indomethacin has been researched along with Neuralgia in 28 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Neuralgia: Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Headaches with marked, specific response to indomethacin occur in children, but the phenotypic spectrum of this phenomenon has not been well-studied." | 9.22 | The spectrum of indomethacin-responsive headaches in children and adolescents. ( Barmherzig, R; Berrahmoune, S; Gelfand, AA; Hershey, AD; Ingelmo, P; Kabbouche, MA; Kacperski, J; Khan, AQ; Kouri, M; Lagman-Bartolome, AM; Mohamed, N; Morris, C; Myers, KA; Orr, SL; Raj, NR; Rao, RR; Saint-Martin, C; Szperka, CL, 2022) |
| "The efficacy of topical aspirin/diethyl ether (ADE) mixture in the treatment of acute herpetic neuralgia and postherpetic neuralgia, suggested in a previous open-label study (De Benedittis et al." | 9.08 | Topical aspirin/diethyl ether mixture versus indomethacin and diclofenac/diethyl ether mixtures for acute herpetic neuralgia and postherpetic neuralgia: a double-blind crossover placebo-controlled study. ( De Benedittis, G; Lorenzetti, A, 1996) |
| "Topical aspirin/diethyl ether (ADE) mixture was used to treat 45 consecutive patients with acute herpetic neuralgia (AHN) (n = 28) and with post-herpetic neuralgia (PHN) (n = 17) in an open-label study." | 9.07 | A new topical treatment for acute herpetic neuralgia and post-herpetic neuralgia: the aspirin/diethyl ether mixture. An open-label study plus a double-blind controlled clinical trial. ( Besana, F; De Benedittis, G; Lorenzetti, A, 1992) |
| "Iontophoretic administration of indomethacin (IND) was applied to investigate its effect in 21 cases of postherpetic neuralgia (PHN), which showed no response to other treatment such as nerve blocks." | 7.68 | [Iontophoretic administration of indomethacin in the treatment of postherpetic neuralgia]. ( Hakuto, T; Hyodo, M; Iwasaku, K; Kato, H; Kurioka, M; Morimoto, E; Morimoto, M, 1991) |
| "Neither N/OFQ nor PGE(2) induced allodynia in NOP(-/-) mice." | 5.33 | The opioid peptide nociceptin/orphanin FQ mediates prostaglandin E2-induced allodynia, tactile pain associated with nerve injury. ( Civelli, O; Ito, S; Matsumura, S; Minami, T; Okuda-Ashitaka, E; Reinscheid, RK; Takeshima, H, 2006) |
| "Headaches with marked, specific response to indomethacin occur in children, but the phenotypic spectrum of this phenomenon has not been well-studied." | 5.22 | The spectrum of indomethacin-responsive headaches in children and adolescents. ( Barmherzig, R; Berrahmoune, S; Gelfand, AA; Hershey, AD; Ingelmo, P; Kabbouche, MA; Kacperski, J; Khan, AQ; Kouri, M; Lagman-Bartolome, AM; Mohamed, N; Morris, C; Myers, KA; Orr, SL; Raj, NR; Rao, RR; Saint-Martin, C; Szperka, CL, 2022) |
| "The efficacy of topical aspirin/diethyl ether (ADE) mixture in the treatment of acute herpetic neuralgia and postherpetic neuralgia, suggested in a previous open-label study (De Benedittis et al." | 5.08 | Topical aspirin/diethyl ether mixture versus indomethacin and diclofenac/diethyl ether mixtures for acute herpetic neuralgia and postherpetic neuralgia: a double-blind crossover placebo-controlled study. ( De Benedittis, G; Lorenzetti, A, 1996) |
| "Topical aspirin/diethyl ether (ADE) mixture was used to treat 45 consecutive patients with acute herpetic neuralgia (AHN) (n = 28) and with post-herpetic neuralgia (PHN) (n = 17) in an open-label study." | 5.07 | A new topical treatment for acute herpetic neuralgia and post-herpetic neuralgia: the aspirin/diethyl ether mixture. An open-label study plus a double-blind controlled clinical trial. ( Besana, F; De Benedittis, G; Lorenzetti, A, 1992) |
| "Lysophosphatidic acid (LPA), an initiator of neuropathic pain, causes allodynia." | 3.78 | Pharmacological characterization of lysophosphatidic acid-induced pain with clinically relevant neuropathic pain drugs. ( Kato, A; Ogawa, K; Shinohara, S; Takasu, K; Yoneda, Y, 2012) |
| "We investigated the effects of OT-7100, a novel analgesic compound (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimidi ne), on prostaglandin E2 biosynthesis in vitro, acute hyperalgesia induced by yeast and substance P in rats and hyperalgesia in rats with a chronic constriction injury to the sciatic nerve (Bennett model), which is a model for peripheral neuropathic pain." | 3.70 | The novel analgesic compound OT-7100 (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimid ine) attenuates mechanical nociceptive responses in animal models of acute and peripheral neuropathic hyperalgesia. ( Iwamoto, T; Kohri, H; Noguchi, K; Ohara, M; Sato, S; Senba, E; Yasuda, T, 1999) |
| "Iontophoretic administration of indomethacin (IND) was applied to investigate its effect in 21 cases of postherpetic neuralgia (PHN), which showed no response to other treatment such as nerve blocks." | 3.68 | [Iontophoretic administration of indomethacin in the treatment of postherpetic neuralgia]. ( Hakuto, T; Hyodo, M; Iwasaku, K; Kato, H; Kurioka, M; Morimoto, E; Morimoto, M, 1991) |
| "Indomethacin is the best treatment both for HC and PH." | 2.55 | Therapeutical approaches to paroxysmal hemicrania, hemicrania continua and short lasting unilateral neuralgiform headache attacks: a critical appraisal. ( Baraldi, C; Cainazzo, MM; Guerzoni, S; Pellesi, L; Pini, LA, 2017) |
| "The neurochemical mechanisms underlying neuropathic pain (NP) are related to peripheral and central sensitization caused by the release of inflammatory mediators in the peripheral damaged tissue and ectopic discharges from the injured nerve, leading to a hyperexcitable state of spinal dorsal horn neurons." | 1.56 | Indomethacin attenuates mechanical allodynia during the organization but not the maintenance of the peripheral neuropathic pain induced by nervus ischiadicus chronic constriction injury. ( Coimbra, NC; da Silva, JA; de Freitas, RL; Dos Santos, IR; Ferreira, SH; Medeiros, AC; Medeiros, P, 2020) |
| "The development of hind paw mechanical allodynia was measured after BCAO using the von Frey test." | 1.43 | Effects of Adjuvant Analgesics on Cerebral Ischemia-Induced Mechanical Allodynia. ( Harada, S; Matsuura, W; Tokuyama, S, 2016) |
| "In addition, PLSN-induced mechanical and thermal hyperalgesia was prevented by systemic (i." | 1.40 | The role of keratinocyte-derived chemokine (KC) on hyperalgesia caused by peripheral nerve injury in mice. ( Calixto, JB; Costa, R; Manjavachi, MN; Quintão, NL, 2014) |
| "Both indomethacin and morphine were able to block or reverse thermal hyperalgesia and normalize gait in the CARR model." | 1.35 | Abnormal gait, due to inflammation but not nerve injury, reflects enhanced nociception in preclinical pain models. ( Cummons, TA; Harrison, JE; Leventhal, L; Lu, P; Piesla, MJ; Strassle, BW; Whiteside, GT, 2009) |
| "Neither N/OFQ nor PGE(2) induced allodynia in NOP(-/-) mice." | 1.33 | The opioid peptide nociceptin/orphanin FQ mediates prostaglandin E2-induced allodynia, tactile pain associated with nerve injury. ( Civelli, O; Ito, S; Matsumura, S; Minami, T; Okuda-Ashitaka, E; Reinscheid, RK; Takeshima, H, 2006) |
| "The lack of awareness of this head pain may possibly be due to its rarity and problems with making the diagnosis." | 1.30 | Supraorbital neuralgia. On the clinical manifestations and a possible therapeutic approach. ( Fredriksen, TA; Pareja, JA; Sjaastad, O; Stolt-Nielsen, A; Vincent, M, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (25.00) | 18.7374 |
| 1990's | 5 (17.86) | 18.2507 |
| 2000's | 4 (14.29) | 29.6817 |
| 2010's | 9 (32.14) | 24.3611 |
| 2020's | 3 (10.71) | 2.80 |
| Authors | Studies |
|---|---|
| Yogeeswari, P | 1 |
| Sharma, M | 1 |
| Samala, G | 1 |
| Gangadhar, M | 1 |
| Karthick, S | 1 |
| Mallipeddi, S | 1 |
| Semwal, A | 1 |
| Sriram, D | 1 |
| Rajagopalan, P | 1 |
| Tracey, H | 1 |
| Chen, Z | 1 |
| Bandyopadhyaya, A | 1 |
| Veeraraghavan, S | 1 |
| Rajagopalan, DR | 1 |
| Salvemini, D | 1 |
| McPhee, I | 1 |
| Viswanadha, S | 1 |
| Rajagopalan, R | 1 |
| Myers, KA | 1 |
| Barmherzig, R | 1 |
| Raj, NR | 1 |
| Berrahmoune, S | 1 |
| Ingelmo, P | 1 |
| Saint-Martin, C | 1 |
| Khan, AQ | 1 |
| Kouri, M | 1 |
| Morris, C | 1 |
| Hershey, AD | 1 |
| Kacperski, J | 1 |
| Kabbouche, MA | 1 |
| Mohamed, N | 1 |
| Rao, RR | 1 |
| Lagman-Bartolome, AM | 1 |
| Gelfand, AA | 1 |
| Szperka, CL | 2 |
| Orr, SL | 1 |
| Ghosh, A | 1 |
| Varghese, L | 1 |
| Burish, MJ | 1 |
| Medeiros, P | 1 |
| Dos Santos, IR | 1 |
| Medeiros, AC | 1 |
| da Silva, JA | 1 |
| Ferreira, SH | 1 |
| de Freitas, RL | 1 |
| Coimbra, NC | 1 |
| Baraldi, C | 1 |
| Pellesi, L | 1 |
| Guerzoni, S | 1 |
| Cainazzo, MM | 1 |
| Pini, LA | 1 |
| Masocha, W | 1 |
| Thomas, A | 1 |
| Manjavachi, MN | 1 |
| Costa, R | 1 |
| Quintão, NL | 2 |
| Calixto, JB | 1 |
| Matsuura, W | 1 |
| Harada, S | 1 |
| Tokuyama, S | 1 |
| Salinas-Abarca, AB | 1 |
| Avila-Rojas, SH | 1 |
| Barragán-Iglesias, P | 1 |
| Pineda-Farias, JB | 1 |
| Granados-Soto, V | 1 |
| Katano, T | 1 |
| Furue, H | 1 |
| Okuda-Ashitaka, E | 2 |
| Tagaya, M | 1 |
| Watanabe, M | 1 |
| Yoshimura, M | 1 |
| Ito, S | 2 |
| Piesla, MJ | 1 |
| Leventhal, L | 1 |
| Strassle, BW | 1 |
| Harrison, JE | 1 |
| Cummons, TA | 1 |
| Lu, P | 1 |
| Whiteside, GT | 1 |
| da Silva, GF | 1 |
| Antonialli, CS | 1 |
| Rocha, LW | 1 |
| Cechinel Filho, V | 1 |
| Cicció, JF | 1 |
| Ogawa, K | 1 |
| Takasu, K | 1 |
| Shinohara, S | 1 |
| Yoneda, Y | 1 |
| Kato, A | 1 |
| Sjaastad, O | 1 |
| Stolt-Nielsen, A | 1 |
| Pareja, JA | 1 |
| Fredriksen, TA | 1 |
| Vincent, M | 1 |
| Minami, T | 1 |
| Matsumura, S | 1 |
| Takeshima, H | 1 |
| Reinscheid, RK | 1 |
| Civelli, O | 1 |
| Daud, A | 1 |
| Habib, N | 1 |
| Riera, AS | 1 |
| Stern, FH | 1 |
| De Benedittis, G | 2 |
| Lorenzetti, A | 2 |
| Yasuda, T | 1 |
| Iwamoto, T | 1 |
| Ohara, M | 1 |
| Sato, S | 1 |
| Kohri, H | 1 |
| Noguchi, K | 1 |
| Senba, E | 1 |
| Napoli, A | 1 |
| Alderuccio, B | 1 |
| Nannetti, A | 1 |
| Besana, F | 1 |
| Morimoto, M | 1 |
| Hakuto, T | 1 |
| Morimoto, E | 1 |
| Kato, H | 1 |
| Iwasaku, K | 1 |
| Kurioka, M | 1 |
| Hyodo, M | 1 |
| Seltzer, Z | 1 |
| Shir, Y | 1 |
| Stambolović, B | 1 |
| Velimirović, D | 1 |
| Baumann, JC | 1 |
| Hoffmann, U | 1 |
| Fantini, F | 1 |
| Colombo, B | 1 |
| G0aspárdy, G | 1 |
| Bálint, G | 1 |
3 reviews available for indomethacin and Neuralgia
| Article | Year |
|---|---|
The spectrum of indomethacin-responsive headaches in children and adolescents.
Topics: Adolescent; Adult; Child; Female; Headache; Humans; Indomethacin; Neuralgia; Paroxysmal Hemicrania; | 2022 |
Trigeminal Autonomic Cephalalgias and Neuralgias in Children and Adolescents: a Narrative Review.
Topics: Adolescent; Adult; Child; Diagnosis, Differential; Humans; Indomethacin; Neuralgia; Trigeminal Auton | 2023 |
Therapeutical approaches to paroxysmal hemicrania, hemicrania continua and short lasting unilateral neuralgiform headache attacks: a critical appraisal.
Topics: Amines; Analgesics; Anticonvulsants; Cyclohexanecarboxylic Acids; Female; Fructose; Gabapentin; gamm | 2017 |
3 trials available for indomethacin and Neuralgia
| Article | Year |
|---|---|
Topical aspirin/diethyl ether mixture versus indomethacin and diclofenac/diethyl ether mixtures for acute herpetic neuralgia and postherpetic neuralgia: a double-blind crossover placebo-controlled study.
Topics: Acute Disease; Administration, Cutaneous; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Di | 1996 |
[Treatment of degenerative and inflammatory joint diseases with or without a new synthetic substance (parsalmide). Controlled clinical trial].
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug | 1977 |
A new topical treatment for acute herpetic neuralgia and post-herpetic neuralgia: the aspirin/diethyl ether mixture. An open-label study plus a double-blind controlled clinical trial.
Topics: Acute Disease; Administration, Topical; Adult; Aged; Aspirin; Diclofenac; Double-Blind Method; Drug | 1992 |
22 other studies available for indomethacin and Neuralgia
| Article | Year |
|---|---|
Discovery of novel tetrahydro-pyrazolo [4,3-c] pyridines for the treatment of neuropathic pain: synthesis and neuropharmacology.
Topics: Animals; Chemistry Techniques, Synthetic; Drug Discovery; Female; Hyperalgesia; Male; Mice; Neuralgi | 2013 |
DDD-028: a potent potential non-opioid, non-cannabinoid analgesic for neuropathic and inflammatory pain.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Azepines; Carbolines; Chronic Disease; | 2014 |
Indomethacin attenuates mechanical allodynia during the organization but not the maintenance of the peripheral neuropathic pain induced by nervus ischiadicus chronic constriction injury.
Topics: Animals; Constriction; Disease Models, Animal; Indomethacin; Male; Neuralgia; Pain Measurement; Pain | 2020 |
Indomethacin plus minocycline coadministration relieves chemotherapy and antiretroviral drug-induced neuropathic pain in a cannabinoid receptors-dependent manner.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti-Retroviral Agents; Ant | 2019 |
The role of keratinocyte-derived chemokine (KC) on hyperalgesia caused by peripheral nerve injury in mice.
Topics: Amines; Analgesics; Animals; Antibodies; Chemokines; Cyclohexanecarboxylic Acids; Cyclooxygenase Inh | 2014 |
Effects of Adjuvant Analgesics on Cerebral Ischemia-Induced Mechanical Allodynia.
Topics: Amines; Analgesics; Animals; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal; Antico | 2016 |
Formalin injection produces long-lasting hypersensitivity with characteristics of neuropathic pain.
Topics: Activating Transcription Factor 3; Amines; Animals; Cyclohexanecarboxylic Acids; Female; Formaldehyd | 2017 |
N-ethylmaleimide-sensitive fusion protein (NSF) is involved in central sensitization in the spinal cord through GluR2 subunit composition switch after inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies; Excitatory Postsynaptic Potentials; Fr | 2008 |
Abnormal gait, due to inflammation but not nerve injury, reflects enhanced nociception in preclinical pain models.
Topics: Amines; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Axotomy; Carrageenan; | 2009 |
Chemical composition and evaluation of the anti-hypernociceptive effect of the essential oil extracted from the leaves of Ugni myricoides on inflammatory and neuropathic models of pain in mice.
Topics: Amines; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Bicyclic Monoterpenes; Carr | 2010 |
Pharmacological characterization of lysophosphatidic acid-induced pain with clinically relevant neuropathic pain drugs.
Topics: Amines; Analgesics; Animals; Calcium Channels; Cyclohexanecarboxylic Acids; Disease Models, Animal; | 2012 |
Supraorbital neuralgia. On the clinical manifestations and a possible therapeutic approach.
Topics: Adult; Carbamazepine; Decompression, Surgical; Female; Headache; Humans; Indomethacin; Male; Middle | 1999 |
The opioid peptide nociceptin/orphanin FQ mediates prostaglandin E2-induced allodynia, tactile pain associated with nerve injury.
Topics: Aminoquinolines; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Benzamides; Din | 2006 |
Anti-inflammatory, anti-nociceptive and antipyretic effects of extracts of Phrygilanthus acutifolius flowers.
Topics: Acetic Acid; Administration, Oral; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non- | 2006 |
Coccygodynia among the geriatric population.
Topics: Aged; Anesthesia, Local; Baths; Coccyx; Female; Humans; Indomethacin; Male; Massage; Methylprednisol | 1967 |
The novel analgesic compound OT-7100 (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimid ine) attenuates mechanical nociceptive responses in animal models of acute and peripheral neuropathic hyperalgesia.
Topics: Amitriptyline; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antide | 1999 |
[Iontophoretic administration of indomethacin in the treatment of postherpetic neuralgia].
Topics: Female; Herpes Zoster; Humans; Indomethacin; Iontophoresis; Male; Neuralgia; Treatment Outcome | 1991 |
Lack of sensitization of primary afferent receptors by prostaglandins in a rat model of causalgic chronic pains.
Topics: Animals; Causalgia; Hindlimb; Indomethacin; Male; Neuralgia; Nociceptors; Prostaglandins; Rats; Scia | 1988 |
[Diagnosis and treatment of rheumatic disorders in the pelvis].
Topics: Antistreptolysin; Blood Sedimentation; Female; Fibromyalgia; Focal Infection; Humans; Indomethacin; | 1974 |
[Experiences with indomethacin in extra-articular rheumatism].
Topics: Gastrointestinal Diseases; Humans; Indomethacin; Neuralgia; Rheumatic Diseases; Spinal Diseases | 1971 |
Use of indomethacin in the treatment of osteoarthrosis and other "minor" rheumatic diseases.
Topics: Adult; Aged; Arthritis, Rheumatoid; Bone Diseases; Female; Humans; Indomethacin; Male; Middle Aged; | 1971 |
[On the effect of the combination of acetylsalicyclic acid with indomethacin in rheumatic pain].
Topics: Adult; Aged; Aspirin; Drug Synergism; Female; Humans; Indomethacin; Joint Diseases; Male; Middle Age | 1967 |