indomethacin has been researched along with Neoplasms in 135 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The modulating activity of indomethacin to vincristine (VCR) was investigated in thirty human pulmonary carcinoma cell lines (adenocarcinoma 9, large cell carcinoma 9, squamous cell carcinoma 6, small cell carcinoma 6) and five other cell lines (colon carcinoma 2, melanoma 1, teratocarcinoma 1, thymoma 1)." | 7.70 | Modulating activity of indomethacin to vincristine cytotoxicity in various human carcinoma cells. ( Fujimura, S; Hasumi, T; Kobayashi, S; Okada, S; Sato, N, 1998) |
| "IMS effectively relieved anticancer drug-induced OM pain and may be useful for immediate self-medication." | 7.01 | Analgesic effects of indomethacin spray on drug-induced oral mucositis pain in patients with cancer: A single-arm cross-sectional study. ( Edo, M; Fujikawa, K; Hata, H; Imamachi, K; Kitagawa, Y; Matsuzaka, M; Sagawa, T; Sato, J; Takada, S; Ueda, M; Yoshikawa, K, 2021) |
| "Some cancers can also be the direct cause of fever." | 6.67 | [Antipyretic effect of indomethacin vs aspirin in fever of tumor origin]. ( Asef, SG; Berbotto, GA; Elias, G; Ostoich, MT; Teglia, O, 1993) |
| " Effects of topical indomethacin (1%) and hydrocortisone (1%) applied before and during radiotherapy were compared for erythema induced by 20 Gy in four fractions (n = 26, 6 MV)." | 5.08 | Do inflammatory processes contribute to radiation induced erythema observed in the skin of humans? ( Back, M; Denham, J; Ferguson, S; Hamilton, C; O'Brien, M; O'Brien, P; Ostwald, P; Simonen, P, 1998) |
| " One hundred eight cancer patients who experienced progressive cachexia due to solid, mainly gastrointestinal tumors were randomized to receive twice daily a cyclo-oxygenase inhibitor (controls; indomethacin, 50 mg twice a day) or indomethacin and erythropoietin, provided on individual basis to prevent development of progressive anemia (study patients; indomethacin, 50 mg twice a day plus rhEPO; range, 12,000-30,000 units per week)." | 5.08 | Protection of metabolic and exercise capacity in unselected weight-losing cancer patients following treatment with recombinant erythropoietin: a randomized prospective study. ( Bosaeus, I; Brevinge, H; Daneryd, P; Körner, U; Lindholm, E; Lundholm, K; Pettersson, C; Sandström, R; Svanberg, E, 1998) |
| " In addition, characterization of the UGT1A locus and genetic studies directed at understanding the role of bilirubin glucuronidation and the biochemical basis of the clinical symptoms found in unconjugated hyperbilirubinemia have uncovered the structural gene polymorphisms associated with Crigler-Najjar's and Gilbert's syndrome." | 4.80 | Human UDP-glucuronosyltransferases: metabolism, expression, and disease. ( Strassburg, CP; Tukey, RH, 2000) |
| " A trial of indomethacin 75 mg/day was advised, which provided complete relief of the headache." | 4.12 | Hemicrania continua secondary to neurogenic paravertebral tumor- a case report. ( Al-Azzawi, O; Heir, GM; Kalladka, M; Khan, J; Kodapala, S; Nainan, MT, 2022) |
| " In this study, we investigated the development of an indomethacin mouth wash(IM-MW)as a novel approach to treat pain due to oral mucositis." | 3.96 | [Optimization of Preparation, and Stability of Indomethacin Mouth Wash for Oral Mucositis Caused by Cancer Therapy]. ( Kiyomi, A; Kuroda, S; Momo, K; Ono, K; Sugiura, M; Yasu, T, 2020) |
| " Most of the tested compounds showed significant anti-inflammatory activity using carrageenan-induced rat paw edema method compared to indomethacin." | 3.80 | 1,2,4-Triazole/oxime hybrids as new strategy for nitric oxide donors: Synthesis, anti-inflammatory, ulceroginicity and antiproliferative activities. ( Abdel-Aziz, M; Abuo-Rahma, Gel-D; Ali, TF; Beshr, EA, 2014) |
| " We report that indomethacin, a nonspecific inhibitor of COX, and NS398, a specific inhibitor of COX2, preserved muscle mass and reduced type 1 TNF receptors in muscles of mice bearing the Lewis lung carcinoma, but not in mice bearing the B16 melanoma." | 3.73 | Inhibitors of COX activity preserve muscle mass in mice bearing the Lewis lung carcinoma, but not the B16 melanoma. ( Graves, E; McCarthy, DO; Ramsay, E, 2006) |
| "The modulating activity of indomethacin to vincristine (VCR) was investigated in thirty human pulmonary carcinoma cell lines (adenocarcinoma 9, large cell carcinoma 9, squamous cell carcinoma 6, small cell carcinoma 6) and five other cell lines (colon carcinoma 2, melanoma 1, teratocarcinoma 1, thymoma 1)." | 3.70 | Modulating activity of indomethacin to vincristine cytotoxicity in various human carcinoma cells. ( Fujimura, S; Hasumi, T; Kobayashi, S; Okada, S; Sato, N, 1998) |
| "This study was designed to determine the effect of local inflammation on nickel subsulfide (Ni3S2) carcinogenesis." | 3.68 | Prevention of nickel subsulfide carcinogenesis by local administration of Mycobacterium bovis antigen in male F344/NCr rats. ( Kasprzak, KS; Ward, JM, 1991) |
| "IMS effectively relieved anticancer drug-induced OM pain and may be useful for immediate self-medication." | 3.01 | Analgesic effects of indomethacin spray on drug-induced oral mucositis pain in patients with cancer: A single-arm cross-sectional study. ( Edo, M; Fujikawa, K; Hata, H; Imamachi, K; Kitagawa, Y; Matsuzaka, M; Sagawa, T; Sato, J; Takada, S; Ueda, M; Yoshikawa, K, 2021) |
| " The recommended phase II dose is 75 mg indomethacin TID given 8 days surrounding standard dosed CAPOX." | 2.87 | Phase I study of combined indomethacin and platinum-based chemotherapy to reduce platinum-induced fatty acids. ( Bloemendal, HJ; Boot, H; Cirkel, GA; Daenen, LGM; De Vos, FY; Gerrits, J; Grootscholten, C; Houthuijzen, JM; Kaing, S; Roodhart, JML; Sessa, C; van der Velden, DL; van Werkhoven, E; Verhoeven-Duif, NM; Voest, EE, 2018) |
| "Indomethacin-treated patients suffered less pain and consumed less additional analgetics compared to the other patient groups." | 2.67 | Anti-inflammatory treatment may prolong survival in undernourished patients with metastatic solid tumors. ( Gelin, J; Gülich, M; Hyltander, A; Kärrefors, I; Körner, U; Lönnroth, C; Lundholm, K; Norli, B; Sandström, R; Svaninger, G, 1994) |
| "Some cancers can also be the direct cause of fever." | 2.67 | [Antipyretic effect of indomethacin vs aspirin in fever of tumor origin]. ( Asef, SG; Berbotto, GA; Elias, G; Ostoich, MT; Teglia, O, 1993) |
| "Therefore, weight-losing cancer patients (n = 60), with normal liver and kidney function tests, were randomized to receive one of four drug treatments for 5 days: (a) Propranolol 80 mg x 2 (beta-adrenoceptor blockade); (b) Indomethacin 50 mg x 2 (prostaglandin synthesis inhibition); (c) Morphine 5 mg x 3 (pain relief) or (d) Placebo x 2." | 2.67 | Evaluation of mechanisms behind elevated energy expenditure in cancer patients with solid tumours. ( Hyltander, A; Körner, U; Lundholm, KG, 1993) |
| "Paraneoplastic fever is well known, and is not an uncommon problem in daily practice." | 2.67 | A randomized trial of the effect of three non-steroid anti-inflammatory agents in ameliorating cancer-induced fever. ( Bacojanis, C; Beldecos, D; Karabelis, A; Karvounis, N; Kosmidis, P; Milonacis, N; Tsavaris, N; Zinelis, A, 1990) |
| "Indomethacin was effective in only one of five patients to whom it was given, and EHDP was effective also in only one of five patients." | 2.65 | Comparative study of available medical therapy for hypercalcemia of malignancy. ( Heath, DA; Mundy, GR; Wilkinson, R, 1983) |
| "Cancer cachexia is a devastating syndrome of advanced malignancy which negatively impacts on patients' morbidity, mortality and quality of life." | 2.49 | Non-steroidal anti-inflammatory drugs for the treatment of cancer cachexia: a systematic review. ( Cantwell, MM; Hughes, CM; Murray, LJ; Parsons, C; Reid, J, 2013) |
| "The experience of treating cancer over the past several decades overwhelmingly demonstrates that the disease continues to evade the vast array of drugs and treatment modalities available in the twenty-first century." | 2.42 | Choline phospholipid metabolism: a target in cancer cells? ( Ackerstaff, E; Bhujwalla, ZM; Glunde, K, 2003) |
| "Overall, Cy820-IMC has superior cancer targetability and enhanced photocytoxicity." | 1.72 | Indomethacin-based near-infrared photosensitizer for targeted photodynamic cancer therapy. ( Chansaenpak, K; Kamkaew, A; Lai, RY; Noisa, P; Siriwibool, S; Sukwattanasinitt, M; Wangngae, S; Wet-Osot, S, 2022) |
| "In breast cancer T47D the ascending order of pronounced nano-micromolar antiproliferative IC50 values (<50µM) was 4d<3d<4a<4b<3b (0." | 1.72 | Antiproliferative Activities of Lipophililic Fluoroquinolones- Based Scaffold Against a Panel of Solid and Liquid Cancer Cell Lines. ( Al-Hiari, Y; AlAlawi, S; AlBashiti, R; AlHadid, A; Kasabri, V; Qashou, E; Telfah, A, 2022) |
| "Compared with controls (R1, and anticancer drug SN-38), TA displayed prolonged tumor retention and enhanced therapeutic efficacy in xenograft mouse models at a reduced dosage." | 1.48 | COX-2 Inhibition mediated anti-angiogenic activatable prodrug potentiates cancer therapy in preclinical models. ( Han, J; Kim, HS; Kim, JS; Ren, WX; Sharma, A, 2018) |
| "A Pt(IV) prodrug (2) composed of cancer-targeting biotin and nonsteroidal anti-inflammatory drug indomethacin in the axial positions of the six-coordinated octahedral geometry derived from cisplatin was developed, which could be highly accumulated in cancer cells more than normal ones and activated by endogenous reducing molecules to release cisplatin and indomethacin moieties simultaneously to inhibit tumor progression synergistically." | 1.46 | Biotin-Pt (IV)-indomethacin hybrid: A targeting anticancer prodrug providing enhanced cancer cellular uptake and reversing cisplatin resistance. ( Fang, L; Gou, S; Hu, W; Hua, W, 2017) |
| "Indomethacin is an NSAID." | 1.39 | Indomethacin inhibits cancer cell migration via attenuation of cellular calcium mobilization. ( Chang, CM; Chang, WC; Chiu, SJ; Chou, YH; Guo, YC; Hou, MF; Hsu, WL; Lee, MH; Tsai, KL; Tsai, YT; Wang, JY, 2013) |
| "Identifying cancer cells and quantifying cancer-related events in particular organelles in a rapid and sensitive fashion are important for early diagnosis and for studies on pathology and therapeutics of cancers." | 1.39 | An off-on COX-2-specific fluorescent probe: targeting the Golgi apparatus of cancer cells. ( Dou, B; Fan, J; Peng, X; Wang, J; Zhang, H; Zhang, S, 2013) |
| "Podophyllotoxin is a natural product that inhibits the polymerization of tubulin and has served as a prototype for the development of diverse antitumor agents in clinical use, such as etoposide, teniposide and etopophos." | 1.39 | Analgesic and anti-inflammatory activity of podophyllotoxin derivatives. ( Abad, A; Del Olmo, E; Guerrero, E; López-Pérez, JL; Montenegro, G; San Feliciano, A, 2013) |
| "An animal model of cancer pain induced by injection of Walker 256 carcinoma cells into the plantar surface of rat hind paw is described." | 1.34 | Walker 256 tumor-bearing rats as a model to study cancer pain. ( Brigatte, P; Curi, R; Cury, Y; Guerra, JL; Gutierrez, VP; Sampaio, SC; Sinhorini, IL, 2007) |
| "Indomethacin is widely used to treat inflammatory and prevent adverse events which frequently accrue in biotherapy." | 1.34 | Indomethacin enhances the cytotoxicity of recombinant human lymphotoxin alpha on tumor cells by suppressing NFkappaB signaling. ( Li, G; Li, R; Liu, Y; Pan, W; Shen, Y; Tan, J; Wang, J; Wang, L; Wang, Z; Wu, F; Wu, J; Xu, Q; Yang, T, 2007) |
| "COX-2 is overexpressed in cancer cells and has become a major target for cancer preventive drugs." | 1.32 | Does the release of arachidonic acid from cells play a role in cancer chemoprevention? ( Levine, L, 2003) |
| "Weight-losing untreated cancer patients had elevated resting energy expenditure compared to undernourished non-cancer patients (23." | 1.32 | Evidence that long-term COX-treatment improves energy homeostasis and body composition in cancer patients with progressive cachexia. ( Bosaeus, I; Daneryd, P; Hyltander, A; Körner, U; Lundholm, K, 2004) |
| "However, NSAIDs produce gastroduodenal ulcers in about 25% of users (often with bleeding and/or perforations) and delay ulcer healing, presumably by blocking prostaglandin synthesis from cyclooxygenase (COX)-1 and COX-2 (ref." | 1.30 | Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: insight into mechanisms and implications for cancer growth and ulcer healing. ( Itani, RM; Jones, MK; Levin, E; Peskar, BM; Sarfeh, IJ; Tarnawski, AS; Wang, H, 1999) |
| "Indomethacin was found to have significant augmenting effect on LAK cell activity at the concentration of 5 x 10(-5) M, whereas aspirin and ponstan did not show the same effect at the same concentration." | 1.29 | The augmentation of lymphokine-activated killer cell activity by indomethacin in vitro is not mediated by prostaglandin E2 suppression. ( Chao, TY; Chu, TM; Ting, CS; Yeh, MY, 1993) |
| "The exact mechanism of anticancer activity of indomethacin still remains unclear." | 1.28 | A proposed mechanism of anticancer activity of indomethacin. ( Szkudliński, MW, 1992) |
| "In vitro NK responses of cancer patients (N = 21) to rIFN-alpha A and rIL-2 were examined." | 1.28 | Impaired NK response of cancer patients to IFN-alpha but not to IL-2: correlation with serum immunosuppressive acidic protein (IAP) and role of suppressor macrophage. ( Aso, H; Ishida, N; Kikuchi, S; Nakamura, T; Tamura, K; Yoshie, O, 1992) |
| "The ability of 13 of the cancer samples to induce muscle proteolysis was significantly inhibited by incubation of muscles in presence of indomethacin (10 microM)." | 1.28 | Bioactivity of skeletal muscle proteolysis-inducing factors in the plasma proteins from cancer patients with weight loss. ( Belizario, JE; Chenker, E; Katz, M; Raw, I, 1991) |
| " This schedule was repeated at least twice more with a one-week interval between cycles, usually at the same dosage level." | 1.28 | Low-dose cyclophosphamide and low-dose interleukin-2 for malignant melanoma. ( Boswell, WD; Bradley, EC; Dean, G; Harel, W; Kempf, RA; Lind, S; Mitchell, MS; Moore, J; Shau, H, 1989) |
| "Macrophages from four of the cancer patients were cytotoxic towards the allogeneic tumor target." | 1.27 | Ability of cancer patients' macrophages to kill autologous tumor targets. Effect of prostaglandin inhibitors on cytotoxicity. ( Cameron, DJ; Majeski, J; Rittenbury, M, 1984) |
| "The cells from cancer patients demonstrated greater AA conversion to PGE and greater indomethacin sensitive immunoregulatory cell function than the cells of normal subjects." | 1.27 | Relationship of arachidonic acid metabolism to indomethacin-sensitive immunoregulatory function and lymphocyte PGE sensitivity in peripheral blood mononuclear cells of disseminated solid tumor cancer patients. ( Braum, DP; Harris, JE; Rubenstein, M, 1984) |
| "Therefore, 146 trials of treatment for hypercalcemia between 1980 and 1983 at the National Cancer Center Hospital, Tokyo, were evaluated retrospectively." | 1.27 | A retrospective evaluation of the medical treatment of malignancy-associated hypercalcemia. ( Abe, K; Adachi, I; Kimura, S; Matsubara, H; Sato, Y; Suemasu, K; Suzuki, M; Yamaguchi, K, 1986) |
| " Inhibition by topical retinoic acid of ODC induction by TPA was partially overcome in a dose-response fashion by PGE." | 1.27 | The role of prostaglandin E1 in ornithine decarboxylase induction by tumor promoters. ( Boutwell, RK; Cleaveland, JS; Ordman, AB; Simsiman, RC, 1986) |
| "This case reports heterotopic ossification which produced ankylosis around the hip joint in a young adult treated with steroids for moderate cognitive defects secondary to brain trauma." | 1.27 | Indomethacin: an adjunct to surgical excision of immature heterotopic bone formation in a patient with a severe head injury. A case report. ( Ritter, MA, 1987) |
| "Patients with advanced neoplasms have a variety of immunologic abnormalities, including the impaired responsiveness of peripheral blood lymphocytes to mitogen and alloantigen." | 1.27 | Monocyte and lymphocyte interaction in patients with advanced cancer. Evidence for deficient IL-1 production. ( Santos, LB; Scheinberg, MA; Yamada, FT, 1985) |
| "Anergic patients with solid tumors were studied for the presence of suppressor cells which could be responsible for their significantly impaired phytohemagglutinin induced lymphocyte proliferation." | 1.26 | Suppressor leukocytes in anergic patients with solid tumors. ( Bankhurst, AD; Goodwin, JS; Kauffman, GR; Saiers, JH; Saiki, JH; Williams, RC, 1980) |
| "Extracts of tumors from patients with humoral hypercalcemia of malignancy (HHM) were tested using an in vitro bone resorption assay in order to investigate the pathogenesis of the hypercalcemia." | 1.26 | Bone resorption and humoral hypercalcemia of malignancy: stimulation of bone resorption in vitro by tumor extracts is inhibited by prostaglandin synthesis inhibitors. ( Fredericks, RS; Minkin, C; Pokress, S; Rude, RK; Sharp, CF; Singer, FR; Tong, M, 1981) |
| "Vaccination of lung cancer patients with Freund's complete adjuvant or Freund's complete adjuvant plus tumor antigen extracts led to increased levels of chemiluminescence and increased levels of adherent cell cytotoxicity without altering indomethacin-sensitive regulatory cell function." | 1.26 | Chemiluminescence, suppression and cytotoxicity in peripheral blood mononuclear cells from solid tumor cancer patients. ( Braun, DP; De Boer, KP; Harris, JE, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 56 (41.48) | 18.7374 |
| 1990's | 25 (18.52) | 18.2507 |
| 2000's | 13 (9.63) | 29.6817 |
| 2010's | 28 (20.74) | 24.3611 |
| 2020's | 13 (9.63) | 2.80 |
| Authors | Studies |
|---|---|
| Tukey, RH | 1 |
| Strassburg, CP | 1 |
| Diamandis, P | 1 |
| Wildenhain, J | 1 |
| Clarke, ID | 1 |
| Sacher, AG | 1 |
| Graham, J | 1 |
| Bellows, DS | 1 |
| Ling, EK | 1 |
| Ward, RJ | 1 |
| Jamieson, LG | 1 |
| Tyers, M | 1 |
| Dirks, PB | 1 |
| Tundis, R | 1 |
| Bonesi, M | 1 |
| Deguin, B | 1 |
| Loizzo, MR | 1 |
| Menichini, F | 2 |
| Conforti, F | 1 |
| Tillequin, F | 1 |
| Salomatina, OV | 1 |
| Markov, AV | 1 |
| Logashenko, EB | 1 |
| Korchagina, DV | 1 |
| Zenkova, MA | 1 |
| Salakhutdinov, NF | 1 |
| Vlassov, VV | 1 |
| Tolstikov, GA | 1 |
| Abuo-Rahma, Gel-D | 1 |
| Abdel-Aziz, M | 1 |
| Beshr, EA | 1 |
| Ali, TF | 1 |
| Bansal, Y | 1 |
| Kaur, M | 1 |
| Silakari, O | 1 |
| Lin, R | 1 |
| Elf, S | 1 |
| Shan, C | 1 |
| Kang, HB | 1 |
| Ji, Q | 1 |
| Zhou, L | 2 |
| Hitosugi, T | 1 |
| Zhang, L | 1 |
| Zhang, S | 3 |
| Seo, JH | 1 |
| Xie, J | 1 |
| Tucker, M | 1 |
| Gu, TL | 1 |
| Sudderth, J | 1 |
| Jiang, L | 1 |
| Mitsche, M | 1 |
| DeBerardinis, RJ | 1 |
| Wu, S | 1 |
| Li, Y | 1 |
| Mao, H | 1 |
| Chen, PR | 1 |
| Wang, D | 1 |
| Chen, GZ | 1 |
| Hurwitz, SJ | 1 |
| Lonial, S | 1 |
| Arellano, ML | 1 |
| Khoury, HJ | 1 |
| Khuri, FR | 1 |
| Lee, BH | 1 |
| Lei, Q | 1 |
| Brat, DJ | 1 |
| Ye, K | 1 |
| Boggon, TJ | 1 |
| He, C | 1 |
| Kang, S | 1 |
| Fan, J | 3 |
| Chen, J | 1 |
| Ali, EMH | 1 |
| Abdel-Maksoud, MS | 1 |
| Oh, CH | 1 |
| Liu, Y | 4 |
| He, S | 1 |
| Chen, Y | 1 |
| Feng, F | 1 |
| Liu, W | 1 |
| Guo, Q | 1 |
| Zhao, L | 1 |
| Sun, H | 1 |
| Brandt, F | 1 |
| Ullrich, M | 1 |
| Laube, M | 1 |
| Kopka, K | 1 |
| Bachmann, M | 1 |
| Löser, R | 1 |
| Pietzsch, J | 1 |
| Pietzsch, HJ | 1 |
| van den Hoff, J | 1 |
| Wodtke, R | 1 |
| Bajpai, A | 1 |
| Chhabria, D | 1 |
| Mishra, T | 1 |
| Kirubakaran, S | 1 |
| Basu, S | 1 |
| Siriwibool, S | 1 |
| Wangngae, S | 1 |
| Chansaenpak, K | 1 |
| Wet-Osot, S | 1 |
| Lai, RY | 1 |
| Noisa, P | 1 |
| Sukwattanasinitt, M | 1 |
| Kamkaew, A | 1 |
| Qashou, E | 1 |
| Al-Hiari, Y | 1 |
| Kasabri, V | 1 |
| AlBashiti, R | 1 |
| AlAlawi, S | 1 |
| Telfah, A | 1 |
| AlHadid, A | 1 |
| Wang, C | 2 |
| Zheng, Y | 2 |
| Wu, C | 1 |
| Wang, X | 1 |
| Huang, M | 1 |
| Wu, X | 1 |
| Zhong, W | 1 |
| Xu, K | 1 |
| Zhang, W | 2 |
| Qian, J | 2 |
| Xu, R | 1 |
| Zhu, H | 1 |
| Hu, L | 1 |
| Yu, B | 1 |
| Zhan, X | 1 |
| Yuan, Y | 2 |
| Zhou, P | 1 |
| Chen, C | 1 |
| Yao, Y | 1 |
| Wang, W | 1 |
| Duan, L | 1 |
| Ono, K | 1 |
| Momo, K | 2 |
| Yasu, T | 1 |
| Kiyomi, A | 1 |
| Sugiura, M | 1 |
| Kuroda, S | 1 |
| Hata, H | 1 |
| Takada, S | 1 |
| Sato, J | 1 |
| Yoshikawa, K | 1 |
| Imamachi, K | 1 |
| Edo, M | 1 |
| Sagawa, T | 1 |
| Fujikawa, K | 1 |
| Ueda, M | 1 |
| Matsuzaka, M | 1 |
| Kitagawa, Y | 1 |
| Mu, X | 1 |
| Tang, Y | 1 |
| Wu, F | 3 |
| Ma, H | 1 |
| Huang, S | 1 |
| Liang, M | 1 |
| Yang, J | 1 |
| Lu, Y | 1 |
| Zhou, X | 2 |
| Li, Z | 1 |
| Kalladka, M | 1 |
| Al-Azzawi, O | 1 |
| Heir, GM | 1 |
| Kodapala, S | 1 |
| Nainan, MT | 1 |
| Khan, J | 1 |
| Lee, JY | 1 |
| Termsarasab, U | 1 |
| Lee, MY | 1 |
| Kim, DH | 1 |
| Lee, SY | 1 |
| Kim, JS | 2 |
| Cho, HJ | 1 |
| Kim, DD | 1 |
| Hu, W | 1 |
| Fang, L | 1 |
| Hua, W | 1 |
| Gou, S | 1 |
| van der Velden, DL | 1 |
| Cirkel, GA | 1 |
| Houthuijzen, JM | 1 |
| van Werkhoven, E | 1 |
| Roodhart, JML | 1 |
| Daenen, LGM | 1 |
| Kaing, S | 1 |
| Gerrits, J | 1 |
| Verhoeven-Duif, NM | 1 |
| Grootscholten, C | 1 |
| Boot, H | 1 |
| Sessa, C | 1 |
| Bloemendal, HJ | 1 |
| De Vos, FY | 1 |
| Voest, EE | 1 |
| Dixon, F | 1 |
| Ziegler, DS | 1 |
| Bajuk, B | 1 |
| Wright, I | 1 |
| Hilder, L | 1 |
| Abdel Latif, ME | 1 |
| Somanathan, A | 1 |
| Oei, JL | 1 |
| Kim, HS | 1 |
| Sharma, A | 1 |
| Ren, WX | 1 |
| Han, J | 1 |
| Yang, M | 1 |
| Zhang, J | 1 |
| Zhu, S | 1 |
| Shi, M | 1 |
| Wang, K | 1 |
| Zhang, C | 1 |
| Long, L | 1 |
| Xiong, Y | 1 |
| Peng, C | 1 |
| Liu, Z | 1 |
| Lin, Y | 2 |
| Jia, Y | 1 |
| Li, X | 1 |
| Lin, CC | 1 |
| Suen, KM | 1 |
| Stainthorp, A | 1 |
| Wieteska, L | 1 |
| Biggs, GS | 1 |
| Leitão, A | 1 |
| Montanari, CA | 1 |
| Ladbury, JE | 1 |
| Guo, YC | 1 |
| Chang, CM | 1 |
| Hsu, WL | 1 |
| Chiu, SJ | 1 |
| Tsai, YT | 1 |
| Chou, YH | 1 |
| Hou, MF | 1 |
| Wang, JY | 1 |
| Lee, MH | 1 |
| Tsai, KL | 1 |
| Chang, WC | 1 |
| Zhang, H | 2 |
| Wang, J | 2 |
| Dou, B | 1 |
| Peng, X | 1 |
| Liu, HW | 1 |
| Huang, CC | 1 |
| Blidner, AG | 1 |
| Salatino, M | 1 |
| Mascanfroni, ID | 1 |
| Diament, MJ | 1 |
| Bal de Kier Joffé, E | 1 |
| Jasnis, MA | 1 |
| Klein, SM | 1 |
| Rabinovich, GA | 1 |
| Chen, D | 1 |
| Zhao, J | 1 |
| Wang, H | 2 |
| An, N | 1 |
| Zhou, Y | 1 |
| Luo, J | 1 |
| Su, W | 1 |
| Liu, C | 1 |
| Li, J | 1 |
| Chennamaneni, S | 1 |
| Gan, C | 1 |
| Lama, R | 1 |
| Zhong, B | 1 |
| Su, B | 1 |
| Totary-Jain, H | 1 |
| Sionov, RV | 1 |
| Gallily, R | 1 |
| Wu, K | 1 |
| Zhang, X | 1 |
| Zhou, J | 1 |
| Pan, T | 1 |
| Fu, Y | 1 |
| Réti, A | 1 |
| Uddin, MJ | 1 |
| Crews, BC | 1 |
| Ghebreselasie, K | 1 |
| Huda, I | 1 |
| Kingsley, PJ | 1 |
| Ansari, MS | 1 |
| Tantawy, MN | 1 |
| Reese, J | 1 |
| Marnett, LJ | 1 |
| Reid, J | 1 |
| Hughes, CM | 1 |
| Murray, LJ | 1 |
| Parsons, C | 1 |
| Cantwell, MM | 1 |
| Mizushima, T | 2 |
| Yamamoto, K | 1 |
| Asano, K | 1 |
| Ito, Y | 1 |
| Matsukawa, N | 1 |
| Kim, S | 1 |
| Yamatodani, A | 1 |
| Guerrero, E | 1 |
| Abad, A | 1 |
| Montenegro, G | 1 |
| Del Olmo, E | 1 |
| López-Pérez, JL | 1 |
| San Feliciano, A | 1 |
| Touhey, S | 1 |
| O'Connor, R | 1 |
| Plunkett, S | 1 |
| Maguire, A | 1 |
| Clynes, M | 1 |
| Levine, L | 2 |
| Ackerstaff, E | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase I Pilot Trial to Study the Safety and Efficacy of Concomitant Radiotherapy and Zoledronic Acid for the Palliation of Bone Metastases From Breast Cancer, Prostate Cancer and Lung Cancer[NCT00264420] | Phase 1 | 4 participants (Actual) | Interventional | 2005-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
16 reviews available for indomethacin and Neoplasms
| Article | Year |
|---|---|
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; | 2000 |
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Humans; Lipogenesis; Neoplasms; | 2015 |
Thieno[2,3-d]pyrimidine as a promising scaffold in medicinal chemistry: Recent advances.
Topics: Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Chemistry, Ph | 2019 |
Overview of AKR1C3: Inhibitor Achievements and Disease Insights.
Topics: Aldo-Keto Reductase Family 1 Member C3; Antineoplastic Agents; Binding Sites; Cell Proliferation; Cl | 2020 |
[Indomethacin Spray Preparation for the Control of Pain Associated with Stomatitis Caused by Chemotherapy and Radiotherapy in Cancer Patients].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Drug Stability; Drug Storage; Humans | 2015 |
Non-steroidal anti-inflammatory drugs for the treatment of cancer cachexia: a systematic review.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Cachexia; Celecoxib; Cyclooxygenase 2 I | 2013 |
[Novel pharmacological effects of NSAIDs and their molecular mechanism].
Topics: Alzheimer Disease; Amyloid beta-Peptides; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Ag | 2012 |
Choline phospholipid metabolism: a target in cancer cells?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Breast Neoplasms; Choline Kinase; En | 2003 |
[Hemostasis and tumor invasion. Therapeutic implications].
Topics: Animals; Antifibrinolytic Agents; Antineoplastic Combined Chemotherapy Protocols; Blood Coagulation | 1984 |
Prostaglandins and the immune response.
Topics: Animals; Antibody Formation; B-Lymphocytes; Cyclic AMP; Cyclic GMP; Cytotoxicity Tests, Immunologic; | 1977 |
Macrophages as regulators of immune responses against tumors.
Topics: Animals; Carrageenan; Cell Adhesion; Cytotoxicity, Immunologic; Humans; Immunity, Cellular; Immunosu | 1979 |
Prostaglandins and hypercalcemic states.
Topics: Adenocarcinoma; Animals; Bone and Bones; Bone Resorption; Humans; Hypercalcemia; Indomethacin; Kidne | 1978 |
[Indomethacin as a modulator of the activity of natural killer cells (a review of the literature)].
Topics: Adjuvants, Immunologic; Animals; Aspirin; Cells, Cultured; Drug Synergism; Humans; Indomethacin; Kil | 1990 |
Prostaglandins and other metabolites of arachidonic acid. An overview for the otolaryngologist.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Aspirin; Blo | 1985 |
Prostaglandins and cancer: an update.
Topics: Animals; Aspirin; Bucladesine; Calcium; Carcinoma; Cell Division; Cell Line; Depression, Chemical; H | 1974 |
[Present position of the toxicology of drugs].
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Amantadine; Aminopterin; Animals; Animals, Newbo | 1970 |
16 trials available for indomethacin and Neoplasms
| Article | Year |
|---|---|
Analgesic effects of indomethacin spray on drug-induced oral mucositis pain in patients with cancer: A single-arm cross-sectional study.
Topics: Analgesics; Cross-Sectional Studies; Humans; Indomethacin; Japan; Middle Aged; Neoplasms; Pain; Phar | 2021 |
Phase I study of combined indomethacin and platinum-based chemotherapy to reduce platinum-induced fatty acids.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cyclooxygenase 1; Cyclooxygenase Inhibi | 2018 |
Comparative study of available medical therapy for hypercalcemia of malignancy.
Topics: Administration, Oral; Adult; Aged; Calcium; Clinical Trials as Topic; Diphosphonates; Etidronic Acid | 1983 |
[Hemostasis and tumor invasion. Therapeutic implications].
Topics: Animals; Antifibrinolytic Agents; Antineoplastic Combined Chemotherapy Protocols; Blood Coagulation | 1984 |
Effects of indomethacin on lymphokine-activated killer cell activities in cancer patients.
Topics: Adjuvants, Immunologic; Adult; Aged; Aged, 80 and over; Cells, Cultured; Dinoprostone; Female; Human | 1995 |
The effect of parenteral indomethacin on T-lymphocyte subpopulations and cytokine production in patients under major surgical operations.
Topics: Adult; Aged; Cytokines; Female; Humans; Hypersensitivity, Delayed; Indomethacin; Injections, Intramu | 1995 |
Anti-inflammatory treatment may prolong survival in undernourished patients with metastatic solid tumors.
Topics: Aged; Drug Administration Schedule; Female; Humans; Indomethacin; Male; Neoplasms; Nutrition Disorde | 1994 |
[Antipyretic effect of indomethacin vs aspirin in fever of tumor origin].
Topics: Aspirin; Body Temperature; Female; Fever; Humans; Indomethacin; Male; Middle Aged; Neoplasms | 1993 |
Evaluation of mechanisms behind elevated energy expenditure in cancer patients with solid tumours.
Topics: Basal Metabolism; Energy Metabolism; Female; Hormones; Humans; Indomethacin; Male; Morphine; Neoplas | 1993 |
Do inflammatory processes contribute to radiation induced erythema observed in the skin of humans?
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Dose Fra | 1998 |
Protection of metabolic and exercise capacity in unselected weight-losing cancer patients following treatment with recombinant erythropoietin: a randomized prospective study.
Topics: Aged; Anemia; Anti-Inflammatory Agents, Non-Steroidal; Cachexia; Cyclooxygenase Inhibitors; Energy M | 1998 |
Epoetin alfa for protection of metabolic and exercise capacity in cancer patients.
Topics: Aged; Anemia; Anti-Inflammatory Agents, Non-Steroidal; Cachexia; Cyclooxygenase Inhibitors; Energy M | 2002 |
[Studies on the analgesic effect of meglumine indomethacinate in neoplasms].
Topics: Analgesics; Clinical Trials as Topic; Drug Evaluation; Female; Humans; Indomethacin; Male; Meglumine | 1976 |
The toxic and hematologic effects of interleukin-1 alpha administered in a phase I trial to patients with advanced malignancies.
Topics: Adult; Aged; Analysis of Variance; Blood Cells; Bone Marrow; Drug Evaluation; Female; Hematopoiesis; | 1992 |
A randomized trial of the effect of three non-steroid anti-inflammatory agents in ameliorating cancer-induced fever.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Female; Fever; Humans; Indomethacin; Male; Napr | 1990 |
Therapeutic activity of 4-allyloxy-3-chlorophenylacetic acid.
Topics: Analgesics; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Codeine; Huma | 1970 |
104 other studies available for indomethacin and Neoplasms
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutic | 2007 |
Cytotoxic activity and inhibitory effect on nitric oxide production of triterpene saponins from the roots of Physospermum verticillatum (Waldst & Kit) (Apiaceae).
Topics: Animals; Antineoplastic Agents, Phytogenic; Apiaceae; Cell Line, Tumor; Cell Survival; Drug Screenin | 2009 |
Synthesis of novel 2-cyano substituted glycyrrhetinic acid derivatives as inhibitors of cancer cells growth and NO production in LPS-activated J-774 cells.
Topics: Cell Proliferation; Glycyrrhetinic Acid; Humans; Lipopolysaccharides; Neoplasms; Nitric Oxide; Struc | 2014 |
1,2,4-Triazole/oxime hybrids as new strategy for nitric oxide donors: Synthesis, anti-inflammatory, ulceroginicity and antiproliferative activities.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Edem | 2014 |
Benzimidazole--ibuprofen/mesalamine conjugates: potential candidates for multifactorial diseases.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Benzimidazoles; Edema; Ibup | 2015 |
"Clickable" Albumin Binders for Modulating the Tumor Uptake of Targeted Radiopharmaceuticals.
Topics: Albumins; Animals; Copper Radioisotopes; Lysine; Mice; Neoplasms; Positron-Emission Tomography; Prot | 2022 |
Small molecule NSAID derivatives for impairing powerhouse in cancer cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Ibuprofen; Indomethacin; Mitochondria; Neoplasms | 2022 |
Indomethacin-based near-infrared photosensitizer for targeted photodynamic cancer therapy.
Topics: Humans; Indomethacin; Neoplasms; Photochemotherapy; Photosensitizing Agents | 2022 |
Antiproliferative Activities of Lipophililic Fluoroquinolones- Based Scaffold Against a Panel of Solid and Liquid Cancer Cell Lines.
Topics: Anti-Inflammatory Agents; Antineoplastic Agents; Caco-2 Cells; Cisplatin; Fluoroquinolones; Humans; | 2022 |
Enzymatic Synthesis of Peptide Nanofibers for Self-Delivery of Indomethacin and Tyroservatide in Cancer Therapy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; HeLa Cells; Humans; Hydrogels; Indomethacin; Mice; | 2022 |
A fluorescent probe for bioimaging of GSH in cancer cells.
Topics: Coumarins; Fluorescent Dyes; Glutathione; Indomethacin; Molecular Conformation; Neoplasms | 2024 |
Characterization of the intestinal absorption of morroniside from Cornus officinalis Sieb. et Zucc via a Caco-2 cell monolayer model.
Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member | 2020 |
Selective bioimaging of cancer cells and detection of HSA with indomethacin-based fluorescent probes.
Topics: Fluorescent Dyes; Humans; Indomethacin; Molecular Docking Simulation; Neoplasms; Protein Binding; Se | 2020 |
[Optimization of Preparation, and Stability of Indomethacin Mouth Wash for Oral Mucositis Caused by Cancer Therapy].
Topics: Humans; Indomethacin; Mouthwashes; Neoplasms; Pain; Stomatitis | 2020 |
A Simple Small Molecule with Synergistic Passive and Active Dual-Targeting Effects for Imaging-Guided Photothermal Cancer Therapy.
Topics: Animals; Anisotropy; Antineoplastic Agents; Carbocyanines; Cell Line, Tumor; Cyclooxygenase 2; Cyclo | 2021 |
Hemicrania continua secondary to neurogenic paravertebral tumor- a case report.
Topics: Adult; Female; Headache; Headache Disorders; Humans; Indomethacin; Neoplasms; Trigeminal Autonomic C | 2022 |
Chemosensitizing indomethacin-conjugated chitosan oligosaccharide nanoparticles for tumor-targeted drug delivery.
Topics: A549 Cells; Animals; Chitosan; Doxorubicin; Drug Delivery Systems; Humans; Indomethacin; Male; Nanop | 2017 |
Biotin-Pt (IV)-indomethacin hybrid: A targeting anticancer prodrug providing enhanced cancer cellular uptake and reversing cisplatin resistance.
Topics: A549 Cells; Biotin; Cisplatin; Drug Resistance, Neoplasm; Hep G2 Cells; Humans; Indomethacin; Neopla | 2017 |
Treatment with nitric oxide in the neonatal intensive care unit is associated with increased risk of childhood cancer.
Topics: Bronchodilator Agents; Female; Glucocorticoids; Humans; Indomethacin; Infant, Newborn; Infant, Prema | 2018 |
COX-2 Inhibition mediated anti-angiogenic activatable prodrug potentiates cancer therapy in preclinical models.
Topics: A549 Cells; Angiogenesis Inhibitors; Animals; Cell Line, Tumor; Cyclooxygenase 2; Cyclooxygenase 2 I | 2018 |
Metalloporphyrin-indomethacin conjugates as new photosensitizers for photodynamic therapy.
Topics: Cell Survival; HeLa Cells; Humans; Indomethacin; Metalloporphyrins; Neoplasms; Photochemotherapy; Ph | 2019 |
Facile Engineering of Indomethacin-Induced Paclitaxel Nanocrystal Aggregates as Carrier-Free Nanomedicine with Improved Synergetic Antitumor Activity.
Topics: Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Synergism; Humans; Immunotherapy; Indometh | 2019 |
Targeting the Shc-EGFR interaction with indomethacin inhibits MAP kinase pathway signalling.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Cell Movement; Drug Repositioning; E | 2019 |
Indomethacin inhibits cancer cell migration via attenuation of cellular calcium mobilization.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Calcium; Calcium Signaling; Cell Line, Tumor; Cell Movement | 2013 |
An off-on COX-2-specific fluorescent probe: targeting the Golgi apparatus of cancer cells.
Topics: Acenaphthenes; Cell Line, Tumor; Cyclooxygenase 2; Fluorescent Dyes; Golgi Apparatus; Humans; Indome | 2013 |
Rapid and sensitive controlled release monitoring method of biomedical combined products with IDM for pain management and cancer treatment.
Topics: Analgesics; Antineoplastic Agents; Calibration; Calorimetry, Differential Scanning; Chromatography, | 2014 |
Differential response of myeloid-derived suppressor cells to the nonsteroidal anti-inflammatory agent indomethacin in tumor-associated and tumor-free microenvironments.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Autoimmunity; Cellular Microenvironment; Disease M | 2015 |
Oxytocin evokes a pulsatile PGE2 release from ileum mucosa and is required for repair of intestinal epithelium after injury.
Topics: Animals; Antineoplastic Agents; Calcium; Cyclooxygenase 2; Dextran Sulfate; Dinoprostone; Disease Mo | 2015 |
Indomethacin derivatives as tubulin stabilizers to inhibit cancer cell proliferation.
Topics: Antineoplastic Agents; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, | 2016 |
Indomethacin sensitizes resistant transformed cells to macrophage cytotoxicity.
Topics: Animals; Cells, Cultured; Cyclooxygenase Inhibitors; Cytotoxicity, Immunologic; Dinoprostone; Female | 2016 |
Finasteride Enhances the Generation of Human Myeloid-Derived Suppressor Cells by Up-Regulating the COX2/PGE2 Pathway.
Topics: Autoimmunity; Cell Line; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Finasteride; Humans; Immune | 2016 |
[Application of non-steroidal anti-inflammatory drugs to enhance 5-fluorouracil efficacy in experimental systems].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line, Tumor; Cyclooxygenase 2; Cyclooxygenase | 2010 |
Fluorinated COX-2 inhibitors as agents in PET imaging of inflammation and cancer.
Topics: Animals; Celecoxib; Cyclooxygenase 2 Inhibitors; Female; Halogenation; Humans; Indomethacin; Inflamm | 2011 |
Involvement of hypothalamic cyclooxygenase-2, interleukin-1β and melanocortin in the development of docetaxel-induced anorexia in rats.
Topics: Animals; Anorexia; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Docetaxel; Hypothalamus | 2012 |
Analgesic and anti-inflammatory activity of podophyllotoxin derivatives.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Carbazoles; Cell Line, Tumor; | 2013 |
Structure-activity relationship of indomethacin analogues for MRP-1, COX-1 and COX-2 inhibition. identification of novel chemotherapeutic drug resistance modulators.
Topics: Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Res | 2002 |
Does the release of arachidonic acid from cells play a role in cancer chemoprevention?
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Apoptosis; Arachidonic Acid; Catechi | 2003 |
Evidence that long-term COX-treatment improves energy homeostasis and body composition in cancer patients with progressive cachexia.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Blood Sedim | 2004 |
Induction of claudin-4 by nonsteroidal anti-inflammatory drugs and its contribution to their chemopreventive effect.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Biomarkers, Tumor; Calcium; Cell Movement; Chemo | 2005 |
The effects of non-selective, preferential-selective and selective COX-inhibitors on the growth of experimental and human tumors in mice related to prostanoid receptors.
Topics: Amyloid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cell Line, Tumor; Cell Surviva | 2005 |
Inhibitors of COX activity preserve muscle mass in mice bearing the Lewis lung carcinoma, but not the B16 melanoma.
Topics: Analysis of Variance; Animals; Cachexia; Carcinoma, Lewis Lung; Cyclooxygenase Inhibitors; Female; I | 2006 |
Walker 256 tumor-bearing rats as a model to study cancer pain.
Topics: Animals; Carcinoma; Cell Line, Tumor; Cyclooxygenase Inhibitors; Disease Models, Animal; Indomethaci | 2007 |
Indomethacin enhances the cytotoxicity of recombinant human lymphotoxin alpha on tumor cells by suppressing NFkappaB signaling.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Dose-Response Relationship, Drug; Humans; Indome | 2007 |
Mexican drug therapy.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Amygdalin; Arthritis; Asthma; Diazepam; Female; Histamin | 1980 |
Abnormal indomethacin-sensitive suppression in peripheral blood mononuclear cells of cancer patients restricts augmentation by interleukin-2.
Topics: Adult; Aged; Dinoprostone; Humans; Immunotherapy; In Vitro Techniques; Indomethacin; Interleukin-2; | 1984 |
[Humoral mechanisms in neoplastic hypercalcemia].
Topics: Calcitonin; Calcium; Cyclic AMP; Humans; Hypercalcemia; Indomethacin; Neoplasms; Parathyroid Hormone | 1984 |
Activation of blood coagulation in cancer: Trousseau's syndrome revisited.
Topics: Antibodies; Aspirin; Blood Coagulation Disorders; Blood Coagulation Factors; Blood Platelets; Cell A | 1983 |
Relationship of arachidonic acid metabolism to indomethacin-sensitive immunoregulatory function and lymphocyte PGE sensitivity in peripheral blood mononuclear cells of disseminated solid tumor cancer patients.
Topics: Adult; Aged; Arachidonic Acid; Arachidonic Acids; Female; Humans; Indomethacin; Leukocytes; Lymphocy | 1984 |
Diagnosis and management of hypercalcemia.
Topics: Calcitonin; Glucocorticoids; Humans; Hypercalcemia; Hyperparathyroidism; Indomethacin; Neoplasms; Ph | 1980 |
Suppressor leukocytes in anergic patients with solid tumors.
Topics: Adult; Concanavalin A; Female; Humans; Immune Tolerance; Indomethacin; Leukocyte Count; Lymphocyte A | 1980 |
[Hypercalcemia in non-parathyroid malignant tumors].
Topics: Adrenal Cortex Hormones; Bone Neoplasms; Diuretics; Humans; Hypercalcemia; Indomethacin; Neoplasms; | 1981 |
Effects of combination chemotherapy on immunoregulatory cells in peripheral blood of solid tumor cancer patients: correlation with rebound overshoot immune function recovery.
Topics: Adult; Aged; Altretamine; Antineoplastic Agents; Cell Adhesion; Drug Therapy, Combination; Fluoroura | 1981 |
Ability of cancer patients' macrophages to kill autologous tumor targets. Effect of prostaglandin inhibitors on cytotoxicity.
Topics: Cells, Cultured; Cytotoxicity Tests, Immunologic; Cytotoxicity, Immunologic; Female; Humans; Indomet | 1984 |
Modulation of antigen-induced leukocyte adherence inhibition by metabolites of arachidonic acid and intracellular nucleotides.
Topics: Antigens, Neoplasm; Antioxidants; Arachidonic Acids; Catechols; Dinoprostone; Humans; Immunologic Te | 1982 |
Bone resorption and humoral hypercalcemia of malignancy: stimulation of bone resorption in vitro by tumor extracts is inhibited by prostaglandin synthesis inhibitors.
Topics: Adult; Animals; Arachidonic Acid; Arachidonic Acids; Biological Assay; Bone and Bones; Bone Resorpti | 1981 |
Chemiluminescence, suppression and cytotoxicity in peripheral blood mononuclear cells from solid tumor cancer patients.
Topics: Adult; Aged; Cytotoxicity, Immunologic; Humans; Immunity, Cellular; Immunosuppression Therapy; Indom | 1982 |
Natural cytotoxicity and antibody-dependent cytotoxicity in solid tumor cancer patients: regulation by adherent cells.
Topics: Adult; Aged; Aging; Antibody-Dependent Cell Cytotoxicity; Antigen-Antibody Complex; Binding Sites; C | 1982 |
[Efficacy of indomethacin in neoplastic fever].
Topics: Adult; Female; Fever; Humans; Indomethacin; Neoplasms | 1982 |
A study of prostaglandin E2, parathormone, and response to indomethacin in patients with hypercalcemia of malignancy.
Topics: Humans; Hypercalcemia; Indomethacin; Neoplasms; Parathyroid Hormone; Prospective Studies; Prostaglan | 1982 |
The response of cancer patients' lymphocytes to mitogen. The effect of indomethacin on adherent and non-adherent cells activity.
Topics: Adult; Aged; Breast Neoplasms; Cell Adhesion; Colonic Neoplasms; Concanavalin A; Humans; Indomethaci | 1981 |
Evidence that prostaglandins modulate lipogenesis in cultured lymphocytes--a comparison with its effect on macrophages and tumour cells.
Topics: Acetates; Animals; Arachidonic Acid; Carbon Radioisotopes; Cells, Cultured; Concanavalin A; DNA; DNA | 1994 |
The augmentation of lymphokine-activated killer cell activity by indomethacin in vitro is not mediated by prostaglandin E2 suppression.
Topics: Aspirin; Cells, Cultured; Cytotoxicity, Immunologic; Dinoprostone; Humans; Indomethacin; Interleukin | 1993 |
Cyclooxygenase inhibitors prevent the induction of tolerance to the toxic effects of tumor necrosis factor.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clinical Protocols; Combined Modality The | 1993 |
Effect of alpha 1-acidic glycoprotein in the ascitic fluid of cancer patients on human NK cells: selective suppression of interferon-induced NK activation.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Ascitic Fluid; Dose-Response Relationship, Immunologic; Hum | 1999 |
Modulating activity of indomethacin to vincristine cytotoxicity in various human carcinoma cells.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; Carcinoma; | 1998 |
Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: insight into mechanisms and implications for cancer growth and ulcer healing.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase | 1999 |
Anti-inflammatory drugs and tumour growth.
Topics: Animals; Aspirin; Bone Neoplasms; Carcinogens; Drug Evaluation; Humans; Indomethacin; Neoplasm Metas | 1979 |
[Kinetics of I-131 fibrinogen in cancer patients: pharmacological approach].
Topics: Aspirin; Blood Coagulation; Fibrinogen; Fibrinolytic Agents; Heparin; Indomethacin; Iodine Radioisot | 1977 |
Effect of indomethacin on blastogenesis of lymphocytes from cancer patients: differentiation of patient types.
Topics: Humans; Immunity, Cellular; Indomethacin; Leiomyosarcoma; Lung Neoplasms; Lymphocyte Activation; Lym | 1979 |
[Indomethacin loading test].
Topics: Calcium; Humans; Hypercalcemia; Indomethacin; Neoplasms; Prostaglandins | 1979 |
Plasma prostaglandin E in patients with cancer with and without hypercalcemia.
Topics: Bone Neoplasms; Female; Humans; Hypercalcemia; Indomethacin; Male; Neoplasm Metastasis; Neoplasms; P | 1976 |
[Paraneoplastic syndrome treated with indomethacin].
Topics: Female; Humans; Indomethacin; Middle Aged; Neoplasm Metastasis; Neoplasms; Osteoarthropathy, Seconda | 1976 |
Prostaglandins as mediators of hypercalcemia associated with certain types of cancer.
Topics: Aspirin; Calcium; Humans; Hypercalcemia; Indomethacin; Male; Middle Aged; Neoplasms; Parathyroid Hor | 1975 |
Editorial: Prostaglandins, hypercalcemia and cancer.
Topics: Animals; Aspirin; Humans; Hypercalcemia; Indomethacin; Mice; Neoplasms; Prostaglandin Antagonists; P | 1975 |
Indomethacin and protein binding of methotrexate.
Topics: Adult; Aged; Blood Proteins; Drug Interactions; Humans; Indomethacin; Methotrexate; Middle Aged; Neo | 1992 |
Protein binding of indomethacin, methotrexate and morphine in patients with cancer.
Topics: Adult; Aged; Blood Proteins; Humans; Indomethacin; Methotrexate; Middle Aged; Morphine; Neoplasms; O | 1992 |
A proposed mechanism of anticancer activity of indomethacin.
Topics: Animals; Antineoplastic Agents; Humans; Indomethacin; Models, Biological; Neoplasms; Prostaglandins | 1992 |
Impaired NK response of cancer patients to IFN-alpha but not to IL-2: correlation with serum immunosuppressive acidic protein (IAP) and role of suppressor macrophage.
Topics: Adult; Cytotoxicity, Immunologic; Dinoprostone; Humans; Indomethacin; Interferon Type I; Interleukin | 1992 |
Phase I trial of recombinant interleukin-2 followed by recombinant tumor necrosis factor in patients with metastatic cancer.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Blood Chemical Analysis; Dr | 1992 |
Prevention of nickel subsulfide carcinogenesis by local administration of Mycobacterium bovis antigen in male F344/NCr rats.
Topics: Animals; Antigens, Bacterial; Carcinogens; Hydrocortisone; Indomethacin; Inflammation; Injections, I | 1991 |
Bioactivity of skeletal muscle proteolysis-inducing factors in the plasma proteins from cancer patients with weight loss.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Blood Proteins; Cachexia; Child; Diaphragm; Fem | 1991 |
The in vitro development of cytotoxicity in response to granulocyte/macrophage-colony-stimulating factor or interferon gamma in the peripheral blood monocytes of patients with solid tumors: modulation by arachidonic acid metabolic inhibitors.
Topics: Adult; Arachidonic Acid; Arachidonic Acids; Cytotoxicity, Immunologic; Granulocyte-Macrophage Colony | 1990 |
New approach to management of malignant ascites with streptococcal preparation OK-432. III. OK-432 attracts natural killer cells through a chemotactic factor released from activated neutrophils.
Topics: Animals; Antibodies, Monoclonal; Antigens, Surface; Ascites; Biological Products; Cells, Cultured; C | 1990 |
Modulation of in vitro antitumor immunity in response to the biological activators interleukin-2, gamma interferon, and granulocyte monocyte-colony stimulating factor in the peripheral blood of cancer patients receiving cytotoxic chemotherapy.
Topics: Adjuvants, Immunologic; Antineoplastic Agents; Colony-Stimulating Factors; Cytotoxicity Tests, Immun | 1989 |
Low-dose cyclophosphamide and low-dose interleukin-2 for malignant melanoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Dose-Response Relatio | 1989 |
The therapeutic potential of interleukin-1 beta in the treatment of chemotherapy- or radiation-induced myelosuppression and in tumor therapy.
Topics: Animals; Antineoplastic Agents; Bacterial Infections; Bone Marrow; Combined Modality Therapy; Diseas | 1989 |
A retrospective evaluation of the medical treatment of malignancy-associated hypercalcemia.
Topics: Adult; Aged; Calcitonin; Calcium; Female; Fluid Therapy; Glucocorticoids; Humans; Hypercalcemia; Ind | 1986 |
The response of human carcinoma cell lines to gamma-linolenic acid with special reference to the effects of agents which influence prostaglandin and thromboxane synthesis.
Topics: Alprostadil; Aspirin; Cell Division; Cell Line; Cell Survival; gamma-Linolenic Acid; Humans; Imidazo | 1985 |
The role of prostaglandin E1 in ornithine decarboxylase induction by tumor promoters.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alprostadil; Animals; Diterpenes; Enzyme Induction; Female; Indome | 1986 |
Indomethacin: an adjunct to surgical excision of immature heterotopic bone formation in a patient with a severe head injury. A case report.
Topics: Adult; Bone and Bones; Cerebral Hemorrhage; Choristoma; Hip Dislocation; Humans; Indomethacin; Male; | 1987 |
Growth factors for human tumor clonogenic cells elaborated by macrophages isolated from human malignant effusions.
Topics: Cells, Cultured; Colony-Stimulating Factors; Humans; Indomethacin; Macrophages; Mitogens; Neoplasms; | 1986 |
A new in vitro model for investigation of tumor cell-platelet-endothelial cell interactions and concomitant eicosanoid biosynthesis.
Topics: Blood Platelets; Cell Aggregation; Cell Communication; Eicosanoic Acids; Endothelium; Epoprostenol; | 1987 |
Cancer prevention.
Topics: Humans; Indomethacin; Isotretinoin; Neoplasms; Ornithine Decarboxylase; Research Design; Tretinoin | 1985 |
Monocyte and lymphocyte interaction in patients with advanced cancer. Evidence for deficient IL-1 production.
Topics: Adolescent; Adult; Aged; Antibodies, Monoclonal; Cell Division; Female; Humans; Indomethacin; Interl | 1985 |
Enhancement of the antiproliferative activity of human interferon by polyamine depletion.
Topics: Aspirin; Cell Division; Cell Line; Doxorubicin; Drug Synergism; Eflornithine; Humans; Indomethacin; | 1985 |
[Action of indomethacin on fever in cancer patients].
Topics: Adolescent; Adult; Aged; Female; Fever; Humans; Indomethacin; Infections; Male; Middle Aged; Neoplas | 1971 |
[Use of meglumine indomethacin in the treatment of pain due to neoplastic diseases].
Topics: Adult; Aged; Amino Sugars; Analgesics; Female; Humans; Indomethacin; Male; Middle Aged; Neoplasm Met | 1972 |
Letter: Indomethacin, prostaglandin and hypercalcemia.
Topics: Alcohol Oxidoreductases; Cyclic AMP; Humans; Hypercalcemia; Indomethacin; Mixed Function Oxygenases; | 1974 |
[Drugs and gastric hemorrhage. Results of 1 year's prospective study].
Topics: Alcoholic Beverages; Anticoagulants; Blood Transfusion; Cortisone; Drug Therapy, Combination; Gastro | 1974 |
Production of histamine-like and prostaglandin-like substances from serum incubated with rat, dog, mouse or human tumours.
Topics: Animals; Aspirin; Blood; Complement System Proteins; Dogs; Histamine; Humans; In Vitro Techniques; I | 1973 |
Letter: Prostaglandins, bone resorption and hyperglycemia.
Topics: Animals; Bone Resorption; Calcium; Indomethacin; Mice; Neoplasms; Prostaglandins | 1974 |
[Antiphlogistic and analgetic effect of indomethazine in patients with inflammatory joint diseases, carcinoma, lymphogranulomatosis and chronic myelosis].
Topics: Adult; Aged; Arthritis; Female; Gout; Hodgkin Disease; Humans; Indomethacin; Leukemia, Myeloid; Male | 1971 |
[Clinical experience with indomethacin].
Topics: Arthritis, Rheumatoid; Hodgkin Disease; Humans; Indomethacin; Joint Diseases; Leukemia, Myeloid; Lup | 1968 |
[On the antipyretic action of indomethacin in Hodgkin's lymphogranuloma and in neoplasms].
Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Antineoplastic Agents; Fever; Hodgkin Disease; Human | 1966 |