Page last updated: 2024-10-29

indomethacin and Osteogenic Sarcoma

indomethacin has been researched along with Osteogenic Sarcoma in 24 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Research Excerpts

ExcerptRelevanceReference
"The effects of tumor necrosis factor alpha (TNF-alpha) on arachidonic acid (AA) metabolism were investigated by prelabeling the human osteoblastic osteosarcoma cell line, G292, with [3H]AA."7.69Tumor necrosis factor alpha stimulates arachidonic acid metabolism in human osteoblastic osteosarcomal cells. ( Dziak, R; Zhang, W, 1996)
"The effects of interleukin-1 alpha (IL-1 alpha) on arachidonic acid (AA) metabolism were studied in the human osteosarcoma cell lines, G292 and SaOS-2."7.68Effects of interleukin-1 alpha on arachidonic acid metabolism in human osteosarcoma osteoblastic cells. ( Dziak, R; Zhang, W, 1993)
"We present evidence for the presence of specific, high-affinity binding sites for tritiated phorbol 12,13-dibutyrate on osteosarcoma-derived (HT-3) cells."3.69Activation of protein kinase C and the involvement of prostaglandin E2 in the inhibition of osteosarcoma-derived cell alkaline phosphatase activity. ( Fukuda, K; Nishioka, S; Saitoh, M; Tanaka, S; Ueno, M, 1995)
"The effects of tumor necrosis factor alpha (TNF-alpha) on arachidonic acid (AA) metabolism were investigated by prelabeling the human osteoblastic osteosarcoma cell line, G292, with [3H]AA."3.69Tumor necrosis factor alpha stimulates arachidonic acid metabolism in human osteoblastic osteosarcomal cells. ( Dziak, R; Zhang, W, 1996)
"9 microM), epidermal growth factor (40 nM), prostaglandin E1 (5 microM), and prostaglandin F1 alpha (5 microM) were examined on calcium signaling in UMR-106 rat osteoblastic osteosarcoma cells."3.68Endothelin-1 modulates calcium signaling by epidermal growth factor, alpha-thrombin, and prostaglandin E1 in UMR-106 osteoblastic cells. ( Stern, PH; Tatrai, A, 1993)
"The effects of interleukin-1 alpha (IL-1 alpha) on arachidonic acid (AA) metabolism were studied in the human osteosarcoma cell lines, G292 and SaOS-2."3.68Effects of interleukin-1 alpha on arachidonic acid metabolism in human osteosarcoma osteoblastic cells. ( Dziak, R; Zhang, W, 1993)
"The effects of bradykinin, analogs and inhibitors on the human osteoblastic osteosarcoma cell lines Saos-2 and G292 and on normal rat calvarial osteoblastic cells were investigated."3.68Second messenger systems stimulated by bradykinin in osteoblastic cells: evidence for B2 receptors. ( Dolce, C; Dziak, R; Hagel-Bradway, SE; Tatakis, DN, 1992)
"Leukotriene B4 (LTB4) is an arachidonic acid lipoxygenase metabolite with well-characterized effects on leukocytes."1.28Effects of leukotrienes on osteoblastic cell proliferation. ( Dziak, R; Ren, W, 1991)
"Indomethacin failed to inhibit the AlF(4-)-induced mitogenesis."1.28Aluminofluoride- and epidermal growth factor-stimulated DNA synthesis in MOB 3-4-F2 cells. ( Kawase, T; Orikasa, M; Suzuki, A, 1991)
"In contrast to KCMI, the increase in bone resorption stimulated by KCMII was accompanied by a parallel increase in the production of PGE2, and inhibition of PGE2 synthesis completely inhibited the bone resorption-stimulating activity of KCMII."1.27Evidence for multiple bone resorption-stimulating factors produced by normal human keratinocytes in culture. ( Fried, RM; Levine, L; Rice, RH; Tashjian, AH; Voelkel, EF, 1988)
"TGF alpha stimulated bone resorption in two organ culture systems, the fetal rat long bone and neonatal mouse calvarial systems."1.27Human recombinant transforming growth factor alpha stimulates bone resorption and inhibits formation in vitro. ( D'Souza, S; Derynck, R; Gowen, M; Harrod, J; Ibbotson, KJ; Mundy, GR; Smith, DD; Winkler, ME, 1986)

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19906 (25.00)18.7374
1990's12 (50.00)18.2507
2000's3 (12.50)29.6817
2010's2 (8.33)24.3611
2020's1 (4.17)2.80

Authors

AuthorsStudies
Mirshahidi, S2
de Necochea-Campion, R2
Moretta, A1
Williams, NL2
Reeves, ME1
Otoukesh, S1
Mirshahidi, HR2
Khosrowpour, S1
Duerksen-Hughes, P1
Zuckerman, LM2
Frames, WL1
Elsissy, JG1
Shields, TG1
Díaz-Rodríguez, L1
García-Martínez, O1
Morales, MA1
Rodríguez-Pérez, L1
Rubio-Ruiz, B1
Ruiz, C1
Coetzee, M1
Haag, M1
Claassen, N1
Kruger, MC1
Shoji, M1
Tanabe, N1
Mitsui, N1
Tanaka, H1
Suzuki, N1
Takeichi, O1
Sugaya, A1
Maeno, M1
Hirata, Y1
Uchihashi, M1
Nakashima, H1
Fujita, T1
Matsukura, S1
Matsui, K1
Hohmann, EL1
Tashjian, AH2
Rodan, SB2
Rodan, GA2
Simmons, HA1
Walenga, RW1
Feinstein, MB1
Raisz, LG1
Fukuda, K1
Ueno, M1
Saitoh, M1
Nishioka, S1
Tanaka, S1
Tatrai, A1
Stern, PH1
Zhang, W2
Dziak, R5
Guignandon, A1
Vico, L1
Alexandre, C1
Lafage-Proust, MH1
Chan, CC1
Rodger, IW1
Roebuck, KA1
Vermes, C1
Carpenter, LR1
Fritz, EA1
Narayanan, R1
Glant, TT1
Tatakis, DN3
Dolce, C1
Hagel-Bradway, SE1
Fawthrop, FW1
Oyajobi, BO1
Bunning, RA1
Russell, RG1
Kohl, AC1
Hansen, C1
Ren, W1
Kawase, T1
Orikasa, M1
Suzuki, A1
Fried, RM1
Voelkel, EF1
Rice, RH1
Levine, L1
Wesolowski, G1
Ibbotson, KJ1
Harrod, J1
Gowen, M1
D'Souza, S1
Smith, DD1
Winkler, ME1
Derynck, R1
Mundy, GR1

Reviews

1 review available for indomethacin and Osteogenic Sarcoma

ArticleYear
Selective cyclooxygenase-2 inhibitors as potential therapeutic agents for inflammatory diseases.
    Advances in experimental medicine and biology, 1997, Volume: 407

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2

1997

Other Studies

23 other studies available for indomethacin and Osteogenic Sarcoma

ArticleYear
Inhibitory Effects of Indomethacin in Human MNNG/HOS Osteosarcoma Cell Line
    Cancer investigation, 2020, Volume: 38, Issue:1

    Topics: Apoptosis; beta Catenin; Bone Neoplasms; Caspase 3; Cell Line, Tumor; Cell Survival; Cyclooxygenase

2020
The effect of non-steroidal anti-inflammatory drugs on osteosarcoma cells.
    European review for medical and pharmacological sciences, 2019, Volume: 23, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Neoplasms; Cell Line, Tumor; Cell Proliferati

2019
Effects of indomethacin, nimesulide, and diclofenac on human MG-63 osteosarcoma cell line.
    Biological research for nursing, 2012, Volume: 14, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Bone Neoplasms; Cell Cycle; Cell Differentiation; Cell Line

2012
Stimulation of prostaglandin E2 (PGE2) production by arachidonic acid, oestrogen and parathyroid hormone in MG-63 and MC3T3-E1 osteoblast-like cells.
    Prostaglandins, leukotrienes, and essential fatty acids, 2005, Volume: 73, Issue:6

    Topics: Animals; Arachidonic Acid; Cell Line; Cell Line, Tumor; Cyclooxygenase 2; Cyclooxygenase Inhibitors;

2005
Lipopolysaccharide stimulates the production of prostaglandin E2 and the receptor Ep4 in osteoblasts.
    Life sciences, 2006, Mar-20, Volume: 78, Issue:17

    Topics: Alkaline Phosphatase; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 1; Cycloo

2006
Specific receptors for epidermal growth factor in human bone tumour cells and its effect on synthesis of prostaglandin E2 by cultured osteosarcoma cell line.
    Acta endocrinologica, 1984, Volume: 107, Issue:1

    Topics: Adult; Alprostadil; Animals; Bone Neoplasms; Bone Resorption; Calcitonin; Cell Line; Child; Cyclic A

1984
Functional receptors for vasoactive intestinal peptide on human osteosarcoma cells.
    Endocrinology, 1984, Volume: 114, Issue:4

    Topics: Binding, Competitive; Cell Line; Cyclic AMP; Humans; Indomethacin; Kinetics; Osteosarcoma; Receptors

1984
Bone resorptive factor produced by osteosarcoma cells with osteoblastic features is PGE2.
    Biochemical and biophysical research communications, 1981, Oct-30, Volume: 102, Issue:4

    Topics: Animals; Bone Neoplasms; Bone Resorption; Cell Line; Chromatography, Thin Layer; Culture Media; Dino

1981
Activation of protein kinase C and the involvement of prostaglandin E2 in the inhibition of osteosarcoma-derived cell alkaline phosphatase activity.
    The Journal of laboratory and clinical medicine, 1995, Volume: 126, Issue:3

    Topics: Alkaline Phosphatase; Binding Sites; Dinoprostone; DNA; Enzyme Activation; Indomethacin; Kinetics; O

1995
Endothelin-1 modulates calcium signaling by epidermal growth factor, alpha-thrombin, and prostaglandin E1 in UMR-106 osteoblastic cells.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1993, Volume: 8, Issue:8

    Topics: Alprostadil; Animals; Cadaverine; Calcium; Endothelins; Epidermal Growth Factor; Indomethacin; Osteo

1993
Effects of interleukin-1 alpha on arachidonic acid metabolism in human osteosarcoma osteoblastic cells.
    Prostaglandins, leukotrienes, and essential fatty acids, 1993, Volume: 49, Issue:1

    Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 6-Ketoprostaglandin F1 alpha; Arachidonic Acid; Dinopros

1993
Shape changes of osteoblastic cells under gravitational variations during parabolic flight--relationship with PGE2 synthesis.
    Cell structure and function, 1995, Volume: 20, Issue:5

    Topics: Animals; Cell Adhesion; Cell Size; Dinoprostone; Gravitation; Indomethacin; Kinetics; Osteoblasts; O

1995
Tumor necrosis factor alpha stimulates arachidonic acid metabolism in human osteoblastic osteosarcomal cells.
    Prostaglandins, leukotrienes, and essential fatty acids, 1996, Volume: 54, Issue:6

    Topics: Arachidonic Acid; Calcimycin; Dinoprostone; Dose-Response Relationship, Drug; Humans; Hydroxyeicosat

1996
Down-regulation of procollagen alpha1[I]] messenger RNA by titanium particles correlates with nuclear factor kappaB (NF-kappaB) activation and increased rel A and NF-kappaB1 binding to the collagen promoter.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2001, Volume: 16, Issue:3

    Topics: Binding Sites; Cytokines; Dinoprostone; DNA-Binding Proteins; Down-Regulation; Humans; I-kappa B Pro

2001
Second messenger systems stimulated by bradykinin in osteoblastic cells: evidence for B2 receptors.
    Bone and mineral, 1992, Volume: 18, Issue:1

    Topics: Amino Acid Sequence; Animals; Bradykinin; Calcium; Cells, Cultured; Cyclic AMP; Dose-Response Relati

1992
The effect of transforming growth factor beta on the plasminogen activator activity of normal human osteoblast-like cells and a human osteosarcoma cell line MG-63.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1992, Volume: 7, Issue:12

    Topics: Bone Remodeling; Cells, Cultured; Cycloheximide; Dactinomycin; Electrophoresis, Polyacrylamide Gel;

1992
Human platelet factor 4 is a direct inhibitor of human osteoblast-like osteosarcoma cell growth.
    Biochemical and biophysical research communications, 1992, Aug-31, Volume: 187, Issue:1

    Topics: Blood; Cell Division; DNA; Humans; Indomethacin; Osteoblasts; Osteosarcoma; Platelet Factor 4; Throm

1992
Effects of interleukin-1, tumor necrosis factor -beta, and forskolin on tissue plasminogen activator activity in human osteoblastic osteosarcoma cells.
    Calcified tissue international, 1992, Volume: 50, Issue:2

    Topics: Colforsin; Growth Substances; Humans; Indomethacin; Interleukin-1; Lymphotoxin-alpha; Osteoblasts; O

1992
Effects of leukotrienes on osteoblastic cell proliferation.
    Calcified tissue international, 1991, Volume: 49, Issue:3

    Topics: Animals; Benzoquinones; Bone Neoplasms; Cell Division; Cells, Cultured; Culture Media, Serum-Free; D

1991
Aluminofluoride- and epidermal growth factor-stimulated DNA synthesis in MOB 3-4-F2 cells.
    Pharmacology & toxicology, 1991, Volume: 69, Issue:5

    Topics: Aluminum; Aluminum Compounds; Animals; Arachidonic Acid; Cell Line; DNA; Epidermal Growth Factor; Fl

1991
Evidence for multiple bone resorption-stimulating factors produced by normal human keratinocytes in culture.
    Endocrinology, 1988, Volume: 122, Issue:6

    Topics: Animals; Biological Assay; Bone and Bones; Bone Resorption; Cells, Cultured; Chromatography, Gel; Cu

1988
Clonal differences in prostaglandin synthesis among osteosarcoma cell lines.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1986, Volume: 1, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Chromatograph

1986
Human recombinant transforming growth factor alpha stimulates bone resorption and inhibits formation in vitro.
    Proceedings of the National Academy of Sciences of the United States of America, 1986, Volume: 83, Issue:7

    Topics: Alkaline Phosphatase; Animals; Bone Resorption; Collagen; Dose-Response Relationship, Drug; Epiderma

1986