indomethacin has been researched along with Ovarian Neoplasms in 11 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Ovarian Neoplasms: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thus our data suggest that residual ovarian cancer is accompanied by increased production of PG1(2) and TxA2, and that prostaglandins have no role in the acute side effects of cancer chemotherapy." | 2.65 | Prostacyclin and thromboxane in ovarian cancer: effect of cytostatics and prostaglandin synthesis inhibitors. ( Kauppila, A; Viinikka, L; Ylikorkala, O, 1983) |
| "In human ovarian cancer cell lines the cyclooxygenase (COX) metabolite Prostaglandin E2 was identified as negative regulator of chemokine secretion, whereas COX inhibition by indomethacin significantly upregulated CXCL9 and CXCL10." | 1.43 | CXCL9 and CXCL10 predict survival and are regulated by cyclooxygenase inhibition in advanced serous ovarian cancer. ( Avril, S; Bronger, H; Delbridge, C; Dorn, J; Kiechle, M; Reuning, U; Schmalfeldt, B; Schmitt, M; Singer, J; Windmüller, C; Zech, D, 2016) |
| " We demonstrate that a reduction of cyclooxygenase 2 gene dosage rescued the ovarian aging phenotype of the Wv mice, whereas homozygous deletion was accompanied by a compensatory increase in ovarian cyclooxygenase 1 expression and prostaglandin E(2) synthesis." | 1.34 | A reduction of cyclooxygenase 2 gene dosage counters the ovarian morphological aging and tumor phenotype in Wv mice. ( Cai, KQ; Hamilton, TC; Klein-Szanto, A; Smedberg, JL; Smith, ER; Xu, XX; Yang, WL, 2007) |
| "Three cases of acute renal insufficiency in pregnant women who were treated with indomethacin for premature labor are reported." | 1.29 | Acute maternal renal insufficiency in premature labor treated with indomethacin. ( Boyd, EL; Nageotte, MP; Powers, DR; Steiger, RM; Towers, CV, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (18.18) | 18.7374 |
| 1990's | 4 (36.36) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 3 (27.27) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nagaraj, AB | 1 |
| Wang, QQ | 1 |
| Joseph, P | 1 |
| Zheng, C | 1 |
| Chen, Y | 1 |
| Kovalenko, O | 1 |
| Singh, S | 1 |
| Armstrong, A | 1 |
| Resnick, K | 1 |
| Zanotti, K | 1 |
| Waggoner, S | 1 |
| Xu, R | 1 |
| DiFeo, A | 1 |
| Valle, BL | 1 |
| D'Souza, T | 1 |
| Becker, KG | 1 |
| Wood, WH | 1 |
| Zhang, Y | 1 |
| Wersto, RP | 1 |
| Morin, PJ | 1 |
| Bronger, H | 1 |
| Singer, J | 1 |
| Windmüller, C | 1 |
| Reuning, U | 1 |
| Zech, D | 1 |
| Delbridge, C | 1 |
| Dorn, J | 1 |
| Kiechle, M | 1 |
| Schmalfeldt, B | 1 |
| Schmitt, M | 1 |
| Avril, S | 1 |
| Spinella, F | 1 |
| Rosanò, L | 1 |
| Di Castro, V | 1 |
| Nicotra, MR | 1 |
| Natali, PG | 1 |
| Bagnato, A | 1 |
| Yang, WL | 1 |
| Cai, KQ | 1 |
| Smedberg, JL | 1 |
| Smith, ER | 1 |
| Klein-Szanto, A | 1 |
| Hamilton, TC | 1 |
| Xu, XX | 1 |
| Ylikorkala, O | 1 |
| Kauppila, A | 1 |
| Viinikka, L | 1 |
| Josse, RG | 1 |
| Wilson, DR | 1 |
| Heersche, JN | 1 |
| Mills, JR | 1 |
| Murray, TM | 1 |
| Johnston, CM | 1 |
| Pearl, L | 1 |
| Hanson, WR | 1 |
| Zhen, W | 1 |
| Geng, L | 1 |
| Hunter, N | 1 |
| Milas, L | 1 |
| Steiger, RM | 1 |
| Boyd, EL | 1 |
| Powers, DR | 1 |
| Nageotte, MP | 1 |
| Towers, CV | 1 |
| Koval'chuk, LV | 1 |
| Pavliuk, AS | 1 |
| Aksenova, NIa | 1 |
| Iakovleva, NV | 1 |
| Nalbandian, SV | 1 |
| Ul'ianova, TIu | 1 |
1 trial available for indomethacin and Ovarian Neoplasms
| Article | Year |
|---|---|
Prostacyclin and thromboxane in ovarian cancer: effect of cytostatics and prostaglandin synthesis inhibitors.
Topics: 6-Ketoprostaglandin F1 alpha; Antineoplastic Combined Chemotherapy Protocols; Aspirin; Epoprostenol; | 1983 |
10 other studies available for indomethacin and Ovarian Neoplasms
| Article | Year |
|---|---|
Using a novel computational drug-repositioning approach (DrugPredict) to rapidly identify potent drug candidates for cancer treatment.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; beta Catenin; Carcinoma, Ovarian Epithelial; Cell | 2018 |
Non-steroidal anti-inflammatory drugs decrease E2F1 expression and inhibit cell growth in ovarian cancer cells.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumo | 2013 |
CXCL9 and CXCL10 predict survival and are regulated by cyclooxygenase inhibition in advanced serous ovarian cancer.
Topics: Cell Line, Tumor; Chemokine CXCL10; Chemokine CXCL9; Cyclooxygenase Inhibitors; Female; Humans; Indo | 2016 |
Inhibition of cyclooxygenase-1 and -2 expression by targeting the endothelin a receptor in human ovarian carcinoma cells.
Topics: Animals; Atrasentan; Blotting, Northern; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cy | 2004 |
A reduction of cyclooxygenase 2 gene dosage counters the ovarian morphological aging and tumor phenotype in Wv mice.
Topics: Adenoma; Aging; Animals; Blotting, Western; Celecoxib; Cell Transformation, Neoplastic; Cyclooxygena | 2007 |
Hypercalcemia with ovarian carcinoma: evidence of a pathogenetic role for prostaglandins.
Topics: Aged; Animals; Biological Assay; Bone Resorption; Cystadenocarcinoma; Female; Humans; Hypercalcemia; | 1981 |
Absence of an association between G-CSF support and clinical response in heavily pre-treated ovarian cancer patients receiving salvage chemotherapy with paclitaxel (Taxol).
Topics: Adult; Aged; Antineoplastic Agents, Phytogenic; Female; Granulocyte Colony-Stimulating Factor; Human | 1995 |
The prostaglandin E1 analog, misoprostol, a normal tissue protector, does not protect four murine tumors in vivo from radiation injury.
Topics: Animals; Cell Division; Dose-Response Relationship, Radiation; Female; Indomethacin; Lung Neoplasms; | 1995 |
Acute maternal renal insufficiency in premature labor treated with indomethacin.
Topics: Acute Kidney Injury; Administration, Oral; Adult; Dyspnea; Female; Fetofetal Transfusion; Humans; Hy | 1993 |
[Assessment of the activity of tumor necrosis factor in normal state and in ovarian tumors].
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Cells, Cultured; Cystadenoma | 1990 |