indomethacin has been researched along with Obesity in 32 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
| Excerpt | Relevance | Reference |
|---|---|---|
| " To examine how administration of the anti-inflammatory compound indomethacin, a general cyclooxygenase inhibitor, affected obesity development and insulin sensitivity, we fed obesity-prone male C57BL/6J mice a high fat/high sucrose (HF/HS) diet or a regular diet supplemented or not with indomethacin (±INDO) for 7 weeks." | 7.80 | Indomethacin treatment prevents high fat diet-induced obesity and insulin resistance but not glucose intolerance in C57BL/6J mice. ( Aune, UL; Borkowski, K; Fjære, E; Haj, FG; Hudson, BD; Keenan, AH; Kristensen, DM; Kristiansen, K; Liaset, B; Ma, T; Madsen, L; Mandrup-Poulsen, T; Milligan, G; Newman, JW; Novotny, GW; Røen, K; Xi, Y, 2014) |
| "To investigate whether prostaglandins (PGs) play a role in the regulation of insulin secretion during starvation, we have studied the effects of two inhibitors of PG synthesis, indomethacin (INDO) and acetylsalicylic acid (ASA), on plasma insulin during a 72-h fast." | 7.66 | Indomethacin and aspirin prevent the starvation-induced fall in plasma insulin. ( Brodows, RG; Lilavivathana, U, 1980) |
| "Indomethacin, a nonsteroidal anti-inflammatory drug, has been shown to induce white adipocyte differentiation; however, its roles in brown adipocyte differentiation and activation in brown adipose tissue (BAT) and obesity are unknown." | 3.88 | Indomethacin Enhances Brown Fat Activity. ( Hammock, BD; Hao, L; Kearns, J; Kodani, SD; Morisseau, C; Scott, S; Sun, X; Wang, S; Wu, D; Zhao, L, 2018) |
| " Magnesium sulfate administration, steroid administration, maternal diabetes mellitus, gestational age at delivery, indomethacin exposure, birthweight, and chorioamnionitis were all considered as possible covariates in the multivariable regression models." | 3.83 | Effect of obesity on neonatal outcomes in pregnancies with preterm premature rupture of membranes. ( DeWitt, PE; Faucett, AM; Gibbs, RS; Metz, TD, 2016) |
| " To examine how administration of the anti-inflammatory compound indomethacin, a general cyclooxygenase inhibitor, affected obesity development and insulin sensitivity, we fed obesity-prone male C57BL/6J mice a high fat/high sucrose (HF/HS) diet or a regular diet supplemented or not with indomethacin (±INDO) for 7 weeks." | 3.80 | Indomethacin treatment prevents high fat diet-induced obesity and insulin resistance but not glucose intolerance in C57BL/6J mice. ( Aune, UL; Borkowski, K; Fjære, E; Haj, FG; Hudson, BD; Keenan, AH; Kristensen, DM; Kristiansen, K; Liaset, B; Ma, T; Madsen, L; Mandrup-Poulsen, T; Milligan, G; Newman, JW; Novotny, GW; Røen, K; Xi, Y, 2014) |
| "To investigate whether prostaglandins (PGs) play a role in the regulation of insulin secretion during starvation, we have studied the effects of two inhibitors of PG synthesis, indomethacin (INDO) and acetylsalicylic acid (ASA), on plasma insulin during a 72-h fast." | 3.66 | Indomethacin and aspirin prevent the starvation-induced fall in plasma insulin. ( Brodows, RG; Lilavivathana, U, 1980) |
| "Thirty-nine patients (46 elbows) with heterotopic ossification treated with excision were identified: 10 patients (16 elbows) had burns, 28 patients (29 elbows) had trauma, and one patient (one elbow) had a closed head injury." | 1.40 | Heterotopic ossification of the elbow treated with surgical resection: risk factors, bony ankylosis, and complications. ( Golz, A; Israel, H; Marra, G; Salazar, D, 2014) |
| "Metformin treatment improved these alterations." | 1.38 | Improvement of metabolic parameters and vascular function by metformin in obese non-diabetic rats. ( Akamine, EH; Carvalho, MH; Filgueira, FP; Fortes, ZB; Hagihara, GN; Lobato, NS; Pariz, JR; Tostes, RC, 2012) |
| "Thus, obesity is associated with the activation of renal ACE in vivo independent of its mRNA expression and enhanced vascular contractility to angiotensin II." | 1.31 | Obesity is associated with tissue-specific activation of renal angiotensin-converting enzyme in vivo: evidence for a regulatory role of endothelin. ( Barton, M; Carmona, R; d'Uscio, LV; Goettsch, W; Haudenschild, CC; Hillen, H; Krieger, JE; Lattmann, T; Lüscher, TF; Morawietz, H; Münter, K; Shaw, S, 2000) |
| "Indomethacin was also ineffective in altering resveratrol activity in arteries from both lean and dietary-obese rats." | 1.31 | The mechanism of resveratrol-induced vasorelaxation differs in the mesenteric resistance arteries of lean and obese rats. ( Doyle, PJ; Naderali, EK; Smith, SL; Williams, G, 2001) |
| " The effects of cyclooxygenase activity were evaluated by a dose-response curve to intrabrachial coinfusion of ACh and indomethacin (500 microg/min)." | 1.31 | Obesity and body fat distribution induce endothelial dysfunction by oxidative stress: protective effect of vitamin C. ( Candigliota, M; Ceravolo, R; Iacopino, S; Mattioli, PL; Perticone, F; Sinopoli, F; Ventura, G, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (21.88) | 18.7374 |
| 1990's | 5 (15.63) | 18.2507 |
| 2000's | 10 (31.25) | 29.6817 |
| 2010's | 8 (25.00) | 24.3611 |
| 2020's | 2 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, H | 1 |
| Simonsen, U | 1 |
| Aalkjaer, C | 1 |
| Wen, X | 1 |
| Su, B | 1 |
| Gao, M | 1 |
| Chen, J | 1 |
| Zhou, D | 1 |
| You, H | 1 |
| Li, N | 1 |
| Chang, S | 1 |
| Cheng, X | 1 |
| Qian, C | 1 |
| Gao, J | 1 |
| Yang, P | 1 |
| Qu, S | 1 |
| Bu, L | 1 |
| Xiao, L | 1 |
| Sonne, SB | 1 |
| Feng, Q | 1 |
| Chen, N | 1 |
| Xia, Z | 1 |
| Li, X | 1 |
| Fang, Z | 1 |
| Zhang, D | 1 |
| Fjære, E | 2 |
| Midtbø, LK | 1 |
| Derrien, M | 1 |
| Hugenholtz, F | 1 |
| Tang, L | 1 |
| Li, J | 1 |
| Zhang, J | 1 |
| Liu, C | 1 |
| Hao, Q | 1 |
| Vogel, UB | 1 |
| Mortensen, A | 1 |
| Kleerebezem, M | 1 |
| Licht, TR | 1 |
| Yang, H | 1 |
| Wang, J | 2 |
| Li, Y | 1 |
| Arumugam, M | 1 |
| Madsen, L | 2 |
| Kristiansen, K | 2 |
| Hao, L | 1 |
| Kearns, J | 1 |
| Scott, S | 1 |
| Wu, D | 1 |
| Kodani, SD | 1 |
| Morisseau, C | 1 |
| Hammock, BD | 1 |
| Sun, X | 1 |
| Zhao, L | 1 |
| Wang, S | 1 |
| Hayward, CE | 1 |
| Cowley, EJ | 1 |
| Mills, TA | 1 |
| Sibley, CP | 1 |
| Wareing, M | 1 |
| Salazar, D | 1 |
| Golz, A | 1 |
| Israel, H | 1 |
| Marra, G | 1 |
| Aune, UL | 1 |
| Røen, K | 1 |
| Keenan, AH | 1 |
| Ma, T | 1 |
| Borkowski, K | 1 |
| Kristensen, DM | 1 |
| Novotny, GW | 1 |
| Mandrup-Poulsen, T | 1 |
| Hudson, BD | 1 |
| Milligan, G | 1 |
| Xi, Y | 1 |
| Newman, JW | 1 |
| Haj, FG | 1 |
| Liaset, B | 1 |
| Faucett, AM | 1 |
| Metz, TD | 1 |
| DeWitt, PE | 1 |
| Gibbs, RS | 1 |
| Goodwill, AG | 1 |
| James, ME | 1 |
| Frisbee, JC | 1 |
| Katakam, PV | 1 |
| Domoki, F | 1 |
| Snipes, JA | 1 |
| Busija, AR | 1 |
| Jarajapu, YP | 1 |
| Busija, DW | 1 |
| Juárez-Oropeza, MA | 1 |
| Mascher, D | 1 |
| Torres-Durán, PV | 1 |
| Farias, JM | 1 |
| Paredes-Carbajal, MC | 1 |
| Mingorance, C | 1 |
| Alvarez de Sotomayor, M | 1 |
| Jiménez-Palacios, FJ | 1 |
| Callejón Mochón, M | 1 |
| Casto, C | 1 |
| Marhuenda, E | 1 |
| Herrera, MD | 1 |
| Belin de Chantemèle, EJ | 1 |
| Vessières, E | 1 |
| Guihot, AL | 1 |
| Toutain, B | 1 |
| Loufrani, L | 1 |
| Henrion, D | 1 |
| Lobato, NS | 1 |
| Filgueira, FP | 1 |
| Hagihara, GN | 1 |
| Akamine, EH | 1 |
| Pariz, JR | 1 |
| Tostes, RC | 1 |
| Carvalho, MH | 1 |
| Fortes, ZB | 1 |
| Kim, JY | 1 |
| Wu, Y | 1 |
| Smas, CM | 1 |
| Lilavivathana, U | 1 |
| Brodows, RG | 1 |
| Julkunen, R | 1 |
| Haapalahti, J | 1 |
| Torstila, I | 1 |
| Miettinen, TA | 1 |
| Mertz, DP | 1 |
| Mendonca, E | 1 |
| Albuquerque, L | 1 |
| Jacome, L | 1 |
| Luis, ML | 1 |
| Rosa, FC | 1 |
| Taniguchi, Y | 1 |
| Moriguchi, S | 1 |
| Kato, M | 1 |
| Sakai, K | 1 |
| Yamamoto, S | 1 |
| Shimizu, E | 1 |
| Sinha, D | 1 |
| Addya, S | 1 |
| Murer, E | 1 |
| Boden, G | 1 |
| Barton, M | 1 |
| Carmona, R | 1 |
| Morawietz, H | 1 |
| d'Uscio, LV | 1 |
| Goettsch, W | 1 |
| Hillen, H | 1 |
| Haudenschild, CC | 1 |
| Krieger, JE | 1 |
| Münter, K | 1 |
| Lattmann, T | 1 |
| Lüscher, TF | 1 |
| Shaw, S | 1 |
| Toda, Y | 1 |
| Kobayashi, T | 1 |
| Naderali, EK | 1 |
| Smith, SL | 1 |
| Doyle, PJ | 1 |
| Williams, G | 1 |
| Perticone, F | 1 |
| Ceravolo, R | 1 |
| Candigliota, M | 1 |
| Ventura, G | 1 |
| Iacopino, S | 1 |
| Sinopoli, F | 1 |
| Mattioli, PL | 1 |
| He, Y | 1 |
| MacLeod, KM | 1 |
| Rose, E | 1 |
| Espinoza, LR | 1 |
| Osterland, CK | 1 |
| Thorpe, PC | 1 |
| Isaac, PF | 1 |
| Rodgers, J | 1 |
| Fernandez-Herlihy, L | 1 |
| Abate, MA | 1 |
| Neely, JL | 1 |
| Layne, RD | 1 |
| D'Alessandri, R | 1 |
| Klotz, H | 1 |
| Prohaska, E | 1 |
| Salmhofer, H | 1 |
| Schmid, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Elbow Heterotopic Ossifications Associated With Radial Head Prosthesis: Risk and Prognostic Factors[NCT05547867] | 60 participants (Anticipated) | Observational | 2022-09-12 | Recruiting | |||
| Effect of Acute or Chronic Ingestion of Sucralose on Serum Insulin in Young and Healthy Adults: a Randomized, Double-blind, Placebo-controlled Trial[NCT03703141] | 95 participants (Actual) | Interventional | 2016-09-27 | Completed | |||
| Effects of Blood Orange Juice Consumption on Endothelial Function in Healthy Overweight/Obese Men and Premenopausal Women of European Origin[NCT03611114] | 16 participants (Actual) | Interventional | 2017-01-10 | Completed | |||
| Modulation of Insulin and Exercise Responses by Vitamin E and Vitamin C[NCT01369043] | 1 participants (Actual) | Interventional | 2011-05-31 | Terminated (stopped due to Lack of successful recruiting, budget cuts, and potential study flaws.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 trials available for indomethacin and Obesity
| Article | Year |
|---|---|
Effects of dietary Spirulina on vascular reactivity.
Topics: Adolescent; Adult; Aged; Animals; Aorta; Arachidonic Acid; Blood Pressure; Cholesterol; Cholesterol, | 2009 |
The usefulness of walking for preventing sarcopenia in dieting postmenopausal women complaining of knee pain.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Appetite Depressants; Body Composition; Combined Moda | 2000 |
A controlled trial of mazindol (Sanjorex, Teronac) in the management of the obese rheumatic patients.
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Diet, Reduci | 1975 |
Interaction of indomethacin and sulindac with labetalol.
Topics: Adult; Aged; Analysis of Variance; Blood Pressure; Body Weight; Chlorides; Drug Interactions; Humans | 1991 |
28 other studies available for indomethacin and Obesity
| Article | Year |
|---|---|
A sex-specific, COX-derived/thromboxane receptor activator causes depolarization and vasoconstriction in male mice mesenteric resistance arteries.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Diabe | 2020 |
Obesity-associated up-regulation of lipocalin 2 protects gastric mucosa cells from apoptotic cell death by reducing endoplasmic reticulum stress.
Topics: Animals; Apoptosis; Case-Control Studies; Cells, Cultured; Disease Models, Animal; Endoplasmic Retic | 2021 |
High-fat feeding rather than obesity drives taxonomical and functional changes in the gut microbiota in mice.
Topics: Animals; Bacteroidetes; Butyrates; Cyclooxygenase Inhibitors; Diet, High-Fat; Dietary Fats; Firmicut | 2017 |
Indomethacin Enhances Brown Fat Activity.
Topics: Adipocytes; Adipose Tissue, Brown; Adipose Tissue, White; Animals; Cell Differentiation; Cell Line; | 2018 |
Maternal obesity impairs specific regulatory pathways in human myometrial arteries.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arteries; Biopsy; Body Mass Index; Body Weight; Endothelium | 2014 |
Heterotopic ossification of the elbow treated with surgical resection: risk factors, bony ankylosis, and complications.
Topics: Adolescent; Adult; Aged; Ankylosis; Anti-Inflammatory Agents, Non-Steroidal; Biomechanical Phenomena | 2014 |
Indomethacin treatment prevents high fat diet-induced obesity and insulin resistance but not glucose intolerance in C57BL/6J mice.
Topics: Animals; Cell Line; Cyclooxygenase Inhibitors; Diet, High-Fat; Fatty Acids, Nonesterified; Glucose T | 2014 |
Effect of obesity on neonatal outcomes in pregnancies with preterm premature rupture of membranes.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Birth Weight; Case-Control Studies; Cerebral Hemorrhage; | 2016 |
Increased vascular thromboxane generation impairs dilation of skeletal muscle arterioles of obese Zucker rats with reduced oxygen tension.
Topics: Animals; Arterioles; Bridged Bicyclo Compounds, Heterocyclic; Cyclooxygenase Inhibitors; Disease Mod | 2008 |
Impaired mitochondria-dependent vasodilation in cerebral arteries of Zucker obese rats with insulin resistance.
Topics: Animals; Cerebral Arteries; Cyclooxygenase Inhibitors; Diazoxide; Disease Models, Animal; Dose-Respo | 2009 |
Effects of chronic treatment with the CB1 antagonist, rimonabant on the blood pressure, and vascular reactivity of obese Zucker rats.
Topics: Acetylcholine; Animals; Aorta; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, D | 2009 |
Cyclooxygenase-2 preserves flow-mediated remodelling in old obese Zucker rat mesenteric arteries.
Topics: Acetylcholine; Age Factors; Animals; Blood Pressure; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Di | 2010 |
Improvement of metabolic parameters and vascular function by metformin in obese non-diabetic rats.
Topics: Acetylcholine; Animals; Blood Pressure; Body Weight; Disease Models, Animal; Dyslipidemias; Epoprost | 2012 |
Characterization of ScAP-23, a new cell line from murine subcutaneous adipose tissue, identifies genes for the molecular definition of preadipocytes.
Topics: 1-Methyl-3-isobutylxanthine; 3T3-L1 Cells; Adipocytes; Adipogenesis; Animals; Biomarkers; Cell Diffe | 2007 |
Indomethacin and aspirin prevent the starvation-induced fall in plasma insulin.
Topics: Adult; Aspirin; Female; Glucagon; Humans; Indomethacin; Insulin; Kinetics; Male; Middle Aged; Obesit | 1980 |
A Bartter-like syndrome after jejunoileal bypass for obesity.
Topics: Adult; Bartter Syndrome; Female; Humans; Hyperaldosteronism; Ileum; Indomethacin; Jejunum; Obesity; | 1982 |
[Gout as a joint disease and as a generalized disease. Incidence, diagnosis and therapy].
Topics: Allopurinol; Colchicine; Diabetes Complications; Gout; Humans; Hypertension; Indomethacin; Kidney Di | 1980 |
Pseudotumor cerebri in a patient with Bartter's syndrome and obesity.
Topics: Adolescent; Bartter Syndrome; Female; Hematologic Tests; Humans; Indomethacin; Obesity; Potassium Ch | 1996 |
[Pathophysiological study on the mucosal defense system of genetically obese Zucker rats].
Topics: Animals; Disease Models, Animal; Ethanol; Gastric Acid; Gastric Emptying; Gastric Mucosa; Indomethac | 1996 |
Decreased mitogen response of splenic lymphocytes in obese Zucker rats is associated with the decreased expression of glucose transporter 1 (GLUT-1).
Topics: Animals; Blood Glucose; Concanavalin A; Cyclooxygenase Inhibitors; Dinoprostone; Female; Glucose; Im | 1998 |
15-Deoxy-delta(12,14) prostaglandin J2: a putative endogenous promoter of adipogenesis suppresses the ob gene.
Topics: Adipose Tissue; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Chromans; DNA-Bin | 1999 |
Obesity is associated with tissue-specific activation of renal angiotensin-converting enzyme in vivo: evidence for a regulatory role of endothelin.
Topics: Angiotensin II; Animals; Aorta; Blood Pressure; Carotid Arteries; Cholesterol; Cyclooxygenase Inhibi | 2000 |
The mechanism of resveratrol-induced vasorelaxation differs in the mesenteric resistance arteries of lean and obese rats.
Topics: Acetylcholine; Animals; Body Weight; Dose-Response Relationship, Drug; Drug Interactions; Endotheliu | 2001 |
Obesity and body fat distribution induce endothelial dysfunction by oxidative stress: protective effect of vitamin C.
Topics: Acetylcholine; Adipose Tissue; Adult; Antioxidants; Ascorbic Acid; Drug Combinations; Endothelium, V | 2001 |
Obesity and body fat distribution induce endothelial dysfunction by oxidative stress: protective effect of vitamin C.
Topics: Acetylcholine; Adipose Tissue; Adult; Antioxidants; Ascorbic Acid; Drug Combinations; Endothelium, V | 2001 |
Obesity and body fat distribution induce endothelial dysfunction by oxidative stress: protective effect of vitamin C.
Topics: Acetylcholine; Adipose Tissue; Adult; Antioxidants; Ascorbic Acid; Drug Combinations; Endothelium, V | 2001 |
Obesity and body fat distribution induce endothelial dysfunction by oxidative stress: protective effect of vitamin C.
Topics: Acetylcholine; Adipose Tissue; Adult; Antioxidants; Ascorbic Acid; Drug Combinations; Endothelium, V | 2001 |
Modulation of noradrenaline-induced vasoconstriction in isolated perfused mesenteric arterial beds from obese Zucker rats in the presence and absence of insulin.
Topics: Animals; Cyclooxygenase Inhibitors; Endothelin Receptor Antagonists; Indomethacin; Insulin; Insulin | 2002 |
Intestinal bypass arthritis: association with circulating immune complexes and HLA B27.
Topics: Adolescent; Arthritis; Female; Histocompatibility Antigens; HLA Antigens; Humans; Immune Complex Dis | 1977 |
Arthritis after jejunoileostomy for intractable obesity.
Topics: Adult; Arthritis; Female; HLA Antigens; Humans; Indomethacin; Intestine, Small; Male; Middle Aged; O | 1977 |
[Gout from the view of a special hospital for rheumatic patients].
Topics: Acute Disease; Adolescent; Adult; Aged; Austria; Child; Cholesterol; Colchicine; Colic; Diabetes Com | 1971 |