indomethacin has been researched along with Osteogenic Sarcoma in 24 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of tumor necrosis factor alpha (TNF-alpha) on arachidonic acid (AA) metabolism were investigated by prelabeling the human osteoblastic osteosarcoma cell line, G292, with [3H]AA." | 7.69 | Tumor necrosis factor alpha stimulates arachidonic acid metabolism in human osteoblastic osteosarcomal cells. ( Dziak, R; Zhang, W, 1996) |
| "The effects of interleukin-1 alpha (IL-1 alpha) on arachidonic acid (AA) metabolism were studied in the human osteosarcoma cell lines, G292 and SaOS-2." | 7.68 | Effects of interleukin-1 alpha on arachidonic acid metabolism in human osteosarcoma osteoblastic cells. ( Dziak, R; Zhang, W, 1993) |
| "We present evidence for the presence of specific, high-affinity binding sites for tritiated phorbol 12,13-dibutyrate on osteosarcoma-derived (HT-3) cells." | 3.69 | Activation of protein kinase C and the involvement of prostaglandin E2 in the inhibition of osteosarcoma-derived cell alkaline phosphatase activity. ( Fukuda, K; Nishioka, S; Saitoh, M; Tanaka, S; Ueno, M, 1995) |
| "The effects of tumor necrosis factor alpha (TNF-alpha) on arachidonic acid (AA) metabolism were investigated by prelabeling the human osteoblastic osteosarcoma cell line, G292, with [3H]AA." | 3.69 | Tumor necrosis factor alpha stimulates arachidonic acid metabolism in human osteoblastic osteosarcomal cells. ( Dziak, R; Zhang, W, 1996) |
| "9 microM), epidermal growth factor (40 nM), prostaglandin E1 (5 microM), and prostaglandin F1 alpha (5 microM) were examined on calcium signaling in UMR-106 rat osteoblastic osteosarcoma cells." | 3.68 | Endothelin-1 modulates calcium signaling by epidermal growth factor, alpha-thrombin, and prostaglandin E1 in UMR-106 osteoblastic cells. ( Stern, PH; Tatrai, A, 1993) |
| "The effects of interleukin-1 alpha (IL-1 alpha) on arachidonic acid (AA) metabolism were studied in the human osteosarcoma cell lines, G292 and SaOS-2." | 3.68 | Effects of interleukin-1 alpha on arachidonic acid metabolism in human osteosarcoma osteoblastic cells. ( Dziak, R; Zhang, W, 1993) |
| "The effects of bradykinin, analogs and inhibitors on the human osteoblastic osteosarcoma cell lines Saos-2 and G292 and on normal rat calvarial osteoblastic cells were investigated." | 3.68 | Second messenger systems stimulated by bradykinin in osteoblastic cells: evidence for B2 receptors. ( Dolce, C; Dziak, R; Hagel-Bradway, SE; Tatakis, DN, 1992) |
| "Leukotriene B4 (LTB4) is an arachidonic acid lipoxygenase metabolite with well-characterized effects on leukocytes." | 1.28 | Effects of leukotrienes on osteoblastic cell proliferation. ( Dziak, R; Ren, W, 1991) |
| "Indomethacin failed to inhibit the AlF(4-)-induced mitogenesis." | 1.28 | Aluminofluoride- and epidermal growth factor-stimulated DNA synthesis in MOB 3-4-F2 cells. ( Kawase, T; Orikasa, M; Suzuki, A, 1991) |
| "In contrast to KCMI, the increase in bone resorption stimulated by KCMII was accompanied by a parallel increase in the production of PGE2, and inhibition of PGE2 synthesis completely inhibited the bone resorption-stimulating activity of KCMII." | 1.27 | Evidence for multiple bone resorption-stimulating factors produced by normal human keratinocytes in culture. ( Fried, RM; Levine, L; Rice, RH; Tashjian, AH; Voelkel, EF, 1988) |
| "TGF alpha stimulated bone resorption in two organ culture systems, the fetal rat long bone and neonatal mouse calvarial systems." | 1.27 | Human recombinant transforming growth factor alpha stimulates bone resorption and inhibits formation in vitro. ( D'Souza, S; Derynck, R; Gowen, M; Harrod, J; Ibbotson, KJ; Mundy, GR; Smith, DD; Winkler, ME, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (25.00) | 18.7374 |
| 1990's | 12 (50.00) | 18.2507 |
| 2000's | 3 (12.50) | 29.6817 |
| 2010's | 2 (8.33) | 24.3611 |
| 2020's | 1 (4.17) | 2.80 |
| Authors | Studies |
|---|---|
| Mirshahidi, S | 2 |
| de Necochea-Campion, R | 2 |
| Moretta, A | 1 |
| Williams, NL | 2 |
| Reeves, ME | 1 |
| Otoukesh, S | 1 |
| Mirshahidi, HR | 2 |
| Khosrowpour, S | 1 |
| Duerksen-Hughes, P | 1 |
| Zuckerman, LM | 2 |
| Frames, WL | 1 |
| Elsissy, JG | 1 |
| Shields, TG | 1 |
| Díaz-Rodríguez, L | 1 |
| García-Martínez, O | 1 |
| Morales, MA | 1 |
| Rodríguez-Pérez, L | 1 |
| Rubio-Ruiz, B | 1 |
| Ruiz, C | 1 |
| Coetzee, M | 1 |
| Haag, M | 1 |
| Claassen, N | 1 |
| Kruger, MC | 1 |
| Shoji, M | 1 |
| Tanabe, N | 1 |
| Mitsui, N | 1 |
| Tanaka, H | 1 |
| Suzuki, N | 1 |
| Takeichi, O | 1 |
| Sugaya, A | 1 |
| Maeno, M | 1 |
| Hirata, Y | 1 |
| Uchihashi, M | 1 |
| Nakashima, H | 1 |
| Fujita, T | 1 |
| Matsukura, S | 1 |
| Matsui, K | 1 |
| Hohmann, EL | 1 |
| Tashjian, AH | 2 |
| Rodan, SB | 2 |
| Rodan, GA | 2 |
| Simmons, HA | 1 |
| Walenga, RW | 1 |
| Feinstein, MB | 1 |
| Raisz, LG | 1 |
| Fukuda, K | 1 |
| Ueno, M | 1 |
| Saitoh, M | 1 |
| Nishioka, S | 1 |
| Tanaka, S | 1 |
| Tatrai, A | 1 |
| Stern, PH | 1 |
| Zhang, W | 2 |
| Dziak, R | 5 |
| Guignandon, A | 1 |
| Vico, L | 1 |
| Alexandre, C | 1 |
| Lafage-Proust, MH | 1 |
| Chan, CC | 1 |
| Rodger, IW | 1 |
| Roebuck, KA | 1 |
| Vermes, C | 1 |
| Carpenter, LR | 1 |
| Fritz, EA | 1 |
| Narayanan, R | 1 |
| Glant, TT | 1 |
| Tatakis, DN | 3 |
| Dolce, C | 1 |
| Hagel-Bradway, SE | 1 |
| Fawthrop, FW | 1 |
| Oyajobi, BO | 1 |
| Bunning, RA | 1 |
| Russell, RG | 1 |
| Kohl, AC | 1 |
| Hansen, C | 1 |
| Ren, W | 1 |
| Kawase, T | 1 |
| Orikasa, M | 1 |
| Suzuki, A | 1 |
| Fried, RM | 1 |
| Voelkel, EF | 1 |
| Rice, RH | 1 |
| Levine, L | 1 |
| Wesolowski, G | 1 |
| Ibbotson, KJ | 1 |
| Harrod, J | 1 |
| Gowen, M | 1 |
| D'Souza, S | 1 |
| Smith, DD | 1 |
| Winkler, ME | 1 |
| Derynck, R | 1 |
| Mundy, GR | 1 |
1 review available for indomethacin and Osteogenic Sarcoma
| Article | Year |
|---|---|
Selective cyclooxygenase-2 inhibitors as potential therapeutic agents for inflammatory diseases.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2 | 1997 |
23 other studies available for indomethacin and Osteogenic Sarcoma
| Article | Year |
|---|---|
Inhibitory Effects of Indomethacin in Human MNNG/HOS Osteosarcoma Cell Line
Topics: Apoptosis; beta Catenin; Bone Neoplasms; Caspase 3; Cell Line, Tumor; Cell Survival; Cyclooxygenase | 2020 |
The effect of non-steroidal anti-inflammatory drugs on osteosarcoma cells.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Neoplasms; Cell Line, Tumor; Cell Proliferati | 2019 |
Effects of indomethacin, nimesulide, and diclofenac on human MG-63 osteosarcoma cell line.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Bone Neoplasms; Cell Cycle; Cell Differentiation; Cell Line | 2012 |
Stimulation of prostaglandin E2 (PGE2) production by arachidonic acid, oestrogen and parathyroid hormone in MG-63 and MC3T3-E1 osteoblast-like cells.
Topics: Animals; Arachidonic Acid; Cell Line; Cell Line, Tumor; Cyclooxygenase 2; Cyclooxygenase Inhibitors; | 2005 |
Lipopolysaccharide stimulates the production of prostaglandin E2 and the receptor Ep4 in osteoblasts.
Topics: Alkaline Phosphatase; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 1; Cycloo | 2006 |
Specific receptors for epidermal growth factor in human bone tumour cells and its effect on synthesis of prostaglandin E2 by cultured osteosarcoma cell line.
Topics: Adult; Alprostadil; Animals; Bone Neoplasms; Bone Resorption; Calcitonin; Cell Line; Child; Cyclic A | 1984 |
Functional receptors for vasoactive intestinal peptide on human osteosarcoma cells.
Topics: Binding, Competitive; Cell Line; Cyclic AMP; Humans; Indomethacin; Kinetics; Osteosarcoma; Receptors | 1984 |
Bone resorptive factor produced by osteosarcoma cells with osteoblastic features is PGE2.
Topics: Animals; Bone Neoplasms; Bone Resorption; Cell Line; Chromatography, Thin Layer; Culture Media; Dino | 1981 |
Activation of protein kinase C and the involvement of prostaglandin E2 in the inhibition of osteosarcoma-derived cell alkaline phosphatase activity.
Topics: Alkaline Phosphatase; Binding Sites; Dinoprostone; DNA; Enzyme Activation; Indomethacin; Kinetics; O | 1995 |
Endothelin-1 modulates calcium signaling by epidermal growth factor, alpha-thrombin, and prostaglandin E1 in UMR-106 osteoblastic cells.
Topics: Alprostadil; Animals; Cadaverine; Calcium; Endothelins; Epidermal Growth Factor; Indomethacin; Osteo | 1993 |
Effects of interleukin-1 alpha on arachidonic acid metabolism in human osteosarcoma osteoblastic cells.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 6-Ketoprostaglandin F1 alpha; Arachidonic Acid; Dinopros | 1993 |
Shape changes of osteoblastic cells under gravitational variations during parabolic flight--relationship with PGE2 synthesis.
Topics: Animals; Cell Adhesion; Cell Size; Dinoprostone; Gravitation; Indomethacin; Kinetics; Osteoblasts; O | 1995 |
Tumor necrosis factor alpha stimulates arachidonic acid metabolism in human osteoblastic osteosarcomal cells.
Topics: Arachidonic Acid; Calcimycin; Dinoprostone; Dose-Response Relationship, Drug; Humans; Hydroxyeicosat | 1996 |
Down-regulation of procollagen alpha1[I]] messenger RNA by titanium particles correlates with nuclear factor kappaB (NF-kappaB) activation and increased rel A and NF-kappaB1 binding to the collagen promoter.
Topics: Binding Sites; Cytokines; Dinoprostone; DNA-Binding Proteins; Down-Regulation; Humans; I-kappa B Pro | 2001 |
Second messenger systems stimulated by bradykinin in osteoblastic cells: evidence for B2 receptors.
Topics: Amino Acid Sequence; Animals; Bradykinin; Calcium; Cells, Cultured; Cyclic AMP; Dose-Response Relati | 1992 |
The effect of transforming growth factor beta on the plasminogen activator activity of normal human osteoblast-like cells and a human osteosarcoma cell line MG-63.
Topics: Bone Remodeling; Cells, Cultured; Cycloheximide; Dactinomycin; Electrophoresis, Polyacrylamide Gel; | 1992 |
Human platelet factor 4 is a direct inhibitor of human osteoblast-like osteosarcoma cell growth.
Topics: Blood; Cell Division; DNA; Humans; Indomethacin; Osteoblasts; Osteosarcoma; Platelet Factor 4; Throm | 1992 |
Effects of interleukin-1, tumor necrosis factor -beta, and forskolin on tissue plasminogen activator activity in human osteoblastic osteosarcoma cells.
Topics: Colforsin; Growth Substances; Humans; Indomethacin; Interleukin-1; Lymphotoxin-alpha; Osteoblasts; O | 1992 |
Effects of leukotrienes on osteoblastic cell proliferation.
Topics: Animals; Benzoquinones; Bone Neoplasms; Cell Division; Cells, Cultured; Culture Media, Serum-Free; D | 1991 |
Aluminofluoride- and epidermal growth factor-stimulated DNA synthesis in MOB 3-4-F2 cells.
Topics: Aluminum; Aluminum Compounds; Animals; Arachidonic Acid; Cell Line; DNA; Epidermal Growth Factor; Fl | 1991 |
Evidence for multiple bone resorption-stimulating factors produced by normal human keratinocytes in culture.
Topics: Animals; Biological Assay; Bone and Bones; Bone Resorption; Cells, Cultured; Chromatography, Gel; Cu | 1988 |
Clonal differences in prostaglandin synthesis among osteosarcoma cell lines.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Chromatograph | 1986 |
Human recombinant transforming growth factor alpha stimulates bone resorption and inhibits formation in vitro.
Topics: Alkaline Phosphatase; Animals; Bone Resorption; Collagen; Dose-Response Relationship, Drug; Epiderma | 1986 |