Page last updated: 2024-10-29

indomethacin and Premature Rupture of Fetal Membranes

indomethacin has been researched along with Premature Rupture of Fetal Membranes in 11 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Research Excerpts

ExcerptRelevanceReference
"Our aim was to estimate if indomethacin therapy prevents preterm birth (PTB) in women with a short cervical length (CL) on transvaginal ultrasound (TVU)."8.83Short cervix on ultrasound: does indomethacin prevent preterm birth? ( Althuisius, SM; Berghella, V; Rust, OA, 2006)
"The purpose of this study was to estimate the effect of indomethacin on the prevention of preterm birth (PTB) in women with an ultrasound-indicated cerclage."7.74Indomethacin administration at the time of ultrasound-indicated cerclage: is there an association with a reduction in spontaneous preterm birth? ( Airoldi, J; Berghella, V; Visintine, J, 2008)
"Our aim was to estimate if indomethacin therapy prevents preterm birth (PTB) in women with a short cervical length (CL) on transvaginal ultrasound (TVU)."4.83Short cervix on ultrasound: does indomethacin prevent preterm birth? ( Althuisius, SM; Berghella, V; Rust, OA, 2006)
" Magnesium sulfate administration, steroid administration, maternal diabetes mellitus, gestational age at delivery, indomethacin exposure, birthweight, and chorioamnionitis were all considered as possible covariates in the multivariable regression models."3.83Effect of obesity on neonatal outcomes in pregnancies with preterm premature rupture of membranes. ( DeWitt, PE; Faucett, AM; Gibbs, RS; Metz, TD, 2016)
"The purpose of this study was to estimate the effect of indomethacin on the prevention of preterm birth (PTB) in women with an ultrasound-indicated cerclage."3.74Indomethacin administration at the time of ultrasound-indicated cerclage: is there an association with a reduction in spontaneous preterm birth? ( Airoldi, J; Berghella, V; Visintine, J, 2008)
"Indomethacin has been tested, in addition to betasympathicomimetic therapy, in cases with an insufficient inhibition of premature labour."1.27Inhibition of premature labour with indomethacin. ( Halle, H, 1987)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19903 (27.27)18.7374
1990's1 (9.09)18.2507
2000's3 (27.27)29.6817
2010's3 (27.27)24.3611
2020's1 (9.09)2.80

Authors

AuthorsStudies
Emeruwa, UN1
Krenitsky, NM1
Sheen, JJ1
Zanardini, C1
Pagani, G1
Fichera, A1
Prefumo, F1
Frusca, T1
Faucett, AM1
Metz, TD1
DeWitt, PE1
Gibbs, RS1
Ventolini, G1
Genrich, TJ1
Roth, J1
Neiger, R1
Ehsanipoor, RM1
Shrivastava, VK1
Lee, RM1
Chan, K1
Galyean, AM1
Garite, TJ1
Rumney, PJ1
Wing, DA1
Berghella, V2
Rust, OA1
Althuisius, SM1
Visintine, J1
Airoldi, J1
Van Overmeire, B1
Slootmaekers, V1
De Loor, J1
Buytaert, P1
Hagendorens, M1
Sys, SU1
Van Reempts, PJ1
Spearing, G1
Fuller, WE1
Halle, H1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Randomized Control Trial Physical Exam Indicated Cerclage in Twin Gestations[NCT02490384]30 participants (Actual)Interventional2015-06-30Terminated (stopped due to due to significant decrease of perinatal mortality in the cerclage group)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for indomethacin and Premature Rupture of Fetal Membranes

ArticleYear
Advances in Management for Preterm Fetuses at Risk of Delivery.
    Clinics in perinatology, 2020, Volume: 47, Issue:4

    Topics: Anti-Bacterial Agents; Anticonvulsants; Betamethasone; Dexamethasone; Female; Fetal Membranes, Prema

2020
Short cervix on ultrasound: does indomethacin prevent preterm birth?
    American journal of obstetrics and gynecology, 2006, Volume: 195, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cervix Uteri; Female; Fetal Membranes, Premature Rupture; H

2006

Trials

1 trial available for indomethacin and Premature Rupture of Fetal Membranes

ArticleYear
A randomized, double-masked trial of prophylactic indomethacin tocolysis versus placebo in women with premature rupture of membranes.
    American journal of perinatology, 2011, Volume: 28, Issue:6

    Topics: Adult; Double-Blind Method; Early Termination of Clinical Trials; Female; Fetal Membranes, Premature

2011

Other Studies

8 other studies available for indomethacin and Premature Rupture of Fetal Membranes

ArticleYear
Cervical cerclage in twin pregnancies.
    Archives of gynecology and obstetrics, 2013, Volume: 288, Issue:2

    Topics: Adult; Anti-Bacterial Agents; Antibiotic Prophylaxis; Cerclage, Cervical; Cervix Uteri; Female; Feta

2013
Effect of obesity on neonatal outcomes in pregnancies with preterm premature rupture of membranes.
    American journal of obstetrics and gynecology, 2016, Volume: 214, Issue:2

    Topics: Adolescent; Adrenal Cortex Hormones; Adult; Birth Weight; Case-Control Studies; Cerebral Hemorrhage;

2016
Pregnancy outcome after placement of 'rescue' Shirodkar cerclage.
    Journal of perinatology : official journal of the California Perinatal Association, 2009, Volume: 29, Issue:4

    Topics: Adolescent; Adult; Bed Rest; Cerclage, Cervical; Cohort Studies; Combined Modality Therapy; Female;

2009
Indomethacin administration at the time of ultrasound-indicated cerclage: is there an association with a reduction in spontaneous preterm birth?
    American journal of obstetrics and gynecology, 2008, Volume: 198, Issue:6

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Cerclage, Cervical; Cervical Length Measurement; Cer

2008
The addition of indomethacin to betamimetics for tocolysis: any benefit for the neonate?
    European journal of obstetrics, gynecology, and reproductive biology, 1998, Volume: 77, Issue:1

    Topics: Adrenergic beta-Agonists; Bronchopulmonary Dysplasia; Cohort Studies; Female; Fetal Membranes, Prema

1998
Alcohol, indomethacin, and salbutamol. A comparative trial of their use in preterm labor.
    Obstetrics and gynecology, 1979, Volume: 53, Issue:2

    Topics: Albuterol; Birth Weight; Drug Therapy, Combination; Ethanol; Female; Fetal Membranes, Premature Rupt

1979
Management of premature labor.
    Clinical obstetrics and gynecology, 1978, Volume: 21, Issue:2

    Topics: Aspirin; Bed Rest; Betamethasone; Estrogens; Ethanol; Female; Fetal Membranes, Premature Rupture; Gl

1978
Inhibition of premature labour with indomethacin.
    Acta chirurgica Hungarica, 1987, Volume: 28, Issue:1

    Topics: Female; Fetal Membranes, Premature Rupture; Humans; Indomethacin; Infant, Low Birth Weight; Infant,

1987