indomethacin has been researched along with Osteogenic Sarcoma in 24 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Excerpt | Relevance | Reference |
---|---|---|
"The effects of tumor necrosis factor alpha (TNF-alpha) on arachidonic acid (AA) metabolism were investigated by prelabeling the human osteoblastic osteosarcoma cell line, G292, with [3H]AA." | 7.69 | Tumor necrosis factor alpha stimulates arachidonic acid metabolism in human osteoblastic osteosarcomal cells. ( Dziak, R; Zhang, W, 1996) |
"The effects of interleukin-1 alpha (IL-1 alpha) on arachidonic acid (AA) metabolism were studied in the human osteosarcoma cell lines, G292 and SaOS-2." | 7.68 | Effects of interleukin-1 alpha on arachidonic acid metabolism in human osteosarcoma osteoblastic cells. ( Dziak, R; Zhang, W, 1993) |
"We present evidence for the presence of specific, high-affinity binding sites for tritiated phorbol 12,13-dibutyrate on osteosarcoma-derived (HT-3) cells." | 3.69 | Activation of protein kinase C and the involvement of prostaglandin E2 in the inhibition of osteosarcoma-derived cell alkaline phosphatase activity. ( Fukuda, K; Nishioka, S; Saitoh, M; Tanaka, S; Ueno, M, 1995) |
"The effects of tumor necrosis factor alpha (TNF-alpha) on arachidonic acid (AA) metabolism were investigated by prelabeling the human osteoblastic osteosarcoma cell line, G292, with [3H]AA." | 3.69 | Tumor necrosis factor alpha stimulates arachidonic acid metabolism in human osteoblastic osteosarcomal cells. ( Dziak, R; Zhang, W, 1996) |
"9 microM), epidermal growth factor (40 nM), prostaglandin E1 (5 microM), and prostaglandin F1 alpha (5 microM) were examined on calcium signaling in UMR-106 rat osteoblastic osteosarcoma cells." | 3.68 | Endothelin-1 modulates calcium signaling by epidermal growth factor, alpha-thrombin, and prostaglandin E1 in UMR-106 osteoblastic cells. ( Stern, PH; Tatrai, A, 1993) |
"The effects of interleukin-1 alpha (IL-1 alpha) on arachidonic acid (AA) metabolism were studied in the human osteosarcoma cell lines, G292 and SaOS-2." | 3.68 | Effects of interleukin-1 alpha on arachidonic acid metabolism in human osteosarcoma osteoblastic cells. ( Dziak, R; Zhang, W, 1993) |
"The effects of bradykinin, analogs and inhibitors on the human osteoblastic osteosarcoma cell lines Saos-2 and G292 and on normal rat calvarial osteoblastic cells were investigated." | 3.68 | Second messenger systems stimulated by bradykinin in osteoblastic cells: evidence for B2 receptors. ( Dolce, C; Dziak, R; Hagel-Bradway, SE; Tatakis, DN, 1992) |
"Leukotriene B4 (LTB4) is an arachidonic acid lipoxygenase metabolite with well-characterized effects on leukocytes." | 1.28 | Effects of leukotrienes on osteoblastic cell proliferation. ( Dziak, R; Ren, W, 1991) |
"Indomethacin failed to inhibit the AlF(4-)-induced mitogenesis." | 1.28 | Aluminofluoride- and epidermal growth factor-stimulated DNA synthesis in MOB 3-4-F2 cells. ( Kawase, T; Orikasa, M; Suzuki, A, 1991) |
"In contrast to KCMI, the increase in bone resorption stimulated by KCMII was accompanied by a parallel increase in the production of PGE2, and inhibition of PGE2 synthesis completely inhibited the bone resorption-stimulating activity of KCMII." | 1.27 | Evidence for multiple bone resorption-stimulating factors produced by normal human keratinocytes in culture. ( Fried, RM; Levine, L; Rice, RH; Tashjian, AH; Voelkel, EF, 1988) |
"TGF alpha stimulated bone resorption in two organ culture systems, the fetal rat long bone and neonatal mouse calvarial systems." | 1.27 | Human recombinant transforming growth factor alpha stimulates bone resorption and inhibits formation in vitro. ( D'Souza, S; Derynck, R; Gowen, M; Harrod, J; Ibbotson, KJ; Mundy, GR; Smith, DD; Winkler, ME, 1986) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 6 (25.00) | 18.7374 |
1990's | 12 (50.00) | 18.2507 |
2000's | 3 (12.50) | 29.6817 |
2010's | 2 (8.33) | 24.3611 |
2020's | 1 (4.17) | 2.80 |
Authors | Studies |
---|---|
Mirshahidi, S | 2 |
de Necochea-Campion, R | 2 |
Moretta, A | 1 |
Williams, NL | 2 |
Reeves, ME | 1 |
Otoukesh, S | 1 |
Mirshahidi, HR | 2 |
Khosrowpour, S | 1 |
Duerksen-Hughes, P | 1 |
Zuckerman, LM | 2 |
Frames, WL | 1 |
Elsissy, JG | 1 |
Shields, TG | 1 |
Díaz-Rodríguez, L | 1 |
García-Martínez, O | 1 |
Morales, MA | 1 |
Rodríguez-Pérez, L | 1 |
Rubio-Ruiz, B | 1 |
Ruiz, C | 1 |
Coetzee, M | 1 |
Haag, M | 1 |
Claassen, N | 1 |
Kruger, MC | 1 |
Shoji, M | 1 |
Tanabe, N | 1 |
Mitsui, N | 1 |
Tanaka, H | 1 |
Suzuki, N | 1 |
Takeichi, O | 1 |
Sugaya, A | 1 |
Maeno, M | 1 |
Hirata, Y | 1 |
Uchihashi, M | 1 |
Nakashima, H | 1 |
Fujita, T | 1 |
Matsukura, S | 1 |
Matsui, K | 1 |
Hohmann, EL | 1 |
Tashjian, AH | 2 |
Rodan, SB | 2 |
Rodan, GA | 2 |
Simmons, HA | 1 |
Walenga, RW | 1 |
Feinstein, MB | 1 |
Raisz, LG | 1 |
Fukuda, K | 1 |
Ueno, M | 1 |
Saitoh, M | 1 |
Nishioka, S | 1 |
Tanaka, S | 1 |
Tatrai, A | 1 |
Stern, PH | 1 |
Zhang, W | 2 |
Dziak, R | 5 |
Guignandon, A | 1 |
Vico, L | 1 |
Alexandre, C | 1 |
Lafage-Proust, MH | 1 |
Chan, CC | 1 |
Rodger, IW | 1 |
Roebuck, KA | 1 |
Vermes, C | 1 |
Carpenter, LR | 1 |
Fritz, EA | 1 |
Narayanan, R | 1 |
Glant, TT | 1 |
Tatakis, DN | 3 |
Dolce, C | 1 |
Hagel-Bradway, SE | 1 |
Fawthrop, FW | 1 |
Oyajobi, BO | 1 |
Bunning, RA | 1 |
Russell, RG | 1 |
Kohl, AC | 1 |
Hansen, C | 1 |
Ren, W | 1 |
Kawase, T | 1 |
Orikasa, M | 1 |
Suzuki, A | 1 |
Fried, RM | 1 |
Voelkel, EF | 1 |
Rice, RH | 1 |
Levine, L | 1 |
Wesolowski, G | 1 |
Ibbotson, KJ | 1 |
Harrod, J | 1 |
Gowen, M | 1 |
D'Souza, S | 1 |
Smith, DD | 1 |
Winkler, ME | 1 |
Derynck, R | 1 |
Mundy, GR | 1 |
1 review available for indomethacin and Osteogenic Sarcoma
Article | Year |
---|---|
Selective cyclooxygenase-2 inhibitors as potential therapeutic agents for inflammatory diseases.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2 | 1997 |
23 other studies available for indomethacin and Osteogenic Sarcoma
Article | Year |
---|---|
Inhibitory Effects of Indomethacin in Human MNNG/HOS Osteosarcoma Cell Line
Topics: Apoptosis; beta Catenin; Bone Neoplasms; Caspase 3; Cell Line, Tumor; Cell Survival; Cyclooxygenase | 2020 |
The effect of non-steroidal anti-inflammatory drugs on osteosarcoma cells.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Neoplasms; Cell Line, Tumor; Cell Proliferati | 2019 |
Effects of indomethacin, nimesulide, and diclofenac on human MG-63 osteosarcoma cell line.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Bone Neoplasms; Cell Cycle; Cell Differentiation; Cell Line | 2012 |
Stimulation of prostaglandin E2 (PGE2) production by arachidonic acid, oestrogen and parathyroid hormone in MG-63 and MC3T3-E1 osteoblast-like cells.
Topics: Animals; Arachidonic Acid; Cell Line; Cell Line, Tumor; Cyclooxygenase 2; Cyclooxygenase Inhibitors; | 2005 |
Lipopolysaccharide stimulates the production of prostaglandin E2 and the receptor Ep4 in osteoblasts.
Topics: Alkaline Phosphatase; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 1; Cycloo | 2006 |
Specific receptors for epidermal growth factor in human bone tumour cells and its effect on synthesis of prostaglandin E2 by cultured osteosarcoma cell line.
Topics: Adult; Alprostadil; Animals; Bone Neoplasms; Bone Resorption; Calcitonin; Cell Line; Child; Cyclic A | 1984 |
Functional receptors for vasoactive intestinal peptide on human osteosarcoma cells.
Topics: Binding, Competitive; Cell Line; Cyclic AMP; Humans; Indomethacin; Kinetics; Osteosarcoma; Receptors | 1984 |
Bone resorptive factor produced by osteosarcoma cells with osteoblastic features is PGE2.
Topics: Animals; Bone Neoplasms; Bone Resorption; Cell Line; Chromatography, Thin Layer; Culture Media; Dino | 1981 |
Activation of protein kinase C and the involvement of prostaglandin E2 in the inhibition of osteosarcoma-derived cell alkaline phosphatase activity.
Topics: Alkaline Phosphatase; Binding Sites; Dinoprostone; DNA; Enzyme Activation; Indomethacin; Kinetics; O | 1995 |
Endothelin-1 modulates calcium signaling by epidermal growth factor, alpha-thrombin, and prostaglandin E1 in UMR-106 osteoblastic cells.
Topics: Alprostadil; Animals; Cadaverine; Calcium; Endothelins; Epidermal Growth Factor; Indomethacin; Osteo | 1993 |
Effects of interleukin-1 alpha on arachidonic acid metabolism in human osteosarcoma osteoblastic cells.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 6-Ketoprostaglandin F1 alpha; Arachidonic Acid; Dinopros | 1993 |
Shape changes of osteoblastic cells under gravitational variations during parabolic flight--relationship with PGE2 synthesis.
Topics: Animals; Cell Adhesion; Cell Size; Dinoprostone; Gravitation; Indomethacin; Kinetics; Osteoblasts; O | 1995 |
Tumor necrosis factor alpha stimulates arachidonic acid metabolism in human osteoblastic osteosarcomal cells.
Topics: Arachidonic Acid; Calcimycin; Dinoprostone; Dose-Response Relationship, Drug; Humans; Hydroxyeicosat | 1996 |
Down-regulation of procollagen alpha1[I]] messenger RNA by titanium particles correlates with nuclear factor kappaB (NF-kappaB) activation and increased rel A and NF-kappaB1 binding to the collagen promoter.
Topics: Binding Sites; Cytokines; Dinoprostone; DNA-Binding Proteins; Down-Regulation; Humans; I-kappa B Pro | 2001 |
Second messenger systems stimulated by bradykinin in osteoblastic cells: evidence for B2 receptors.
Topics: Amino Acid Sequence; Animals; Bradykinin; Calcium; Cells, Cultured; Cyclic AMP; Dose-Response Relati | 1992 |
The effect of transforming growth factor beta on the plasminogen activator activity of normal human osteoblast-like cells and a human osteosarcoma cell line MG-63.
Topics: Bone Remodeling; Cells, Cultured; Cycloheximide; Dactinomycin; Electrophoresis, Polyacrylamide Gel; | 1992 |
Human platelet factor 4 is a direct inhibitor of human osteoblast-like osteosarcoma cell growth.
Topics: Blood; Cell Division; DNA; Humans; Indomethacin; Osteoblasts; Osteosarcoma; Platelet Factor 4; Throm | 1992 |
Effects of interleukin-1, tumor necrosis factor -beta, and forskolin on tissue plasminogen activator activity in human osteoblastic osteosarcoma cells.
Topics: Colforsin; Growth Substances; Humans; Indomethacin; Interleukin-1; Lymphotoxin-alpha; Osteoblasts; O | 1992 |
Effects of leukotrienes on osteoblastic cell proliferation.
Topics: Animals; Benzoquinones; Bone Neoplasms; Cell Division; Cells, Cultured; Culture Media, Serum-Free; D | 1991 |
Aluminofluoride- and epidermal growth factor-stimulated DNA synthesis in MOB 3-4-F2 cells.
Topics: Aluminum; Aluminum Compounds; Animals; Arachidonic Acid; Cell Line; DNA; Epidermal Growth Factor; Fl | 1991 |
Evidence for multiple bone resorption-stimulating factors produced by normal human keratinocytes in culture.
Topics: Animals; Biological Assay; Bone and Bones; Bone Resorption; Cells, Cultured; Chromatography, Gel; Cu | 1988 |
Clonal differences in prostaglandin synthesis among osteosarcoma cell lines.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Chromatograph | 1986 |
Human recombinant transforming growth factor alpha stimulates bone resorption and inhibits formation in vitro.
Topics: Alkaline Phosphatase; Animals; Bone Resorption; Collagen; Dose-Response Relationship, Drug; Epiderma | 1986 |