; Cefazolin; Cerclage, Cervical; Clindamyc

2020
Cervical stitch (cerclage) in combination with other treatments for preventing spontaneous preterm birth in singleton pregnancies.
    The Cochrane database of systematic reviews, 2020, 09-24, Volume: 9

    Topics: Albuterol; Analgesics, Opioid; Anti-Bacterial Agents; Bias; Cefazolin; Cerclage, Cervical; Clindamyc

2020
Cervical stitch (cerclage) in combination with other treatments for preventing spontaneous preterm birth in singleton pregnancies.
    The Cochrane database of systematic reviews, 2020, 09-24, Volume: 9

    Topics: Albuterol; Analgesics, Opioid; Anti-Bacterial Agents; Bias; Cefazolin; Cerclage, Cervical; Clindamyc

2020
Cervical stitch (cerclage) in combination with other treatments for preventing spontaneous preterm birth in singleton pregnancies.
    The Cochrane database of systematic reviews, 2020, 09-24, Volume: 9

    Topics: Albuterol; Analgesics, Opioid; Anti-Bacterial Agents; Bias; Cefazolin; Cerclage, Cervical; Clindamyc

2020
Cervical stitch (cerclage) in combination with other treatments for preventing spontaneous preterm birth in singleton pregnancies.
    The Cochrane database of systematic reviews, 2020, 09-24, Volume: 9

    Topics: Albuterol; Analgesics, Opioid; Anti-Bacterial Agents; Bias; Cefazolin; Cerclage, Cervical; Clindamyc

2020
Cervical stitch (cerclage) in combination with other treatments for preventing spontaneous preterm birth in singleton pregnancies.
    The Cochrane database of systematic reviews, 2020, 09-24, Volume: 9

    Topics: Albuterol; Analgesics, Opioid; Anti-Bacterial Agents; Bias; Cefazolin; Cerclage, Cervical; Clindamyc

2020
Cervical stitch (cerclage) in combination with other treatments for preventing spontaneous preterm birth in singleton pregnancies.
    The Cochrane database of systematic reviews, 2020, 09-24, Volume: 9

    Topics: Albuterol; Analgesics, Opioid; Anti-Bacterial Agents; Bias; Cefazolin; Cerclage, Cervical; Clindamyc

2020
Cervical stitch (cerclage) in combination with other treatments for preventing spontaneous preterm birth in singleton pregnancies.
    The Cochrane database of systematic reviews, 2020, 09-24, Volume: 9

    Topics: Albuterol; Analgesics, Opioid; Anti-Bacterial Agents; Bias; Cefazolin; Cerclage, Cervical; Clindamyc

2020
Cervical stitch (cerclage) in combination with other treatments for preventing spontaneous preterm birth in singleton pregnancies.
    The Cochrane database of systematic reviews, 2020, 09-24, Volume: 9

    Topics: Albuterol; Analgesics, Opioid; Anti-Bacterial Agents; Bias; Cefazolin; Cerclage, Cervical; Clindamyc

2020
Cervical stitch (cerclage) in combination with other treatments for preventing spontaneous preterm birth in singleton pregnancies.
    The Cochrane database of systematic reviews, 2020, 09-24, Volume: 9

    Topics: Albuterol; Analgesics, Opioid; Anti-Bacterial Agents; Bias; Cefazolin; Cerclage, Cervical; Clindamyc

2020
Cervical stitch (cerclage) in combination with other treatments for preventing spontaneous preterm birth in singleton pregnancies.
    The Cochrane database of systematic reviews, 2020, 09-24, Volume: 9

    Topics: Albuterol; Analgesics, Opioid; Anti-Bacterial Agents; Bias; Cefazolin; Cerclage, Cervical; Clindamyc

2020
Cervical stitch (cerclage) in combination with other treatments for preventing spontaneous preterm birth in singleton pregnancies.
    The Cochrane database of systematic reviews, 2020, 09-24, Volume: 9

    Topics: Albuterol; Analgesics, Opioid; Anti-Bacterial Agents; Bias; Cefazolin; Cerclage, Cervical; Clindamyc

2020
Cervical stitch (cerclage) in combination with other treatments for preventing spontaneous preterm birth in singleton pregnancies.
    The Cochrane database of systematic reviews, 2020, 09-24, Volume: 9

    Topics: Albuterol; Analgesics, Opioid; Anti-Bacterial Agents; Bias; Cefazolin; Cerclage, Cervical; Clindamyc

2020
Cervical stitch (cerclage) in combination with other treatments for preventing spontaneous preterm birth in singleton pregnancies.
    The Cochrane database of systematic reviews, 2020, 09-24, Volume: 9

    Topics: Albuterol; Analgesics, Opioid; Anti-Bacterial Agents; Bias; Cefazolin; Cerclage, Cervical; Clindamyc

2020
Advances in Management for Preterm Fetuses at Risk of Delivery.
    Clinics in perinatology, 2020, Volume: 47, Issue:4

    Topics: Anti-Bacterial Agents; Anticonvulsants; Betamethasone; Dexamethasone; Female; Fetal Membranes, Prema

2020
Prevention of Prematurity: Advances and Opportunities.
    Clinics in perinatology, 2018, Volume: 45, Issue:3

    Topics: Anti-Infective Agents; Aspirin; Cerclage, Cervical; Cesarean Section; Female; Humans; Indomethacin;

2018
What do we know about tocolytic effectiveness and how do we use this information in guidelines? A comparison of evidence grading.
    BJOG : an international journal of obstetrics and gynaecology, 2013, Volume: 120, Issue:13

    Topics: Adrenergic beta-Agonists; Attitude of Health Personnel; Calcium Channel Blockers; Evidence-Based Med

2013
Tocolytics used as adjunctive therapy at the time of cerclage placement: a systematic review.
    Journal of perinatology : official journal of the California Perinatal Association, 2015, Volume: 35, Issue:8

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cerclage, Cervical; Chemotherapy, Adjuvant; Female; Humans;

2015
Cyclo-oxygenase (COX) inhibitors for treating preterm labour.
    The Cochrane database of systematic reviews, 2015, Jun-05, Issue:6

    Topics: Calcium Channel Blockers; Cyclooxygenase Inhibitors; Female; Humans; Indomethacin; Magnesium Sulfate

2015
Short cervix on ultrasound: does indomethacin prevent preterm birth?
    American journal of obstetrics and gynecology, 2006, Volume: 195, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cervix Uteri; Female; Fetal Membranes, Premature Rupture; H

2006

Trials

6 trials available for indomethacin and Preterm Birth

ArticleYear
Physical examination-indicated cerclage in twin pregnancy: a randomized controlled trial.
    American journal of obstetrics and gynecology, 2020, Volume: 223, Issue:6

    Topics: Adult; Anti-Bacterial Agents; Asymptomatic Diseases; Cerclage, Cervical; Cervical Length Measurement

2020
The effectiveness of nifedipine/indomethacin combination therapy and nifedipine monotherapy for postponing preterm birth (25-34 weeks of gestation) in Sudanese women: a randomized clinical trial study protocol.
    BMC pregnancy and childbirth, 2021, Jun-29, Volume: 21, Issue:1

    Topics: Adolescent; Adult; Combined Modality Therapy; Female; Gestational Age; Humans; Indomethacin; Infant,

2021
A comparative study on the efficacy of nifedipine and indomethacin for prevention of preterm birth as monotherapy and combination therapy: a randomized clinical trial.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2020, Volume: 33, Issue:19

    Topics: Female; Humans; Indomethacin; Infant; Infant, Newborn; Nifedipine; Obstetric Labor, Premature; Pregn

2020
Prevention of preterm delivery with vaginal progesterone in women with preterm labour (4P): randomised double-blind placebo-controlled trial.
    BJOG : an international journal of obstetrics and gynaecology, 2015, Volume: 122, Issue:1

    Topics: Administration, Intravaginal; Adult; Apgar Score; Birth Weight; Double-Blind Method; Female; Humans;

2015
Prevention of preterm delivery with vaginal progesterone in women with preterm labour (4P): randomised double-blind placebo-controlled trial.
    BJOG : an international journal of obstetrics and gynaecology, 2015, Volume: 122, Issue:1

    Topics: Administration, Intravaginal; Adult; Apgar Score; Birth Weight; Double-Blind Method; Female; Humans;

2015
Prevention of preterm delivery with vaginal progesterone in women with preterm labour (4P): randomised double-blind placebo-controlled trial.
    BJOG : an international journal of obstetrics and gynaecology, 2015, Volume: 122, Issue:1

    Topics: Administration, Intravaginal; Adult; Apgar Score; Birth Weight; Double-Blind Method; Female; Humans;

2015
Prevention of preterm delivery with vaginal progesterone in women with preterm labour (4P): randomised double-blind placebo-controlled trial.
    BJOG : an international journal of obstetrics and gynaecology, 2015, Volume: 122, Issue:1

    Topics: Administration, Intravaginal; Adult; Apgar Score; Birth Weight; Double-Blind Method; Female; Humans;

2015
A randomized, double-masked trial of prophylactic indomethacin tocolysis versus placebo in women with premature rupture of membranes.
    American journal of perinatology, 2011, Volume: 28, Issue:6

    Topics: Adult; Double-Blind Method; Early Termination of Clinical Trials; Female; Fetal Membranes, Premature

2011
Comparison of the efficacy and adverse effects of nifedipine and indomethacin for the treatment of preterm labor.
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2011, Volume: 113, Issue:3

    Topics: Adult; Drug Administration Schedule; Female; Humans; Indomethacin; Nifedipine; Obstetric Labor, Prem

2011

Other Studies

28 other studies available for indomethacin and Preterm Birth

ArticleYear
Efficacy of long-term indomethacin therapy in prolonging pregnancy after fetoscopic laser surgery for twin-to-twin transfusion syndrome: a collaborative cohort study.
    BJOG : an international journal of obstetrics and gynaecology, 2022, Volume: 129, Issue:4

    Topics: Adult; Female; Fetofetal Transfusion; Fetoscopy; Gestational Age; Humans; Indomethacin; Laser Therap

2022
Relationship of Notch Signal, Surfactant Protein A, and Indomethacin in Cervix During Preterm Birth: Mast Cell and Jagged-2 May Be Key in Understanding Infection-mediated Preterm Birth.
    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2022, Volume: 70, Issue:2

    Topics: Animals; Cervix Uteri; Female; Indomethacin; Jagged-2 Protein; Lipopolysaccharides; Mast Cells; Mice

2022
Impact of quality improvement outreach education on the incidence of acute brain injury in transported neonates born premature.
    Journal of perinatology : official journal of the California Perinatal Association, 2022, Volume: 42, Issue:10

    Topics: Brain Injuries; Female; Gestational Age; Humans; Incidence; Indomethacin; Infant, Newborn; Pregnancy

2022
Assessing the Potency of the Novel Tocolytics 2-APB, Glycyl-H-1152, and HC-067047 in Pregnant Human Myometrium.
    Reproductive sciences (Thousand Oaks, Calif.), 2023, Volume: 30, Issue:1

    Topics: Aminophylline; Female; Humans; Indomethacin; Infant, Newborn; Myometrium; Nifedipine; Pregnancy; Pre

2023
Efficacy of ultrasound-indicated cerclage in twin pregnancies: a retrospective case-control study matched by cervical length.
    American journal of obstetrics & gynecology MFM, 2023, Volume: 5, Issue:3

    Topics: Case-Control Studies; Cerclage, Cervical; Cervix Uteri; Female; Humans; Indomethacin; Infant, Newbor

2023
Predictors of a non-response to prophylactic indomethacin for patent ductus arteriosus in preterm infants.
    Pediatrics and neonatology, 2023, Volume: 64, Issue:4

    Topics: Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Female; Humans; Ibuprofen; Indomethacin; Infan

2023
The relationship between antenatal indomethacin as a tocolytic drug and neonatal outcomes: a retrospective cohort study.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2021, Volume: 34, Issue:18

    Topics: Cohort Studies; Ductus Arteriosus, Patent; Female; Humans; Indomethacin; Infant; Infant, Newborn; In

2021
PATENT DUCTUS ARTERIOSUS CLOSURE: EXPERIENCE FROM A TERTIARY REFERRAL CENTER.
    Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo, 2020, Volume: 39

    Topics: Acetaminophen; Ductus Arteriosus, Patent; Female; Gestational Age; Humans; Ibuprofen; Indomethacin;

2020
The effect of antenatal indomethacin on extremely preterm neonatal kidney function.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2022, Volume: 35, Issue:25

    Topics: Acute Kidney Injury; Adult; Cohort Studies; Creatinine; Female; Humans; Indomethacin; Infant; Infant

2022
Cervical cerclage in twin pregnancies.
    Archives of gynecology and obstetrics, 2013, Volume: 288, Issue:2

    Topics: Adult; Anti-Bacterial Agents; Antibiotic Prophylaxis; Cerclage, Cervical; Cervix Uteri; Female; Feta

2013
Effect of obesity on neonatal outcomes in pregnancies with preterm premature rupture of membranes.
    American journal of obstetrics and gynecology, 2016, Volume: 214, Issue:2

    Topics: Adolescent; Adrenal Cortex Hormones; Adult; Birth Weight; Case-Control Studies; Cerebral Hemorrhage;

2016
Perinatal Outcomes after Short versus Prolonged Indomethacin for Tocolysis in Women with Preterm Labor.
    American journal of perinatology, 2016, Volume: 33, Issue:9

    Topics: Adult; Drug Administration Schedule; Enterocolitis, Necrotizing; Female; Gestational Age; Humans; In

2016
Drug delivery to the human and mouse uterus using immunoliposomes targeted to the oxytocin receptor.
    American journal of obstetrics and gynecology, 2017, Volume: 216, Issue:3

    Topics: Albuterol; Animals; Drug Delivery Systems; Female; Indomethacin; Liposomes; Mice; Myometrium; Nifedi

2017
Uterus-targeted liposomes for preterm labor management: studies in pregnant mice.
    Scientific reports, 2016, 10-11, Volume: 6

    Topics: Animals; Disease Models, Animal; Drug Compounding; Female; Gene Expression; Hormone Antagonists; Hum

2016
Does indomethacin prevent preterm birth in women with cervical dilatation in the second trimester?
    American journal of perinatology, 2009, Volume: 26, Issue:1

    Topics: Adult; Amniocentesis; Anti-Bacterial Agents; Birth Weight; Cerclage, Cervical; Cohort Studies; Deliv

2009
Treatment of patent ductus arteriosus: indomethacin or ibuprofen?
    American journal of perinatology, 2010, Volume: 27, Issue:5

    Topics: Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Female; Humans; Ibuprofen; Indomethacin; Infan

2010
Regulation of progesterone receptor A and B expression in human preterm, term, and postterm placental villi.
    Acta obstetricia et gynecologica Scandinavica, 2010, Volume: 89, Issue:5

    Topics: Adult; Blotting, Western; China; Chorionic Villi; Chorionic Villi Sampling; Cohort Studies; Female;

2010
Antenatal indomethacin tocolysis is associated with an increased need for surgical ligation of patent ductus arteriosus in preterm infants.
    Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC, 2010, Volume: 32, Issue:5

    Topics: Adult; Case-Control Studies; Cohort Studies; Ductus Arteriosus, Patent; Female; Humans; Indomethacin

2010
[Treatment of preterm delivery--therapeutic algorithm].
    Akusherstvo i ginekologiia, 2011, Volume: 50 Suppl 2

    Topics: Ambroxol; Anti-Inflammatory Agents, Non-Steroidal; Calcium Channel Blockers; Expectorants; Female; G

2011
[Our treatment approach for preterm birth].
    Akusherstvo i ginekologiia, 2011, Volume: 50 Suppl 2

    Topics: Adrenal Cortex Hormones; Adrenergic beta-2 Receptor Agonists; Anti-Bacterial Agents; Anti-Inflammato

2011
Protective effects of indomethacin and dexamethasone in a goat model with intrauterine balloon aortic valvuloplasty.
    Journal of biomedical science, 2012, Aug-13, Volume: 19, Issue:1

    Topics: Animals; Aortic Valve Stenosis; Balloon Valvuloplasty; Dexamethasone; Female; Goats; Indomethacin; M

2012
Maternal azithromycin therapy for Ureaplasma intraamniotic infection delays preterm delivery and reduces fetal lung injury in a primate model.
    American journal of obstetrics and gynecology, 2012, Volume: 207, Issue:6

    Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; A

2012
Deleterious effects of indomethacin in the mid-gestation human intestine.
    Genomics, 2013, Volume: 101, Issue:3

    Topics: Aborted Fetus; Anti-Inflammatory Agents; Female; Humans; Indomethacin; Intestinal Mucosa; Intestines

2013
Possible antenatal and perinatal related factors in development of cystic periventricular leukomalacia.
    Brain & development, 2005, Volume: 27, Issue:1

    Topics: Apgar Score; Case-Control Studies; Causality; Cerebral Palsy; Chorioamnionitis; Comorbidity; Female;

2005
[Therapy of chronic idiopathic hydramnios with indomethacin].
    Akusherstvo i ginekologiia, 2004, Volume: 43 Suppl 3

    Topics: Chronic Disease; Female; Gestational Age; Humans; Indomethacin; Infant, Newborn; Polyhydramnios; Pre

2004
Preterm birth: a cost benefit analysis.
    Seminars in perinatology, 2004, Volume: 28, Issue:6

    Topics: Adrenal Cortex Hormones; Age Factors; Brain Diseases; Cardiovascular Agents; Cost-Benefit Analysis;

2004
Vaginal versus oral indomethacin in a rabbit model for non-infection-mediated preterm birth: an alternate tocolytic approach.
    American journal of obstetrics and gynecology, 2006, Volume: 195, Issue:4

    Topics: Administration, Intravaginal; Administration, Oral; Animals; Cervix Uteri; Female; Indomethacin; Mat

2006
Indomethacin administration at the time of ultrasound-indicated cerclage: is there an association with a reduction in spontaneous preterm birth?
    American journal of obstetrics and gynecology, 2008, Volume: 198, Issue:6

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Cerclage, Cervical; Cervical Length Measurement; Cer

2008