indomethacin has been researched along with Polyuria in 34 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Polyuria: Urination of a large volume of urine with an increase in urinary frequency, commonly seen in diabetes (DIABETES MELLITUS; DIABETES INSIPIDUS).
| Excerpt | Relevance | Reference |
|---|---|---|
| "We investigated the effect of combining indomethacin and desmopressin in treating children with monosymptomatic nocturnal enuresis (MNE) and desmopressin-resistant nocturnal polyuria." | 9.24 | Combination treatment of nocturnal enuresis with desmopressin and indomethacin. ( Djurhuus, JC; Faerch, M; Hagstroem, S; Kamperis, K; Mahler, B; Rittig, S, 2017) |
| "Furosemide is one of the most common drug used to treat anasarca in childhood nephrotic syndrome." | 7.88 | Furosemide-induced tubular dysfunction responding to prostaglandin synthesis inhibitor therapy in a child with nephrotic syndrome. ( Dawman, L; Santhiya, S; Sharma, A; Tiewsoh, K; Varma, TH, 2018) |
| "We evaluated the acute effect of indomethacin on renal water and solute handling in children with coexisting monosymptomatic nocturnal enuresis and desmopressin resistant nocturnal polyuria, and in healthy controls." | 7.78 | Effect of indomethacin on desmopressin resistant nocturnal polyuria and nocturnal enuresis. ( Bower, WF; Djurhuus, JC; Kamperis, K; Rittig, S, 2012) |
| "One of the mechanisms by which Li evokes polyuria is thought to be impairment of arginine vasopressin (AVP)-sensitive adenylate cyclase (AdC) in cells of the renal collecting duct." | 7.68 | Cellular mechanism of lithium-induced nephrogenic diabetes insipidus in rats. ( Asano, Y; Homma, S; Kusano, E; Murayama, N; Takeda, S; Tetsuka, T; Yamaki, M, 1991) |
| "Nephrogenic diabetes insipidus (NDI) is a frequent complication in patients receiving long-term lithium therapy." | 7.67 | Indomethacin in the treatment of lithium-induced nephrogenic diabetes insipidus. ( Allen, HM; Allon, M; Deck, LV; Jackson, RL; Winchester, MD, 1989) |
| " The prostaglandin synthetase inhibitor, indomethacin, rapidly corrected the polyuria both initially and on rechallenge, independent of change in glomerular filtration rate." | 7.67 | Indomethacin in streptozocin-induced nephrogenic diabetes insipidus. ( Bourke, E; de Pertuz, Y; Delaney, V; Nixon, D, 1987) |
| "Lithium intoxication causes polyuria, central nervous system manifestations, and ultimately stupor progressing to coma." | 7.67 | Indomethacin treatment in a patient with lithium-induced polyuria. ( Donker, AJ; ter Wee, PM; van Hoek, B, 1985) |
| " Treatment with indomethacin during DOCA-induced hypokalemia, polyuria, hypernatremia, and increased urinary PG, restored urinary PGs to control values, and corrected the polyuria and hypernatremia without a change in serum potassium." | 7.66 | The role of prostaglandins in diabetes insipidus produced by desoxycorticosterone in the dog. ( Bartter, FC; Düsing, R; Gill, JR; Güllner, HG, 1982) |
| "We investigated the effect of combining indomethacin and desmopressin in treating children with monosymptomatic nocturnal enuresis (MNE) and desmopressin-resistant nocturnal polyuria." | 5.24 | Combination treatment of nocturnal enuresis with desmopressin and indomethacin. ( Djurhuus, JC; Faerch, M; Hagstroem, S; Kamperis, K; Mahler, B; Rittig, S, 2017) |
| "Furosemide is one of the most common drug used to treat anasarca in childhood nephrotic syndrome." | 3.88 | Furosemide-induced tubular dysfunction responding to prostaglandin synthesis inhibitor therapy in a child with nephrotic syndrome. ( Dawman, L; Santhiya, S; Sharma, A; Tiewsoh, K; Varma, TH, 2018) |
| "We evaluated the acute effect of indomethacin on renal water and solute handling in children with coexisting monosymptomatic nocturnal enuresis and desmopressin resistant nocturnal polyuria, and in healthy controls." | 3.78 | Effect of indomethacin on desmopressin resistant nocturnal polyuria and nocturnal enuresis. ( Bower, WF; Djurhuus, JC; Kamperis, K; Rittig, S, 2012) |
| " Treatment of -/- pups with indomethacin from day 1 prevented growth retardation and 10% treated for 3 weeks survived, although as adults they exhibited severe polyuria (10 ml/day), extreme hydronephrosis, low plasma potassium, high blood pH, hypercalciuria, and proteinuria." | 3.70 | Uncompensated polyuria in a mouse model of Bartter's syndrome. ( Chernavvsky, DR; Gitelman, HJ; Gomez, RA; Igarashi, P; Smithies, O; Takahashi, N, 2000) |
| "One of the mechanisms by which Li evokes polyuria is thought to be impairment of arginine vasopressin (AVP)-sensitive adenylate cyclase (AdC) in cells of the renal collecting duct." | 3.68 | Cellular mechanism of lithium-induced nephrogenic diabetes insipidus in rats. ( Asano, Y; Homma, S; Kusano, E; Murayama, N; Takeda, S; Tetsuka, T; Yamaki, M, 1991) |
| "We have evaluated the effects of indomethacin (I) and of a rich in linoleic acid phosphatidylcholine (E) on the renal function and on the PGE urinary excretion during steady hypotonic polyuria." | 3.67 | [Relation between acute changes in diuresis and renal prostaglandins. I: Induced hypotonic polyuria]. ( Agnoli, GC; Andreone, P; Cacciari, M; Garutti, C; Ikonomu, E, 1984) |
| "Nephrogenic diabetes insipidus (NDI) is a frequent complication in patients receiving long-term lithium therapy." | 3.67 | Indomethacin in the treatment of lithium-induced nephrogenic diabetes insipidus. ( Allen, HM; Allon, M; Deck, LV; Jackson, RL; Winchester, MD, 1989) |
| " The prostaglandin synthetase inhibitor, indomethacin, rapidly corrected the polyuria both initially and on rechallenge, independent of change in glomerular filtration rate." | 3.67 | Indomethacin in streptozocin-induced nephrogenic diabetes insipidus. ( Bourke, E; de Pertuz, Y; Delaney, V; Nixon, D, 1987) |
| "Lithium intoxication causes polyuria, central nervous system manifestations, and ultimately stupor progressing to coma." | 3.67 | Indomethacin treatment in a patient with lithium-induced polyuria. ( Donker, AJ; ter Wee, PM; van Hoek, B, 1985) |
| "Studies were performed in conscious rats to evaluate the role of renal prostaglandin biosynthesis in demeclocycline-induced polyuria." | 3.66 | Effect of prostaglandin inhibition on demeclocycline administration in conscious rats. ( Kirschenbaum, MA; Lowe, AG; Serros, ER, 1980) |
| " Treatment with indomethacin during DOCA-induced hypokalemia, polyuria, hypernatremia, and increased urinary PG, restored urinary PGs to control values, and corrected the polyuria and hypernatremia without a change in serum potassium." | 3.66 | The role of prostaglandins in diabetes insipidus produced by desoxycorticosterone in the dog. ( Bartter, FC; Düsing, R; Gill, JR; Güllner, HG, 1982) |
| "Antenatal Bartter syndrome is characterized by severe polyhydramnios in mother leading to premature delivery." | 1.40 | Antenatal Bartter syndrome. ( Afzal, M; Anwar, V; Azam, S; Khan, EA; Khan, WA; Rafiq, S; Yaqoob, A, 2014) |
| "Bartter syndrome is a group of rare autosomal-recessive disorders caused by a defect in distal tubule transport of sodium and chloride." | 1.38 | Classic Bartter syndrome: a rare cause of failure to thrive in a child. ( da Silva, JE; Mendes, L; Mendes, P; Vieira, H, 2012) |
| "Antenatal Bartter Syndrome (ABS) is a rare autosomic recessive tubulopathy characterized by idiopathic hydramnios, fetal polyuria and elevated levels of amniotic chloride." | 1.32 | [Prenatal Bartter's syndrome. Report of two cases]. ( Billiemaz, K; Collet, F; Lavocat, MP; Prieur, F; Seffert, P; Tourne, G; Varlet, MN, 2003) |
| "(3) Indomethacin treatment resulted in changes in mean arterial pressure (increase) and creatinine cl." | 1.28 | Effects of experimental potassium depletion on renal function and urinary prostanoid excretion in normal women during hypotonic polyuria. ( Agnoli, GC; Borgatti, R; Cacciari, M; Garutti, C; Ikonomu, E; Lenzi, P; Marinelli, M, 1990) |
| "Treatment with aspirin and indomethacin reduced urinary PGE excretion and was associated with a decrease in daily calcium excretion." | 1.27 | Idiopathic hypercalciuria associated with hyperreninemia and high urinary prostaglandin E. ( Davidman, M; Fish, A; Houser, M; Sinaiko, A; Smith, C; Zimmerman, B, 1984) |
| "Indomethacin was incorporated into the infusate for 15 min, at 3 h 52." | 1.27 | Renal response to vasopressin and indomethacin in cisplatin-treated rats. ( Harpur, ES; Lote, CJ; Phipps, DJ; Thewles, A, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (50.00) | 18.7374 |
| 1990's | 9 (26.47) | 18.2507 |
| 2000's | 2 (5.88) | 29.6817 |
| 2010's | 6 (17.65) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Varma, TH | 1 |
| Sharma, A | 1 |
| Santhiya, S | 1 |
| Dawman, L | 1 |
| Tiewsoh, K | 1 |
| Afzal, M | 1 |
| Khan, EA | 1 |
| Khan, WA | 1 |
| Anwar, V | 1 |
| Yaqoob, A | 1 |
| Rafiq, S | 1 |
| Azam, S | 1 |
| Kamperis, K | 2 |
| Hagstroem, S | 1 |
| Faerch, M | 1 |
| Mahler, B | 1 |
| Rittig, S | 2 |
| Djurhuus, JC | 2 |
| Vieira, H | 1 |
| Mendes, L | 1 |
| Mendes, P | 1 |
| da Silva, JE | 1 |
| Wan, J | 1 |
| Bower, WF | 1 |
| Tourne, G | 1 |
| Collet, F | 1 |
| Varlet, MN | 1 |
| Billiemaz, K | 1 |
| Prieur, F | 1 |
| Lavocat, MP | 1 |
| Seffert, P | 1 |
| Houser, M | 1 |
| Zimmerman, B | 1 |
| Davidman, M | 1 |
| Smith, C | 1 |
| Sinaiko, A | 1 |
| Fish, A | 1 |
| Agnoli, GC | 4 |
| Andreone, P | 1 |
| Cacciari, M | 4 |
| Garutti, C | 3 |
| Ikonomu, E | 4 |
| Serros, ER | 2 |
| Lowe, AG | 1 |
| Kirschenbaum, MA | 2 |
| Monn, E | 1 |
| Rutecki, GW | 1 |
| Cox, JW | 1 |
| Robertson, GW | 1 |
| Francisco, LL | 1 |
| Ferris, TF | 2 |
| Düsing, R | 1 |
| Gill, JR | 1 |
| Güllner, HG | 1 |
| Bartter, FC | 1 |
| Pies, R | 1 |
| Martin, A | 1 |
| Williams, MP | 1 |
| Jones, CL | 1 |
| Johnstone, LM | 1 |
| Walker, RG | 1 |
| McCredie, DA | 1 |
| Powell, HR | 1 |
| Liaw, LC | 1 |
| Banerjee, K | 1 |
| Coulthard, MG | 1 |
| Takahashi, N | 1 |
| Chernavvsky, DR | 1 |
| Gomez, RA | 1 |
| Igarashi, P | 1 |
| Gitelman, HJ | 1 |
| Smithies, O | 1 |
| Galvez, OG | 1 |
| Roberts, BW | 1 |
| Mishkind, MH | 1 |
| Bay, WH | 1 |
| Borgatti, R | 3 |
| Lenzi, P | 3 |
| Marinelli, M | 3 |
| Smoyer, WE | 1 |
| Yamaki, M | 1 |
| Kusano, E | 1 |
| Tetsuka, T | 1 |
| Takeda, S | 1 |
| Homma, S | 1 |
| Murayama, N | 1 |
| Asano, Y | 1 |
| Kollmann, E | 1 |
| Seyberth, HW | 1 |
| Sulyok, E | 1 |
| Passavanti, G | 1 |
| Buongiorno, E | 1 |
| De Fino, G | 1 |
| Rutigliano, G | 1 |
| Giannattasio, M | 1 |
| Coratelli, P | 1 |
| Allen, HM | 1 |
| Jackson, RL | 1 |
| Winchester, MD | 1 |
| Deck, LV | 1 |
| Allon, M | 1 |
| Delaney, V | 1 |
| de Pertuz, Y | 1 |
| Nixon, D | 1 |
| Bourke, E | 1 |
| Lote, CJ | 1 |
| Harpur, ES | 1 |
| Thewles, A | 1 |
| Phipps, DJ | 1 |
| Davidai, G | 1 |
| Alon, U | 1 |
| Jaffe, M | 1 |
| Hochberg, Z | 1 |
| Grindlinger, GA | 1 |
| Boylan, MJ | 1 |
| ter Wee, PM | 1 |
| van Hoek, B | 1 |
| Donker, AJ | 1 |
| Fujii, T | 1 |
| Misumi, S | 1 |
| Takeda, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Indomethacin in Monosymptomatic Enuresis Nocturnal[NCT00226122] | Phase 4 | 56 participants (Actual) | Interventional | 2003-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for indomethacin and Polyuria
| Article | Year |
|---|---|
Clinical management of lithium-induced polyuria.
Topics: Amiloride; Diabetes Insipidus; Drug Administration Schedule; Humans; Hydrochlorothiazide; Indomethac | 1993 |
2 trials available for indomethacin and Polyuria
| Article | Year |
|---|---|
Combination treatment of nocturnal enuresis with desmopressin and indomethacin.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Child; Cross-Over Studies; Deamino Arginine Vas | 2017 |
Urinary prostanoid excretion in healthy women with different degrees of induced potassium depletion.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Chlorides; Dinoprostone; Female; Glomerular Filtration Rate; Hu | 1992 |
31 other studies available for indomethacin and Polyuria
| Article | Year |
|---|---|
Furosemide-induced tubular dysfunction responding to prostaglandin synthesis inhibitor therapy in a child with nephrotic syndrome.
Topics: Alkalosis; Bartter Syndrome; Child, Preschool; Cyclooxygenase Inhibitors; Diuretics; Female; Furosem | 2018 |
Antenatal Bartter syndrome.
Topics: Bartter Syndrome; Chlorides; Fatal Outcome; Female; Humans; Hypokalemia; Hyponatremia; Indomethacin; | 2014 |
Classic Bartter syndrome: a rare cause of failure to thrive in a child.
Topics: Alkalosis; Anti-Inflammatory Agents, Non-Steroidal; Bartter Syndrome; Failure to Thrive; Female; Hum | 2012 |
Editorial comment.
Topics: Cyclooxygenase Inhibitors; Humans; Indomethacin; Nocturnal Enuresis; Polyuria | 2012 |
Effect of indomethacin on desmopressin resistant nocturnal polyuria and nocturnal enuresis.
Topics: Adolescent; Antidiuretic Agents; Child; Cyclooxygenase Inhibitors; Deamino Arginine Vasopressin; Dru | 2012 |
[Prenatal Bartter's syndrome. Report of two cases].
Topics: Adult; Amniocentesis; Anti-Inflammatory Agents, Non-Steroidal; Bartter Syndrome; Chloride Channels; | 2003 |
Idiopathic hypercalciuria associated with hyperreninemia and high urinary prostaglandin E.
Topics: Aspirin; Bartter Syndrome; Calcium; Humans; Hyperaldosteronism; Indomethacin; Infant; Male; Nephroca | 1984 |
[Relation between acute changes in diuresis and renal prostaglandins. I: Induced hypotonic polyuria].
Topics: Adult; Diuresis; Female; Glomerular Filtration Rate; Humans; Indomethacin; Kidney Function Tests; Li | 1984 |
Effect of prostaglandin inhibition on demeclocycline administration in conscious rats.
Topics: Animals; Body Weight; Demeclocycline; Female; Glomerular Filtration Rate; Indomethacin; Polyuria; Pr | 1980 |
Prostaglandin synthetase inhibitors in the treatment of nephrogenic diabetes insipidus.
Topics: Aspirin; Body Water; Child; Cyclooxygenase Inhibitors; Diabetes Insipidus; Humans; Hydrochlorothiazi | 1981 |
Prostaglandin-dependent polyuria in hypercalcemia.
Topics: Animals; Calcitriol; Female; Hypercalcemia; Indomethacin; Kidney; Polyuria; Prostaglandins; Prostagl | 1981 |
Urinary concentrating ability and antidiuretic hormone responsiveness in the potassium-depleted dog.
Topics: Animals; Dinoprostone; Diuresis; Dogs; Female; Hypokalemia; Indomethacin; Kidney; Kidney Concentrati | 1982 |
The role of prostaglandins in diabetes insipidus produced by desoxycorticosterone in the dog.
Topics: Animals; Desoxycorticosterone; Diabetes Insipidus; Dogs; Female; Indomethacin; Polyuria; Potassium; | 1982 |
Lithium-induced polyuria.
Topics: Bipolar Disorder; Humans; Indomethacin; Lithium; Polyuria | 1993 |
An extreme example of the neonatal form of Bartter's syndrome.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Bartter Syndrome; Body Weight; Fatal Outcome; Humans; Indom | 1996 |
Dose related growth response to indometacin in Gitelman syndrome.
Topics: Bartter Syndrome; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Female; Growth Disord | 1999 |
Uncompensated polyuria in a mouse model of Bartter's syndrome.
Topics: Animals; Bartter Syndrome; Calcium; Carrier Proteins; Disease Models, Animal; Electrolytes; Hydronep | 2000 |
Studies of the mechanism of contralateral polyuria after renal artery stenosis.
Topics: Animals; Blood Pressure; Dogs; Glomerular Filtration Rate; Indomethacin; Polyuria; Prostaglandins E; | 1977 |
Medical management of postobstructive polyuria.
Topics: Diabetes Insipidus; Humans; Hydrochlorothiazide; Indomethacin; Infant, Newborn; Male; Polyuria; Uret | 1991 |
Cellular mechanism of lithium-induced nephrogenic diabetes insipidus in rats.
Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Animals; Arginine Vasopressin; Chlorides; Chol | 1991 |
[Hyperprostaglandin E syndrome in a nine-year-old child].
Topics: Calcium; Child; Female; Growth Disorders; Humans; Indomethacin; Intellectual Disability; Polyuria; P | 1990 |
Effects of experimental potassium depletion on renal function and urinary prostanoid excretion in normal women during hypotonic polyuria.
Topics: Adult; Analysis of Variance; Female; Humans; Indomethacin; Kidney; Kidney Function Tests; Lypressin; | 1990 |
Lithium induced polyuria and polydipsia.
Topics: Adult; Creatinine; Diabetes Insipidus; Drinking; Female; Humans; Indomethacin; Kidney Concentrating | 1989 |
[Renal function in experimental potassium depletion. II. Indomethacin and effects of lysine-8-vasopressin in hypotonic polyuria].
Topics: 6-Ketoprostaglandin F1 alpha; Dinoprostone; Female; Humans; Indomethacin; Kidney; Lypressin; Polyuri | 1989 |
Indomethacin in the treatment of lithium-induced nephrogenic diabetes insipidus.
Topics: Adult; Diabetes Insipidus; Female; Humans; Indomethacin; Kidney Diseases; Lithium; Polyuria | 1989 |
Indomethacin in streptozocin-induced nephrogenic diabetes insipidus.
Topics: Administration, Oral; Adolescent; Diabetes Insipidus; Drug Evaluation; Female; Glomerular Filtration | 1987 |
Renal response to vasopressin and indomethacin in cisplatin-treated rats.
Topics: Animals; Cisplatin; Dinoprostone; Indomethacin; Kidney; Male; Osmolar Concentration; Polyuria; Potas | 1987 |
Post-obstructive urinary concentrating defect. A case study in the role of prostaglandins.
Topics: Child, Preschool; Dinoprost; Dinoprostone; Humans; Hydrochlorothiazide; Indomethacin; Kidney Concent | 1987 |
Amelioration by indomethacin of lithium-induced polyuria.
Topics: Adult; Diabetes Insipidus; Female; Humans; Indomethacin; Lithium; Mood Disorders; Polyuria | 1987 |
Indomethacin treatment in a patient with lithium-induced polyuria.
Topics: Coma; Female; Humans; Hypernatremia; Indomethacin; Lithium; Lithium Carbonate; Middle Aged; Polyuria | 1985 |
Management of polyuria subsequent to pituitary surgery based on the diurnal pattern of urinary excretion.
Topics: Adenoma; Adolescent; Adult; Aged; Circadian Rhythm; Diabetes Insipidus; Female; Humans; Indomethacin | 1985 |