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indomethacin and Nerve Degeneration

indomethacin has been researched along with Nerve Degeneration in 5 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.

Research Excerpts

ExcerptRelevanceReference
" 2 Delta(9)-and Delta(8)-tetrahydrocannabinol (THC) were toxic when added directly to SH-SY5Y neuroblastoma cells."1.32Reduction of human monocytic cell neurotoxicity and cytokine secretion by ligands of the cannabinoid-type CB2 receptor. ( Bissonnette, CJ; Klegeris, A; McGeer, PL, 2003)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19901 (20.00)18.7374
1990's1 (20.00)18.2507
2000's2 (40.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Halim, M1
Yee, DJ1
Sames, D1
Huong, NQ1
Nakamura, Y1
Kuramoto, N1
Yoneyama, M1
Nagashima, R1
Shiba, T1
Yamaguchi, T1
Hasebe, S1
Ogita, K1
Klegeris, A1
Bissonnette, CJ1
McGeer, PL1
Nakano, M1
Matsui, H1
Miaki, K1
Tsuji, H1
Neufeld, AH1
Chavis, RM1
Sears, ML1

Other Studies

5 other studies available for indomethacin and Nerve Degeneration

ArticleYear
Imaging induction of cytoprotective enzymes in intact human cells: coumberone, a metabolic reporter for human AKR1C enzymes reveals activation by panaxytriol, an active component of red ginseng.
    Journal of the American Chemical Society, 2008, Oct-29, Volume: 130, Issue:43

    Topics: 3-Hydroxysteroid Dehydrogenases; Aldo-Keto Reductase Family 1 Member C3; Animals; Antineoplastic Age

2008
Indomethacin ameliorates trimethyltin-induced neuronal damage in vivo by attenuating oxidative stress in the dentate gyrus of mice.
    Biological & pharmaceutical bulletin, 2011, Volume: 34, Issue:12

    Topics: Aldehydes; Animals; Caspase 3; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dentat

2011
Reduction of human monocytic cell neurotoxicity and cytokine secretion by ligands of the cannabinoid-type CB2 receptor.
    British journal of pharmacology, 2003, Volume: 139, Issue:4

    Topics: Astrocytes; Camphanes; Cannabinoid Receptor Modulators; Cannabinoids; Cell Line; Cytokines; Dronabin

2003
Postlaminectomy adhesion of the cauda equina. Inhibitory effects of anti-inflammatory drugs on cauda equina adhesion in rats.
    Spine, 1998, Feb-01, Volume: 23, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arachnoiditis; Cauda Equ

1998
Degeneration release of norepinephrine causes transient ocular hyperemia mediated by prostaglandins.
    Investigative ophthalmology, 1973, Volume: 12, Issue:3

    Topics: Animals; Conjunctiva; Fluorescein Angiography; Hyperemia; Indomethacin; Intraocular Pressure; Iris;

1973