indomethacin has been researched along with Precancerous Conditions in 15 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Precancerous Conditions: Pathological conditions that tend eventually to become malignant.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Lung cancer is the leading cause of cancer-related death worldwide." | 1.38 | Non-invasive X-ray micro-computed tomographic evaluation of indomethacin on urethane-induced lung carcinogenesis in mice. ( Hayakawa, T; Imai, T; Imaida, K; Komiya, M; Mutoh, M; Takahashi, M; Tsuta, K; Ueno, T; Wakabayashi, K; Yanaka, A; Yoshimoto, M, 2012) |
| "Aspirin may suppress tumour incidence via salicylate by enhancing apoptosis in carcinogen-initiated cells." | 1.30 | Non-steroidol anti-inflammatory drug effect on crypt cell proliferation and apoptosis during initiation of rat colon carcinogenesis. ( Barnes, CJ; Cameron, IL; Hardman, WE; Lee, M, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (40.00) | 18.7374 |
| 1990's | 7 (46.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (13.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ota, Y | 1 |
| Imai, T | 2 |
| Hasumura, M | 1 |
| Cho, YM | 1 |
| Takami, S | 1 |
| Oyamada, T | 1 |
| Hirose, M | 2 |
| Nishikawa, A | 2 |
| Ogawa, K | 2 |
| Ueno, T | 1 |
| Imaida, K | 2 |
| Yoshimoto, M | 1 |
| Hayakawa, T | 1 |
| Takahashi, M | 1 |
| Yanaka, A | 1 |
| Tsuta, K | 1 |
| Komiya, M | 1 |
| Wakabayashi, K | 1 |
| Mutoh, M | 1 |
| Telang, NT | 1 |
| Bockman, RS | 1 |
| Sarkar, NH | 1 |
| Shibata, M | 1 |
| Hasegawa, R | 1 |
| Hagiwara, A | 1 |
| Ito, N | 1 |
| Shirai, T | 1 |
| Tanaka, T | 3 |
| Kojima, T | 2 |
| Okumura, A | 1 |
| Sugie, S | 2 |
| Mori, H | 3 |
| Charalambous, D | 1 |
| Farmer, C | 1 |
| O'Brien, PE | 1 |
| Barnes, CJ | 1 |
| Cameron, IL | 1 |
| Hardman, WE | 1 |
| Lee, M | 1 |
| Włodarski, K | 1 |
| Luczak, M | 1 |
| Galus, R | 1 |
| Włodarski, P | 1 |
| Yoshimi, N | 1 |
| Servais, P | 1 |
| Taton, G | 1 |
| Galand, P | 1 |
| Mori, Y | 1 |
| Morishita, Y | 1 |
| Wei, WZ | 2 |
| Fulton, A | 2 |
| Winkelhake, J | 1 |
| Heppner, G | 2 |
| Malone, K | 1 |
| Yron, I | 1 |
| Schickler, M | 1 |
| Fisch, B | 1 |
| Pinkas, H | 1 |
| Ovadia, J | 1 |
| Witz, IP | 1 |
| Nagasawa, H | 1 |
| Naito, T | 1 |
15 other studies available for indomethacin and Precancerous Conditions
| Article | Year |
|---|---|
Prostaglandin synthases influence thyroid follicular cell proliferation but not carcinogenesis in rats initiated with N-bis(2-hydroxypropyl)nitrosamine.
Topics: Adenocarcinoma, Follicular; Animals; Antithyroid Agents; Cell Proliferation; Cyclooxygenase 2; Cyclo | 2012 |
Non-invasive X-ray micro-computed tomographic evaluation of indomethacin on urethane-induced lung carcinogenesis in mice.
Topics: Adenocarcinoma; Adenoma; Animals; Antineoplastic Agents; Carcinogens; Humans; Hyperplasia; Immunohis | 2012 |
Fatty acid-induced modifications of mouse mammary alveolar lesions in organ culture.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Fatty Acids; Female; Indomethacin; Mammary Glands, Ani | 1984 |
Chemoprevention by dehydroepiandrosterone and indomethacin in a rat multiorgan carcinogenesis model.
Topics: Animals; Anticarcinogenic Agents; Dehydroepiandrosterone; Disease Models, Animal; Hyperplasia; Indom | 1995 |
Inhibitory effect of the non-steroidal anti-inflammatory drugs, indomethacin and piroxicam on 2-acetylaminofluorene-induced hepatocarcinogenesis in male ACI/N rats.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Indomethacin; Liver; Liver Neoplasms, Experimental; Mal | 1993 |
Sulindac and indomethacin inhibit formation of aberrant crypt foci in the colons of dimethyl hydrazine treated rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carcinogens; Colon; Dimethylhydrazines; Indomethac | 1996 |
Non-steroidol anti-inflammatory drug effect on crypt cell proliferation and apoptosis during initiation of rat colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apopt | 1998 |
Local hypertrophic/hyperplastic changes of keratinizing squamous epithelium of pinna induced by concanavalin A and other immunomodulators in mice.
Topics: Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Marrow Transplantatio | 1999 |
Inhibitory effect of the non-steroidal anti-inflammatory drug, indomethacin on the naturally occurring carcinogen, 1-hydroxyanthraquinone in male ACI/N rats.
Topics: Adenocarcinoma; Animals; Anthraquinones; Carcinoma, Squamous Cell; Colonic Neoplasms; Enterocolitis; | 1991 |
Modulation by indomethacin of diethylnitrosamine-induced early changes in c-myc and c-ras expression and late incidence of preneoplastic lesions in rat liver.
Topics: Animals; Diethylnitrosamine; Female; Gene Expression; Genes, ras; Indomethacin; Liver Neoplasms, Exp | 1990 |
Inhibitory effects of non-steroidal anti-inflammatory drugs, piroxicam and indomethacin on 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in male ACI/N rats.
Topics: 4-Nitroquinoline-1-oxide; Animals; Indomethacin; Male; Nitroquinolines; Ornithine Decarboxylase Inhi | 1989 |
Correlation of natural killer activity with tumorigenesis of a preneoplastic mouse mammary lesion.
Topics: Animals; Female; G(M1) Ganglioside; Glycosphingolipids; Indomethacin; Interleukin-2; Killer Cells, N | 1989 |
Modulation of lymphocytic infiltrates in C4 mouse mammary tumors.
Topics: Animals; Cell Movement; Dinoprostone; Female; Hyperplasia; Indomethacin; Interleukin-2; Mammary Glan | 1989 |
The immune system during the pre-cancer and the early cancer period. IL-2 production by PBL from post-menopausal women with and without endometrial carcinoma.
Topics: B-Lymphocytes; Carcinoma; Female; Humans; Indomethacin; Interleukin-2; Lymphocyte Activation; Macrop | 1986 |
Inhibition by indomethacin of spontaneous mammary tumorigenesis in SHN mice.
Topics: Animals; Body Weight; Cell Transformation, Neoplastic; Estrus; Female; Indomethacin; Mammary Neoplas | 1986 |