indomethacin has been researched along with Periodontal Diseases in 16 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Periodontal Diseases: Pathological processes involving the PERIODONTIUM including the gum (GINGIVA), the alveolar bone (ALVEOLAR PROCESS), the DENTAL CEMENTUM, and the PERIODONTAL LIGAMENT.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Indomethacin was shown to (i) delay the onset and to suppress the magnitude of the acute inflammatory reaction, and (ii) decrease the degree of alveolar bone resorption." | 5.26 | Suppression of inflammation and bone resorption by indomethacin during experimental periodontitis in dogs. ( Lindhe, J; Nyman, S; Schroeder, HE, 1979) |
| "Bone resorption was assessed in cultured mouse calvarial bone by quantifying the mobilization of minerals and the release of lysosomal enzymes." | 1.28 | Stimulation of bone resorption and cell proliferation in vitro by human gingival fibroblasts from patients with periodontal disease. ( Hänström, L; Lerner, UH; Sjöström, S, 1990) |
| "Indomethacin was shown to (i) delay the onset and to suppress the magnitude of the acute inflammatory reaction, and (ii) decrease the degree of alveolar bone resorption." | 1.26 | Suppression of inflammation and bone resorption by indomethacin during experimental periodontitis in dogs. ( Lindhe, J; Nyman, S; Schroeder, HE, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (62.50) | 18.7374 |
| 1990's | 4 (25.00) | 18.2507 |
| 2000's | 2 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cetin, EO | 1 |
| Buduneli, N | 1 |
| Atlihan, E | 1 |
| Kirilmaz, L | 1 |
| Rausch-Fan, X | 1 |
| Ulm, C | 1 |
| Jensen-Jarolim, E | 1 |
| Schedle, A | 1 |
| Boltz-Nitulescu, G | 1 |
| Rausch, WD | 1 |
| Matejka, M | 1 |
| Lasfargues, JJ | 2 |
| Saffar, JL | 2 |
| Yamasaki, K | 1 |
| Miura, F | 1 |
| Suda, T | 1 |
| Howell, TH | 3 |
| Williams, RC | 3 |
| Sturtridge, WC | 1 |
| Nyman, S | 1 |
| Schroeder, HE | 1 |
| Lindhe, J | 1 |
| Steinberg, AD | 1 |
| Lipowski, J | 1 |
| LeBreton, G | 1 |
| Meghji, S | 1 |
| Henderson, B | 1 |
| Nair, S | 1 |
| Wilson, M | 2 |
| Lerner, UH | 1 |
| Hänström, L | 1 |
| Sjöström, S | 1 |
| Kamin, S | 1 |
| Harvey, W | 1 |
| Jeffcoat, MK | 2 |
| Hall, CM | 2 |
| Johnson, HG | 2 |
| Wechter, WJ | 2 |
| Goldhaber, P | 3 |
| Offenbacher, S | 1 |
| Rabadjija, L | 1 |
| Beyer, WR | 1 |
| Kornhauser, A | 1 |
2 reviews available for indomethacin and Periodontal Diseases
| Article | Year |
|---|---|
Nonsteroidal antiinflammatory drugs as inhibitors of periodontal disease progression.
Topics: Alveolar Bone Loss; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Resorption; Flurbiprofen; | 1993 |
Bone resorption in tissue culture and its relevance to periodontal disease.
Topics: Alveolar Process; Bone Development; Bone Resorption; Culture Techniques; Gingiva; Heparin; Humans; H | 1973 |
14 other studies available for indomethacin and Periodontal Diseases
| Article | Year |
|---|---|
In vitro studies on controlled-release cellulose acetate films for local delivery of chlorhexidine, indomethacin, and meloxicam.
Topics: Anti-Infective Agents, Local; Anti-Inflammatory Agents; Cellulose; Chlorhexidine; Delayed-Action Pre | 2004 |
Interleukin-1beta-induced prostaglandin E2 production by human gingival fibroblasts is upregulated by glycine.
Topics: Analysis of Variance; Cell Proliferation; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Cyclo | 2005 |
Effect of indomethacin on bone destruction during experimental periodontal disease in the hamster.
Topics: Animals; Bone Resorption; Calcitonin; Cricetinae; Indomethacin; Osteoclasts; Periodontal Diseases | 1983 |
[A new non-steroidal anti-inflammatory agent in periodontology, oxametacine (a study of 85 cases)].
Topics: Adult; Aged; Anti-Inflammatory Agents; Female; Humans; Indomethacin; Male; Middle Aged; Periodontal | 1984 |
Prostaglandin as a mediator of bone resorption induced by experimental tooth movement in rats.
Topics: Alveolar Process; Animals; Bone Resorption; Indomethacin; Male; Orthodontic Appliances; Osteoclasts; | 1980 |
Pharmacology and therapeutics of bone.
Topics: Animals; Bone Resorption; Calcitonin; Calcium; Cyclic AMP; Endotoxins; Glucocorticoids; Humans; Hydr | 1975 |
Suppression of inflammation and bone resorption by indomethacin during experimental periodontitis in dogs.
Topics: Alveolar Process; Animals; Bone Resorption; Connective Tissue; Dogs; Gingival Crevicular Fluid; Indo | 1979 |
In vitro platelet serotonin secretion and inhibition on variously treated root surfaces.
Topics: Animals; Blood Platelets; Carbon Radioisotopes; Cell Degranulation; Citrates; Citric Acid; Collagen; | 1992 |
Inhibition of bone DNA and collagen production by surface-associated material from bacteria implicated in the pathology of periodontal disease.
Topics: Aggregatibacter actinomycetemcomitans; Animals; Bacteria; Bacterial Capsules; Bone and Bones; Cells, | 1992 |
Stimulation of bone resorption and cell proliferation in vitro by human gingival fibroblasts from patients with periodontal disease.
Topics: Adult; Animals; Bone and Bones; Bone Resorption; Calcitonin; Calcium; Calcium Radioisotopes; Cell Di | 1990 |
Bone resorbing activity of purified capsular material from Actinobacillus actinomycetemcomitans.
Topics: Actinobacillus; Alveolar Process; Animals; Bacterial Outer Membrane Proteins; Bone Resorption; Glyco | 1985 |
Indomethacin or flurbiprofen treatment of periodontitis in beagles: comparison of effect on bone loss.
Topics: Alveolar Process; Animals; Bone Resorption; Dogs; Female; Flurbiprofen; Indomethacin; Periodontal Di | 1987 |
Indomethacin or flurbiprofen treatment of periodontitis in beagles: effect on crevicular fluid arachidonic acid metabolites compared with effect on alveolar bone loss.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Bone Resorption; Cyclooxygenase Inhibitors; Dogs; Fema | 1988 |
[Root reactions during treatment with indomethacin in the rat].
Topics: Alveolar Process; Animals; Bone Resorption; Indomethacin; Male; Periodontal Diseases; Periodontal Li | 1988 |