indomethacin has been researched along with Osteolysis in 14 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Osteolysis: Dissolution of bone that particularly involves the removal or loss of calcium.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Previous studies have shown that the prostaglandin synthesis inhibitor indomethacin reduced osteolysis produced by the experimental VX2 carcinoma, probably by inhibiting the stimulation of osteoclasts by prostaglandin E2." | 3.66 | The effect of prostaglandin synthesis inhibitors and diphosphonates on tumour-mediated osteolysis. ( Galasko, CS; Lacey, E; Rushton, S; Samuel, AW, 1980) |
| "Osteolysis effected in vitro by breast carcinomas can be inhibited by aspirin." | 3.65 | Human breast tumour-induced osteolysis and prostaglandins. ( Dowsett, M; Easty, DM; Easty, GC; Neville, AM; Powles, TJ, 1976) |
| " WCM stimulated adenylate cyclase in osteoblast like cells, the dose-response curve paralleling that of hPTHrP(1-34)." | 1.28 | Osteolytic activity of Walker carcinosarcoma 256 is due to parathyroid hormone-related protein (PTHrP). ( Grohe, U; Krieg, P; Lempert, UG; Maurer, E; Minne, HW; Rappel, S; Scharla, SH; Ziegler, R, 1991) |
| "Osteolysis is estimated by the amount of 45Ca released from bone to medium, the mice being given injections of 45Ca on their day of birth." | 1.26 | Inhibition by two diphosphonates of bone lysis in tumor-conditioned media. ( Barras, C; Baud, M; Courvoisier, B; Jung, A; Mermillod, B, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (71.43) | 18.7374 |
| 1990's | 2 (14.29) | 18.2507 |
| 2000's | 2 (14.29) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jung, A | 1 |
| Mermillod, B | 1 |
| Barras, C | 1 |
| Baud, M | 1 |
| Courvoisier, B | 1 |
| Tsao, SW | 2 |
| Burman, JF | 2 |
| Carter, RL | 2 |
| Ritchie, GA | 1 |
| Easty, DM | 3 |
| Easty, GC | 3 |
| Galasko, CS | 2 |
| Samuel, AW | 1 |
| Rushton, S | 1 |
| Lacey, E | 1 |
| Frost, A | 1 |
| Jonsson, KB | 1 |
| Ridefelt, P | 1 |
| Nilsson, O | 1 |
| Ljunghall, S | 1 |
| Ljunggren, O | 1 |
| Brown, RE | 1 |
| Meghji, S | 1 |
| Morrison, MS | 1 |
| Henderson, B | 1 |
| Arnett, TR | 1 |
| Coombes, RC | 1 |
| Neville, AM | 3 |
| Gazet, JC | 2 |
| Ford, HT | 1 |
| Nash, AG | 1 |
| Baker, JW | 1 |
| Powles, JT | 1 |
| Dowsett, M | 2 |
| Powles, TJ | 2 |
| Rawlins, R | 1 |
| Bennett, A | 1 |
| Scharla, SH | 1 |
| Minne, HW | 1 |
| Lempert, UG | 1 |
| Krieg, P | 1 |
| Rappel, S | 1 |
| Maurer, E | 1 |
| Grohe, U | 1 |
| Ziegler, R | 1 |
| Thomson, BM | 1 |
| Mundy, GR | 1 |
| Chambers, TJ | 1 |
14 other studies available for indomethacin and Osteolysis
| Article | Year |
|---|---|
Inhibition by two diphosphonates of bone lysis in tumor-conditioned media.
Topics: Animals; Bone Resorption; Clodronic Acid; Culture Media; Diphosphonates; Etidronic Acid; Indomethaci | 1981 |
Hypercalcaemia and in vitro osteolysis associated with xenografts of squamous carcinomas of the tongue.
Topics: Animals; Bone Resorption; Calcium; Carcinoma, Squamous Cell; Culture Techniques; Dinoprost; Dinopros | 1983 |
The direct inhibition of prostaglandin synthetase of human breast cancer tumor tissue by tamoxifen.
Topics: Bone Neoplasms; Bone Resorption; Breast Neoplasms; Cyclooxygenase Inhibitors; Dose-Response Relation | 1980 |
Some mechanisms of local bone destruction by squamous carcinomas of the head and neck.
Topics: Adult; Animals; Bone Resorption; Carcinoma, Squamous Cell; Cell Line; Female; Head and Neck Neoplasm | 1981 |
The effect of prostaglandin synthesis inhibitors and diphosphonates on tumour-mediated osteolysis.
Topics: Animals; Bone Resorption; Breast Neoplasms; Culture Techniques; Diphosphonates; Flurbiprofen; Humans | 1980 |
Thrombin, but not bradykinin, stimulates proliferation in isolated human osteoblasts, via a mechanism not dependent on endogenous prostaglandin formation.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Bradykinin; Cell Count; Cell Division; Cells, Cultured; Chr | 1999 |
Cyclo-oxygenase-2 in the osteolytic lesions of Langerhans cell histiocytosis.
Topics: Antibodies; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Giant Cells; H | 2000 |
pH dependence of bone resorption: mouse calvarial osteoclasts are activated by acidosis.
Topics: Acid-Base Equilibrium; Acidosis; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bicarbonates; Cal | 2001 |
Agents affecting osteolysis in patients with breast cancer.
Topics: Anti-Inflammatory Agents; Aspirin; Bone Neoplasms; Bone Resorption; Breast Neoplasms; Calcitonin; Fe | 1979 |
In vitro osteolysis by human breast tumours.
Topics: Aspirin; Bone Neoplasms; Bone Resorption; Breast Neoplasms; Calcium; Female; Humans; In Vitro Techni | 1977 |
Timing of indomethacin in the control of prostaglandins, osteoclasts and bone destruction produced by VX2 carcinoma in rabbits.
Topics: Animals; Bone Resorption; Cell Division; Drug Administration Schedule; Female; Indomethacin; Male; N | 1979 |
Human breast tumour-induced osteolysis and prostaglandins.
Topics: Aspirin; Bone Resorption; Breast Neoplasms; Female; Humans; Indomethacin; Osteolysis; Prostaglandins | 1976 |
Osteolytic activity of Walker carcinosarcoma 256 is due to parathyroid hormone-related protein (PTHrP).
Topics: Adenylyl Cyclases; Animals; Carcinoma 256, Walker; Culture Media; Cyclic AMP; Dexamethasone; Disease | 1991 |
Tumor necrosis factors alpha and beta induce osteoblastic cells to stimulate osteoclastic bone resorption.
Topics: Animals; Bone Resorption; Cattle; Glycoproteins; In Vitro Techniques; Indomethacin; Osteoblasts; Ost | 1987 |