Page last updated: 2024-10-29

indomethacin and Polyuria

indomethacin has been researched along with Polyuria in 34 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Polyuria: Urination of a large volume of urine with an increase in urinary frequency, commonly seen in diabetes (DIABETES MELLITUS; DIABETES INSIPIDUS).

Research Excerpts

ExcerptRelevanceReference
"We investigated the effect of combining indomethacin and desmopressin in treating children with monosymptomatic nocturnal enuresis (MNE) and desmopressin-resistant nocturnal polyuria."9.24Combination treatment of nocturnal enuresis with desmopressin and indomethacin. ( Djurhuus, JC; Faerch, M; Hagstroem, S; Kamperis, K; Mahler, B; Rittig, S, 2017)
"Furosemide is one of the most common drug used to treat anasarca in childhood nephrotic syndrome."7.88Furosemide-induced tubular dysfunction responding to prostaglandin synthesis inhibitor therapy in a child with nephrotic syndrome. ( Dawman, L; Santhiya, S; Sharma, A; Tiewsoh, K; Varma, TH, 2018)
"We evaluated the acute effect of indomethacin on renal water and solute handling in children with coexisting monosymptomatic nocturnal enuresis and desmopressin resistant nocturnal polyuria, and in healthy controls."7.78Effect of indomethacin on desmopressin resistant nocturnal polyuria and nocturnal enuresis. ( Bower, WF; Djurhuus, JC; Kamperis, K; Rittig, S, 2012)
"One of the mechanisms by which Li evokes polyuria is thought to be impairment of arginine vasopressin (AVP)-sensitive adenylate cyclase (AdC) in cells of the renal collecting duct."7.68Cellular mechanism of lithium-induced nephrogenic diabetes insipidus in rats. ( Asano, Y; Homma, S; Kusano, E; Murayama, N; Takeda, S; Tetsuka, T; Yamaki, M, 1991)
"Nephrogenic diabetes insipidus (NDI) is a frequent complication in patients receiving long-term lithium therapy."7.67Indomethacin in the treatment of lithium-induced nephrogenic diabetes insipidus. ( Allen, HM; Allon, M; Deck, LV; Jackson, RL; Winchester, MD, 1989)
" The prostaglandin synthetase inhibitor, indomethacin, rapidly corrected the polyuria both initially and on rechallenge, independent of change in glomerular filtration rate."7.67Indomethacin in streptozocin-induced nephrogenic diabetes insipidus. ( Bourke, E; de Pertuz, Y; Delaney, V; Nixon, D, 1987)
"Lithium intoxication causes polyuria, central nervous system manifestations, and ultimately stupor progressing to coma."7.67Indomethacin treatment in a patient with lithium-induced polyuria. ( Donker, AJ; ter Wee, PM; van Hoek, B, 1985)
" Treatment with indomethacin during DOCA-induced hypokalemia, polyuria, hypernatremia, and increased urinary PG, restored urinary PGs to control values, and corrected the polyuria and hypernatremia without a change in serum potassium."7.66The role of prostaglandins in diabetes insipidus produced by desoxycorticosterone in the dog. ( Bartter, FC; Düsing, R; Gill, JR; Güllner, HG, 1982)
"We investigated the effect of combining indomethacin and desmopressin in treating children with monosymptomatic nocturnal enuresis (MNE) and desmopressin-resistant nocturnal polyuria."5.24Combination treatment of nocturnal enuresis with desmopressin and indomethacin. ( Djurhuus, JC; Faerch, M; Hagstroem, S; Kamperis, K; Mahler, B; Rittig, S, 2017)
"Furosemide is one of the most common drug used to treat anasarca in childhood nephrotic syndrome."3.88Furosemide-induced tubular dysfunction responding to prostaglandin synthesis inhibitor therapy in a child with nephrotic syndrome. ( Dawman, L; Santhiya, S; Sharma, A; Tiewsoh, K; Varma, TH, 2018)
"We evaluated the acute effect of indomethacin on renal water and solute handling in children with coexisting monosymptomatic nocturnal enuresis and desmopressin resistant nocturnal polyuria, and in healthy controls."3.78Effect of indomethacin on desmopressin resistant nocturnal polyuria and nocturnal enuresis. ( Bower, WF; Djurhuus, JC; Kamperis, K; Rittig, S, 2012)
" Treatment of -/- pups with indomethacin from day 1 prevented growth retardation and 10% treated for 3 weeks survived, although as adults they exhibited severe polyuria (10 ml/day), extreme hydronephrosis, low plasma potassium, high blood pH, hypercalciuria, and proteinuria."3.70Uncompensated polyuria in a mouse model of Bartter's syndrome. ( Chernavvsky, DR; Gitelman, HJ; Gomez, RA; Igarashi, P; Smithies, O; Takahashi, N, 2000)
"One of the mechanisms by which Li evokes polyuria is thought to be impairment of arginine vasopressin (AVP)-sensitive adenylate cyclase (AdC) in cells of the renal collecting duct."3.68Cellular mechanism of lithium-induced nephrogenic diabetes insipidus in rats. ( Asano, Y; Homma, S; Kusano, E; Murayama, N; Takeda, S; Tetsuka, T; Yamaki, M, 1991)
"We have evaluated the effects of indomethacin (I) and of a rich in linoleic acid phosphatidylcholine (E) on the renal function and on the PGE urinary excretion during steady hypotonic polyuria."3.67[Relation between acute changes in diuresis and renal prostaglandins. I: Induced hypotonic polyuria]. ( Agnoli, GC; Andreone, P; Cacciari, M; Garutti, C; Ikonomu, E, 1984)
"Nephrogenic diabetes insipidus (NDI) is a frequent complication in patients receiving long-term lithium therapy."3.67Indomethacin in the treatment of lithium-induced nephrogenic diabetes insipidus. ( Allen, HM; Allon, M; Deck, LV; Jackson, RL; Winchester, MD, 1989)
" The prostaglandin synthetase inhibitor, indomethacin, rapidly corrected the polyuria both initially and on rechallenge, independent of change in glomerular filtration rate."3.67Indomethacin in streptozocin-induced nephrogenic diabetes insipidus. ( Bourke, E; de Pertuz, Y; Delaney, V; Nixon, D, 1987)
"Lithium intoxication causes polyuria, central nervous system manifestations, and ultimately stupor progressing to coma."3.67Indomethacin treatment in a patient with lithium-induced polyuria. ( Donker, AJ; ter Wee, PM; van Hoek, B, 1985)
"Studies were performed in conscious rats to evaluate the role of renal prostaglandin biosynthesis in demeclocycline-induced polyuria."3.66Effect of prostaglandin inhibition on demeclocycline administration in conscious rats. ( Kirschenbaum, MA; Lowe, AG; Serros, ER, 1980)
" Treatment with indomethacin during DOCA-induced hypokalemia, polyuria, hypernatremia, and increased urinary PG, restored urinary PGs to control values, and corrected the polyuria and hypernatremia without a change in serum potassium."3.66The role of prostaglandins in diabetes insipidus produced by desoxycorticosterone in the dog. ( Bartter, FC; Düsing, R; Gill, JR; Güllner, HG, 1982)
"Antenatal Bartter syndrome is characterized by severe polyhydramnios in mother leading to premature delivery."1.40Antenatal Bartter syndrome. ( Afzal, M; Anwar, V; Azam, S; Khan, EA; Khan, WA; Rafiq, S; Yaqoob, A, 2014)
"Bartter syndrome is a group of rare autosomal-recessive disorders caused by a defect in distal tubule transport of sodium and chloride."1.38Classic Bartter syndrome: a rare cause of failure to thrive in a child. ( da Silva, JE; Mendes, L; Mendes, P; Vieira, H, 2012)
"Antenatal Bartter Syndrome (ABS) is a rare autosomic recessive tubulopathy characterized by idiopathic hydramnios, fetal polyuria and elevated levels of amniotic chloride."1.32[Prenatal Bartter's syndrome. Report of two cases]. ( Billiemaz, K; Collet, F; Lavocat, MP; Prieur, F; Seffert, P; Tourne, G; Varlet, MN, 2003)
"(3) Indomethacin treatment resulted in changes in mean arterial pressure (increase) and creatinine cl."1.28Effects of experimental potassium depletion on renal function and urinary prostanoid excretion in normal women during hypotonic polyuria. ( Agnoli, GC; Borgatti, R; Cacciari, M; Garutti, C; Ikonomu, E; Lenzi, P; Marinelli, M, 1990)
"Treatment with aspirin and indomethacin reduced urinary PGE excretion and was associated with a decrease in daily calcium excretion."1.27Idiopathic hypercalciuria associated with hyperreninemia and high urinary prostaglandin E. ( Davidman, M; Fish, A; Houser, M; Sinaiko, A; Smith, C; Zimmerman, B, 1984)
"Indomethacin was incorporated into the infusate for 15 min, at 3 h 52."1.27Renal response to vasopressin and indomethacin in cisplatin-treated rats. ( Harpur, ES; Lote, CJ; Phipps, DJ; Thewles, A, 1987)

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-199017 (50.00)18.7374
1990's9 (26.47)18.2507
2000's2 (5.88)29.6817
2010's6 (17.65)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Varma, TH1
Sharma, A1
Santhiya, S1
Dawman, L1
Tiewsoh, K1
Afzal, M1
Khan, EA1
Khan, WA1
Anwar, V1
Yaqoob, A1
Rafiq, S1
Azam, S1
Kamperis, K2
Hagstroem, S1
Faerch, M1
Mahler, B1
Rittig, S2
Djurhuus, JC2
Vieira, H1
Mendes, L1
Mendes, P1
da Silva, JE1
Wan, J1
Bower, WF1
Tourne, G1
Collet, F1
Varlet, MN1
Billiemaz, K1
Prieur, F1
Lavocat, MP1
Seffert, P1
Houser, M1
Zimmerman, B1
Davidman, M1
Smith, C1
Sinaiko, A1
Fish, A1
Agnoli, GC4
Andreone, P1
Cacciari, M4
Garutti, C3
Ikonomu, E4
Serros, ER2
Lowe, AG1
Kirschenbaum, MA2
Monn, E1
Rutecki, GW1
Cox, JW1
Robertson, GW1
Francisco, LL1
Ferris, TF2
Düsing, R1
Gill, JR1
Güllner, HG1
Bartter, FC1
Pies, R1
Martin, A1
Williams, MP1
Jones, CL1
Johnstone, LM1
Walker, RG1
McCredie, DA1
Powell, HR1
Liaw, LC1
Banerjee, K1
Coulthard, MG1
Takahashi, N1
Chernavvsky, DR1
Gomez, RA1
Igarashi, P1
Gitelman, HJ1
Smithies, O1
Galvez, OG1
Roberts, BW1
Mishkind, MH1
Bay, WH1
Borgatti, R3
Lenzi, P3
Marinelli, M3
Smoyer, WE1
Yamaki, M1
Kusano, E1
Tetsuka, T1
Takeda, S1
Homma, S1
Murayama, N1
Asano, Y1
Kollmann, E1
Seyberth, HW1
Sulyok, E1
Passavanti, G1
Buongiorno, E1
De Fino, G1
Rutigliano, G1
Giannattasio, M1
Coratelli, P1
Allen, HM1
Jackson, RL1
Winchester, MD1
Deck, LV1
Allon, M1
Delaney, V1
de Pertuz, Y1
Nixon, D1
Bourke, E1
Lote, CJ1
Harpur, ES1
Thewles, A1
Phipps, DJ1
Davidai, G1
Alon, U1
Jaffe, M1
Hochberg, Z1
Grindlinger, GA1
Boylan, MJ1
ter Wee, PM1
van Hoek, B1
Donker, AJ1
Fujii, T1
Misumi, S1
Takeda, F1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Effect of Indomethacin in Monosymptomatic Enuresis Nocturnal[NCT00226122]Phase 456 participants (Actual)Interventional2003-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for indomethacin and Polyuria

ArticleYear
Clinical management of lithium-induced polyuria.
    Hospital & community psychiatry, 1993, Volume: 44, Issue:5

    Topics: Amiloride; Diabetes Insipidus; Drug Administration Schedule; Humans; Hydrochlorothiazide; Indomethac

1993

Trials

2 trials available for indomethacin and Polyuria

ArticleYear
Combination treatment of nocturnal enuresis with desmopressin and indomethacin.
    Pediatric nephrology (Berlin, Germany), 2017, Volume: 32, Issue:4

    Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Child; Cross-Over Studies; Deamino Arginine Vas

2017
Urinary prostanoid excretion in healthy women with different degrees of induced potassium depletion.
    Prostaglandins, leukotrienes, and essential fatty acids, 1992, Volume: 46, Issue:1

    Topics: 6-Ketoprostaglandin F1 alpha; Adult; Chlorides; Dinoprostone; Female; Glomerular Filtration Rate; Hu

1992

Other Studies

31 other studies available for indomethacin and Polyuria

ArticleYear
Furosemide-induced tubular dysfunction responding to prostaglandin synthesis inhibitor therapy in a child with nephrotic syndrome.
    CEN case reports, 2018, Volume: 7, Issue:2

    Topics: Alkalosis; Bartter Syndrome; Child, Preschool; Cyclooxygenase Inhibitors; Diuretics; Female; Furosem

2018
Antenatal Bartter syndrome.
    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2014, Volume: 24 Suppl 2

    Topics: Bartter Syndrome; Chlorides; Fatal Outcome; Female; Humans; Hypokalemia; Hyponatremia; Indomethacin;

2014
Classic Bartter syndrome: a rare cause of failure to thrive in a child.
    BMJ case reports, 2012, Jun-28, Volume: 2012

    Topics: Alkalosis; Anti-Inflammatory Agents, Non-Steroidal; Bartter Syndrome; Failure to Thrive; Female; Hum

2012
Editorial comment.
    The Journal of urology, 2012, Volume: 188, Issue:5

    Topics: Cyclooxygenase Inhibitors; Humans; Indomethacin; Nocturnal Enuresis; Polyuria

2012
Effect of indomethacin on desmopressin resistant nocturnal polyuria and nocturnal enuresis.
    The Journal of urology, 2012, Volume: 188, Issue:5

    Topics: Adolescent; Antidiuretic Agents; Child; Cyclooxygenase Inhibitors; Deamino Arginine Vasopressin; Dru

2012
[Prenatal Bartter's syndrome. Report of two cases].
    Journal de gynecologie, obstetrique et biologie de la reproduction, 2003, Volume: 32, Issue:8 Pt 1

    Topics: Adult; Amniocentesis; Anti-Inflammatory Agents, Non-Steroidal; Bartter Syndrome; Chloride Channels;

2003
Idiopathic hypercalciuria associated with hyperreninemia and high urinary prostaglandin E.
    Kidney international, 1984, Volume: 26, Issue:2

    Topics: Aspirin; Bartter Syndrome; Calcium; Humans; Hyperaldosteronism; Indomethacin; Infant; Male; Nephroca

1984
[Relation between acute changes in diuresis and renal prostaglandins. I: Induced hypotonic polyuria].
    Bollettino della Societa italiana di biologia sperimentale, 1984, Aug-31, Volume: 60, Issue:8

    Topics: Adult; Diuresis; Female; Glomerular Filtration Rate; Humans; Indomethacin; Kidney Function Tests; Li

1984
Effect of prostaglandin inhibition on demeclocycline administration in conscious rats.
    Prostaglandins and medicine, 1980, Volume: 5, Issue:3

    Topics: Animals; Body Weight; Demeclocycline; Female; Glomerular Filtration Rate; Indomethacin; Polyuria; Pr

1980
Prostaglandin synthetase inhibitors in the treatment of nephrogenic diabetes insipidus.
    Acta paediatrica Scandinavica, 1981, Volume: 70, Issue:1

    Topics: Aspirin; Body Water; Child; Cyclooxygenase Inhibitors; Diabetes Insipidus; Humans; Hydrochlorothiazi

1981
Prostaglandin-dependent polyuria in hypercalcemia.
    The American journal of physiology, 1981, Volume: 241, Issue:3

    Topics: Animals; Calcitriol; Female; Hypercalcemia; Indomethacin; Kidney; Polyuria; Prostaglandins; Prostagl

1981
Urinary concentrating ability and antidiuretic hormone responsiveness in the potassium-depleted dog.
    The Journal of laboratory and clinical medicine, 1982, Volume: 100, Issue:1

    Topics: Animals; Dinoprostone; Diuresis; Dogs; Female; Hypokalemia; Indomethacin; Kidney; Kidney Concentrati

1982
The role of prostaglandins in diabetes insipidus produced by desoxycorticosterone in the dog.
    Endocrinology, 1982, Volume: 110, Issue:2

    Topics: Animals; Desoxycorticosterone; Diabetes Insipidus; Dogs; Female; Indomethacin; Polyuria; Potassium;

1982
Lithium-induced polyuria.
    Hospital & community psychiatry, 1993, Volume: 44, Issue:12

    Topics: Bipolar Disorder; Humans; Indomethacin; Lithium; Polyuria

1993
An extreme example of the neonatal form of Bartter's syndrome.
    Pediatric nephrology (Berlin, Germany), 1996, Volume: 10, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Bartter Syndrome; Body Weight; Fatal Outcome; Humans; Indom

1996
Dose related growth response to indometacin in Gitelman syndrome.
    Archives of disease in childhood, 1999, Volume: 81, Issue:6

    Topics: Bartter Syndrome; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Female; Growth Disord

1999
Uncompensated polyuria in a mouse model of Bartter's syndrome.
    Proceedings of the National Academy of Sciences of the United States of America, 2000, May-09, Volume: 97, Issue:10

    Topics: Animals; Bartter Syndrome; Calcium; Carrier Proteins; Disease Models, Animal; Electrolytes; Hydronep

2000
Studies of the mechanism of contralateral polyuria after renal artery stenosis.
    The Journal of clinical investigation, 1977, Volume: 59, Issue:4

    Topics: Animals; Blood Pressure; Dogs; Glomerular Filtration Rate; Indomethacin; Polyuria; Prostaglandins E;

1977
Medical management of postobstructive polyuria.
    American journal of diseases of children (1960), 1991, Volume: 145, Issue:12

    Topics: Diabetes Insipidus; Humans; Hydrochlorothiazide; Indomethacin; Infant, Newborn; Male; Polyuria; Uret

1991
Cellular mechanism of lithium-induced nephrogenic diabetes insipidus in rats.
    The American journal of physiology, 1991, Volume: 261, Issue:3 Pt 2

    Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Animals; Arginine Vasopressin; Chlorides; Chol

1991
[Hyperprostaglandin E syndrome in a nine-year-old child].
    Orvosi hetilap, 1990, Feb-11, Volume: 131, Issue:6

    Topics: Calcium; Child; Female; Growth Disorders; Humans; Indomethacin; Intellectual Disability; Polyuria; P

1990
Effects of experimental potassium depletion on renal function and urinary prostanoid excretion in normal women during hypotonic polyuria.
    Clinical physiology (Oxford, England), 1990, Volume: 10, Issue:4

    Topics: Adult; Analysis of Variance; Female; Humans; Indomethacin; Kidney; Kidney Function Tests; Lypressin;

1990
Lithium induced polyuria and polydipsia.
    Advances in experimental medicine and biology, 1989, Volume: 252

    Topics: Adult; Creatinine; Diabetes Insipidus; Drinking; Female; Humans; Indomethacin; Kidney Concentrating

1989
[Renal function in experimental potassium depletion. II. Indomethacin and effects of lysine-8-vasopressin in hypotonic polyuria].
    Bollettino della Societa italiana di biologia sperimentale, 1989, Volume: 65, Issue:12

    Topics: 6-Ketoprostaglandin F1 alpha; Dinoprostone; Female; Humans; Indomethacin; Kidney; Lypressin; Polyuri

1989
Indomethacin in the treatment of lithium-induced nephrogenic diabetes insipidus.
    Archives of internal medicine, 1989, Volume: 149, Issue:5

    Topics: Adult; Diabetes Insipidus; Female; Humans; Indomethacin; Kidney Diseases; Lithium; Polyuria

1989
Indomethacin in streptozocin-induced nephrogenic diabetes insipidus.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 1987, Volume: 9, Issue:1

    Topics: Administration, Oral; Adolescent; Diabetes Insipidus; Drug Evaluation; Female; Glomerular Filtration

1987
Renal response to vasopressin and indomethacin in cisplatin-treated rats.
    Clinical science (London, England : 1979), 1987, Volume: 73, Issue:4

    Topics: Animals; Cisplatin; Dinoprostone; Indomethacin; Kidney; Male; Osmolar Concentration; Polyuria; Potas

1987
Post-obstructive urinary concentrating defect. A case study in the role of prostaglandins.
    Acta paediatrica Scandinavica, 1987, Volume: 76, Issue:6

    Topics: Child, Preschool; Dinoprost; Dinoprostone; Humans; Hydrochlorothiazide; Indomethacin; Kidney Concent

1987
Amelioration by indomethacin of lithium-induced polyuria.
    Critical care medicine, 1987, Volume: 15, Issue:5

    Topics: Adult; Diabetes Insipidus; Female; Humans; Indomethacin; Lithium; Mood Disorders; Polyuria

1987
Indomethacin treatment in a patient with lithium-induced polyuria.
    Intensive care medicine, 1985, Volume: 11, Issue:2

    Topics: Coma; Female; Humans; Hypernatremia; Indomethacin; Lithium; Lithium Carbonate; Middle Aged; Polyuria

1985
Management of polyuria subsequent to pituitary surgery based on the diurnal pattern of urinary excretion.
    Surgical neurology, 1985, Volume: 23, Issue:1

    Topics: Adenoma; Adolescent; Adult; Aged; Circadian Rhythm; Diabetes Insipidus; Female; Humans; Indomethacin

1985