indomethacin has been researched along with Potassium Deficiency in 19 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Potassium Deficiency: A condition due to decreased dietary intake of potassium, as in starvation or failure to administer in intravenous solutions, or to gastrointestinal loss in diarrhea, chronic laxative abuse, vomiting, gastric suction, or bowel diversion. Severe potassium deficiency may produce muscular weakness and lead to paralysis and respiratory failure. Muscular malfunction may result in hypoventilation, paralytic ileus, hypotension, muscle twitches, tetany, and rhabomyolysis. Nephropathy from potassium deficit impairs the concentrating mechanism, producing POLYURIA and decreased maximal urinary concentrating ability with secondary POLYDIPSIA. (Merck Manual, 16th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " In vivo prostaglandin inhibition with indomethacin or meclofenamate significantly increased urinary osmolality after 12 h of dehydration and exogenous vasopressin (1." | 3.67 | Prostaglandins and the urinary concentrating defect in potassium-depleted rabbits. ( Lifschitz, MD; McKinney, TD; Raymond, KH, 1987) |
| "(3) Indomethacin treatment resulted in changes in mean arterial pressure (increase) and creatinine cl." | 1.28 | Effects of experimental potassium depletion on renal function and urinary prostanoid excretion in normal women during hypotonic polyuria. ( Agnoli, GC; Borgatti, R; Cacciari, M; Garutti, C; Ikonomu, E; Lenzi, P; Marinelli, M, 1990) |
| "Treatment with indomethacin, 10 mg/day for 5 days, partially reversed the increase in the urinary excretion of norepinephrine metabolites." | 1.27 | Endogenously synthesized prostaglandins stimulate sympathetic nervous system activity. ( Güllner, HG, 1983) |
| "Pretreatment with indomethacin significantly improved CIn and CPAH, and potassium repletion abolished this effect entirely." | 1.27 | Captopril enhances aminoglycoside nephrotoxicity in potassium-depleted rats. ( Baker, JD; Boatman, JE; Klotman, PE; Volpp, BD; Yarger, WE, 1985) |
| "Although chronic potassium deficiency is a common clinical problem, the hemodynamic consequences of chronic sustained potassium depletion have not been clearly delineated." | 1.26 | Mechanism of the decreased renal blood flow in the potassium-depleted conscious rat. ( Dickmann, D; Linas, SL, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (73.68) | 18.7374 |
| 1990's | 5 (26.32) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Linas, SL | 1 |
| Dickmann, D | 1 |
| Güllner, HG | 2 |
| Düsing, R | 2 |
| Bartter, FC | 2 |
| Gill, JR | 1 |
| Lake, CR | 1 |
| Harrison, LC | 1 |
| Bhathena, S | 1 |
| Recant, L | 1 |
| Beck, N | 1 |
| Shaw, JO | 1 |
| Agnoli, GC | 10 |
| Borgatti, R | 10 |
| Cacciari, M | 10 |
| Ikonomu, E | 10 |
| Lenzi, P | 8 |
| Marinelli, M | 10 |
| Garutti, C | 8 |
| Rosa, RM | 1 |
| Epstein, FH | 1 |
| Stoff, JS | 1 |
| Klotman, PE | 1 |
| Boatman, JE | 1 |
| Volpp, BD | 1 |
| Baker, JD | 1 |
| Yarger, WE | 1 |
| Dorigoni, S | 4 |
| Raymond, KH | 1 |
| Lifschitz, MD | 1 |
| McKinney, TD | 1 |
| Takamitsu, Y | 1 |
| Kunau, RT | 1 |
1 trial available for indomethacin and Potassium Deficiency
| Article | Year |
|---|---|
Urinary prostanoid excretion in healthy women with different degrees of induced potassium depletion.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Chlorides; Dinoprostone; Female; Glomerular Filtration Rate; Hu | 1992 |
18 other studies available for indomethacin and Potassium Deficiency
| Article | Year |
|---|---|
Mechanism of the decreased renal blood flow in the potassium-depleted conscious rat.
Topics: Angiotensin II; Animals; Blood Pressure; Consciousness; Indomethacin; Male; Potassium Deficiency; Pr | 1982 |
Endogenously synthesized prostaglandins stimulate sympathetic nervous system activity.
Topics: Animals; Indomethacin; Metanephrine; Methoxyhydroxyphenylglycol; Normetanephrine; Potassium Deficien | 1983 |
Effects of moderate short-term potassium depletion in normal humans. The role of prostaglandins.
Topics: Aldosterone; Angiotensin II; Female; Humans; Indomethacin; Norepinephrine; Potassium; Potassium Defi | 1980 |
Impairment of insulin secretion during experimental potassium depletion is not corrected by the prostaglandin synthesis inhibitor, indomethacin.
Topics: Adult; Blood Glucose; Female; Glucagon; Glucose Tolerance Test; Humans; Indomethacin; Insulin; Insul | 1981 |
Thromboxane B2 and prostaglandin E2 in the K+-depleted rat kidney.
Topics: Animals; Imidazoles; In Vitro Techniques; Indomethacin; Kidney; Male; Microsomes; Potassium; Potassi | 1981 |
Effects of angiotensin-converting enzyme inhibition on renal dysfunction induced by moderate potassium depletion in healthy women.
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Enalapril; Female; Humans; Indomethacin; Kidney Fun | 1994 |
[Selective inhibitory effects of experimental potassium depletion on urinary excretion of prostanoids and their possible functional significance].
Topics: Adult; Diuresis; Female; Humans; Indomethacin; Natriuresis; Potassium; Potassium Deficiency; Prostag | 1990 |
The renal concentrating defect associated with potassium depletion is independent of prostaglandin E2.
Topics: Adult; Cation Exchange Resins; Dinoprostone; Female; Humans; Indomethacin; Kidney Concentrating Abil | 1990 |
Effects of experimental potassium depletion on renal function and urinary prostanoid excretion in normal women during hypotonic polyuria.
Topics: Adult; Analysis of Variance; Female; Humans; Indomethacin; Kidney; Kidney Function Tests; Lypressin; | 1990 |
Captopril enhances aminoglycoside nephrotoxicity in potassium-depleted rats.
Topics: Aminoglycosides; Angiotensin-Converting Enzyme Inhibitors; Animals; Aprotinin; Captopril; Gentamicin | 1985 |
[Renal function in experimental potassium depletion. II. Indomethacin and effects of lysine-8-vasopressin in hypotonic polyuria].
Topics: 6-Ketoprostaglandin F1 alpha; Dinoprostone; Female; Humans; Indomethacin; Kidney; Lypressin; Polyuri | 1989 |
[Further research on the role of prostanoids in controlling renal function in humans in normal potassium balance and acute experimental potassium depletion. I: Studies of normal potassium balance. Effects of indomethacin].
Topics: Dinoprostone; Female; Humans; Indomethacin; Kidney; Potassium; Potassium Deficiency; Prostaglandins; | 1989 |
[Further research on the role of prostanoids in controlling renal function in humans in normal potassium balance and acute experimental potassium depletion. III: Effects of indomethacin in potassium depletion].
Topics: Acute Disease; Female; Humans; Indomethacin; Kidney; Potassium Deficiency; Prostaglandins | 1989 |
[Role of prostanoids in the control of renal function in normal potassium balance and in acute experimental potassium depletion. 4. Relation of extrarenal parameters, renal function parameters and urinary excretion of prostanoids].
Topics: 6-Ketoprostaglandin F1 alpha; Chlorides; Dinoprostone; Diuresis; Humans; Indomethacin; Kidney Functi | 1989 |
Prostaglandins and the urinary concentrating defect in potassium-depleted rabbits.
Topics: Adenylate Cyclase Toxin; Animals; Dehydration; Female; Indomethacin; Kidney Concentrating Ability; K | 1987 |
[Functional role of prostanoids in acute and moderate potassium depletion].
Topics: Acute Disease; Diet; Diuresis; Female; Humans; Indomethacin; Kidney; Lypressin; Potassium Deficiency | 1986 |
[Correlation of acute potassium depletion, prostanoids and renal function].
Topics: Acute Disease; Diuresis; Female; Humans; Indomethacin; Kidney; Lypressin; Natriuresis; Potassium Def | 1986 |
Effect of indomethacin on papillary solute concentration in the potassium-deficient rat.
Topics: Animals; Body Water; Chlorides; Indomethacin; Kidney Medulla; Male; Osmolar Concentration; Potassium | 1986 |