indomethacin has been researched along with Osteoarthritis, Knee in 8 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Osteoarthritis, Knee: Noninflammatory degenerative disease of the knee joint consisting of three large categories: conditions that block normal synchronous movement, conditions that produce abnormal pathways of motion, and conditions that cause stress concentration resulting in changes to articular cartilage. (Crenshaw, Campbell's Operative Orthopaedics, 8th ed, p2019)
| Excerpt | Relevance | Reference |
|---|---|---|
| " As for adverse events, gastrointestinal complaints were dominant in both treatment groups, but significantly more patients interrupted the treatment in the indomethacin group (22." | 2.74 | [Randomized, double blind, multicentre, parallel group study to compare efficacy and safety of acemetacin and indometacin in patients with activated osteoarthrosis of the knee]. ( Gallacchi, G; Hodinka, L, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 6 (75.00) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bertin, P | 1 |
| Taieb, C | 1 |
| de Boer, TN | 1 |
| Huisman, AM | 1 |
| Polak, AA | 1 |
| Niehoff, AG | 1 |
| van Rinsum, AC | 1 |
| Saris, D | 1 |
| Bijlsma, JW | 1 |
| Lafeber, FJ | 1 |
| Mastbergen, SC | 1 |
| Gallacchi, G | 1 |
| Hodinka, L | 1 |
| Towheed, TE | 1 |
| Leeb, BF | 1 |
| Bucsi, L | 1 |
| Keszthelyi, B | 1 |
| Böhmova, J | 1 |
| Valesova, M | 1 |
| Hawel, R | 1 |
| Mayrhofer, F | 1 |
| Singer, F | 1 |
| Aglas, F | 1 |
| Bröll, H | 1 |
| Pomonis, JD | 1 |
| Boulet, JM | 1 |
| Gottshall, SL | 1 |
| Phillips, S | 1 |
| Sellers, R | 1 |
| Bunton, T | 1 |
| Walker, K | 1 |
| Lequesne, MG | 1 |
| Gencosmanoglu, BE | 1 |
| Eryavuz, M | 1 |
| Dervisoglu, S | 1 |
3 trials available for indomethacin and Osteoarthritis, Knee
| Article | Year |
|---|---|
The chondroprotective effect of selective COX-2 inhibition in osteoarthritis: ex vivo evaluation of human cartilage tissue after in vivo treatment.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, Knee; Cartilage, Articular | 2009 |
[Randomized, double blind, multicentre, parallel group study to compare efficacy and safety of acemetacin and indometacin in patients with activated osteoarthrosis of the knee].
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female; Humans; Indomethacin; Ma | 2009 |
[Treatment of osteoarthritis of the knee joint. Efficacy and tolerance to acemetacin slow release in comparison to celecoxib].
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Confidence Intervals; Data Interpretation | 2004 |
5 other studies available for indomethacin and Osteoarthritis, Knee
| Article | Year |
|---|---|
NSAID-sparing effect of glucosamine hydrochloride in patients with knee osteoarthritis: an analysis of data from a French database.
Topics: Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Databases, Factual; Female; France; Gluco | 2014 |
Published meta-analyses of pharmacological therapies for osteoarthritis.
Topics: Acetaminophen; Administration, Topical; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Chondroi | 2002 |
Development and pharmacological characterization of a rat model of osteoarthritis pain.
Topics: Alkylating Agents; Analgesics, Opioid; Animals; Celecoxib; Cyclooxygenase Inhibitors; Disease Models | 2005 |
Is there preliminary in-vivo evidences of an influence of nonsteroidal antiinflammatory drug treatment on osteoarthritis progression? Part I.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Apazone; Disease Progression; Humans; Indomethacin; Osteoar | 1999 |
Effects of some nonsteroidal anti-inflammatory drugs on articular cartilage of rats in an experimental model of osteoarthritis.
Topics: Alkylating Agents; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Diclofena | 2001 |