indomethacin has been researched along with Precursor Cell Lymphoblastic Leukemia-Lymphoma in 3 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Precursor Cell Lymphoblastic Leukemia-Lymphoma: A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The indomethacin treatment increased the level of p53 in the leukemic cells, implying that COX inhibition might reduce progression of ALL by attenuating protective paracrine PGE2 signaling from bone marrow stroma to leukemic cells." | 1.51 | Targeting cyclooxygenase by indomethacin decelerates progression of acute lymphoblastic leukemia in a xenograft model. ( Bhagwat, S; Blomhoff, HK; Burman, MM; Duthil, E; Ford, A; Gilljam, KM; Naderi, EH; Richartz, N; Ruud, E; Skah, S, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Richartz, N | 1 |
| Duthil, E | 1 |
| Ford, A | 1 |
| Naderi, EH | 1 |
| Bhagwat, S | 1 |
| Gilljam, KM | 1 |
| Burman, MM | 1 |
| Ruud, E | 1 |
| Blomhoff, HK | 1 |
| Skah, S | 1 |
| Maca, RD | 1 |
| Brown, RE | 1 |
| Alade, SL | 1 |
| Wu, MC | 1 |
| Wu, FM | 1 |
| Bowman, WP | 1 |
3 other studies available for indomethacin and Precursor Cell Lymphoblastic Leukemia-Lymphoma
| Article | Year |
|---|---|
Targeting cyclooxygenase by indomethacin decelerates progression of acute lymphoblastic leukemia in a xenograft model.
Topics: Animals; Biomarkers; Bone Marrow; Cell Line, Tumor; Child; Child, Preschool; Cyclooxygenase Inhibito | 2019 |
Enhancement of etoposide and methotrexate sensitivity by indomethacin in vitro.
Topics: Animals; Bleomycin; Drug Synergism; Etoposide; Humans; Indomethacin; Leukemia, Myelogenous, Chronic, | 1991 |
Lipoperoxidation and T-cell leukemia of childhood. Effects of indomethacin.
Topics: Child; Dinoprostone; Female; Humans; Indomethacin; Leukemia-Lymphoma, Adult T-Cell; Leukocyte Count; | 1989 |