indomethacin and Neoplasm Metastasis
indomethacin has been researched along with Neoplasm Metastasis in 69 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Neoplasm Metastasis: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
" We conducted a prospective randomized trial of alpha-interferon given with or without indomethacin to patients with malignant melanoma to determine what effect, if any, indomethacin might have on the toxic, immunomodulatory, and therapeutic properties of interferon in this disease." | 9.06 | Randomized trial of recombinant alpha 2b-interferon with or without indomethacin in patients with metastatic malignant melanoma. ( Clark, JW; Crum, E; Hawkins, MJ; Jones, MJ; Longo, DL; McKnight, JE; Miller, RL; Smith, JW; Steis, RG; Urba, WJ, 1989) |
"Growth and metastasis to the lung of the human breast cancer cell line MDA-MB-435 in nude mice fed a high-fat (20% wt/wt) high-linoleic acid (LA; 12% wt/wt) diet were significantly reduced by the addition of the cyclooxygenase inhibitor indomethacin to the drinking water at a dose of 10 micrograms/ml (approximately 1 mg/kg body wt)." | 7.69 | Dietary linoleic acid-stimulated human breast cancer cell growth and metastasis in nude mice and their suppression by indomethacin, a cyclooxygenase inhibitor. ( Connolly, JM; Liu, XH; Rose, DP, 1996) |
" We therefore assessed the effect of Indomethacin and aspirin on some parameters of calcium metabolism in patients with breast cancer." | 7.65 | Failure of indomethacin to reduce hypercalcemia in patients with breast cancer. ( Bondy, PK; Coombes, RC; Neville, AM; Powles, TJ, 1976) |
"The hypercalcemia was unresponsive to hydration and oral phosphate." | 5.25 | Indomethacin-responsive hypercalcemia in a patient with renal-cell adenocarcinoma. ( Alexander, RW; Brereton, HD; DeVita, VT; Halushka, PV; Keiser, HR; Mason, DM, 1974) |
" We conducted a prospective randomized trial of alpha-interferon given with or without indomethacin to patients with malignant melanoma to determine what effect, if any, indomethacin might have on the toxic, immunomodulatory, and therapeutic properties of interferon in this disease." | 5.06 | Randomized trial of recombinant alpha 2b-interferon with or without indomethacin in patients with metastatic malignant melanoma. ( Clark, JW; Crum, E; Hawkins, MJ; Jones, MJ; Longo, DL; McKnight, JE; Miller, RL; Smith, JW; Steis, RG; Urba, WJ, 1989) |
"Growth and metastasis to the lung of the human breast cancer cell line MDA-MB-435 in nude mice fed a high-fat (20% wt/wt) high-linoleic acid (LA; 12% wt/wt) diet were significantly reduced by the addition of the cyclooxygenase inhibitor indomethacin to the drinking water at a dose of 10 micrograms/ml (approximately 1 mg/kg body wt)." | 3.69 | Dietary linoleic acid-stimulated human breast cancer cell growth and metastasis in nude mice and their suppression by indomethacin, a cyclooxygenase inhibitor. ( Connolly, JM; Liu, XH; Rose, DP, 1996) |
" We report here that inhibitors of both the cyclooxygenase and lipoxygenase pathways of arachidonic acid metabolism convert mouse melanoma and human fibrosarcoma cells to a non invasive state by reducing the production of MMP-2, an enzyme required for the degradation of basement membranes." | 3.69 | Identification of arachidonic acid pathways required for the invasive and metastatic activity of malignant tumor cells. ( Martin, GR; Reich, R, 1996) |
" Treatment of mice with 100 micrograms of indomethacin, a potent inhibitor of prostaglandin synthesis, prior to the injection of rhuIL-1 alpha, prevented the increase in number of bone metastases." | 3.68 | Effect of IL-1 on experimental bone/bone-marrow metastases. ( Arguello, F; Baggs, RB; Cohen, HJ; Frantz, CN; Graves, BT; Harwell, SE, 1992) |
"Indomethacine, protamine-sulphate and hydrocortisone were found to decrease the activity of metastatic processes of Lewis carcinoma after the removal of the primary tumour." | 3.67 | [Effect of actions inhibiting neovascularization of the metastasis of Lewis lung carcinoma]. ( Balitskiĭ, KP; Lisniak, IA; Sopotsinskaia, EB, 1985) |
" We therefore assessed the effect of Indomethacin and aspirin on some parameters of calcium metabolism in patients with breast cancer." | 3.65 | Failure of indomethacin to reduce hypercalcemia in patients with breast cancer. ( Bondy, PK; Coombes, RC; Neville, AM; Powles, TJ, 1976) |
"Prostaglandin D2 was able to reduce in vitro aggregation of platelets from C57 black mice." | 2.36 | Prostaglandins and metastasis. ( Stringfellow, DA, 1983) |
"Castrate-resistant prostate cancer (CRPC) is a fatal, metastatic form of prostate cancer." | 1.39 | Development of potent and selective indomethacin analogues for the inhibition of AKR1C3 (Type 5 17β-hydroxysteroid dehydrogenase/prostaglandin F synthase) in castrate-resistant prostate cancer. ( Adeniji, AO; Byrns, MC; Chen, M; Christianson, DW; Jin, Y; Liedtke, AJ; Marnett, LJ; Penning, TM, 2013) |
"EP3 antagonism had no effect on tumor metastasis." | 1.33 | Prostaglandin E receptor EP4 antagonism inhibits breast cancer metastasis. ( Fulton, AM; Kundu, N; Ma, X; Rifat, S; Walser, T, 2006) |
"Using a murine model of metastatic breast cancer, we show that PGE(2) levels are positively correlated with increased tumorigenic and metastatic potential." | 1.31 | Increased cyclooxygenase-2 (cox-2) expression and activity in a murine model of metastatic breast cancer. ( Dorsey, R; Fulton, AM; Kundu, N; Yang, Q, 2001) |
"tumor growth, secondary lung metastasis and splenocyte cytotoxicity against YAC-1 lymphoma cells (51Cr release assay)." | 1.29 | Effects of histamine type-2 receptor antagonists on indomethacin and IL-2 immunotherapy of metastasis. ( Khoo, NK; Lala, PK; Saarloos, MN, 1993) |
"Concerning the effect of rTNF on metastasis, we found that the metastasis to lung was promoted by 1 x 10(5) units of rTNF and the promotion of metastasis was restricted by indomethacin." | 1.29 | Promotion of metastases by tumor necrosis factor in rats bearing Dunning R3327 MAT-LyLu prostatic cancer. ( Iizumi, T; Soma, GI; Umeda, T; Yazaki, T, 1993) |
" These agents were tested either alone for the prevention of metastasis or in combination with IL-2 for the eradication of established metastasis." | 1.28 | Immunotherapy of mammary adenocarcinoma metastases in C3H/HeN mice with chronic administration of cyclo-oxygenase inhibitors alone or in combination with IL-2. ( Chan, FP; Khoo, NK; Lala, PK; Saarloos, MN, 1992) |
"Indomethacin treatment to rats bearing dimethylhydrazine-induced colonic cancer resulted in increased mortality (p less than 0." | 1.27 | Enhancement of colonic cancer by indomethacin treatment in dimethylhydrazine pretreated rats. ( Abate, S; Califano, G; Danzi, M; Ferulano, GP, 1984) |
"Tumor volume, metastasis, and determination of regression of primary tumor have been evaluated." | 1.27 | Nb rat prostate adenocarcinoma model androgen-sensitive tumor: metastasis control. ( Drago, JR; Fralisch, A; Weed, P, 1983) |
" A chronic administration of indomethacin in the drinking water (14 micrograms/ml) to mice beginning on Day 4 after subcutaneous transplantation of 10(6) tumor cells resulted in a significant reduction in the growth rate of primary tumors in all hosts and led to a complete or nearly complete abrogation of lung metastasis in T-58- or C3-transplanted hosts examined at 1 month after tumor transplantation; C10-transplanted mice showed no metastasis in the control or the treated group." | 1.27 | Indomethacin therapy abrogates the prostaglandin-mediated suppression of natural killer activity in tumor-bearing mice and prevents tumor metastasis. ( Lala, PK; Parhar, RS; Singh, P, 1986) |
"Treatment with indomethacin substantially reduced the levels of PGs, particularly PGE2 in tumor tissue, inhibited the tumor growth, particularly the early stage of cell proliferation, prolonged the survival time, eliminated tumors in the abdominal cavity, and inhibited metastatic tumor recurrence after surgery." | 1.27 | [Anti-cancer treatment with prostaglandin synthetase inhibitor in animal models]. ( Masuda, T; Nagasawa, O; Narisawa, T; Niwa, M; Ogata, N; Takahashi, M, 1986) |
"resulted in a greater number of lung metastases than did injection of metastatic cells alone." | 1.27 | Effect of prostaglandin E2-producing nonmetastatic Lewis lung carcinoma cells on the migration of prostaglandin E2-responsive metastatic Lewis lung carcinoma cells. ( Wepsic, HT; Young, ME; Young, MR, 1987) |
" Treatment of mice with a higher dosage of IM (20 micrograms/ml), decreased tumor metastasis even further compared to controls, but did not decrease tumor growth rate compared to the lower dosage of IM (10 micrograms/ml)." | 1.27 | Inhibition of growth and linoleate-enhanced metastasis of a transplantable mouse mammary tumor by indomethacin. ( Chapkin, RS; Erickson, KL; Hubbard, NE, 1988) |
"The spontaneous metastasis of the highly metastatic tumor designated 410." | 1.27 | Interactions of natural effector cells and prostaglandins in the control of metastasis. ( Fulton, AM, 1987) |
"In addition, spontaneous metastasis of two highly metastatic tumors was partially inhibited by p." | 1.27 | Relationships of prostaglandin E and natural killer sensitivity to metastatic potential in murine mammary adenocarcinomas. ( Fulton, AM; Heppner, GH, 1985) |
"Indomethacin may suppress the local acceleration of calcium metabolism." | 1.26 | Effects of prostaglandin on experimental bone malignancy and on scintigrams of bone and marrow. ( Ito, Y; Muranaka, A; Nagai, K; Otsuka, N; Terashima, H; Yanagimoto, S, 1981) |
"The hypercalcemia was unresponsive to hydration and oral phosphate." | 1.25 | Indomethacin-responsive hypercalcemia in a patient with renal-cell adenocarcinoma. ( Alexander, RW; Brereton, HD; DeVita, VT; Halushka, PV; Keiser, HR; Mason, DM, 1974) |
Research
Studies (69)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 44 (63.77) | 18.7374 |
1990's | 17 (24.64) | 18.2507 |
2000's | 3 (4.35) | 29.6817 |
2010's | 5 (7.25) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors
Authors | Studies |
---|---|
Liedtke, AJ | 1 |
Adeniji, AO | 1 |
Chen, M | 1 |
Byrns, MC | 1 |
Jin, Y | 1 |
Christianson, DW | 1 |
Marnett, LJ | 1 |
Penning, TM | 1 |
Wu, L | 1 |
Wang, W | 1 |
Dai, M | 1 |
Li, H | 1 |
Chen, C | 1 |
Wang, D | 1 |
Lönnroth, C | 1 |
Andersson, M | 1 |
Asting, AG | 1 |
Nordgren, S | 1 |
Lundholm, K | 1 |
Jukić, MK | 1 |
Luetić, AT | 1 |
Skudar-Lukinović, V | 1 |
Andreis, I | 1 |
Han, R | 1 |
Xiong, J | 1 |
Xiao, R | 1 |
Altaf, E | 1 |
Wang, J | 1 |
Liu, Y | 1 |
Xu, H | 1 |
Ding, Q | 1 |
Zhang, Q | 1 |
Page, GG | 1 |
Ma, X | 1 |
Kundu, N | 2 |
Rifat, S | 1 |
Walser, T | 1 |
Fulton, AM | 6 |
Stringfellow, DA | 2 |
Cattan, A | 1 |
Otsuka, N | 1 |
Ito, Y | 1 |
Nagai, K | 1 |
Terashima, H | 1 |
Yanagimoto, S | 1 |
Muranaka, A | 1 |
Young, MR | 6 |
Knies, S | 1 |
Danzi, M | 1 |
Ferulano, GP | 1 |
Abate, S | 1 |
Califano, G | 1 |
Drago, JR | 2 |
Weed, P | 1 |
Fralisch, A | 1 |
Warshaw, AL | 1 |
Carey, RW | 1 |
Robinson, DR | 1 |
Giraldi, T | 1 |
Sava, G | 1 |
Kopitar, M | 1 |
Brzin, J | 1 |
Turk, V | 1 |
Saarloos, MN | 2 |
Khoo, NK | 2 |
Lala, PK | 3 |
Iizumi, T | 1 |
Yazaki, T | 1 |
Umeda, T | 1 |
Soma, GI | 1 |
Connolly, JM | 1 |
Liu, XH | 1 |
Rose, DP | 1 |
Reich, R | 1 |
Martin, GR | 1 |
Lozano, Y | 1 |
Djordjevic, A | 1 |
Maier, GD | 1 |
Young, ME | 2 |
Blaya, C | 1 |
Crespo, J | 1 |
Crespo, A | 1 |
Aliño, SF | 3 |
Kobayashi, S | 1 |
Okada, S | 1 |
Hasumi, T | 1 |
Sato, N | 1 |
Fujimura, S | 1 |
Yang, Q | 1 |
Dorsey, R | 1 |
Puppo, N | 1 |
De Thomatis, M | 1 |
Oddone, G | 1 |
Fitzpatrick, FA | 1 |
Benvenisti, D | 1 |
Goldberg, H | 1 |
Seyberth, HW | 1 |
Segre, GV | 1 |
Hamet, P | 1 |
Sweetman, BJ | 1 |
Potts, JT | 1 |
Oates, JA | 1 |
Easty, GC | 3 |
Dowsett, M | 1 |
Powles, TJ | 4 |
Easty, DM | 3 |
Gazet, JC | 1 |
Neville, AM | 4 |
Eilon, G | 1 |
Mundy, GR | 1 |
Pollard, M | 1 |
Chang, CF | 1 |
Luckert, PH | 1 |
Galasko, CS | 1 |
Bennett, A | 1 |
Robertson, RP | 2 |
Baylink, DJ | 2 |
Metz, SA | 1 |
Cummings, KB | 1 |
Coombes, RC | 1 |
Bondy, PK | 1 |
Guida, B | 1 |
Piersantelli, N | 1 |
Marini, BJ | 1 |
Adkison, HW | 1 |
Arguello, F | 1 |
Baggs, RB | 1 |
Graves, BT | 1 |
Harwell, SE | 1 |
Cohen, HJ | 1 |
Frantz, CN | 1 |
Negrier, MS | 1 |
Pourreau, CN | 1 |
Palmer, PA | 1 |
Ranchere, JY | 1 |
Mercatello, A | 1 |
Viens, P | 1 |
Blaise, D | 1 |
Jasmin, C | 1 |
Misset, JL | 1 |
Franks, CR | 1 |
Chan, FP | 1 |
Zhang, SZ | 1 |
Chong, YC | 1 |
Barbero, MC | 1 |
Garcia, M | 1 |
Almena, A | 1 |
Duffie, GP | 1 |
Okada, F | 1 |
Tada, M | 1 |
Hosokawa, M | 1 |
Kobayashi, H | 1 |
Tang, DG | 1 |
Tian, HS | 1 |
Ellis, LM | 1 |
Copeland, EM | 1 |
Bland, KI | 1 |
Sitren, HS | 1 |
Taraskina, NP | 1 |
Iunker, VM | 1 |
Surkova, OIu | 1 |
Sopotsinskaia, EB | 1 |
Lisniak, IA | 1 |
Balitskiĭ, KP | 1 |
Ishihara, K | 1 |
Deichman, GI | 1 |
Kashleva, HA | 1 |
Kluchareva, TE | 1 |
Matveeva, VA | 1 |
Miller, RL | 1 |
Steis, RG | 1 |
Clark, JW | 1 |
Smith, JW | 1 |
Crum, E | 1 |
McKnight, JE | 1 |
Hawkins, MJ | 1 |
Jones, MJ | 1 |
Longo, DL | 1 |
Urba, WJ | 1 |
Wei, WZ | 1 |
Fulton, A | 2 |
Winkelhake, J | 1 |
Heppner, G | 2 |
Parhar, RS | 1 |
Singh, P | 1 |
Narisawa, T | 1 |
Takahashi, M | 1 |
Masuda, T | 1 |
Nagasawa, O | 1 |
Ogata, N | 1 |
Niwa, M | 1 |
Wepsic, HT | 1 |
Talmadge, JE | 1 |
Bowersox, O | 1 |
Tribble, H | 1 |
Lee, SH | 1 |
Shepard, HM | 1 |
Liggitt, D | 1 |
Shmal'ko, IuP | 1 |
Grinzhevskaia, SN | 1 |
Hubbard, NE | 1 |
Chapkin, RS | 1 |
Erickson, KL | 1 |
Hilario, E | 1 |
Unda, F | 1 |
Hanchin, CM | 1 |
Butler, WB | 1 |
Mahan, M | 1 |
Meunier, J | 1 |
Newby, M | 1 |
Yamashina, K | 1 |
Heppner, GH | 1 |
Lombard, JS | 1 |
De Marzi, S | 1 |
Morini, V | 1 |
LiVolsi, VA | 1 |
Clark, SA | 1 |
Brereton, HD | 1 |
Halushka, PV | 1 |
Alexander, RW | 1 |
Mason, DM | 1 |
Keiser, HR | 1 |
DeVita, VT | 1 |
Clinical Trials (1)
Trial Overview
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Atavistic Chemotherapy and Immunotherapy in Advanced, Metastatic, and Otherwise Incurable and Lethal Cancers Under Conventional Treatments[NCT02366884] | Phase 2 | 250 participants (Anticipated) | Interventional | 2011-07-26 | Recruiting | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Reviews
3 reviews available for indomethacin and Neoplasm Metastasis
Article | Year |
---|---|
The immune-suppressive effects of pain.
Topics: Analgesics, Opioid; Animals; Bupivacaine; Cyclooxygenase Inhibitors; Fentanyl; Humans; Immune Tolera | 2003 |
Prostaglandins and metastasis.
Topics: Animals; Cell Line; Cytotoxicity, Immunologic; Immunity, Innate; Indomethacin; Interferons; Killer C | 1983 |
[Hemostasis and tumor invasion. Therapeutic implications].
Topics: Animals; Antifibrinolytic Agents; Antineoplastic Combined Chemotherapy Protocols; Blood Coagulation | 1984 |
Trials
2 trials available for indomethacin and Neoplasm Metastasis
Article | Year |
---|---|
[Hemostasis and tumor invasion. Therapeutic implications].
Topics: Animals; Antifibrinolytic Agents; Antineoplastic Combined Chemotherapy Protocols; Blood Coagulation | 1984 |
Randomized trial of recombinant alpha 2b-interferon with or without indomethacin in patients with metastatic malignant melanoma.
Topics: Adult; Aged; Aspirin; Clinical Trials as Topic; Female; Humans; Indomethacin; Interferon Type I; Kil | 1989 |
Other Studies
65 other studies available for indomethacin and Neoplasm Metastasis
Article | Year |
---|---|
Development of potent and selective indomethacin analogues for the inhibition of AKR1C3 (Type 5 17β-hydroxysteroid dehydrogenase/prostaglandin F synthase) in castrate-resistant prostate cancer.
Topics: 3-Hydroxysteroid Dehydrogenases; Aldo-Keto Reductase Family 1 Member C3; Catalytic Domain; Enzyme In | 2013 |
PPARα ligand, AVE8134, and cyclooxygenase inhibitor therapy synergistically suppress lung cancer growth and metastasis.
Topics: Animals; Antineoplastic Agents; Benzoates; Bezafibrate; Cell Line, Tumor; Cell Movement; Cell Prolif | 2019 |
Preoperative low dose NSAID treatment influences the genes for stemness, growth, invasion and metastasis in colorectal cancer.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Biomarkers, Tumor; Celecoxib; Colorectal Neoplasms; Female; | 2014 |
The antimetastatic effect of macrophages restored by indomethacin: concomitant tumor immunity model.
Topics: Adoptive Transfer; Animals; Female; Indomethacin; Lung Neoplasms; Macrophages; Male; Mammary Neoplas | 2010 |
Activation of β-catenin signaling is critical for doxorubicin-induced epithelial-mesenchymal transition in BGC-823 gastric cancer cell line.
Topics: beta Catenin; Cell Line, Tumor; Cell Movement; Doxorubicin; Enzyme Activation; Epithelial-Mesenchyma | 2013 |
Prostaglandin E receptor EP4 antagonism inhibits breast cancer metastasis.
Topics: Animals; Biphenyl Compounds; Cyclooxygenase 2 Inhibitors; Female; Indomethacin; Mammary Neoplasms, E | 2006 |
Effects of prostaglandin on experimental bone malignancy and on scintigrams of bone and marrow.
Topics: Animals; Bone and Bones; Bone Marrow; Bone Neoplasms; Calcium; Diphosphonates; Indomethacin; Mitomyc | 1981 |
Prostaglandin E production by Lewis lung carcinoma: mechanism for tumor establishment in vivo.
Topics: Animals; Cells, Cultured; Culture Media; Dinoprostone; Female; Indomethacin; Lung Neoplasms; Mice; M | 1984 |
Enhancement of colonic cancer by indomethacin treatment in dimethylhydrazine pretreated rats.
Topics: Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Drug Synergism; Female; Indomethacin; M | 1984 |
Nb rat prostate adenocarcinoma model androgen-sensitive tumor: metastasis control.
Topics: Adenocarcinoma; Animals; Castration; Cyclophosphamide; Disease Models, Animal; Heparin; Indomethacin | 1983 |
Control of fever associated with visceral cancers by indomethacin.
Topics: Abdominal Neoplasms; Adenocarcinoma; Adult; Aged; Female; Fever; Humans; Indomethacin; Liver Neoplas | 1981 |
Neutral proteinase inhibitors and antimetastatic effects in mice.
Topics: Animals; Aurintricarboxylic Acid; Chloroquine; Indomethacin; Lung Neoplasms; Mice; Mice, Inbred C57B | 1980 |
Effects of histamine type-2 receptor antagonists on indomethacin and IL-2 immunotherapy of metastasis.
Topics: Adenocarcinoma; Adjuvants, Immunologic; Animals; Cimetidine; Famotidine; Female; Histamine H2 Antago | 1993 |
Promotion of metastases by tumor necrosis factor in rats bearing Dunning R3327 MAT-LyLu prostatic cancer.
Topics: Adenocarcinoma; Animals; Dinoprostone; Humans; Indomethacin; Lung Neoplasms; Male; Neoplasm Metastas | 1993 |
Dietary linoleic acid-stimulated human breast cancer cell growth and metastasis in nude mice and their suppression by indomethacin, a cyclooxygenase inhibitor.
Topics: Animals; Breast Neoplasms; Cell Division; Cyclooxygenase Inhibitors; Dietary Fats; Eicosanoids; Fema | 1996 |
Identification of arachidonic acid pathways required for the invasive and metastatic activity of malignant tumor cells.
Topics: Animals; Arachidonic Acid; Caffeine; Collagen; Cyclooxygenase Inhibitors; Dinoprost; Drug Combinatio | 1996 |
Tumor responsiveness to the metastasis-stimulatory effects of prostaglandin E2 is restricted by protein phosphatases.
Topics: Animals; Cell Movement; Dinoprostone; Indomethacin; Lung Neoplasms; Mice; Neoplasm Invasiveness; Neo | 1997 |
Effect of the protein kinase inhibitors, 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine H-7 and N-(2-[methylamino]ethyl)-5-isoquinoline-sulfonamide H-8 on Lewis lung carcinoma tumor progression.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carcinoma, Lewis Lung; Cell Division; Cycloo | 1998 |
The marked anticancer effect of combined VCR, MTX, and indomethacin against drug-resistant recurrent small cell lung carcinoma after conventional chemotherapy: report of a case.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Cyclooxygenase Inhibitors; Dr | 1999 |
Increased cyclooxygenase-2 (cox-2) expression and activity in a murine model of metastatic breast cancer.
Topics: Animals; Breast Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxy | 2001 |
[Clinical use of indomethacin administered intravenously in the analgesic treatment of neoplasms with bone metastases].
Topics: Adolescent; Adult; Aged; Bone Neoplasms; Female; Humans; Indomethacin; Infusions, Parenteral; Inject | 1975 |
Anti-inflammatory drugs and tumour growth.
Topics: Animals; Aspirin; Bone Neoplasms; Carcinogens; Drug Evaluation; Humans; Indomethacin; Neoplasm Metas | 1979 |
Prostaglandin D2 controls pulmonary metastasis of malignant melanoma cells.
Topics: Animals; Cyclooxygenase Inhibitors; Indomethacin; Lung Neoplasms; Melanoma; Mice; Neoplasm Metastasi | 1979 |
Letter: Prostaglandins, indomethacin and hypercalcemia in neoplastic disease.
Topics: Aged; Carcinoma, Squamous Cell; Humans; Hypercalcemia; Indomethacin; Liver Neoplasms; Lung Neoplasms | 1975 |
Characterization of the group of patients with the hypercalcemia of cancer who respond to treatment with prostaglandin synthesis inhibitors.
Topics: Aspirin; Calcium; Cyclic AMP; Humans; Hypercalcemia; Hyperparathyroidism; Indomethacin; Neoplasm Met | 1976 |
In vitro osteolysis by human breast tumours.
Topics: Aspirin; Bone Neoplasms; Bone Resorption; Breast Neoplasms; Calcium; Female; Humans; In Vitro Techni | 1977 |
Direct resorption of bone by human breast cancer cells in vitro.
Topics: Bone Neoplasms; Bone Resorption; Breast Neoplasms; Cell Line; Female; Humans; Indomethacin; Neoplasm | 1978 |
Investigations on prostatic adenocarcinomas in rats.
Topics: Adenocarcinoma; Anesthetics; Animals; Aspirin; Cell Line; Female; Immunotherapy; Indomethacin; Lung | 1977 |
Relationship of bone destruction in skeletal metastases to osteoclast activation and prostaglandins.
Topics: Animals; Bone Neoplasms; Bone Resorption; Indomethacin; Lung Neoplasms; Neoplasm Metastasis; Neoplas | 1976 |
Plasma prostaglandin E in patients with cancer with and without hypercalcemia.
Topics: Bone Neoplasms; Female; Humans; Hypercalcemia; Indomethacin; Male; Neoplasm Metastasis; Neoplasms; P | 1976 |
Failure of indomethacin to reduce hypercalcemia in patients with breast cancer.
Topics: Aspirin; Bone Neoplasms; Breast Neoplasms; Calcium; Creatinine; Female; Humans; Hydroxyproline; Hype | 1976 |
[Paraneoplastic syndrome treated with indomethacin].
Topics: Female; Humans; Indomethacin; Middle Aged; Neoplasm Metastasis; Neoplasms; Osteoarthropathy, Seconda | 1976 |
Elevated prostaglandins and suppressed parathyroid hormone associated with hypercalcemia and renal cell carcinoma.
Topics: Adenocarcinoma; Calcium; Humans; Hypercalcemia; Indomethacin; Kidney Cortex; Liver; Liver Neoplasms; | 1975 |
Effect of IL-1 on experimental bone/bone-marrow metastases.
Topics: Animals; Bone Marrow Diseases; Bone Neoplasms; Granulocyte-Macrophage Colony-Stimulating Factor; Ind | 1992 |
Phase I trial of recombinant interleukin-2 followed by recombinant tumor necrosis factor in patients with metastatic cancer.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Blood Chemical Analysis; Dr | 1992 |
Immunotherapy of mammary adenocarcinoma metastases in C3H/HeN mice with chronic administration of cyclo-oxygenase inhibitors alone or in combination with IL-2.
Topics: Adenocarcinoma; Animals; Cell Division; Cyclooxygenase Inhibitors; Drug Therapy, Combination; Female | 1992 |
Role of the prostaglandin E2 receptor in mammary tumor metastasis.
Topics: Animals; Cyclic AMP; Dinoprostone; Indomethacin; Mammary Neoplasms, Animal; Mice; Mice, Inbred BALB | 1991 |
Correlation between secretion pattern and metastatic potential from drug-treated 3LL tumor cell line.
Topics: Animals; Calcimycin; Female; Indomethacin; Lung Neoplasms; Mice; Mice, Inbred BALB C; Molecular Weig | 1991 |
Tumoricidal activity of alveolar and peritoneal macrophages of C57BL/6 mice bearing metastatic or nonmetastatic variants of Lewis lung carcinoma.
Topics: Animals; Cytotoxicity, Immunologic; Dinoprostone; Indomethacin; Lung Neoplasms; Macrophages; Mice; N | 1991 |
Association of increased tumor cell responsiveness to prostaglandin E2 with more aggressive tumor behavior.
Topics: Animals; Cell Line; Cell Movement; Clone Cells; Dinoprostone; Fibrosarcoma; Genetic Variation; Indom | 1991 |
The inhibitory effects of prostaglandin E1 and indomethacin on the growth and metastasis of transplanted Lewis lung carcinoma in C57BL mice.
Topics: Adolescent; Alprostadil; Animals; Child; Cyclic AMP; Cyclic GMP; Female; Humans; Indomethacin; Lung | 1990 |
Inhibition of tumor growth and metastasis by chronic intravenous infusion of prostaglandin E1.
Topics: Alprostadil; Animals; Disease Models, Animal; Indomethacin; Infusions, Intravenous; Lung Neoplasms; | 1990 |
[Characteristics of metastasis and antimetastatic activity of macrophages in mice after postoperative immunomodulation].
Topics: Adjuvants, Immunologic; Animals; Dinoprostone; Indomethacin; Lung Neoplasms; Macrophages; Male; Mamm | 1990 |
[Effect of actions inhibiting neovascularization of the metastasis of Lewis lung carcinoma].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Drug Evaluation, Preclinical; Hy | 1985 |
[Therapeutic response of interferon-beta in malignant melanoma].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Dacarbazine; Female; Humans; | 1986 |
Clustering of discrete cell properties essential for tumorigenicity and metastasis. II. Studies of Syrian hamster embryo fibroblasts transformed by Rous sarcoma virus.
Topics: Animals; Avian Sarcoma Viruses; Carmustine; Cell Transformation, Viral; Cells, Cultured; Cricetinae; | 1989 |
Correlation of natural killer activity with tumorigenesis of a preneoplastic mouse mammary lesion.
Topics: Animals; Female; G(M1) Ganglioside; Glycosphingolipids; Indomethacin; Interleukin-2; Killer Cells, N | 1989 |
Indomethacin therapy abrogates the prostaglandin-mediated suppression of natural killer activity in tumor-bearing mice and prevents tumor metastasis.
Topics: Animals; Cytotoxicity, Immunologic; Dinoprostone; Indomethacin; Killer Cells, Natural; Mammary Neopl | 1986 |
[Anti-cancer treatment with prostaglandin synthetase inhibitor in animal models].
Topics: Animals; Cell Division; Cyclooxygenase Inhibitors; Disease Models, Animal; Humans; Indomethacin; Mic | 1986 |
Effect of prostaglandin E2-producing nonmetastatic Lewis lung carcinoma cells on the migration of prostaglandin E2-responsive metastatic Lewis lung carcinoma cells.
Topics: 16,16-Dimethylprostaglandin E2; Animals; Clone Cells; Dinoprostone; Indomethacin; Lung Neoplasms; Mi | 1987 |
Toxicity of tumor necrosis factor is synergistic with gamma-interferon and can be reduced with cyclooxygenase inhibitors.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aspirin; Bone Marrow; Cyclooxygenase Inhibi | 1987 |
[Effect of prostaglandins on metastatic spread after surgical removal of tumors and pain stress in mice].
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Indomethacin; Male; Mice; Mice, Inbred C57BL; Neoplasm | 1987 |
Inhibition of growth and linoleate-enhanced metastasis of a transplantable mouse mammary tumor by indomethacin.
Topics: Animals; Drug Interactions; Female; Indomethacin; Linoleic Acid; Linoleic Acids; Mammary Neoplasms, | 1988 |
Differential distribution of B16F10 melanoma cells in the liver lobule.
Topics: Animals; Cell Line; Female; Indomethacin; Liver Neoplasms; Male; Melanoma; Mice; Mice, Inbred Strain | 1988 |
Heterogeneity of prostaglandin E2 binding in murine mammary tumor cells differing in metastatic potential.
Topics: Animals; Binding, Competitive; Dinoprostone; Indomethacin; Kinetics; Mammary Neoplasms, Experimental | 1988 |
Interactions of natural effector cells and prostaglandins in the control of metastasis.
Topics: Animals; Female; Indomethacin; Killer Cells, Natural; Lung Neoplasms; Male; Mice; Mice, Inbred BALB | 1987 |
Prostaglandin E2 production by EL 4 leukemia cells from C57BL/6 mice: mechanism for tumor dissemination.
Topics: Animals; Cell Line; Cell Movement; Cells, Cultured; Dinoprostone; Indomethacin; Leukemia, Experiment | 1985 |
Differential sensitivity of metastatic versus nonmetastatic mammary tumor cells to macrophage-mediated cytostasis.
Topics: Animals; Cell Line; Cytotoxicity, Immunologic; Dinoprostone; Indomethacin; Killer Cells, Natural; Li | 1985 |
Relationships of prostaglandin E and natural killer sensitivity to metastatic potential in murine mammary adenocarcinomas.
Topics: Adenocarcinoma; Animals; Catechols; Cell Line; Female; Indomethacin; Killer Cells, Natural; Male; Ma | 1985 |
Metastasis in the androgen-insensitive Nb rat prostatic carcinoma system.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cortisone; Disease Models, Animal; Drug Therapy, Com | 1985 |
[Use of meglumine indomethacin in the treatment of pain due to neoplastic diseases].
Topics: Adult; Aged; Amino Sugars; Analgesics; Female; Humans; Indomethacin; Male; Middle Aged; Neoplasm Met | 1972 |
Anti-metastatic effect of aspirin.
Topics: Animals; Aspirin; Bone Neoplasms; Bone Resorption; Carcinoma 256, Walker; Indomethacin; Lysosomes; N | 1973 |
Anti-metastatic effect of aspirin.
Topics: Animals; Aspirin; Bone Neoplasms; Bone Resorption; In Vitro Techniques; Indomethacin; Mice; Neoplasm | 1973 |
The inhibition by aspirin and indomethacin of osteolytic tumor deposits and hypercalcaemia in rats with Walker tumour, and its possible application to human breast cancer.
Topics: Animals; Aspirin; Bone and Bones; Bone Neoplasms; Bone Resorption; Breast Neoplasms; Calcium; Calciu | 1973 |
Indomethacin-responsive hypercalcemia in a patient with renal-cell adenocarcinoma.
Topics: Adenocarcinoma; Administration, Oral; Calcium; Humans; Hypercalcemia; Indomethacin; Kidney Neoplasms | 1974 |