indomethacin has been researched along with Persistent Fetal Circulation Syndrome in 19 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Persistent Fetal Circulation Syndrome: A syndrome of persistent PULMONARY HYPERTENSION in the newborn infant (INFANT, NEWBORN) without demonstrable HEART DISEASES. This neonatal condition can be caused by severe pulmonary vasoconstriction (reactive type), hypertrophy of pulmonary arterial muscle (hypertrophic type), or abnormally developed pulmonary arterioles (hypoplastic type). The newborn patient exhibits CYANOSIS and ACIDOSIS due to the persistence of fetal circulatory pattern of right-to-left shunting of blood through a patent ductus arteriosus (DUCTUS ARTERIOSUS, PATENT) and at times a patent foramen ovale (FORAMEN OVALE, PATENT).
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study sought to determine the effect of combined treatment of hypoxia plus indomethacin on pulmonary vascular remodeling in fetal rats." | 7.77 | Fetal pulmonary vascular remodeling in a rat model induced by hypoxia and indomethacin. ( Du, LZ; Gu, WZ; Li, RY; Wu, XL; Xu, XF, 2011) |
| "When Indomethacin in a dosage of 175 mg/day was used to treat threatened premature labour more than 70% of cases carried on until 37 weeks." | 6.37 | [Value and dangers of indomethacin used in pregnancy. Apropos of 304 treated patients]. ( Barrat, J; Bouillie, J; Boyer, F; Keskes, J; Marpeau, L; Pigné, A; Vincenti, O, 1988) |
| "This study sought to determine the effect of combined treatment of hypoxia plus indomethacin on pulmonary vascular remodeling in fetal rats." | 3.77 | Fetal pulmonary vascular remodeling in a rat model induced by hypoxia and indomethacin. ( Du, LZ; Gu, WZ; Li, RY; Wu, XL; Xu, XF, 2011) |
| "When Indomethacin in a dosage of 175 mg/day was used to treat threatened premature labour more than 70% of cases carried on until 37 weeks." | 2.37 | [Value and dangers of indomethacin used in pregnancy. Apropos of 304 treated patients]. ( Barrat, J; Bouillie, J; Boyer, F; Keskes, J; Marpeau, L; Pigné, A; Vincenti, O, 1988) |
| "Indomethacin-treated animals had an increased saccular wall mass, decreased airspace mass, and a decreased capillary to saccular wall ratio (P less than 0." | 1.26 | Effects of indomethacin on fetal rat lungs: a possible cause of persistent fetal circulation (PFC). ( Bloor, CM; Friedman, WF; Harker, LC; Kirkpatrick, SE, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (47.37) | 18.7374 |
| 1990's | 3 (15.79) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (15.79) | 24.3611 |
| 2020's | 4 (21.05) | 2.80 |
| Authors | Studies |
|---|---|
| Bai, C | 1 |
| Chang, Q | 1 |
| Wu, H | 1 |
| Meng, F | 1 |
| Sharma, P | 1 |
| Beam, K | 1 |
| Levy, P | 1 |
| Beam, AL | 1 |
| Steflik, HJ | 1 |
| Wessler, LA | 1 |
| Shugart, WW | 1 |
| Wagner, CL | 1 |
| Selewski, DT | 1 |
| Twombley, KE | 1 |
| Newman, JC | 1 |
| Atz, AM | 1 |
| Annibale, DJ | 1 |
| Lopata, SM | 1 |
| Slaughter, JC | 1 |
| Gillam-Krakauer, M | 1 |
| Reese, J | 1 |
| Mahajan, CN | 1 |
| Afolayan, AJ | 1 |
| Eis, A | 1 |
| Teng, RJ | 1 |
| Konduri, GG | 1 |
| Bancalari, E | 1 |
| Jain, D | 1 |
| Xu, XF | 1 |
| Gu, WZ | 1 |
| Wu, XL | 1 |
| Li, RY | 1 |
| Du, LZ | 1 |
| Turner, GR | 1 |
| Levin, DL | 1 |
| Harker, LC | 1 |
| Kirkpatrick, SE | 1 |
| Friedman, WF | 1 |
| Bloor, CM | 1 |
| Yeh, TF | 1 |
| Thalji, A | 1 |
| Luken, L | 1 |
| Lilien, L | 1 |
| Carr, I | 1 |
| Pildes, RS | 1 |
| Molina, V | 1 |
| Krauel, J | 1 |
| Baraibar, R | 1 |
| Campistol, J | 1 |
| Maria, B | 1 |
| Oriot, D | 1 |
| Boussemart, T | 1 |
| Berthier, M | 1 |
| Bonneau, D | 1 |
| Coisne, D | 1 |
| Patole, S | 1 |
| Lee, J | 1 |
| Whitehall, J | 1 |
| Slavík, Z | 1 |
| Zborilová, B | 1 |
| Hruda, J | 1 |
| Marpeau, L | 1 |
| Keskes, J | 1 |
| Vincenti, O | 1 |
| Boyer, F | 1 |
| Bouillie, J | 1 |
| Pigné, A | 1 |
| Barrat, J | 1 |
| Demello, DE | 1 |
| Murphy, JD | 1 |
| Aronovitz, MJ | 1 |
| Davies, P | 1 |
| Reid, LM | 1 |
| Gersony, WM | 1 |
| Leititis, JU | 1 |
| Burghard, R | 1 |
| Gordjani, N | 1 |
| Wildberg, A | 1 |
| Seyberth, HW | 1 |
| Brandis, M | 1 |
2 reviews available for indomethacin and Persistent Fetal Circulation Syndrome
| Article | Year |
|---|---|
[Value and dangers of indomethacin used in pregnancy. Apropos of 304 treated patients].
Topics: Abortion, Threatened; Acute Kidney Injury; Ductus Arteriosus, Patent; Female; Fetal Death; Fetus; Hu | 1988 |
Patent ductus arteriosus in the neonate.
Topics: Alprostadil; Blood Circulation; Clinical Trials as Topic; Digoxin; Ductus Arteriosus; Ductus Arterio | 1986 |
2 trials available for indomethacin and Persistent Fetal Circulation Syndrome
| Article | Year |
|---|---|
Improved lung compliance following indomethacin therapy in premature infants with persistent ductus arteriosus.
Topics: Birth Weight; Blood Gas Analysis; Gestational Age; Humans; Hydrogen-Ion Concentration; Indomethacin; | 1981 |
Patent ductus arteriosus in the neonate.
Topics: Alprostadil; Blood Circulation; Clinical Trials as Topic; Digoxin; Ductus Arteriosus; Ductus Arterio | 1986 |
16 other studies available for indomethacin and Persistent Fetal Circulation Syndrome
| Article | Year |
|---|---|
Effect of fetal lung maturation on the treatment of patent ductus arteriosus in premature infants.
Topics: Ductus Arteriosus, Patent; Humans; Indomethacin; Infant; Infant, Newborn; Infant, Premature; Lung; P | 2023 |
PD(AI): the role of artificial intelligence in the management of patent ductus arteriosus.
Topics: Artificial Intelligence; Ductus Arteriosus, Patent; Humans; Indomethacin; Infant, Newborn; Infant, P | 2023 |
Indomethacin patent ductus arteriosus prophylaxis in the modern era: renal implications.
Topics: Ductus Arteriosus; Ductus Arteriosus, Patent; Humans; Indomethacin; Infant, Newborn; Infant, Prematu | 2023 |
The patent ductus arteriosus management debate: it's not over yet.
Topics: Ductus Arteriosus, Patent; Humans; Indomethacin; Infant, Newborn; Infant, Premature; Persistent Feta | 2021 |
Altered prostanoid metabolism contributes to impaired angiogenesis in persistent pulmonary hypertension in a fetal lamb model.
Topics: Animals; Blotting, Western; Cyclooxygenase 1; Cyclooxygenase 2; Cytochrome P-450 Enzyme System; Endo | 2015 |
Management of Patent Ductus Arteriosus: Are We Looking at the Right Outcomes?
Topics: Ductus Arteriosus, Patent; Humans; Ibuprofen; Indomethacin; Infant, Newborn; Infant, Premature; Pers | 2017 |
Fetal pulmonary vascular remodeling in a rat model induced by hypoxia and indomethacin.
Topics: Actins; Animals; Animals, Newborn; Blotting, Western; Cardiovascular Agents; Disease Models, Animal; | 2011 |
Prostaglandin synthesis inhibition in persistent pulmonary hypertension of the newborn.
Topics: Animals; Blood Pressure; Ductus Arteriosus, Patent; Female; Fetus; Humans; Hypertension, Pulmonary; | 1984 |
Effects of indomethacin on fetal rat lungs: a possible cause of persistent fetal circulation (PFC).
Topics: Animals; Animals, Newborn; Female; Fetus; Humans; Indomethacin; Infant, Newborn; Lung; Persistent Fe | 1981 |
[Persistance of fetal circulation. a case associated to maternal indomethacin administration (author's transl)].
Topics: Female; Hemodynamics; Humans; Indomethacin; Infant, Newborn; Labor, Obstetric; Male; Persistent Feta | 1980 |
[Prostaglandin and threat of premature labour inhibitors. 1. The possibilities and consequences (as given in the literature) (author's transl)].
Topics: Anti-Inflammatory Agents; Female; Humans; Indomethacin; Infant, Newborn; Labor, Obstetric; Maternal- | 1980 |
Paradoxical effect of inhaled nitric oxide in a newborn with pulmonary hypertension.
Topics: Administration, Inhalation; Diseases in Twins; Female; Humans; Hypoxia; Indomethacin; Infant, Newbor | 1993 |
Adenosine infusion in the management of a micropremi neonate with pulmonary hypertension.
Topics: Adenosine; Anti-Inflammatory Agents, Non-Steroidal; Ductus Arteriosus, Patent; Fatal Outcome; Humans | 1998 |
[The persistent pulmonary hypertension syndrome in neonates after intrauterine exposure to indomethacin].
Topics: Female; Fetus; Humans; Indomethacin; Infant, Newborn; Male; Persistent Fetal Circulation Syndrome; P | 1990 |
Effects of indomethacin in utero on the pulmonary vasculature of the newborn guinea pig.
Topics: Animals; Animals, Newborn; Ductus Arteriosus; Female; Guinea Pigs; Humans; Indomethacin; Infant, New | 1987 |
Effect of a modified fluid therapy on renal function during indomethacin therapy for persistent ductus arteriosus.
Topics: Creatinine; Fluid Therapy; Glomerular Filtration Rate; Humans; Indomethacin; Infant; Infant, Newborn | 1987 |