Page last updated: 2024-10-29

indomethacin and Obesity

indomethacin has been researched along with Obesity in 32 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).

Research Excerpts

ExcerptRelevanceReference
" To examine how administration of the anti-inflammatory compound indomethacin, a general cyclooxygenase inhibitor, affected obesity development and insulin sensitivity, we fed obesity-prone male C57BL/6J mice a high fat/high sucrose (HF/HS) diet or a regular diet supplemented or not with indomethacin (±INDO) for 7 weeks."7.80Indomethacin treatment prevents high fat diet-induced obesity and insulin resistance but not glucose intolerance in C57BL/6J mice. ( Aune, UL; Borkowski, K; Fjære, E; Haj, FG; Hudson, BD; Keenan, AH; Kristensen, DM; Kristiansen, K; Liaset, B; Ma, T; Madsen, L; Mandrup-Poulsen, T; Milligan, G; Newman, JW; Novotny, GW; Røen, K; Xi, Y, 2014)
"To investigate whether prostaglandins (PGs) play a role in the regulation of insulin secretion during starvation, we have studied the effects of two inhibitors of PG synthesis, indomethacin (INDO) and acetylsalicylic acid (ASA), on plasma insulin during a 72-h fast."7.66Indomethacin and aspirin prevent the starvation-induced fall in plasma insulin. ( Brodows, RG; Lilavivathana, U, 1980)
"Indomethacin, a nonsteroidal anti-inflammatory drug, has been shown to induce white adipocyte differentiation; however, its roles in brown adipocyte differentiation and activation in brown adipose tissue (BAT) and obesity are unknown."3.88Indomethacin Enhances Brown Fat Activity. ( Hammock, BD; Hao, L; Kearns, J; Kodani, SD; Morisseau, C; Scott, S; Sun, X; Wang, S; Wu, D; Zhao, L, 2018)
" Magnesium sulfate administration, steroid administration, maternal diabetes mellitus, gestational age at delivery, indomethacin exposure, birthweight, and chorioamnionitis were all considered as possible covariates in the multivariable regression models."3.83Effect of obesity on neonatal outcomes in pregnancies with preterm premature rupture of membranes. ( DeWitt, PE; Faucett, AM; Gibbs, RS; Metz, TD, 2016)
" To examine how administration of the anti-inflammatory compound indomethacin, a general cyclooxygenase inhibitor, affected obesity development and insulin sensitivity, we fed obesity-prone male C57BL/6J mice a high fat/high sucrose (HF/HS) diet or a regular diet supplemented or not with indomethacin (±INDO) for 7 weeks."3.80Indomethacin treatment prevents high fat diet-induced obesity and insulin resistance but not glucose intolerance in C57BL/6J mice. ( Aune, UL; Borkowski, K; Fjære, E; Haj, FG; Hudson, BD; Keenan, AH; Kristensen, DM; Kristiansen, K; Liaset, B; Ma, T; Madsen, L; Mandrup-Poulsen, T; Milligan, G; Newman, JW; Novotny, GW; Røen, K; Xi, Y, 2014)
"To investigate whether prostaglandins (PGs) play a role in the regulation of insulin secretion during starvation, we have studied the effects of two inhibitors of PG synthesis, indomethacin (INDO) and acetylsalicylic acid (ASA), on plasma insulin during a 72-h fast."3.66Indomethacin and aspirin prevent the starvation-induced fall in plasma insulin. ( Brodows, RG; Lilavivathana, U, 1980)
"Thirty-nine patients (46 elbows) with heterotopic ossification treated with excision were identified: 10 patients (16 elbows) had burns, 28 patients (29 elbows) had trauma, and one patient (one elbow) had a closed head injury."1.40Heterotopic ossification of the elbow treated with surgical resection: risk factors, bony ankylosis, and complications. ( Golz, A; Israel, H; Marra, G; Salazar, D, 2014)
"Metformin treatment improved these alterations."1.38Improvement of metabolic parameters and vascular function by metformin in obese non-diabetic rats. ( Akamine, EH; Carvalho, MH; Filgueira, FP; Fortes, ZB; Hagihara, GN; Lobato, NS; Pariz, JR; Tostes, RC, 2012)
"Thus, obesity is associated with the activation of renal ACE in vivo independent of its mRNA expression and enhanced vascular contractility to angiotensin II."1.31Obesity is associated with tissue-specific activation of renal angiotensin-converting enzyme in vivo: evidence for a regulatory role of endothelin. ( Barton, M; Carmona, R; d'Uscio, LV; Goettsch, W; Haudenschild, CC; Hillen, H; Krieger, JE; Lattmann, T; Lüscher, TF; Morawietz, H; Münter, K; Shaw, S, 2000)
"Indomethacin was also ineffective in altering resveratrol activity in arteries from both lean and dietary-obese rats."1.31The mechanism of resveratrol-induced vasorelaxation differs in the mesenteric resistance arteries of lean and obese rats. ( Doyle, PJ; Naderali, EK; Smith, SL; Williams, G, 2001)
" The effects of cyclooxygenase activity were evaluated by a dose-response curve to intrabrachial coinfusion of ACh and indomethacin (500 microg/min)."1.31Obesity and body fat distribution induce endothelial dysfunction by oxidative stress: protective effect of vitamin C. ( Candigliota, M; Ceravolo, R; Iacopino, S; Mattioli, PL; Perticone, F; Sinopoli, F; Ventura, G, 2001)

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-19907 (21.88)18.7374
1990's5 (15.63)18.2507
2000's10 (31.25)29.6817
2010's8 (25.00)24.3611
2020's2 (6.25)2.80

Authors

AuthorsStudies
Chen, H1
Simonsen, U1
Aalkjaer, C1
Wen, X1
Su, B1
Gao, M1
Chen, J1
Zhou, D1
You, H1
Li, N1
Chang, S1
Cheng, X1
Qian, C1
Gao, J1
Yang, P1
Qu, S1
Bu, L1
Xiao, L1
Sonne, SB1
Feng, Q1
Chen, N1
Xia, Z1
Li, X1
Fang, Z1
Zhang, D1
Fjære, E2
Midtbø, LK1
Derrien, M1
Hugenholtz, F1
Tang, L1
Li, J1
Zhang, J1
Liu, C1
Hao, Q1
Vogel, UB1
Mortensen, A1
Kleerebezem, M1
Licht, TR1
Yang, H1
Wang, J2
Li, Y1
Arumugam, M1
Madsen, L2
Kristiansen, K2
Hao, L1
Kearns, J1
Scott, S1
Wu, D1
Kodani, SD1
Morisseau, C1
Hammock, BD1
Sun, X1
Zhao, L1
Wang, S1
Hayward, CE1
Cowley, EJ1
Mills, TA1
Sibley, CP1
Wareing, M1
Salazar, D1
Golz, A1
Israel, H1
Marra, G1
Aune, UL1
Røen, K1
Keenan, AH1
Ma, T1
Borkowski, K1
Kristensen, DM1
Novotny, GW1
Mandrup-Poulsen, T1
Hudson, BD1
Milligan, G1
Xi, Y1
Newman, JW1
Haj, FG1
Liaset, B1
Faucett, AM1
Metz, TD1
DeWitt, PE1
Gibbs, RS1
Goodwill, AG1
James, ME1
Frisbee, JC1
Katakam, PV1
Domoki, F1
Snipes, JA1
Busija, AR1
Jarajapu, YP1
Busija, DW1
Juárez-Oropeza, MA1
Mascher, D1
Torres-Durán, PV1
Farias, JM1
Paredes-Carbajal, MC1
Mingorance, C1
Alvarez de Sotomayor, M1
Jiménez-Palacios, FJ1
Callejón Mochón, M1
Casto, C1
Marhuenda, E1
Herrera, MD1
Belin de Chantemèle, EJ1
Vessières, E1
Guihot, AL1
Toutain, B1
Loufrani, L1
Henrion, D1
Lobato, NS1
Filgueira, FP1
Hagihara, GN1
Akamine, EH1
Pariz, JR1
Tostes, RC1
Carvalho, MH1
Fortes, ZB1
Kim, JY1
Wu, Y1
Smas, CM1
Lilavivathana, U1
Brodows, RG1
Julkunen, R1
Haapalahti, J1
Torstila, I1
Miettinen, TA1
Mertz, DP1
Mendonca, E1
Albuquerque, L1
Jacome, L1
Luis, ML1
Rosa, FC1
Taniguchi, Y1
Moriguchi, S1
Kato, M1
Sakai, K1
Yamamoto, S1
Shimizu, E1
Sinha, D1
Addya, S1
Murer, E1
Boden, G1
Barton, M1
Carmona, R1
Morawietz, H1
d'Uscio, LV1
Goettsch, W1
Hillen, H1
Haudenschild, CC1
Krieger, JE1
Münter, K1
Lattmann, T1
Lüscher, TF1
Shaw, S1
Toda, Y1
Kobayashi, T1
Naderali, EK1
Smith, SL1
Doyle, PJ1
Williams, G1
Perticone, F1
Ceravolo, R1
Candigliota, M1
Ventura, G1
Iacopino, S1
Sinopoli, F1
Mattioli, PL1
He, Y1
MacLeod, KM1
Rose, E1
Espinoza, LR1
Osterland, CK1
Thorpe, PC1
Isaac, PF1
Rodgers, J1
Fernandez-Herlihy, L1
Abate, MA1
Neely, JL1
Layne, RD1
D'Alessandri, R1
Klotz, H1
Prohaska, E1
Salmhofer, H1
Schmid, L1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Elbow Heterotopic Ossifications Associated With Radial Head Prosthesis: Risk and Prognostic Factors[NCT05547867]60 participants (Anticipated)Observational2022-09-12Recruiting
Effect of Acute or Chronic Ingestion of Sucralose on Serum Insulin in Young and Healthy Adults: a Randomized, Double-blind, Placebo-controlled Trial[NCT03703141]95 participants (Actual)Interventional2016-09-27Completed
Effects of Blood Orange Juice Consumption on Endothelial Function in Healthy Overweight/Obese Men and Premenopausal Women of European Origin[NCT03611114]16 participants (Actual)Interventional2017-01-10Completed
Modulation of Insulin and Exercise Responses by Vitamin E and Vitamin C[NCT01369043]1 participants (Actual)Interventional2011-05-31Terminated (stopped due to Lack of successful recruiting, budget cuts, and potential study flaws.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

4 trials available for indomethacin and Obesity

ArticleYear
Effects of dietary Spirulina on vascular reactivity.
    Journal of medicinal food, 2009, Volume: 12, Issue:1

    Topics: Adolescent; Adult; Aged; Animals; Aorta; Arachidonic Acid; Blood Pressure; Cholesterol; Cholesterol,

2009
The usefulness of walking for preventing sarcopenia in dieting postmenopausal women complaining of knee pain.
    Annals of the New York Academy of Sciences, 2000, Volume: 904

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Appetite Depressants; Body Composition; Combined Moda

2000
A controlled trial of mazindol (Sanjorex, Teronac) in the management of the obese rheumatic patients.
    Current therapeutic research, clinical and experimental, 1975, Volume: 17, Issue:2

    Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Diet, Reduci

1975
Interaction of indomethacin and sulindac with labetalol.
    British journal of clinical pharmacology, 1991, Volume: 31, Issue:3

    Topics: Adult; Aged; Analysis of Variance; Blood Pressure; Body Weight; Chlorides; Drug Interactions; Humans

1991

Other Studies

28 other studies available for indomethacin and Obesity

ArticleYear
A sex-specific, COX-derived/thromboxane receptor activator causes depolarization and vasoconstriction in male mice mesenteric resistance arteries.
    Basic & clinical pharmacology & toxicology, 2020, Volume: 127, Issue:2

    Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Diabe

2020
Obesity-associated up-regulation of lipocalin 2 protects gastric mucosa cells from apoptotic cell death by reducing endoplasmic reticulum stress.
    Cell death & disease, 2021, 02-26, Volume: 12, Issue:2

    Topics: Animals; Apoptosis; Case-Control Studies; Cells, Cultured; Disease Models, Animal; Endoplasmic Retic

2021
High-fat feeding rather than obesity drives taxonomical and functional changes in the gut microbiota in mice.
    Microbiome, 2017, 04-08, Volume: 5, Issue:1

    Topics: Animals; Bacteroidetes; Butyrates; Cyclooxygenase Inhibitors; Diet, High-Fat; Dietary Fats; Firmicut

2017
Indomethacin Enhances Brown Fat Activity.
    The Journal of pharmacology and experimental therapeutics, 2018, Volume: 365, Issue:3

    Topics: Adipocytes; Adipose Tissue, Brown; Adipose Tissue, White; Animals; Cell Differentiation; Cell Line;

2018
Maternal obesity impairs specific regulatory pathways in human myometrial arteries.
    Biology of reproduction, 2014, Volume: 90, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arteries; Biopsy; Body Mass Index; Body Weight; Endothelium

2014
Heterotopic ossification of the elbow treated with surgical resection: risk factors, bony ankylosis, and complications.
    Clinical orthopaedics and related research, 2014, Volume: 472, Issue:7

    Topics: Adolescent; Adult; Aged; Ankylosis; Anti-Inflammatory Agents, Non-Steroidal; Biomechanical Phenomena

2014
Indomethacin treatment prevents high fat diet-induced obesity and insulin resistance but not glucose intolerance in C57BL/6J mice.
    The Journal of biological chemistry, 2014, Jun-06, Volume: 289, Issue:23

    Topics: Animals; Cell Line; Cyclooxygenase Inhibitors; Diet, High-Fat; Fatty Acids, Nonesterified; Glucose T

2014
Effect of obesity on neonatal outcomes in pregnancies with preterm premature rupture of membranes.
    American journal of obstetrics and gynecology, 2016, Volume: 214, Issue:2

    Topics: Adolescent; Adrenal Cortex Hormones; Adult; Birth Weight; Case-Control Studies; Cerebral Hemorrhage;

2016
Increased vascular thromboxane generation impairs dilation of skeletal muscle arterioles of obese Zucker rats with reduced oxygen tension.
    American journal of physiology. Heart and circulatory physiology, 2008, Volume: 295, Issue:4

    Topics: Animals; Arterioles; Bridged Bicyclo Compounds, Heterocyclic; Cyclooxygenase Inhibitors; Disease Mod

2008
Impaired mitochondria-dependent vasodilation in cerebral arteries of Zucker obese rats with insulin resistance.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2009, Volume: 296, Issue:2

    Topics: Animals; Cerebral Arteries; Cyclooxygenase Inhibitors; Diazoxide; Disease Models, Animal; Dose-Respo

2009
Effects of chronic treatment with the CB1 antagonist, rimonabant on the blood pressure, and vascular reactivity of obese Zucker rats.
    Obesity (Silver Spring, Md.), 2009, Volume: 17, Issue:7

    Topics: Acetylcholine; Animals; Aorta; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, D

2009
Cyclooxygenase-2 preserves flow-mediated remodelling in old obese Zucker rat mesenteric arteries.
    Cardiovascular research, 2010, Jun-01, Volume: 86, Issue:3

    Topics: Acetylcholine; Age Factors; Animals; Blood Pressure; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Di

2010
Improvement of metabolic parameters and vascular function by metformin in obese non-diabetic rats.
    Life sciences, 2012, Jan-30, Volume: 90, Issue:5-6

    Topics: Acetylcholine; Animals; Blood Pressure; Body Weight; Disease Models, Animal; Dyslipidemias; Epoprost

2012
Characterization of ScAP-23, a new cell line from murine subcutaneous adipose tissue, identifies genes for the molecular definition of preadipocytes.
    Physiological genomics, 2007, Oct-22, Volume: 31, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; 3T3-L1 Cells; Adipocytes; Adipogenesis; Animals; Biomarkers; Cell Diffe

2007
Indomethacin and aspirin prevent the starvation-induced fall in plasma insulin.
    The Journal of clinical endocrinology and metabolism, 1980, Volume: 50, Issue:5

    Topics: Adult; Aspirin; Female; Glucagon; Humans; Indomethacin; Insulin; Kinetics; Male; Middle Aged; Obesit

1980
A Bartter-like syndrome after jejunoileal bypass for obesity.
    Acta medica Scandinavica, 1982, Volume: 211, Issue:6

    Topics: Adult; Bartter Syndrome; Female; Humans; Hyperaldosteronism; Ileum; Indomethacin; Jejunum; Obesity;

1982
[Gout as a joint disease and as a generalized disease. Incidence, diagnosis and therapy].
    Fortschritte der Medizin, 1980, Aug-07, Volume: 98, Issue:29

    Topics: Allopurinol; Colchicine; Diabetes Complications; Gout; Humans; Hypertension; Indomethacin; Kidney Di

1980
Pseudotumor cerebri in a patient with Bartter's syndrome and obesity.
    Nephron, 1996, Volume: 72, Issue:1

    Topics: Adolescent; Bartter Syndrome; Female; Hematologic Tests; Humans; Indomethacin; Obesity; Potassium Ch

1996
[Pathophysiological study on the mucosal defense system of genetically obese Zucker rats].
    [Hokkaido igaku zasshi] The Hokkaido journal of medical science, 1996, Volume: 71, Issue:6

    Topics: Animals; Disease Models, Animal; Ethanol; Gastric Acid; Gastric Emptying; Gastric Mucosa; Indomethac

1996
Decreased mitogen response of splenic lymphocytes in obese Zucker rats is associated with the decreased expression of glucose transporter 1 (GLUT-1).
    The American journal of clinical nutrition, 1998, Volume: 67, Issue:6

    Topics: Animals; Blood Glucose; Concanavalin A; Cyclooxygenase Inhibitors; Dinoprostone; Female; Glucose; Im

1998
15-Deoxy-delta(12,14) prostaglandin J2: a putative endogenous promoter of adipogenesis suppresses the ob gene.
    Metabolism: clinical and experimental, 1999, Volume: 48, Issue:6

    Topics: Adipose Tissue; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Chromans; DNA-Bin

1999
Obesity is associated with tissue-specific activation of renal angiotensin-converting enzyme in vivo: evidence for a regulatory role of endothelin.
    Hypertension (Dallas, Tex. : 1979), 2000, Volume: 35, Issue:1 Pt 2

    Topics: Angiotensin II; Animals; Aorta; Blood Pressure; Carotid Arteries; Cholesterol; Cyclooxygenase Inhibi

2000
The mechanism of resveratrol-induced vasorelaxation differs in the mesenteric resistance arteries of lean and obese rats.
    Clinical science (London, England : 1979), 2001, Volume: 100, Issue:1

    Topics: Acetylcholine; Animals; Body Weight; Dose-Response Relationship, Drug; Drug Interactions; Endotheliu

2001
Obesity and body fat distribution induce endothelial dysfunction by oxidative stress: protective effect of vitamin C.
    Diabetes, 2001, Volume: 50, Issue:1

    Topics: Acetylcholine; Adipose Tissue; Adult; Antioxidants; Ascorbic Acid; Drug Combinations; Endothelium, V

2001
Obesity and body fat distribution induce endothelial dysfunction by oxidative stress: protective effect of vitamin C.
    Diabetes, 2001, Volume: 50, Issue:1

    Topics: Acetylcholine; Adipose Tissue; Adult; Antioxidants; Ascorbic Acid; Drug Combinations; Endothelium, V

2001
Obesity and body fat distribution induce endothelial dysfunction by oxidative stress: protective effect of vitamin C.
    Diabetes, 2001, Volume: 50, Issue:1

    Topics: Acetylcholine; Adipose Tissue; Adult; Antioxidants; Ascorbic Acid; Drug Combinations; Endothelium, V

2001
Obesity and body fat distribution induce endothelial dysfunction by oxidative stress: protective effect of vitamin C.
    Diabetes, 2001, Volume: 50, Issue:1

    Topics: Acetylcholine; Adipose Tissue; Adult; Antioxidants; Ascorbic Acid; Drug Combinations; Endothelium, V

2001
Modulation of noradrenaline-induced vasoconstriction in isolated perfused mesenteric arterial beds from obese Zucker rats in the presence and absence of insulin.
    Canadian journal of physiology and pharmacology, 2002, Volume: 80, Issue:3

    Topics: Animals; Cyclooxygenase Inhibitors; Endothelin Receptor Antagonists; Indomethacin; Insulin; Insulin

2002
Intestinal bypass arthritis: association with circulating immune complexes and HLA B27.
    The Journal of rheumatology, 1977,Summer, Volume: 4, Issue:2

    Topics: Adolescent; Arthritis; Female; Histocompatibility Antigens; HLA Antigens; Humans; Immune Complex Dis

1977
Arthritis after jejunoileostomy for intractable obesity.
    The Journal of rheumatology, 1977,Summer, Volume: 4, Issue:2

    Topics: Adult; Arthritis; Female; HLA Antigens; Humans; Indomethacin; Intestine, Small; Male; Middle Aged; O

1977
[Gout from the view of a special hospital for rheumatic patients].
    Wiener klinische Wochenschrift, 1971, Mar-19, Volume: 83, Issue:11

    Topics: Acute Disease; Adolescent; Adult; Aged; Austria; Child; Cholesterol; Colchicine; Colic; Diabetes Com

1971