Page last updated: 2024-10-29

indomethacin and Neoplasm Metastasis

indomethacin has been researched along with Neoplasm Metastasis in 69 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Neoplasm Metastasis: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.

Research Excerpts

ExcerptRelevanceReference
" We conducted a prospective randomized trial of alpha-interferon given with or without indomethacin to patients with malignant melanoma to determine what effect, if any, indomethacin might have on the toxic, immunomodulatory, and therapeutic properties of interferon in this disease."9.06Randomized trial of recombinant alpha 2b-interferon with or without indomethacin in patients with metastatic malignant melanoma. ( Clark, JW; Crum, E; Hawkins, MJ; Jones, MJ; Longo, DL; McKnight, JE; Miller, RL; Smith, JW; Steis, RG; Urba, WJ, 1989)
"Growth and metastasis to the lung of the human breast cancer cell line MDA-MB-435 in nude mice fed a high-fat (20% wt/wt) high-linoleic acid (LA; 12% wt/wt) diet were significantly reduced by the addition of the cyclooxygenase inhibitor indomethacin to the drinking water at a dose of 10 micrograms/ml (approximately 1 mg/kg body wt)."7.69Dietary linoleic acid-stimulated human breast cancer cell growth and metastasis in nude mice and their suppression by indomethacin, a cyclooxygenase inhibitor. ( Connolly, JM; Liu, XH; Rose, DP, 1996)
" We therefore assessed the effect of Indomethacin and aspirin on some parameters of calcium metabolism in patients with breast cancer."7.65Failure of indomethacin to reduce hypercalcemia in patients with breast cancer. ( Bondy, PK; Coombes, RC; Neville, AM; Powles, TJ, 1976)
"The hypercalcemia was unresponsive to hydration and oral phosphate."5.25Indomethacin-responsive hypercalcemia in a patient with renal-cell adenocarcinoma. ( Alexander, RW; Brereton, HD; DeVita, VT; Halushka, PV; Keiser, HR; Mason, DM, 1974)
" We conducted a prospective randomized trial of alpha-interferon given with or without indomethacin to patients with malignant melanoma to determine what effect, if any, indomethacin might have on the toxic, immunomodulatory, and therapeutic properties of interferon in this disease."5.06Randomized trial of recombinant alpha 2b-interferon with or without indomethacin in patients with metastatic malignant melanoma. ( Clark, JW; Crum, E; Hawkins, MJ; Jones, MJ; Longo, DL; McKnight, JE; Miller, RL; Smith, JW; Steis, RG; Urba, WJ, 1989)
"Growth and metastasis to the lung of the human breast cancer cell line MDA-MB-435 in nude mice fed a high-fat (20% wt/wt) high-linoleic acid (LA; 12% wt/wt) diet were significantly reduced by the addition of the cyclooxygenase inhibitor indomethacin to the drinking water at a dose of 10 micrograms/ml (approximately 1 mg/kg body wt)."3.69Dietary linoleic acid-stimulated human breast cancer cell growth and metastasis in nude mice and their suppression by indomethacin, a cyclooxygenase inhibitor. ( Connolly, JM; Liu, XH; Rose, DP, 1996)
" We report here that inhibitors of both the cyclooxygenase and lipoxygenase pathways of arachidonic acid metabolism convert mouse melanoma and human fibrosarcoma cells to a non invasive state by reducing the production of MMP-2, an enzyme required for the degradation of basement membranes."3.69Identification of arachidonic acid pathways required for the invasive and metastatic activity of malignant tumor cells. ( Martin, GR; Reich, R, 1996)
" Treatment of mice with 100 micrograms of indomethacin, a potent inhibitor of prostaglandin synthesis, prior to the injection of rhuIL-1 alpha, prevented the increase in number of bone metastases."3.68Effect of IL-1 on experimental bone/bone-marrow metastases. ( Arguello, F; Baggs, RB; Cohen, HJ; Frantz, CN; Graves, BT; Harwell, SE, 1992)
"Indomethacine, protamine-sulphate and hydrocortisone were found to decrease the activity of metastatic processes of Lewis carcinoma after the removal of the primary tumour."3.67[Effect of actions inhibiting neovascularization of the metastasis of Lewis lung carcinoma]. ( Balitskiĭ, KP; Lisniak, IA; Sopotsinskaia, EB, 1985)
" We therefore assessed the effect of Indomethacin and aspirin on some parameters of calcium metabolism in patients with breast cancer."3.65Failure of indomethacin to reduce hypercalcemia in patients with breast cancer. ( Bondy, PK; Coombes, RC; Neville, AM; Powles, TJ, 1976)
"Prostaglandin D2 was able to reduce in vitro aggregation of platelets from C57 black mice."2.36Prostaglandins and metastasis. ( Stringfellow, DA, 1983)
"Castrate-resistant prostate cancer (CRPC) is a fatal, metastatic form of prostate cancer."1.39Development of potent and selective indomethacin analogues for the inhibition of AKR1C3 (Type 5 17β-hydroxysteroid dehydrogenase/prostaglandin F synthase) in castrate-resistant prostate cancer. ( Adeniji, AO; Byrns, MC; Chen, M; Christianson, DW; Jin, Y; Liedtke, AJ; Marnett, LJ; Penning, TM, 2013)
"EP3 antagonism had no effect on tumor metastasis."1.33Prostaglandin E receptor EP4 antagonism inhibits breast cancer metastasis. ( Fulton, AM; Kundu, N; Ma, X; Rifat, S; Walser, T, 2006)
"Using a murine model of metastatic breast cancer, we show that PGE(2) levels are positively correlated with increased tumorigenic and metastatic potential."1.31Increased cyclooxygenase-2 (cox-2) expression and activity in a murine model of metastatic breast cancer. ( Dorsey, R; Fulton, AM; Kundu, N; Yang, Q, 2001)
"tumor growth, secondary lung metastasis and splenocyte cytotoxicity against YAC-1 lymphoma cells (51Cr release assay)."1.29Effects of histamine type-2 receptor antagonists on indomethacin and IL-2 immunotherapy of metastasis. ( Khoo, NK; Lala, PK; Saarloos, MN, 1993)
"Concerning the effect of rTNF on metastasis, we found that the metastasis to lung was promoted by 1 x 10(5) units of rTNF and the promotion of metastasis was restricted by indomethacin."1.29Promotion of metastases by tumor necrosis factor in rats bearing Dunning R3327 MAT-LyLu prostatic cancer. ( Iizumi, T; Soma, GI; Umeda, T; Yazaki, T, 1993)
" These agents were tested either alone for the prevention of metastasis or in combination with IL-2 for the eradication of established metastasis."1.28Immunotherapy of mammary adenocarcinoma metastases in C3H/HeN mice with chronic administration of cyclo-oxygenase inhibitors alone or in combination with IL-2. ( Chan, FP; Khoo, NK; Lala, PK; Saarloos, MN, 1992)
"Indomethacin treatment to rats bearing dimethylhydrazine-induced colonic cancer resulted in increased mortality (p less than 0."1.27Enhancement of colonic cancer by indomethacin treatment in dimethylhydrazine pretreated rats. ( Abate, S; Califano, G; Danzi, M; Ferulano, GP, 1984)
"Tumor volume, metastasis, and determination of regression of primary tumor have been evaluated."1.27Nb rat prostate adenocarcinoma model androgen-sensitive tumor: metastasis control. ( Drago, JR; Fralisch, A; Weed, P, 1983)
" A chronic administration of indomethacin in the drinking water (14 micrograms/ml) to mice beginning on Day 4 after subcutaneous transplantation of 10(6) tumor cells resulted in a significant reduction in the growth rate of primary tumors in all hosts and led to a complete or nearly complete abrogation of lung metastasis in T-58- or C3-transplanted hosts examined at 1 month after tumor transplantation; C10-transplanted mice showed no metastasis in the control or the treated group."1.27Indomethacin therapy abrogates the prostaglandin-mediated suppression of natural killer activity in tumor-bearing mice and prevents tumor metastasis. ( Lala, PK; Parhar, RS; Singh, P, 1986)
"Treatment with indomethacin substantially reduced the levels of PGs, particularly PGE2 in tumor tissue, inhibited the tumor growth, particularly the early stage of cell proliferation, prolonged the survival time, eliminated tumors in the abdominal cavity, and inhibited metastatic tumor recurrence after surgery."1.27[Anti-cancer treatment with prostaglandin synthetase inhibitor in animal models]. ( Masuda, T; Nagasawa, O; Narisawa, T; Niwa, M; Ogata, N; Takahashi, M, 1986)
"resulted in a greater number of lung metastases than did injection of metastatic cells alone."1.27Effect of prostaglandin E2-producing nonmetastatic Lewis lung carcinoma cells on the migration of prostaglandin E2-responsive metastatic Lewis lung carcinoma cells. ( Wepsic, HT; Young, ME; Young, MR, 1987)
" Treatment of mice with a higher dosage of IM (20 micrograms/ml), decreased tumor metastasis even further compared to controls, but did not decrease tumor growth rate compared to the lower dosage of IM (10 micrograms/ml)."1.27Inhibition of growth and linoleate-enhanced metastasis of a transplantable mouse mammary tumor by indomethacin. ( Chapkin, RS; Erickson, KL; Hubbard, NE, 1988)
"The spontaneous metastasis of the highly metastatic tumor designated 410."1.27Interactions of natural effector cells and prostaglandins in the control of metastasis. ( Fulton, AM, 1987)
"In addition, spontaneous metastasis of two highly metastatic tumors was partially inhibited by p."1.27Relationships of prostaglandin E and natural killer sensitivity to metastatic potential in murine mammary adenocarcinomas. ( Fulton, AM; Heppner, GH, 1985)
"Indomethacin may suppress the local acceleration of calcium metabolism."1.26Effects of prostaglandin on experimental bone malignancy and on scintigrams of bone and marrow. ( Ito, Y; Muranaka, A; Nagai, K; Otsuka, N; Terashima, H; Yanagimoto, S, 1981)
"The hypercalcemia was unresponsive to hydration and oral phosphate."1.25Indomethacin-responsive hypercalcemia in a patient with renal-cell adenocarcinoma. ( Alexander, RW; Brereton, HD; DeVita, VT; Halushka, PV; Keiser, HR; Mason, DM, 1974)

Research

Studies (69)

TimeframeStudies, this research(%)All Research%
pre-199044 (63.77)18.7374
1990's17 (24.64)18.2507
2000's3 (4.35)29.6817
2010's5 (7.25)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Liedtke, AJ1
Adeniji, AO1
Chen, M1
Byrns, MC1
Jin, Y1
Christianson, DW1
Marnett, LJ1
Penning, TM1
Wu, L1
Wang, W1
Dai, M1
Li, H1
Chen, C1
Wang, D1
Lönnroth, C1
Andersson, M1
Asting, AG1
Nordgren, S1
Lundholm, K1
Jukić, MK1
Luetić, AT1
Skudar-Lukinović, V1
Andreis, I1
Han, R1
Xiong, J1
Xiao, R1
Altaf, E1
Wang, J1
Liu, Y1
Xu, H1
Ding, Q1
Zhang, Q1
Page, GG1
Ma, X1
Kundu, N2
Rifat, S1
Walser, T1
Fulton, AM6
Stringfellow, DA2
Cattan, A1
Otsuka, N1
Ito, Y1
Nagai, K1
Terashima, H1
Yanagimoto, S1
Muranaka, A1
Young, MR6
Knies, S1
Danzi, M1
Ferulano, GP1
Abate, S1
Califano, G1
Drago, JR2
Weed, P1
Fralisch, A1
Warshaw, AL1
Carey, RW1
Robinson, DR1
Giraldi, T1
Sava, G1
Kopitar, M1
Brzin, J1
Turk, V1
Saarloos, MN2
Khoo, NK2
Lala, PK3
Iizumi, T1
Yazaki, T1
Umeda, T1
Soma, GI1
Connolly, JM1
Liu, XH1
Rose, DP1
Reich, R1
Martin, GR1
Lozano, Y1
Djordjevic, A1
Maier, GD1
Young, ME2
Blaya, C1
Crespo, J1
Crespo, A1
Aliño, SF3
Kobayashi, S1
Okada, S1
Hasumi, T1
Sato, N1
Fujimura, S1
Yang, Q1
Dorsey, R1
Puppo, N1
De Thomatis, M1
Oddone, G1
Fitzpatrick, FA1
Benvenisti, D1
Goldberg, H1
Seyberth, HW1
Segre, GV1
Hamet, P1
Sweetman, BJ1
Potts, JT1
Oates, JA1
Easty, GC3
Dowsett, M1
Powles, TJ4
Easty, DM3
Gazet, JC1
Neville, AM4
Eilon, G1
Mundy, GR1
Pollard, M1
Chang, CF1
Luckert, PH1
Galasko, CS1
Bennett, A1
Robertson, RP2
Baylink, DJ2
Metz, SA1
Cummings, KB1
Coombes, RC1
Bondy, PK1
Guida, B1
Piersantelli, N1
Marini, BJ1
Adkison, HW1
Arguello, F1
Baggs, RB1
Graves, BT1
Harwell, SE1
Cohen, HJ1
Frantz, CN1
Negrier, MS1
Pourreau, CN1
Palmer, PA1
Ranchere, JY1
Mercatello, A1
Viens, P1
Blaise, D1
Jasmin, C1
Misset, JL1
Franks, CR1
Chan, FP1
Zhang, SZ1
Chong, YC1
Barbero, MC1
Garcia, M1
Almena, A1
Duffie, GP1
Okada, F1
Tada, M1
Hosokawa, M1
Kobayashi, H1
Tang, DG1
Tian, HS1
Ellis, LM1
Copeland, EM1
Bland, KI1
Sitren, HS1
Taraskina, NP1
Iunker, VM1
Surkova, OIu1
Sopotsinskaia, EB1
Lisniak, IA1
Balitskiĭ, KP1
Ishihara, K1
Deichman, GI1
Kashleva, HA1
Kluchareva, TE1
Matveeva, VA1
Miller, RL1
Steis, RG1
Clark, JW1
Smith, JW1
Crum, E1
McKnight, JE1
Hawkins, MJ1
Jones, MJ1
Longo, DL1
Urba, WJ1
Wei, WZ1
Fulton, A2
Winkelhake, J1
Heppner, G2
Parhar, RS1
Singh, P1
Narisawa, T1
Takahashi, M1
Masuda, T1
Nagasawa, O1
Ogata, N1
Niwa, M1
Wepsic, HT1
Talmadge, JE1
Bowersox, O1
Tribble, H1
Lee, SH1
Shepard, HM1
Liggitt, D1
Shmal'ko, IuP1
Grinzhevskaia, SN1
Hubbard, NE1
Chapkin, RS1
Erickson, KL1
Hilario, E1
Unda, F1
Hanchin, CM1
Butler, WB1
Mahan, M1
Meunier, J1
Newby, M1
Yamashina, K1
Heppner, GH1
Lombard, JS1
De Marzi, S1
Morini, V1
LiVolsi, VA1
Clark, SA1
Brereton, HD1
Halushka, PV1
Alexander, RW1
Mason, DM1
Keiser, HR1
DeVita, VT1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Atavistic Chemotherapy and Immunotherapy in Advanced, Metastatic, and Otherwise Incurable and Lethal Cancers Under Conventional Treatments[NCT02366884]Phase 2250 participants (Anticipated)Interventional2011-07-26Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for indomethacin and Neoplasm Metastasis

ArticleYear
The immune-suppressive effects of pain.
    Advances in experimental medicine and biology, 2003, Volume: 521

    Topics: Analgesics, Opioid; Animals; Bupivacaine; Cyclooxygenase Inhibitors; Fentanyl; Humans; Immune Tolera

2003
Prostaglandins and metastasis.
    Symposium on Fundamental Cancer Research, 1983, Volume: 36

    Topics: Animals; Cell Line; Cytotoxicity, Immunologic; Immunity, Innate; Indomethacin; Interferons; Killer C

1983
[Hemostasis and tumor invasion. Therapeutic implications].
    Bulletin du cancer, 1984, Volume: 71, Issue:5

    Topics: Animals; Antifibrinolytic Agents; Antineoplastic Combined Chemotherapy Protocols; Blood Coagulation

1984

Trials

2 trials available for indomethacin and Neoplasm Metastasis

ArticleYear
[Hemostasis and tumor invasion. Therapeutic implications].
    Bulletin du cancer, 1984, Volume: 71, Issue:5

    Topics: Animals; Antifibrinolytic Agents; Antineoplastic Combined Chemotherapy Protocols; Blood Coagulation

1984
Randomized trial of recombinant alpha 2b-interferon with or without indomethacin in patients with metastatic malignant melanoma.
    Cancer research, 1989, Apr-01, Volume: 49, Issue:7

    Topics: Adult; Aged; Aspirin; Clinical Trials as Topic; Female; Humans; Indomethacin; Interferon Type I; Kil

1989

Other Studies

65 other studies available for indomethacin and Neoplasm Metastasis

ArticleYear
Development of potent and selective indomethacin analogues for the inhibition of AKR1C3 (Type 5 17β-hydroxysteroid dehydrogenase/prostaglandin F synthase) in castrate-resistant prostate cancer.
    Journal of medicinal chemistry, 2013, Mar-28, Volume: 56, Issue:6

    Topics: 3-Hydroxysteroid Dehydrogenases; Aldo-Keto Reductase Family 1 Member C3; Catalytic Domain; Enzyme In

2013
PPARα ligand, AVE8134, and cyclooxygenase inhibitor therapy synergistically suppress lung cancer growth and metastasis.
    BMC cancer, 2019, Dec-02, Volume: 19, Issue:1

    Topics: Animals; Antineoplastic Agents; Benzoates; Bezafibrate; Cell Line, Tumor; Cell Movement; Cell Prolif

2019
Preoperative low dose NSAID treatment influences the genes for stemness, growth, invasion and metastasis in colorectal cancer.
    International journal of oncology, 2014, Volume: 45, Issue:6

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Biomarkers, Tumor; Celecoxib; Colorectal Neoplasms; Female;

2014
The antimetastatic effect of macrophages restored by indomethacin: concomitant tumor immunity model.
    Collegium antropologicum, 2010, Volume: 34, Issue:3

    Topics: Adoptive Transfer; Animals; Female; Indomethacin; Lung Neoplasms; Macrophages; Male; Mammary Neoplas

2010
Activation of β-catenin signaling is critical for doxorubicin-induced epithelial-mesenchymal transition in BGC-823 gastric cancer cell line.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2013, Volume: 34, Issue:1

    Topics: beta Catenin; Cell Line, Tumor; Cell Movement; Doxorubicin; Enzyme Activation; Epithelial-Mesenchyma

2013
Prostaglandin E receptor EP4 antagonism inhibits breast cancer metastasis.
    Cancer research, 2006, Mar-15, Volume: 66, Issue:6

    Topics: Animals; Biphenyl Compounds; Cyclooxygenase 2 Inhibitors; Female; Indomethacin; Mammary Neoplasms, E

2006
Effects of prostaglandin on experimental bone malignancy and on scintigrams of bone and marrow.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1981, Volume: 22, Issue:5

    Topics: Animals; Bone and Bones; Bone Marrow; Bone Neoplasms; Calcium; Diphosphonates; Indomethacin; Mitomyc

1981
Prostaglandin E production by Lewis lung carcinoma: mechanism for tumor establishment in vivo.
    Journal of the National Cancer Institute, 1984, Volume: 72, Issue:4

    Topics: Animals; Cells, Cultured; Culture Media; Dinoprostone; Female; Indomethacin; Lung Neoplasms; Mice; M

1984
Enhancement of colonic cancer by indomethacin treatment in dimethylhydrazine pretreated rats.
    Carcinogenesis, 1984, Volume: 5, Issue:2

    Topics: Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Drug Synergism; Female; Indomethacin; M

1984
Nb rat prostate adenocarcinoma model androgen-sensitive tumor: metastasis control.
    Journal of surgical oncology, 1983, Volume: 24, Issue:1

    Topics: Adenocarcinoma; Animals; Castration; Cyclophosphamide; Disease Models, Animal; Heparin; Indomethacin

1983
Control of fever associated with visceral cancers by indomethacin.
    Surgery, 1981, Volume: 89, Issue:4

    Topics: Abdominal Neoplasms; Adenocarcinoma; Adult; Aged; Female; Fever; Humans; Indomethacin; Liver Neoplas

1981
Neutral proteinase inhibitors and antimetastatic effects in mice.
    European journal of cancer, 1980, Volume: 16, Issue:4

    Topics: Animals; Aurintricarboxylic Acid; Chloroquine; Indomethacin; Lung Neoplasms; Mice; Mice, Inbred C57B

1980
Effects of histamine type-2 receptor antagonists on indomethacin and IL-2 immunotherapy of metastasis.
    Clinical & experimental metastasis, 1993, Volume: 11, Issue:3

    Topics: Adenocarcinoma; Adjuvants, Immunologic; Animals; Cimetidine; Famotidine; Female; Histamine H2 Antago

1993
Promotion of metastases by tumor necrosis factor in rats bearing Dunning R3327 MAT-LyLu prostatic cancer.
    Urologia internationalis, 1993, Volume: 51, Issue:2

    Topics: Adenocarcinoma; Animals; Dinoprostone; Humans; Indomethacin; Lung Neoplasms; Male; Neoplasm Metastas

1993
Dietary linoleic acid-stimulated human breast cancer cell growth and metastasis in nude mice and their suppression by indomethacin, a cyclooxygenase inhibitor.
    Nutrition and cancer, 1996, Volume: 25, Issue:3

    Topics: Animals; Breast Neoplasms; Cell Division; Cyclooxygenase Inhibitors; Dietary Fats; Eicosanoids; Fema

1996
Identification of arachidonic acid pathways required for the invasive and metastatic activity of malignant tumor cells.
    Prostaglandins, 1996, Volume: 51, Issue:1

    Topics: Animals; Arachidonic Acid; Caffeine; Collagen; Cyclooxygenase Inhibitors; Dinoprost; Drug Combinatio

1996
Tumor responsiveness to the metastasis-stimulatory effects of prostaglandin E2 is restricted by protein phosphatases.
    Advances in experimental medicine and biology, 1997, Volume: 400A

    Topics: Animals; Cell Movement; Dinoprostone; Indomethacin; Lung Neoplasms; Mice; Neoplasm Invasiveness; Neo

1997
Effect of the protein kinase inhibitors, 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine H-7 and N-(2-[methylamino]ethyl)-5-isoquinoline-sulfonamide H-8 on Lewis lung carcinoma tumor progression.
    European journal of pharmacology, 1998, Jul-31, Volume: 354, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carcinoma, Lewis Lung; Cell Division; Cycloo

1998
The marked anticancer effect of combined VCR, MTX, and indomethacin against drug-resistant recurrent small cell lung carcinoma after conventional chemotherapy: report of a case.
    Surgery today, 1999, Volume: 29, Issue:7

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Cyclooxygenase Inhibitors; Dr

1999
Increased cyclooxygenase-2 (cox-2) expression and activity in a murine model of metastatic breast cancer.
    International journal of cancer, 2001, Sep-01, Volume: 93, Issue:5

    Topics: Animals; Breast Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxy

2001
[Clinical use of indomethacin administered intravenously in the analgesic treatment of neoplasms with bone metastases].
    La Clinica terapeutica, 1975, Jun-30, Volume: 73, Issue:6

    Topics: Adolescent; Adult; Aged; Bone Neoplasms; Female; Humans; Indomethacin; Infusions, Parenteral; Inject

1975
Anti-inflammatory drugs and tumour growth.
    Lancet (London, England), 1979, Feb-24, Volume: 1, Issue:8113

    Topics: Animals; Aspirin; Bone Neoplasms; Carcinogens; Drug Evaluation; Humans; Indomethacin; Neoplasm Metas

1979
Prostaglandin D2 controls pulmonary metastasis of malignant melanoma cells.
    Nature, 1979, Nov-01, Volume: 282, Issue:5734

    Topics: Animals; Cyclooxygenase Inhibitors; Indomethacin; Lung Neoplasms; Melanoma; Mice; Neoplasm Metastasi

1979
Letter: Prostaglandins, indomethacin and hypercalcemia in neoplastic disease.
    The New England journal of medicine, 1975, May-29, Volume: 292, Issue:22

    Topics: Aged; Carcinoma, Squamous Cell; Humans; Hypercalcemia; Indomethacin; Liver Neoplasms; Lung Neoplasms

1975
Characterization of the group of patients with the hypercalcemia of cancer who respond to treatment with prostaglandin synthesis inhibitors.
    Transactions of the Association of American Physicians, 1976, Volume: 89

    Topics: Aspirin; Calcium; Cyclic AMP; Humans; Hypercalcemia; Hyperparathyroidism; Indomethacin; Neoplasm Met

1976
In vitro osteolysis by human breast tumours.
    Proceedings of the Royal Society of Medicine, 1977, Volume: 70, Issue:3

    Topics: Aspirin; Bone Neoplasms; Bone Resorption; Breast Neoplasms; Calcium; Female; Humans; In Vitro Techni

1977
Direct resorption of bone by human breast cancer cells in vitro.
    Nature, 1978, Dec-14, Volume: 276, Issue:5689

    Topics: Bone Neoplasms; Bone Resorption; Breast Neoplasms; Cell Line; Female; Humans; Indomethacin; Neoplasm

1978
Investigations on prostatic adenocarcinomas in rats.
    Oncology, 1977, Volume: 34, Issue:3

    Topics: Adenocarcinoma; Anesthetics; Animals; Aspirin; Cell Line; Female; Immunotherapy; Indomethacin; Lung

1977
Relationship of bone destruction in skeletal metastases to osteoclast activation and prostaglandins.
    Nature, 1976, Oct-07, Volume: 263, Issue:5577

    Topics: Animals; Bone Neoplasms; Bone Resorption; Indomethacin; Lung Neoplasms; Neoplasm Metastasis; Neoplas

1976
Plasma prostaglandin E in patients with cancer with and without hypercalcemia.
    The Journal of clinical endocrinology and metabolism, 1976, Volume: 43, Issue:6

    Topics: Bone Neoplasms; Female; Humans; Hypercalcemia; Indomethacin; Male; Neoplasm Metastasis; Neoplasms; P

1976
Failure of indomethacin to reduce hypercalcemia in patients with breast cancer.
    Prostaglandins, 1976, Volume: 12, Issue:6

    Topics: Aspirin; Bone Neoplasms; Breast Neoplasms; Calcium; Creatinine; Female; Humans; Hydroxyproline; Hype

1976
[Paraneoplastic syndrome treated with indomethacin].
    La Clinica terapeutica, 1976, Nov-30, Volume: 79, Issue:4

    Topics: Female; Humans; Indomethacin; Middle Aged; Neoplasm Metastasis; Neoplasms; Osteoarthropathy, Seconda

1976
Elevated prostaglandins and suppressed parathyroid hormone associated with hypercalcemia and renal cell carcinoma.
    The Journal of clinical endocrinology and metabolism, 1975, Volume: 41, Issue:1

    Topics: Adenocarcinoma; Calcium; Humans; Hypercalcemia; Indomethacin; Kidney Cortex; Liver; Liver Neoplasms;

1975
Effect of IL-1 on experimental bone/bone-marrow metastases.
    International journal of cancer, 1992, Nov-11, Volume: 52, Issue:5

    Topics: Animals; Bone Marrow Diseases; Bone Neoplasms; Granulocyte-Macrophage Colony-Stimulating Factor; Ind

1992
Phase I trial of recombinant interleukin-2 followed by recombinant tumor necrosis factor in patients with metastatic cancer.
    Journal of immunotherapy : official journal of the Society for Biological Therapy, 1992, Volume: 11, Issue:2

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Blood Chemical Analysis; Dr

1992
Immunotherapy of mammary adenocarcinoma metastases in C3H/HeN mice with chronic administration of cyclo-oxygenase inhibitors alone or in combination with IL-2.
    Clinical & experimental metastasis, 1992, Volume: 10, Issue:4

    Topics: Adenocarcinoma; Animals; Cell Division; Cyclooxygenase Inhibitors; Drug Therapy, Combination; Female

1992
Role of the prostaglandin E2 receptor in mammary tumor metastasis.
    Cancer research, 1991, Apr-15, Volume: 51, Issue:8

    Topics: Animals; Cyclic AMP; Dinoprostone; Indomethacin; Mammary Neoplasms, Animal; Mice; Mice, Inbred BALB

1991
Correlation between secretion pattern and metastatic potential from drug-treated 3LL tumor cell line.
    Cellular and molecular biology, 1991, Volume: 37, Issue:5

    Topics: Animals; Calcimycin; Female; Indomethacin; Lung Neoplasms; Mice; Mice, Inbred BALB C; Molecular Weig

1991
Tumoricidal activity of alveolar and peritoneal macrophages of C57BL/6 mice bearing metastatic or nonmetastatic variants of Lewis lung carcinoma.
    Journal of leukocyte biology, 1991, Volume: 49, Issue:1

    Topics: Animals; Cytotoxicity, Immunologic; Dinoprostone; Indomethacin; Lung Neoplasms; Macrophages; Mice; N

1991
Association of increased tumor cell responsiveness to prostaglandin E2 with more aggressive tumor behavior.
    Invasion & metastasis, 1991, Volume: 11, Issue:1

    Topics: Animals; Cell Line; Cell Movement; Clone Cells; Dinoprostone; Fibrosarcoma; Genetic Variation; Indom

1991
The inhibitory effects of prostaglandin E1 and indomethacin on the growth and metastasis of transplanted Lewis lung carcinoma in C57BL mice.
    Chinese medical journal, 1990, Volume: 103, Issue:3

    Topics: Adolescent; Alprostadil; Animals; Child; Cyclic AMP; Cyclic GMP; Female; Humans; Indomethacin; Lung

1990
Inhibition of tumor growth and metastasis by chronic intravenous infusion of prostaglandin E1.
    Annals of surgery, 1990, Volume: 212, Issue:1

    Topics: Alprostadil; Animals; Disease Models, Animal; Indomethacin; Infusions, Intravenous; Lung Neoplasms;

1990
[Characteristics of metastasis and antimetastatic activity of macrophages in mice after postoperative immunomodulation].
    Eksperimental'naia onkologiia, 1990, Volume: 12, Issue:4

    Topics: Adjuvants, Immunologic; Animals; Dinoprostone; Indomethacin; Lung Neoplasms; Macrophages; Male; Mamm

1990
[Effect of actions inhibiting neovascularization of the metastasis of Lewis lung carcinoma].
    Eksperimental'naia onkologiia, 1985, Volume: 7, Issue:5

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Drug Evaluation, Preclinical; Hy

1985
[Therapeutic response of interferon-beta in malignant melanoma].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1986, Volume: 13, Issue:4 Pt 1

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Dacarbazine; Female; Humans;

1986
Clustering of discrete cell properties essential for tumorigenicity and metastasis. II. Studies of Syrian hamster embryo fibroblasts transformed by Rous sarcoma virus.
    International journal of cancer, 1989, Nov-15, Volume: 44, Issue:5

    Topics: Animals; Avian Sarcoma Viruses; Carmustine; Cell Transformation, Viral; Cells, Cultured; Cricetinae;

1989
Correlation of natural killer activity with tumorigenesis of a preneoplastic mouse mammary lesion.
    Cancer research, 1989, May-15, Volume: 49, Issue:10

    Topics: Animals; Female; G(M1) Ganglioside; Glycosphingolipids; Indomethacin; Interleukin-2; Killer Cells, N

1989
Indomethacin therapy abrogates the prostaglandin-mediated suppression of natural killer activity in tumor-bearing mice and prevents tumor metastasis.
    Cellular immunology, 1986, Apr-15, Volume: 99, Issue:1

    Topics: Animals; Cytotoxicity, Immunologic; Dinoprostone; Indomethacin; Killer Cells, Natural; Mammary Neopl

1986
[Anti-cancer treatment with prostaglandin synthetase inhibitor in animal models].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1986, Volume: 13, Issue:4 Pt 2

    Topics: Animals; Cell Division; Cyclooxygenase Inhibitors; Disease Models, Animal; Humans; Indomethacin; Mic

1986
Effect of prostaglandin E2-producing nonmetastatic Lewis lung carcinoma cells on the migration of prostaglandin E2-responsive metastatic Lewis lung carcinoma cells.
    Cancer research, 1987, Jul-15, Volume: 47, Issue:14

    Topics: 16,16-Dimethylprostaglandin E2; Animals; Clone Cells; Dinoprostone; Indomethacin; Lung Neoplasms; Mi

1987
Toxicity of tumor necrosis factor is synergistic with gamma-interferon and can be reduced with cyclooxygenase inhibitors.
    The American journal of pathology, 1987, Volume: 128, Issue:3

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aspirin; Bone Marrow; Cyclooxygenase Inhibi

1987
[Effect of prostaglandins on metastatic spread after surgical removal of tumors and pain stress in mice].
    Eksperimental'naia onkologiia, 1987, Volume: 9, Issue:5

    Topics: Animals; Arachidonic Acid; Arachidonic Acids; Indomethacin; Male; Mice; Mice, Inbred C57BL; Neoplasm

1987
Inhibition of growth and linoleate-enhanced metastasis of a transplantable mouse mammary tumor by indomethacin.
    Cancer letters, 1988, Dec-01, Volume: 43, Issue:1-2

    Topics: Animals; Drug Interactions; Female; Indomethacin; Linoleic Acid; Linoleic Acids; Mammary Neoplasms,

1988
Differential distribution of B16F10 melanoma cells in the liver lobule.
    Experimental cell biology, 1988, Volume: 56, Issue:6

    Topics: Animals; Cell Line; Female; Indomethacin; Liver Neoplasms; Male; Melanoma; Mice; Mice, Inbred Strain

1988
Heterogeneity of prostaglandin E2 binding in murine mammary tumor cells differing in metastatic potential.
    Invasion & metastasis, 1988, Volume: 8, Issue:1

    Topics: Animals; Binding, Competitive; Dinoprostone; Indomethacin; Kinetics; Mammary Neoplasms, Experimental

1988
Interactions of natural effector cells and prostaglandins in the control of metastasis.
    Journal of the National Cancer Institute, 1987, Volume: 78, Issue:4

    Topics: Animals; Female; Indomethacin; Killer Cells, Natural; Lung Neoplasms; Male; Mice; Mice, Inbred BALB

1987
Prostaglandin E2 production by EL 4 leukemia cells from C57BL/6 mice: mechanism for tumor dissemination.
    Journal of the National Cancer Institute, 1985, Volume: 74, Issue:1

    Topics: Animals; Cell Line; Cell Movement; Cells, Cultured; Dinoprostone; Indomethacin; Leukemia, Experiment

1985
Differential sensitivity of metastatic versus nonmetastatic mammary tumor cells to macrophage-mediated cytostasis.
    Journal of the National Cancer Institute, 1985, Volume: 75, Issue:4

    Topics: Animals; Cell Line; Cytotoxicity, Immunologic; Dinoprostone; Indomethacin; Killer Cells, Natural; Li

1985
Relationships of prostaglandin E and natural killer sensitivity to metastatic potential in murine mammary adenocarcinomas.
    Cancer research, 1985, Volume: 45, Issue:10

    Topics: Adenocarcinoma; Animals; Catechols; Cell Line; Female; Indomethacin; Killer Cells, Natural; Male; Ma

1985
Metastasis in the androgen-insensitive Nb rat prostatic carcinoma system.
    Journal of surgical oncology, 1985, Volume: 28, Issue:4

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cortisone; Disease Models, Animal; Drug Therapy, Com

1985
[Use of meglumine indomethacin in the treatment of pain due to neoplastic diseases].
    La Clinica terapeutica, 1972, Jul-19, Volume: 62, Issue:2

    Topics: Adult; Aged; Amino Sugars; Analgesics; Female; Humans; Indomethacin; Male; Middle Aged; Neoplasm Met

1972
Anti-metastatic effect of aspirin.
    Lancet (London, England), 1973, Jul-14, Volume: 2, Issue:7820

    Topics: Animals; Aspirin; Bone Neoplasms; Bone Resorption; Carcinoma 256, Walker; Indomethacin; Lysosomes; N

1973
Anti-metastatic effect of aspirin.
    Lancet (London, England), 1973, Aug-04, Volume: 2, Issue:7823

    Topics: Animals; Aspirin; Bone Neoplasms; Bone Resorption; In Vitro Techniques; Indomethacin; Mice; Neoplasm

1973
The inhibition by aspirin and indomethacin of osteolytic tumor deposits and hypercalcaemia in rats with Walker tumour, and its possible application to human breast cancer.
    British journal of cancer, 1973, Volume: 28, Issue:4

    Topics: Animals; Aspirin; Bone and Bones; Bone Neoplasms; Bone Resorption; Breast Neoplasms; Calcium; Calciu

1973
Indomethacin-responsive hypercalcemia in a patient with renal-cell adenocarcinoma.
    The New England journal of medicine, 1974, Jun-11, Volume: 291, Issue:2

    Topics: Adenocarcinoma; Administration, Oral; Calcium; Humans; Hypercalcemia; Indomethacin; Kidney Neoplasms

1974
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