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indomethacin and Peptic Ulcer Perforation

indomethacin has been researched along with Peptic Ulcer Perforation in 19 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Peptic Ulcer Perforation: Penetration of a PEPTIC ULCER through the wall of DUODENUM or STOMACH allowing the leakage of luminal contents into the PERITONEAL CAVITY.

Research Excerpts

ExcerptRelevanceReference
" Indomethacin treatment precipitated gastric ulceration, which led to the formation of a gastro-colic fistula."3.66Gastro-colic fistula secondary to benign gastric ulceration. ( Taylor, R, 1978)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-199017 (89.47)18.7374
1990's1 (5.26)18.2507
2000's1 (5.26)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
WANKA, J1
JONES, LI1
WOOD, PH1
DIXON, AS1
VECCHIO, C1
FONTANA, A1
TAVAZZI, L1
Risty, GM1
Najarian, MM1
Shapiro, SB1
Campbel, AN1
Beasley, JR1
Kenna, AP1
Galmiche, JM1
Pinsard, M1
Thompson, MR2
Gray, PH1
Pemberton, PJ1
Langman, MJ1
Henry, D1
Donnelly, P1
Morris, AF1
Hughes, AO1
Omogbai, EK1
Ozolua, RI1
Idaewor, PE1
Isah, AO1
Taylor, R1
Jacyna, MR1
Shepherd, AN1
Kolbasa, KP1
Lancaster, C1
Olafsson, AS1
Gilbertson, SK1
Robert, A1
Langridge, CJ1
Hodgkinson, R1
Woolf, D1
Emmanuel, JH1
Montgomery, RD1
Nicoloff, DM1
Puylaert, CB1

Reviews

1 review available for indomethacin and Peptic Ulcer Perforation

ArticleYear
Multiple indomethacin-induced jejunal ulcerations with perforation: a case report with histology.
    The American surgeon, 2007, Volume: 73, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Indomethacin; Intestinal Mucosa; Jejunal Di

2007

Trials

1 trial available for indomethacin and Peptic Ulcer Perforation

ArticleYear
A five-year clinical trial of indomethacin in osteoarthrosis of the hip.
    The Practitioner, 1973, Volume: 210, Issue:257

    Topics: Aged; Clinical Trials as Topic; Female; Gastrointestinal Hemorrhage; Hip Joint; Humans; Indomethacin

1973

Other Studies

17 other studies available for indomethacin and Peptic Ulcer Perforation

ArticleYear
INDOMETHACIN IN RHEUMATIC DISEASES. A CONTROLLED CLINICAL TRIAL.
    Annals of the rheumatic diseases, 1964, Volume: 23

    Topics: Arthritis; Arthritis, Rheumatoid; Aspirin; Biomedical Research; Drug Hypersensitivity; Gastrointesti

1964
[ON THE GASTRO-LESIONAL EFFECT OF INDOMETHACIN].
    Archivio "E. Maragliano" di patologia e clinica, 1964, Volume: 20

    Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Indoles; Indomethacin; Peptic Ulcer Perforation;

1964
Life-threatening illness in those with severe mental handicap.
    Lancet (London, England), 1981, May-16, Volume: 1, Issue:8229

    Topics: Female; Humans; Indomethacin; Infant, Newborn; Infant, Newborn, Diseases; Peptic Ulcer Perforation;

1981
[Pyopneumopericarditis complicating a perforated hiatus hernia ulcer (author's transl)].
    Journal de radiologie, 1982, Volume: 63, Issue:3

    Topics: Aged; Female; Hernia, Diaphragmatic; Hernia, Hiatal; Humans; Indomethacin; Peptic Ulcer Perforation;

1982
Indomethacin and perforated duodenal ulcer.
    British medical journal, 1980, Feb-16, Volume: 280, Issue:6212

    Topics: Aged; Arthritis; Duodenal Ulcer; Female; Humans; Indomethacin; Middle Aged; Peptic Ulcer Perforation

1980
Gastric perforation associated with indomethacin therapy in a pre-term infant.
    Australian paediatric journal, 1980, Volume: 16, Issue:1

    Topics: Ductus Arteriosus, Patent; Female; Humans; Indomethacin; Infant, Newborn; Infant, Premature; Infant,

1980
Indomethacin and perforated duodenal ulcer.
    British medical journal, 1980, Apr-19, Volume: 280, Issue:6221

    Topics: Duodenal Ulcer; Female; Humans; Indomethacin; Middle Aged; Peptic Ulcer Perforation

1980
Indomethacin and perforated duodenal ulcer.
    British medical journal, 1980, Jul-19, Volume: 281, Issue:6234

    Topics: Duodenal Ulcer; Humans; Indomethacin; Peptic Ulcer Perforation; Stomach Ulcer

1980
Indomethacin and perforated duodenal ulcer.
    British medical journal, 1980, Jun-28, Volume: 280, Issue:6231

    Topics: Duodenal Ulcer; Female; Humans; Indomethacin; Middle Aged; Peptic Ulcer Perforation; Stomach Ulcer

1980
Some studies on the rodenticidal action of indomethacin.
    Drug and chemical toxicology, 1999, Volume: 22, Issue:4

    Topics: Administration, Oral; Animals; Bile Ducts; Body Weight; Cholestyramine Resin; Diazepam; Drug Interac

1999
Gastro-colic fistula secondary to benign gastric ulceration.
    Postgraduate medical journal, 1978, Volume: 54, Issue:630

    Topics: Aged; Colonic Diseases; Female; Gastric Fistula; Humans; Indomethacin; Intestinal Fistula; Peptic Ul

1978
Perforated ulcer in the elderly.
    Lancet (London, England), 1985, Dec-07, Volume: 2, Issue:8467

    Topics: Aged; Female; Humans; Indomethacin; Peptic Ulcer Perforation

1985
Indomethacin-induced gastric antral ulcers in hamsters.
    Gastroenterology, 1988, Volume: 95, Issue:4

    Topics: Administration, Oral; Animals; Aspirin; Cimetidine; Cricetinae; Dinoprostone; Disease Models, Animal

1988
A patient with unusual powers of recovery.
    The New Zealand medical journal, 1987, Jul-08, Volume: 100, Issue:827

    Topics: Aged; Duodenal Ulcer; Humans; Indomethacin; Male; Osteoarthritis; Peptic Ulcer Hemorrhage; Peptic Ul

1987
Gastric ulcer and the anti-arthritic drugs.
    Postgraduate medical journal, 1971, Volume: 47, Issue:546

    Topics: Adult; Aged; Arthritis, Rheumatoid; Female; Humans; Indomethacin; Male; Middle Aged; Peptic Ulcer He

1971
Indomethacin. Effect on gastric secretion, parietal cell population, and ulcer provocation in the dog.
    Archives of surgery (Chicago, Ill. : 1960), 1968, Volume: 97, Issue:5

    Topics: Animals; Dogs; Gastric Juice; Gastric Mucosa; Indomethacin; Peptic Ulcer Hemorrhage; Peptic Ulcer Pe

1968
Barium perforation of a peptic ulcer and barium granuloma of the colon. A report of two rare complications in radiological examination.
    Radiologia clinica et biologica, 1969, Volume: 38, Issue:1

    Topics: Arthritis, Rheumatoid; Barium; Colon; Duodenum; Esophagus; Granuloma; Humans; Indomethacin; Male; Mi

1969