indomethacin has been researched along with Periodontitis in 30 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Periodontitis: Inflammation and loss of connective tissues supporting or surrounding the teeth. This may involve any part of the PERIODONTIUM. Periodontitis is currently classified by disease progression (CHRONIC PERIODONTITIS; AGGRESSIVE PERIODONTITIS) instead of age of onset. (From 1999 International Workshop for a Classification of Periodontal Diseases and Conditions, American Academy of Periodontology)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We examined the effects of calcium gluconate, an anti-inflammatory calcium salt, on ligature-induced experimental periodontitis and related alveolar bone loss." | 7.77 | Effects of calcium gluconate on experimental periodontitis and alveolar bone loss in rats. ( Cho, HR; Kang, SJ; Ku, SK; Lee, YJ; Sung, YS, 2011) |
| "We investigated the effect of etoricoxib, a selective cyclooxygenase-2 inhibitor, and indomethacin, a non-selective cyclooxygenase inhibitor, on experimental periodontitis, and compared their gastrointestinal side effects." | 7.74 | Comparison of etoricoxib and indomethacin for the treatment of experimental periodontitis in rats. ( Azoubel, MC; Bezerra, D; Brito, GA; Menezes, AM; Oriá, RB; Ribeiro, RA, 2007) |
| "The action on bone remodelling of indomethacin, a potent inhibitor of prostaglandin (PG) synthesis, was determined in hamster periodontitis and compared to that of calcitonin." | 7.67 | A histometric study of the effect of indomethacin and calcitonin on bone remodelling in hamster periodontitis. ( Lasfargues, JJ; Saffar, JL, 1984) |
| "The aim of this study was to test the effect of a high dose (6 mg/kg/d) of indomethacin, a PG-synthesis inhibitor, on hamster periodontitis and to verify a possible systemic skeletal action." | 7.67 | Periodontal and femoral bone status in periodontitis-affected hamsters receiving a high dose indomethacin treatment. ( Carter-Bartlett, P; Dersot, JM; Saffar, JL, 1989) |
| "Indomethacin was shown to (i) delay the onset and to suppress the magnitude of the acute inflammatory reaction, and (ii) decrease the degree of alveolar bone resorption." | 5.26 | Suppression of inflammation and bone resorption by indomethacin during experimental periodontitis in dogs. ( Lindhe, J; Nyman, S; Schroeder, HE, 1979) |
| "In a rat model of experimental periodontitis it was investigated whether the presence of the inflammatory disease induced changes in carbachol-induced fluid secretion in parotid glands, by monitoring potassium release." | 3.78 | Influence of experimental periodontitis on cholinergic stimulation of K⁺ release in rat parotid glands. ( Busch, L; Miozza, VA; Sánchez, GA, 2012) |
| "We examined the effects of calcium gluconate, an anti-inflammatory calcium salt, on ligature-induced experimental periodontitis and related alveolar bone loss." | 3.77 | Effects of calcium gluconate on experimental periodontitis and alveolar bone loss in rats. ( Cho, HR; Kang, SJ; Ku, SK; Lee, YJ; Sung, YS, 2011) |
| "We investigated the effect of etoricoxib, a selective cyclooxygenase-2 inhibitor, and indomethacin, a non-selective cyclooxygenase inhibitor, on experimental periodontitis, and compared their gastrointestinal side effects." | 3.74 | Comparison of etoricoxib and indomethacin for the treatment of experimental periodontitis in rats. ( Azoubel, MC; Bezerra, D; Brito, GA; Menezes, AM; Oriá, RB; Ribeiro, RA, 2007) |
| "Analysis of treatment results of inflammatory periodontal diseases with different drugs has shown high effectiveness of immobilized on polysorb indomethacin in the treatment of gingivitis and periodontitis." | 3.71 | [Treatment of inflammatory diseases of the periodontium using immobilized indomethacin]. ( Garazha, NN; Zelenskaia, AV, 2001) |
| "The present data for the first time demonstrate the possible implication of routine caffeine intake in the acceleration of pathological conditions of periodontitis." | 3.70 | Combined effects of caffeine and prostaglandin E2 on the proliferation of osteoblast-like cells (UMR106-01). ( Cheuk, G; Kamagata-Kiyoura, Y; Nakamoto, T; Ohta, M; Saltzman, MJ; Yazdani, M, 1999) |
| "The action on bone remodelling of indomethacin, a potent inhibitor of prostaglandin (PG) synthesis, was determined in hamster periodontitis and compared to that of calcitonin." | 3.67 | A histometric study of the effect of indomethacin and calcitonin on bone remodelling in hamster periodontitis. ( Lasfargues, JJ; Saffar, JL, 1984) |
| "The aim of this study was to test the effect of a high dose (6 mg/kg/d) of indomethacin, a PG-synthesis inhibitor, on hamster periodontitis and to verify a possible systemic skeletal action." | 3.67 | Periodontal and femoral bone status in periodontitis-affected hamsters receiving a high dose indomethacin treatment. ( Carter-Bartlett, P; Dersot, JM; Saffar, JL, 1989) |
| "Periodontitis was produced by a ligature placed around the cervix of the two lower first molar." | 1.36 | Increase nitric oxide synthase activity in parotid glands from rats with experimental periodontitis. ( Borda, E; Busch, L; Miozza, V; S-Borda, L, 2010) |
| "Arachidonic acid metabolites have been implicated in development of periodontal disease, especially those derived from the cyclo-oxygenase (COX) pathway." | 1.35 | Role of systemic and local administration of selective inhibitors of cyclo-oxygenase 1 and 2 in an experimental model of periodontal disease in rats. ( Caliari, MV; Duarte, ID; Francischi, JN; Maltos, KL; Pacheco, CM; Queiroz-Junior, CM, 2009) |
| "Indomethacin, which is an inhibitor of PGE(2) synthesis, reduced more than 88% of the osteoclast formation induced by each bacterial sonicate." | 1.33 | Prostaglandin E(2) is a main mediator in receptor activator of nuclear factor-kappaB ligand-dependent osteoclastogenesis induced by Porphyromonas gingivalis, Treponema denticola, and Treponema socranskii. ( Cha, JH; Choi, BK; Kim, KW; Moon, SY; Yoo, YJ, 2005) |
| "Indomethacin was used to inhibit the synthesis of PGE2 and eliminate its effect on the production of IL-1." | 1.30 | Effects of sex hormones on production of interleukin-1 by human peripheral monocytes. ( Iwamoto, Y; Miyagi, M; Morishita, M, 1999) |
| "Indomethacin was shown to (i) delay the onset and to suppress the magnitude of the acute inflammatory reaction, and (ii) decrease the degree of alveolar bone resorption." | 1.26 | Suppression of inflammation and bone resorption by indomethacin during experimental periodontitis in dogs. ( Lindhe, J; Nyman, S; Schroeder, HE, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (46.67) | 18.7374 |
| 1990's | 4 (13.33) | 18.2507 |
| 2000's | 9 (30.00) | 29.6817 |
| 2010's | 3 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Queiroz-Junior, CM | 1 |
| Pacheco, CM | 1 |
| Maltos, KL | 1 |
| Caliari, MV | 1 |
| Duarte, ID | 1 |
| Francischi, JN | 1 |
| Miozza, V | 1 |
| Borda, E | 1 |
| S-Borda, L | 1 |
| Busch, L | 2 |
| Ku, SK | 1 |
| Cho, HR | 1 |
| Sung, YS | 1 |
| Kang, SJ | 1 |
| Lee, YJ | 1 |
| Miozza, VA | 1 |
| Sánchez, GA | 1 |
| Sun, C | 1 |
| Ouyang, X | 1 |
| Choi, BK | 1 |
| Moon, SY | 1 |
| Cha, JH | 1 |
| Kim, KW | 1 |
| Yoo, YJ | 1 |
| Tanaka, S | 1 |
| Fakher, M | 1 |
| Barbour, SE | 1 |
| Schenkein, HA | 1 |
| Tew, JG | 1 |
| Azoubel, MC | 1 |
| Menezes, AM | 1 |
| Bezerra, D | 1 |
| Oriá, RB | 1 |
| Ribeiro, RA | 2 |
| Brito, GA | 2 |
| Weaks-Dybvig, M | 1 |
| Sanavi, F | 1 |
| Zander, H | 1 |
| Rifkin, BR | 1 |
| Nuki, K | 1 |
| Soskolne, WA | 1 |
| Raisz, LG | 1 |
| Kornman, KS | 1 |
| Alander, C | 1 |
| Saffar, JL | 2 |
| Lasfargues, JJ | 1 |
| Knychalska-Karwan, Z | 2 |
| Krówczyński, L | 1 |
| Krasowska, H | 1 |
| Kosowska, K | 1 |
| Lejman, L | 1 |
| Ivanyi, L | 1 |
| Topic, B | 1 |
| Lydyard, PM | 1 |
| Müller, W | 1 |
| Loomer, PM | 1 |
| Ellen, RP | 1 |
| Tenenbaum, HC | 1 |
| Corry, D | 1 |
| Moran, J | 1 |
| Kamagata-Kiyoura, Y | 1 |
| Ohta, M | 1 |
| Cheuk, G | 1 |
| Yazdani, M | 1 |
| Saltzman, MJ | 1 |
| Nakamoto, T | 1 |
| Morishita, M | 1 |
| Miyagi, M | 1 |
| Iwamoto, Y | 1 |
| Bezerra, MM | 1 |
| de Lima, V | 1 |
| Alencar, VB | 1 |
| Vieira, IB | 1 |
| Rocha, FA | 1 |
| Rubinstein, I | 1 |
| Potempa, J | 1 |
| Travis, J | 1 |
| Gao, XP | 1 |
| Zelenskaia, AV | 1 |
| Garazha, NN | 1 |
| Tilakaratne, A | 1 |
| Soory, M | 1 |
| Nyman, S | 1 |
| Schroeder, HE | 1 |
| Lindhe, J | 1 |
| Page, RC | 1 |
| Clagett, JA | 1 |
| Engel, LD | 1 |
| Wilde, G | 1 |
| Sims, T | 1 |
| Carter-Bartlett, P | 1 |
| Dersot, JM | 1 |
| Williams, RC | 1 |
| Jeffcoat, MK | 1 |
| Howell, TH | 1 |
| Hall, CM | 1 |
| Johnson, HG | 1 |
| Wechter, WJ | 1 |
| Goldhaber, P | 1 |
| Vogel, RI | 1 |
| Schneider, L | 1 |
| Goteiner, D | 1 |
| Ciesielska, M | 1 |
| Chomyszyn-Gajewska, M | 1 |
| Gawrzewska, B | 1 |
| Kaczmarczyk-Stachowska, A | 1 |
| Prostak-Kosowska, K | 1 |
| Baloş, K | 1 |
| Baran, CC | 1 |
| Eren, K | 1 |
| Koralp, L | 1 |
| Günhan, O | 1 |
| Hefti, A | 1 |
| Erhardt, A | 1 |
1 trial available for indomethacin and Periodontitis
| Article | Year |
|---|---|
[The effects of indomethcin rinse on the periodontal inflammation].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Double-Blind Method; Gingival Crevicular Flui | 2002 |
29 other studies available for indomethacin and Periodontitis
| Article | Year |
|---|---|
Role of systemic and local administration of selective inhibitors of cyclo-oxygenase 1 and 2 in an experimental model of periodontal disease in rats.
Topics: Alveolar Bone Loss; Animals; Arachidonic Acid; Celecoxib; Cyclooxygenase Inhibitors; Disease Models, | 2009 |
Increase nitric oxide synthase activity in parotid glands from rats with experimental periodontitis.
Topics: Adenine; Amylases; Animals; Calcium; Cyclic AMP-Dependent Protein Kinase Catalytic Subunits; Cycloox | 2010 |
Effects of calcium gluconate on experimental periodontitis and alveolar bone loss in rats.
Topics: Alveolar Bone Loss; Analysis of Variance; Animals; Anti-Inflammatory Agents; Body Weight; Calcium Gl | 2011 |
Influence of experimental periodontitis on cholinergic stimulation of K⁺ release in rat parotid glands.
Topics: Animals; Carbachol; Cell Membrane; Cholinergic Agonists; Cyclooxygenase Inhibitors; Disease Models, | 2012 |
Prostaglandin E(2) is a main mediator in receptor activator of nuclear factor-kappaB ligand-dependent osteoclastogenesis induced by Porphyromonas gingivalis, Treponema denticola, and Treponema socranskii.
Topics: Acid Phosphatase; Animals; Carrier Proteins; Cattle; Cell Differentiation; Dinoprostone; Glycoprotei | 2005 |
Influence of proinflammatory cytokines on Actinobacillus actinomycetemcomitans specific IgG responses.
Topics: Actinobacillus Infections; Aggregatibacter actinomycetemcomitans; Animals; Anti-Inflammatory Agents, | 2006 |
Comparison of etoricoxib and indomethacin for the treatment of experimental periodontitis in rats.
Topics: Alveolar Bone Loss; Animals; Cyclooxygenase Inhibitors; Etoricoxib; Female; Gastric Mucosa; Indometh | 2007 |
The effect of indomethacin on alveolar bone loss in experimental periodontitis.
Topics: Alveolar Process; Animals; Bone Resorption; Indomethacin; Male; Osteoclasts; Periodontitis; Saimiri; | 1982 |
Bone resorbing activity of gingiva from beagle dogs following metronidazole and indomethacin therapy.
Topics: Alveolar Process; Animals; Bone Resorption; Dogs; Gingivitis; Indomethacin; Metronidazole; Periodont | 1981 |
A histometric study of the effect of indomethacin and calcitonin on bone remodelling in hamster periodontitis.
Topics: Animals; Bone and Bones; Bone Resorption; Calcitonin; Cricetinae; Indomethacin; Male; Mesocricetus; | 1984 |
[Indomethacin in the treatment of stomatitis and periodontitis].
Topics: Adult; Female; Humans; Indomethacin; Male; Periodontitis; Stomatitis; Stomatitis, Aphthous | 1980 |
The role of TG lymphocytes in cell-mediated immunity in patients with periodontal disease.
Topics: Adult; Female; Gingivitis; Humans; Immunity, Cellular; Immunoglobulin G; Indomethacin; Lymphocyte Ac | 1981 |
Stereology of inflammatory connective tissue infiltrates in oral mucosa.
Topics: Animals; Connective Tissue; Dogs; Gingiva; Gingivitis; Indomethacin; Inflammation; Microscopy, Elect | 1980 |
Characterization of inhibitory effects of suspected periodontopathogens on osteogenesis in vitro.
Topics: Animals; Chick Embryo; Culture Techniques; Hot Temperature; Indomethacin; Lipopolysaccharides; Osteo | 1995 |
Assessment of acrylic bone cement as a local delivery vehicle for the application of non-steroidal anti-inflammatory drugs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Bone Cements; Cells, Cultured; Delayed-Action Preparations; | 1998 |
Combined effects of caffeine and prostaglandin E2 on the proliferation of osteoblast-like cells (UMR106-01).
Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Cell Division; Cell Line; Colforsin; Cyclic AMP; Cyc | 1999 |
Effects of sex hormones on production of interleukin-1 by human peripheral monocytes.
Topics: Adult; Cells, Cultured; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; E | 1999 |
Selective cyclooxygenase-2 inhibition prevents alveolar bone loss in experimental periodontitis in rats.
Topics: Alveolar Bone Loss; Alveolar Process; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; | 2000 |
Mechanisms mediating Porphyromonas gingivalis gingipain RgpA-induced oral mucosa inflammation in vivo.
Topics: Adhesins, Bacterial; Animals; Bradykinin; Capillary Permeability; Catalytic Domain; Cricetinae; Cyst | 2001 |
[Treatment of inflammatory diseases of the periodontium using immobilized indomethacin].
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Indomethacin; Male; Midd | 2001 |
The modulation of androgen metabolism by estradiol, minocycline, and indomethacin in a cell culture model.
Topics: Analysis of Variance; Androgens; Androstenedione; Anti-Bacterial Agents; Anti-Inflammatory Agents, N | 2002 |
Suppression of inflammation and bone resorption by indomethacin during experimental periodontitis in dogs.
Topics: Alveolar Process; Animals; Bone Resorption; Connective Tissue; Dogs; Gingival Crevicular Fluid; Indo | 1979 |
Effects of prostaglandin on the antigen- and mitogen-driven responses of peripheral blood lymphocytes from patients with adult and juvenile periodontitis.
Topics: Actinomyces; Adolescent; Adult; Antigens; Concanavalin A; Cytotoxicity, Immunologic; Humans; Indomet | 1978 |
Periodontal and femoral bone status in periodontitis-affected hamsters receiving a high dose indomethacin treatment.
Topics: Alveolar Process; Animals; Bone Resorption; Cricetinae; Femur; Indomethacin; Injections, Subcutaneou | 1989 |
Indomethacin or flurbiprofen treatment of periodontitis in beagles: comparison of effect on bone loss.
Topics: Alveolar Process; Animals; Bone Resorption; Dogs; Female; Flurbiprofen; Indomethacin; Periodontal Di | 1987 |
The effects of a topically-active non-steroidal anti-inflammatory drug on ligature-induced periodontal disease in the squirrel monkey.
Topics: Administration, Topical; Alveolar Process; Animals; Anti-Inflammatory Agents; Bone Resorption; Conne | 1986 |
[Metindonium in the treatment of inflammatory forms of periodontopathies].
Topics: Cetrimonium; Cetrimonium Compounds; Humans; Indomethacin; Periodontitis; Quaternary Ammonium Compoun | 1987 |
[The effect of systematically given indomethacin on bone resorption].
Topics: Bone Resorption; Humans; Indomethacin; Osteoclasts; Periodontitis | 1987 |
[Effect of indomethacin on the development of periodontitis in relatively gnotobiotic rats].
Topics: Actinomyces; Animals; Bone Resorption; Dose-Response Relationship, Drug; Drug Evaluation, Preclinica | 1985 |