Page last updated: 2024-10-29

indomethacin and Necrotizing Enterocolitis

indomethacin has been researched along with Necrotizing Enterocolitis in 59 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Research Excerpts

ExcerptRelevanceReference
"The use of indomethacin as a tocolytic agent for preterm labor is associated with an increased risk for severe intraventricular hemorrhage, necrotizing enterocolitis, and periventricular leukomalacia."8.91Antenatal exposure to indomethacin increases the risk of severe intraventricular hemorrhage, necrotizing enterocolitis, and periventricular leukomalacia: a systematic review with metaanalysis. ( Hammers, AL; Kaunitz, AM; Sanchez-Ramos, L, 2015)
"To determine if intestinal perforations before 14 days (either spontaneous (SIP) or necrotizing enterocolitis-induced) are increased when infants who received antenatal betamethasone shortly before birth are treated with prophylactic indomethacin (PINDO)."8.31Prophylactic indomethacin, antenatal betamethasone, and the risk of intestinal perforation in infants <28 weeks' gestation. ( Clyman, RI; Hills, NK, 2023)
"Postnatal indomethacin is reportedly associated with an increased incidence of necrotizing enterocolitis (NEC) in preterm infants."7.77The risk of necrotizing enterocolitis after indomethacin tocolysis. ( Holzhausen, KA; Kellogg, H; Lulic-Botica, M; Pruder, S; Salari, V; Sood, BG; Thomas, R, 2011)
"To examine the ontogeny of salivary epidermal growth factor (sEGF) in premature infants and to determine the relation of sEGF to the development of necrotizing enterocolitis (NEC)."7.74Ontogeny of salivary epidermal growth factor and necrotizing enterocolitis. ( Erwin, CR; Leonard, AC; Ryan, AL; Seeger, K; Warner, BB; Warner, BW, 2007)
"A retrospective study to compare the incidence of NEC, NEC-related gastrointestinal complications and isolated gastrointestinal perforation among premature infants treated for a PDA with either, indomethacin alone (I), surgical ligation alone (L), or indomethacin followed by surgical ligation (I-L)."7.72Necrotizing enterocolitis and gastrointestinal complications after indomethacin therapy and surgical ligation in premature infants with patent ductus arteriosus. ( Adams, JM; Adams, K; Baetiong, A; Chen, A; O'Donovan, DJ; Smith, EO; Weisman, LE, 2003)
"Tocolysis with indomethacin as a single agent was not associated with necrotizing enterocolitis in this case-control study."7.70Indomethacin tocolysis and risk of necrotizing enterocolitis. ( Dooley, SL; Grobman, WA; Holtzman, RB; Parilla, BV; Thomas, HA, 2000)
"(2) Multiple analyses showed that patent ductus arteriosus(PDA) (odds ratio[OR] = 5."5.91Patent ductus arterious and increased conjugated bilirubin in the second week after birth are independent risk factors for necrotizing enterocolitis in preterm infants: an observational study. ( Cui, S; Han, X, 2023)
"Expectant management for PDA in extremely premature infants was noninferior to early ibuprofen treatment with respect to necrotizing enterocolitis, bronchopulmonary dysplasia, or death at 36 weeks' postmenstrual age."5.69Expectant Management or Early Ibuprofen for Patent Ductus Arteriosus. ( Avino, D; de Baat, T; De Bisschop, B; de Boode, WP; de Vries, WB; Derriks, F; Dijk, PH; Dijkman, KP; Donders, R; Henriksen, TB; Hocq, C; Hundscheid, T; Kooi, EMW; Kroon, AA; Kyng, KJ; Meeus, M; Mulder, AL; Mulder-de Tollenaer, SM; Nuytemans, DHGM; Onland, W; van Kaam, AH; Van Overmeire, B; Vijlbrief, DC; Villamor, E; Visser, R; Zecic, A, 2023)
"Indomethacin has been also used in women with short cervices as well as in those with idiopathic polyhydramnios."5.38Indomethacin in pregnancy: applications and safety. ( Abou-Ghannam, G; Nassar, AH; Usta, IM, 2012)
"The effect of patent ductus arteriosus on necrotizing enterocolitis was assessed using multiple regression analysis."5.33Patent ductus arteriosus, indomethacin and necrotizing enterocolitis in very low birth weight infants: a population-based study. ( Dollberg, S; Lusky, A; Reichman, B, 2005)
"Indomethacin use has been implicated as a co-risk factor for SIP when combined with glucocorticoids, but previous evidence argued against indomethacin being an independent risk factor when used prophylactically."5.33New insights into spontaneous intestinal perforation using a national data set: (1) SIP is associated with early indomethacin exposure. ( Attridge, JT; Clark, R; Gordon, PV; Walker, MW, 2006)
" We used the GRADE approach to assess the certainty of evidence for the following outcomes: failure of PDA closure within one week of administration of the first dose of indomethacin; bronchopulmonary dysplasia (BPD) at 28 days' postnatal age and at 36 weeks' postmenstrual age; proportion of infants requiring surgical ligation or transcatheter occlusion; all-cause neonatal mortality; necrotizing enterocolitis (NEC) (≥ Bell stage 2); and mucocutaneous or gastrointestinal bleeding."5.12Indomethacin for symptomatic patent ductus arteriosus in preterm infants. ( Evans, P; Flyer, JN; Mitra, S; O'Reilly, D; Soll, R, 2021)
" In view of this and with its higher incidence of necrotizing enterocolitis, we do not recommend using prolonged low-dose indomethacin for closing the patent ductus arteriosus in very low birth weight infants."5.10Randomized trial of prolonged low-dose versus conventional-dose indomethacin for treating patent ductus arteriosus in very low birth weight infants. ( Lee, J; Leong, JY; Rajadurai, VS; Tan, KW; Wong, EH; Wong, KY, 2003)
"In extremely-low-birth-weight infants, prophylaxis with indomethacin does not improve the rate of survival without neurosensory impairment at 18 months, despite the fact that it reduces the frequency of patent ductus arteriosus and severe periventricular and intraventricular hemorrhage."5.09Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants. ( Davis, P; Moddemann, D; Ohlsson, A; Roberts, RS; Saigal, S; Schmidt, B; Solimano, A; Vincer, M; Wright, LL, 2001)
" Moderate certainty evidence showed a reduction in NEC following administration of a combination of species of probiotics, probiotics (any), antenatal corticosteroids in pregnant women at risk of preterm birth, and ibuprofen versus indomethacin for treatment of patent ductus arteriosus (PDA)."5.05An Overview of Systematic Reviews of Randomized-Controlled Trials for Preventing Necrotizing Enterocolitis in Preterm Infants. ( Ei-Saie, A; Maheshwari, A; Neu, J; Pammi, M; Xiong, T, 2020)
"A high dose of oral ibuprofen was associated with a higher likelihood of hemodynamically significant PDA closure vs standard doses of intravenous ibuprofen or intravenous indomethacin; placebo or no treatment did not significantly change the likelihood of mortality, necrotizing enterocolitis, or intraventricular hemorrhage."4.98Association of Placebo, Indomethacin, Ibuprofen, and Acetaminophen With Closure of Hemodynamically Significant Patent Ductus Arteriosus in Preterm Infants: A Systematic Review and Meta-analysis. ( Florez, ID; Mbuagbaw, L; Mitra, S; Sadeghirad, B; Tamayo, ME; Thabane, L; Vanniyasingam, T; Veroniki, AA; Zea, AM; Zhang, Y, 2018)
" Oral ibuprofen is associated with lower instance of necrotizing enterocolitis."4.95Patent Ductus Arteriosus in the Preterm Infant: Diagnostic and Treatment Options. ( Keim-Malpass, J; Prescott, S, 2017)
"The use of indomethacin as a tocolytic agent for preterm labor is associated with an increased risk for severe intraventricular hemorrhage, necrotizing enterocolitis, and periventricular leukomalacia."4.91Antenatal exposure to indomethacin increases the risk of severe intraventricular hemorrhage, necrotizing enterocolitis, and periventricular leukomalacia: a systematic review with metaanalysis. ( Hammers, AL; Kaunitz, AM; Sanchez-Ramos, L, 2015)
"Antenatal indomethacin may be associated with an increased risk of periventricular leukomalacia and necrotizing enterocolitis in premature infants and therefore should be used judiciously for tocolysis."4.84Metaanalysis of the effect of antenatal indomethacin on neonatal outcomes. ( Amin, SB; Glantz, JC; Sinkin, RA, 2007)
"To determine if intestinal perforations before 14 days (either spontaneous (SIP) or necrotizing enterocolitis-induced) are increased when infants who received antenatal betamethasone shortly before birth are treated with prophylactic indomethacin (PINDO)."4.31Prophylactic indomethacin, antenatal betamethasone, and the risk of intestinal perforation in infants <28 weeks' gestation. ( Clyman, RI; Hills, NK, 2023)
" Magnesium sulfate administration, steroid administration, maternal diabetes mellitus, gestational age at delivery, indomethacin exposure, birthweight, and chorioamnionitis were all considered as possible covariates in the multivariable regression models."3.83Effect of obesity on neonatal outcomes in pregnancies with preterm premature rupture of membranes. ( DeWitt, PE; Faucett, AM; Gibbs, RS; Metz, TD, 2016)
"To compare the incidence of medical closure of patent ductus arteriosus (PDA) and adverse events (acute renal dysfunction, necrotizing enterocolitis, spontaneous intestinal perforation, and gastrointestinal bleeding) between preterm infants who received indomethacin and ibuprofen for the treatment of PDA."3.79Effectiveness and safety of indomethacin versus ibuprofen for the treatment of patent ductus arteriosus in preterm infants. ( Bali, V; Harabor, A; Kamaluddeen, M; Sivanandan, S; Soraisham, AS, 2013)
" Infants who had PDA and survived beyond 72 hours were included in multivariable logistic regression analyses that compared mortality or any severe neonatal morbidity (intraventricular hemorrhage grades ≥ 3, retinopathy of prematurity stages ≥ 3, bronchopulmonary dysplasia, or necrotizing enterocolitis stages ≥ 2) between treatment groups (conservative management, indomethacin only, surgical ligation only, or both indomethacin and ligation)."3.78Treatment of patent ductus arteriosus and neonatal mortality/morbidities: adjustment for treatment selection bias. ( Allen, AC; Aziz, K; Lee, SK; Mirea, L; Ohlsson, A; Sankaran, K; Seshia, M; Shah, PS, 2012)
"In infants with VLBW, oral ibuprofen is as effective as intravenous indomethacin for closure of PDA and is associated with significantly fewer cases of necrotizing enterocolitis among infants with birth body weights <1250 g and significantly lower rates of elevated creatinine levels among neonates with birth body weights ranging from 1000 to 1500 g."3.78Oral ibuprofen versus intravenous indomethacin for closure of patent ductus arteriosus in very low birth weight infants. ( Chen, HN; Hsiao, CC; Lee, CH; Lee, ML; Tsao, LY, 2012)
"Postnatal indomethacin is reportedly associated with an increased incidence of necrotizing enterocolitis (NEC) in preterm infants."3.77The risk of necrotizing enterocolitis after indomethacin tocolysis. ( Holzhausen, KA; Kellogg, H; Lulic-Botica, M; Pruder, S; Salari, V; Sood, BG; Thomas, R, 2011)
"Diet, indomethacin, and early use of dexamethasone have been implicated as possible causes of necrotizing enterocolitis and intestinal perforation."3.74Prevention of necrotizing enterocolitis in preterm infants: a 20-year experience. ( Achanti, B; Lilien, L; Mehta, SK; Pietz, J; Stepka, EC, 2007)
"To examine the ontogeny of salivary epidermal growth factor (sEGF) in premature infants and to determine the relation of sEGF to the development of necrotizing enterocolitis (NEC)."3.74Ontogeny of salivary epidermal growth factor and necrotizing enterocolitis. ( Erwin, CR; Leonard, AC; Ryan, AL; Seeger, K; Warner, BB; Warner, BW, 2007)
"In this retrospective study, we tested the following hypotheses: rates of severe intraventricular hemorrhage (SIVH) and early neonatal survival are similar among extremely low birth weight (ELBW) infants treated with combination prophylaxis of phenobarbital and indomethacin compared with phenobarbital alone or no prophylaxis; and rates of patent ductus arteriosus (PDA) and necrotizing enterocolitis (NEC) are similar among indomethacin-exposed and nonexposed ELBW infants."3.73Combining phenobarbital and indomethacin to improve early neonatal outcomes in the extremely low birth weight infant. ( Ekekezie, II; Mundy, DC; Okah, FA, 2005)
"A retrospective study to compare the incidence of NEC, NEC-related gastrointestinal complications and isolated gastrointestinal perforation among premature infants treated for a PDA with either, indomethacin alone (I), surgical ligation alone (L), or indomethacin followed by surgical ligation (I-L)."3.72Necrotizing enterocolitis and gastrointestinal complications after indomethacin therapy and surgical ligation in premature infants with patent ductus arteriosus. ( Adams, JM; Adams, K; Baetiong, A; Chen, A; O'Donovan, DJ; Smith, EO; Weisman, LE, 2003)
"Preterm infants with exposure to antenatal indomethacin might be at increased risk of grade I and II intraventricular haemorrhage and those with both ante- and postnatal exposure at an increased risk of necrotising enterocolitis and sepsis."3.70Perinatal indomethacin treatment and neonatal complications in preterm infants. ( Ikonen, S; Ojala, R; Tammela, O, 2000)
"Tocolysis with indomethacin as a single agent was not associated with necrotizing enterocolitis in this case-control study."3.70Indomethacin tocolysis and risk of necrotizing enterocolitis. ( Dooley, SL; Grobman, WA; Holtzman, RB; Parilla, BV; Thomas, HA, 2000)
"Indomethacin has been the standard treatment to close a PDA but is associated with renal, gastrointestinal, and cerebral side effects."2.66Ibuprofen for the prevention of patent ductus arteriosus in preterm and/or low birth weight infants. ( Ohlsson, A; Shah, SS, 2020)
"Management of persistently patent ductus arteriosus (PDA) in extremely low-birth-weight infants (ELBWIs) requires attention due to the risk of tissue hypoperfusion."1.91Association between gastrointestinal perforation and patent ductus arteriosus in extremely-low-birth-weight infants: a retrospective study of our decade-long experience. ( Ibara, S; Ieiri, S; Ikee, T; Ikoma, S; Kawano, M; Kawano, T; Machigashira, S; Masuya, R; Matsukubo, M; Murakami, M; Muto, M; Nakame, K; Noguchi, H; Sugita, K; Torikai, M, 2023)
"(2) Multiple analyses showed that patent ductus arteriosus(PDA) (odds ratio[OR] = 5."1.91Patent ductus arterious and increased conjugated bilirubin in the second week after birth are independent risk factors for necrotizing enterocolitis in preterm infants: an observational study. ( Cui, S; Han, X, 2023)
"Symptomatic patent ductus arteriosus (sPDA) is the most common heart abnormality in preterm infants."1.62High Dose Indomethacin for Patent Ductus Arteriosus Closure Increases Neonatal Morbidity. ( Atkinson, A; Berger, MR; Gerull, R; Nelle, M; Waldvogel, S; Wilbeaux, M, 2021)
"Indomethacin has been administered for longer durations to prolong gestation in extreme prematurity."1.43Perinatal Outcomes after Short versus Prolonged Indomethacin for Tocolysis in Women with Preterm Labor. ( Behnia, F; Costantine, M; Dutta, EH; Harirah, H; Saade, G, 2016)
"The aim of this study is to compare patent ductus arteriosus (PDA) management strategies and outcomes between the Neonatal Research Network of Japan (NRNJ) with proactive functional echocardiography and the Canadian Neonatal Network (CNN) with selective conventional echocardiography practice."1.42Patent ductus arteriosus management and outcomes in Japan and Canada: comparison of proactive and selective approaches. ( Fujimura, M; Isayama, T; Kusuda, S; Lee, SK; Mirea, L; Mori, R; Shah, PS, 2015)
"Indomethacin has been also used in women with short cervices as well as in those with idiopathic polyhydramnios."1.38Indomethacin in pregnancy: applications and safety. ( Abou-Ghannam, G; Nassar, AH; Usta, IM, 2012)
"The effect of patent ductus arteriosus on necrotizing enterocolitis was assessed using multiple regression analysis."1.33Patent ductus arteriosus, indomethacin and necrotizing enterocolitis in very low birth weight infants: a population-based study. ( Dollberg, S; Lusky, A; Reichman, B, 2005)
" The total dosage was the same for both groups."1.33Continuous indomethacin infusion may be less effective than bolus infusions for ductal closure in very low birth weight infants. ( Bos, AF; de Vries, NK; Elzenga, NJ; Jaarsma, AS; Jagroep, FK, 2005)
"Indomethacin use has been implicated as a co-risk factor for SIP when combined with glucocorticoids, but previous evidence argued against indomethacin being an independent risk factor when used prophylactically."1.33New insights into spontaneous intestinal perforation using a national data set: (1) SIP is associated with early indomethacin exposure. ( Attridge, JT; Clark, R; Gordon, PV; Walker, MW, 2006)

Research

Studies (59)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (1.69)18.2507
2000's22 (37.29)29.6817
2010's25 (42.37)24.3611
2020's11 (18.64)2.80

Authors

AuthorsStudies
Hundscheid, T2
Onland, W2
Kooi, EMW2
Vijlbrief, DC2
de Vries, WB2
Dijkman, KP2
van Kaam, AH2
Villamor, E2
Kroon, AA2
Visser, R2
Mulder-de Tollenaer, SM2
De Bisschop, B2
Dijk, PH2
Avino, D2
Hocq, C2
Zecic, A2
Meeus, M2
de Baat, T2
Derriks, F2
Henriksen, TB2
Kyng, KJ2
Donders, R2
Nuytemans, DHGM2
Van Overmeire, B2
Mulder, AL2
de Boode, WP2
Muto, M1
Sugita, K1
Murakami, M1
Ikoma, S1
Kawano, M1
Masuya, R1
Matsukubo, M1
Kawano, T1
Machigashira, S1
Nakame, K1
Torikai, M1
Ikee, T1
Noguchi, H1
Ibara, S1
Ieiri, S1
Clyman, RI2
Hills, NK1
Han, X1
Cui, S1
Xiong, T1
Maheshwari, A1
Neu, J1
Ei-Saie, A1
Pammi, M1
Waldvogel, S1
Atkinson, A1
Wilbeaux, M1
Nelle, M1
Berger, MR1
Gerull, R1
Ohlsson, A5
Shah, SS3
Isayama, T2
Kusuda, S2
Reichman, B2
Lee, SK4
Lehtonen, L1
Norman, M1
Adams, M1
Bassler, D1
Helenius, K1
Hakansson, S1
Yang, J1
Jain, A2
Shah, PS5
Gephart, SM1
Underwood, MA1
Rosito, S1
Kim, JH1
Caplan, MS1
Mitra, S3
Scrivens, A1
von Kursell, AM1
Disher, T1
Evans, P1
O'Reilly, D1
Flyer, JN1
Soll, R1
Florez, ID1
Tamayo, ME1
Mbuagbaw, L1
Vanniyasingam, T1
Veroniki, AA1
Zea, AM1
Zhang, Y1
Sadeghirad, B1
Thabane, L1
Nair, J1
Lakshminrusimha, S1
Walia, R2
Li, D1
Rosito, G1
Slagle, T1
Hammers, AL2
Sanchez-Ramos, L2
Kaunitz, AM2
Kirtsman, M1
Yoon, EW1
Ojah, C1
Cieslak, Z1
Mirea, L2
Mori, R1
Fujimura, M1
Hallman, M1
Pesonen, E1
Teramo, K1
Faucett, AM1
Metz, TD1
DeWitt, PE1
Gibbs, RS1
Chen, Y1
Chang, KT1
Lian, DW1
Lu, H1
Roy, S1
Laksmi, NK1
Low, Y1
Krishnaswamy, G1
Pierro, A1
Ong, CC1
Louis, D1
Torgalkar, R1
Shah, J1
Dutta, EH1
Behnia, F1
Harirah, H1
Costantine, M1
Saade, G1
Haw, MP1
Talavera, MM1
Bixler, G1
Cozzi, C1
Dail, J1
Miller, RR1
McClead, R1
Reber, K1
Prescott, S1
Keim-Malpass, J1
Gordon, PV2
Swanson, JR1
Clark, R2
Sharma, R1
Hudak, ML1
Tepas, JJ1
Wludyka, PS1
Teng, RJ1
Hastings, LK1
Renfro, WH1
Marvin, WJ1
El-Khuffash, AF1
McNamara, PJ1
Sood, BG1
Lulic-Botica, M1
Holzhausen, KA1
Pruder, S1
Kellogg, H1
Salari, V1
Thomas, R1
Abou-Ghannam, G1
Usta, IM1
Nassar, AH1
Saldeño, YP1
Favareto, V1
Mirpuri, J1
Sankaran, K1
Seshia, M1
Allen, AC1
Aziz, K1
Lee, CH1
Chen, HN1
Tsao, LY1
Hsiao, CC1
Lee, ML1
Sivanandan, S1
Bali, V1
Soraisham, AS1
Harabor, A1
Kamaluddeen, M1
Hwang, H1
Murphy, JJ1
Gow, KW1
Magee, JF1
Bekhit, E1
Jamieson, D1
O'Donovan, DJ1
Baetiong, A1
Adams, K1
Chen, A1
Smith, EO1
Adams, JM1
Weisman, LE1
Lee, J1
Rajadurai, VS1
Tan, KW1
Wong, KY1
Wong, EH1
Leong, JY1
Okah, FA1
Mundy, DC1
Ekekezie, II1
Dollberg, S1
Lusky, A1
de Vries, NK1
Jagroep, FK1
Jaarsma, AS1
Elzenga, NJ1
Bos, AF1
Doyle, NM1
Gardner, MO1
Wells, L1
Qualls, C1
Papile, LA1
Attridge, JT1
Walker, MW1
Bloom, BT1
Patole, SK1
Kumaran, V1
Travadi, JN1
Brooks, JM1
Doherty, DA1
Pietz, J1
Achanti, B1
Lilien, L1
Stepka, EC1
Mehta, SK1
Kawase, Y1
Ishii, T1
Arai, H1
Uga, N1
Warner, BB1
Ryan, AL1
Seeger, K1
Leonard, AC1
Erwin, CR1
Warner, BW1
Fakhraee, SH1
Badiee, Z1
Mojtahedzadeh, S1
Kazemian, M1
Kelishadi, R1
Amin, SB1
Sinkin, RA1
Glantz, JC1
Madan, J1
Fiascone, J1
Balasubramanian, V1
Griffith, J1
Hagadorn, JI1
Narayanan, M1
Schlueter, M1
Kamitsuka, MD1
Horton, MK1
Williams, MA1
Ojala, R1
Ikonen, S1
Tammela, O1
Parilla, BV1
Grobman, WA1
Holtzman, RB1
Thomas, HA1
Dooley, SL1
Adamska, E1
Schmidt, B1
Davis, P1
Moddemann, D1
Roberts, RS1
Saigal, S1
Solimano, A1
Vincer, M1
Wright, LL1

Clinical Trials (12)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Multi-center, Randomized Non-inferiority Trial of Early Treatment Versus Expectative Management of Patent Ductus Arteriosus in Preterm Infants (BeNeDuctus Trial - Belgium Netherlands Ductus Trial)[NCT02884219]273 participants (Actual)Interventional2016-12-23Completed
Impact of Early Targeted Ibuprofene Treatment of Patent Ductus Arteriosus (PDA) on Long Term Neurodevelopmental Outcome in Very Premature Infants (TRIOCAPI)[NCT01630278]Phase 3363 participants (Actual)Interventional2012-03-31Completed
Liberal Versus Restrictive Platelet Transfusion for Treatment of Hemodynamically Significant Patent Ductus Arteriosus in Thrombocytopenic Preterm Neonates- A Randomized Open Label, Controlled Trial[NCT03022253]Phase 344 participants (Anticipated)Interventional2016-03-31Completed
RIC-NEC Phase II Feasibility Randomized Controlled Trial: Remote Ischemic Conditioning in Necrotizing Enterocolitis[NCT05279664]Phase 278 participants (Anticipated)Interventional2022-09-01Not yet recruiting
Combination of Acetaminophen and Ibuprofen in the Management of Patent Ductus Arteriosus in Premature Infants: A Pilot Study[NCT03103022]Phase 120 participants (Actual)Interventional2017-06-12Completed
Randomized, Placebo Controlled Trial of Indomethacin for Tocolysis[NCT01869361]Early Phase 10 participants (Actual)Interventional2020-08-01Withdrawn (stopped due to Due to much lower than expected numbers of eligible patients and lack of PI time, the study was not started.)
Generic Database: A Survey of Morbidity and Mortality in Very Low Birth Weight Infants[NCT00063063]80,000 participants (Anticipated)Observational1987-01-31Recruiting
Intestinal Function in Neonates With Complex Congenital Heart Disease[NCT01475357]27 participants (Actual)Interventional2011-10-31Completed
Collaborative Research Group for Necrotizing Enterocolitis[NCT00828451]29 participants (Actual)Interventional2008-05-31Completed
Trial of Indomethacin Prophylaxis in Preterm Infants (TIPP)[NCT00009646]Phase 31,202 participants (Actual)Interventional1993-11-30Completed
High-Dose Erythropoietin in Very Low Birth Weight Infants for the Potential Treatment of Prematurity-Related Cerebral Hemorrhagic-Ischemic Injury: A Phase II Safety/Tolerability Study[NCT00589953]Phase 222 participants (Actual)Interventional2007-07-31Terminated
Follow-up Visit of High Risk Infants[NCT00009633]68,000 participants (Anticipated)Observational1993-01-31Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

EGF Gene Sequencing

Identification of computationally predicted functional variants in EGF gene (NCT00828451)
Timeframe: Sampling occurred on average day of life 9 with a range from day of life 7 to 21

Interventionpercentage of participants with variant (Number)
Preterm Infants for EGF Profiles11

Salivary EGF (Epidermal Growth Factor) Protein Levels

Salivary EGF protein levels obtained from oral swabs were analyzed by commercially available EGF ELISA kit (R &D systems Inc). EGF protein levels were normalized to micrograms of protein in saliva, and expressed as picogram of EGF protein per microgram of total salivary protein. (NCT00828451)
Timeframe: Sampling occurred on average day of life 9 with a range from day of life 7 to 21

Interventionpicograms EGF/ microgram of protein (Median)
Preterm Infants for EGF Profiles15

Urinary EGF Protein Levels

Urinary EGF protein levels obtained from free flowing urine samples retrieved from subject diaper were analyzed by commercially available EGF ELISA kit (R &D systems Inc). EGF protein levels were normalized to milligrams of creatinine in urine, and expressed as nanograms of EGF protein per milligram of urinary creatinine. (NCT00828451)
Timeframe: Sampling occurred on average day of life 9 with a range from day of life 7 to 21

Interventionnanograms of EGF/mg of creatinine (Median)
Preterm Infants for EGF Profiles48

Reviews

14 reviews available for indomethacin and Necrotizing Enterocolitis

ArticleYear
An Overview of Systematic Reviews of Randomized-Controlled Trials for Preventing Necrotizing Enterocolitis in Preterm Infants.
    Neonatology, 2020, Volume: 117, Issue:1

    Topics: Administration, Oral; Adrenal Cortex Hormones; Ductus Arteriosus, Patent; Enterocolitis, Necrotizing

2020
Ibuprofen for the prevention of patent ductus arteriosus in preterm and/or low birth weight infants.
    The Cochrane database of systematic reviews, 2020, 01-27, Volume: 1

    Topics: Cerebral Hemorrhage; Cyclooxygenase Inhibitors; Drug-Related Side Effects and Adverse Reactions; Duc

2020
Grading the evidence to identify strategies to modify risk for necrotizing enterocolitis.
    Pediatric research, 2020, Volume: 88, Issue:Suppl 1

    Topics: Adrenal Cortex Hormones; Anemia; Anti-Bacterial Agents; Ductus Arteriosus, Patent; Enterocolitis, Ne

2020
Early treatment versus expectant management of hemodynamically significant patent ductus arteriosus for preterm infants.
    The Cochrane database of systematic reviews, 2020, 12-10, Volume: 12

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cause of Death; Cerebral Intraventricular Hemorrhage; Chron

2020
Indomethacin for symptomatic patent ductus arteriosus in preterm infants.
    The Cochrane database of systematic reviews, 2021, 01-15, Volume: 1

    Topics: Bias; Bronchopulmonary Dysplasia; Cause of Death; Cyclooxygenase Inhibitors; Ductus Arteriosus, Pate

2021
Association of Placebo, Indomethacin, Ibuprofen, and Acetaminophen With Closure of Hemodynamically Significant Patent Ductus Arteriosus in Preterm Infants: A Systematic Review and Meta-analysis.
    JAMA, 2018, 03-27, Volume: 319, Issue:12

    Topics: Acetaminophen; Administration, Intravenous; Administration, Oral; Bayes Theorem; Cerebral Hemorrhage

2018
Role of NO and other vascular mediators in the etiopathogenesis of necrotizing enterocolitis.
    Frontiers in bioscience (Scholar edition), 2019, 03-01, Volume: 11, Issue:1

    Topics: Age of Onset; Animals; Arginine; Catecholamines; Disease Models, Animal; Dogs; Endothelins; Enteroco

2019
Ibuprofen for the treatment of patent ductus arteriosus in preterm and/or low birth weight infants.
    The Cochrane database of systematic reviews, 2013, Apr-30, Issue:4

    Topics: Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Enterocolitis, Necrotizing; Humans; Ibuprofen;

2013
Antenatal exposure to indomethacin increases the risk of severe intraventricular hemorrhage, necrotizing enterocolitis, and periventricular leukomalacia: a systematic review with metaanalysis.
    American journal of obstetrics and gynecology, 2015, Volume: 212, Issue:4

    Topics: Cerebral Ventricles; Enterocolitis, Necrotizing; Female; Humans; Indomethacin; Infant, Newborn; Infa

2015
Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight (or both) infants.
    The Cochrane database of systematic reviews, 2015, Feb-18, Issue:2

    Topics: Administration, Oral; Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Enterocolitis, Necrotizi

2015
Surgical Intervention in Preterm Neonates with Patent Ductus Arteriosus.
    Current pediatric reviews, 2016, Volume: 12, Issue:2

    Topics: Bronchopulmonary Dysplasia; Combined Modality Therapy; Cyclooxygenase Inhibitors; Ductus Arteriosus,

2016
Patent Ductus Arteriosus in the Preterm Infant: Diagnostic and Treatment Options.
    Advances in neonatal care : official journal of the National Association of Neonatal Nurses, 2017, Volume: 17, Issue:1

    Topics: Biomarkers; Cardiac Catheterization; Conservative Treatment; Cyclooxygenase Inhibitors; Ductus Arter

2017
Metaanalysis of the effect of antenatal indomethacin on neonatal outcomes.
    American journal of obstetrics and gynecology, 2007, Volume: 197, Issue:5

    Topics: Enterocolitis, Necrotizing; Female; Humans; Indomethacin; Infant, Newborn; Infant, Premature; Infant

2007
[Ibuprofen--a new application for pharmacological closure of patent ductus arteriosus in preterm infants. Preliminary report].
    Medycyna wieku rozwojowego, 2000, Volume: 4, Issue:2 Suppl 3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Bronchopulmonary Dysplasia; Clinical Trials as Topic; Ductu

2000

Trials

4 trials available for indomethacin and Necrotizing Enterocolitis

ArticleYear
Expectant Management or Early Ibuprofen for Patent Ductus Arteriosus.
    The New England journal of medicine, 2023, Mar-16, Volume: 388, Issue:11

    Topics: Bronchopulmonary Dysplasia; Ductus Arteriosus, Patent; Echocardiography; Enterocolitis, Necrotizing;

2023
Expectant Management or Early Ibuprofen for Patent Ductus Arteriosus.
    The New England journal of medicine, 2023, Mar-16, Volume: 388, Issue:11

    Topics: Bronchopulmonary Dysplasia; Ductus Arteriosus, Patent; Echocardiography; Enterocolitis, Necrotizing;

2023
Expectant Management or Early Ibuprofen for Patent Ductus Arteriosus.
    The New England journal of medicine, 2023, Mar-16, Volume: 388, Issue:11

    Topics: Bronchopulmonary Dysplasia; Ductus Arteriosus, Patent; Echocardiography; Enterocolitis, Necrotizing;

2023
Expectant Management or Early Ibuprofen for Patent Ductus Arteriosus.
    The New England journal of medicine, 2023, Mar-16, Volume: 388, Issue:11

    Topics: Bronchopulmonary Dysplasia; Ductus Arteriosus, Patent; Echocardiography; Enterocolitis, Necrotizing;

2023
Randomized trial of prolonged low-dose versus conventional-dose indomethacin for treating patent ductus arteriosus in very low birth weight infants.
    Pediatrics, 2003, Volume: 112, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Drug Administration Schedule; Ductus Arteriosus, Patent; Ec

2003
Comparison of oral ibuprofen and indomethacin therapy for patent ductus arteriosus in preterm infants.
    Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2007, Volume: 9, Issue:5

    Topics: Administration, Oral; Ductus Arteriosus, Patent; Enterocolitis, Necrotizing; Humans; Ibuprofen; Indo

2007
Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants.
    The New England journal of medicine, 2001, Jun-28, Volume: 344, Issue:26

    Topics: Blindness; Cerebral Palsy; Cognition Disorders; Ductus Arteriosus, Patent; Enterocolitis, Necrotizin

2001
Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants.
    The New England journal of medicine, 2001, Jun-28, Volume: 344, Issue:26

    Topics: Blindness; Cerebral Palsy; Cognition Disorders; Ductus Arteriosus, Patent; Enterocolitis, Necrotizin

2001
Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants.
    The New England journal of medicine, 2001, Jun-28, Volume: 344, Issue:26

    Topics: Blindness; Cerebral Palsy; Cognition Disorders; Ductus Arteriosus, Patent; Enterocolitis, Necrotizin

2001
Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants.
    The New England journal of medicine, 2001, Jun-28, Volume: 344, Issue:26

    Topics: Blindness; Cerebral Palsy; Cognition Disorders; Ductus Arteriosus, Patent; Enterocolitis, Necrotizin

2001
Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants.
    The New England journal of medicine, 2001, Jun-28, Volume: 344, Issue:26

    Topics: Blindness; Cerebral Palsy; Cognition Disorders; Ductus Arteriosus, Patent; Enterocolitis, Necrotizin

2001
Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants.
    The New England journal of medicine, 2001, Jun-28, Volume: 344, Issue:26

    Topics: Blindness; Cerebral Palsy; Cognition Disorders; Ductus Arteriosus, Patent; Enterocolitis, Necrotizin

2001
Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants.
    The New England journal of medicine, 2001, Jun-28, Volume: 344, Issue:26

    Topics: Blindness; Cerebral Palsy; Cognition Disorders; Ductus Arteriosus, Patent; Enterocolitis, Necrotizin

2001
Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants.
    The New England journal of medicine, 2001, Jun-28, Volume: 344, Issue:26

    Topics: Blindness; Cerebral Palsy; Cognition Disorders; Ductus Arteriosus, Patent; Enterocolitis, Necrotizin

2001
Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants.
    The New England journal of medicine, 2001, Jun-28, Volume: 344, Issue:26

    Topics: Blindness; Cerebral Palsy; Cognition Disorders; Ductus Arteriosus, Patent; Enterocolitis, Necrotizin

2001

Other Studies

41 other studies available for indomethacin and Necrotizing Enterocolitis

ArticleYear
Association between gastrointestinal perforation and patent ductus arteriosus in extremely-low-birth-weight infants: a retrospective study of our decade-long experience.
    Pediatric surgery international, 2023, Feb-15, Volume: 39, Issue:1

    Topics: Ductus Arteriosus, Patent; Enterocolitis, Necrotizing; Humans; Ibuprofen; Indomethacin; Infant, Extr

2023
Prophylactic indomethacin, antenatal betamethasone, and the risk of intestinal perforation in infants <28 weeks' gestation.
    Journal of perinatology : official journal of the California Perinatal Association, 2023, Volume: 43, Issue:10

    Topics: Betamethasone; Enterocolitis, Necrotizing; Female; Humans; Indomethacin; Infant; Infant, Newborn; In

2023
Patent ductus arterious and increased conjugated bilirubin in the second week after birth are independent risk factors for necrotizing enterocolitis in preterm infants: an observational study.
    BMC pediatrics, 2023, 07-13, Volume: 23, Issue:1

    Topics: Bilirubin; Child; Ductus Arteriosus, Patent; Enterocolitis, Necrotizing; Female; Fetal Diseases; Hum

2023
High Dose Indomethacin for Patent Ductus Arteriosus Closure Increases Neonatal Morbidity.
    American journal of perinatology, 2021, Volume: 38, Issue:7

    Topics: Bronchopulmonary Dysplasia; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Ductus Arte

2021
Neonatal Intensive Care Unit-Level Patent Ductus Arteriosus Treatment Rates and Outcomes in Infants Born Extremely Preterm.
    The Journal of pediatrics, 2020, Volume: 220

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Canada; Cardiovascular Surgical Procedures; Cerebral

2020
Probiotics for the prevention of necrotizing enterocolitis in neonates: an 8-year retrospective cohort study.
    Journal of clinical pharmacy and therapeutics, 2013, Volume: 38, Issue:6

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Birth Weight; Breast Feeding; Cohort Studies; Ductus Arteri

2013
Nil-per-os days and necrotizing enterocolitis in extremely preterm infants.
    American journal of perinatology, 2015, Volume: 32, Issue:8

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Canada; Case-Control Studies; Ductus Arteriosus, Patent; En

2015
Patent ductus arteriosus management and outcomes in Japan and Canada: comparison of proactive and selective approaches.
    American journal of perinatology, 2015, Volume: 32, Issue:11

    Topics: Bronchopulmonary Dysplasia; Canada; Cerebral Hemorrhage; Comorbidity; Cyclooxygenase Inhibitors; Duc

2015
Reply: To PMID 25448524.
    American journal of obstetrics and gynecology, 2015, Volume: 213, Issue:6

    Topics: Enterocolitis, Necrotizing; Female; Humans; Indomethacin; Intracranial Hemorrhages; Leukomalacia, Pe

2015
Indomethacin as a tocolytic harmful to preterm infant.
    American journal of obstetrics and gynecology, 2015, Volume: 213, Issue:6

    Topics: Enterocolitis, Necrotizing; Female; Humans; Indomethacin; Intracranial Hemorrhages; Leukomalacia, Pe

2015
Effect of obesity on neonatal outcomes in pregnancies with preterm premature rupture of membranes.
    American journal of obstetrics and gynecology, 2016, Volume: 214, Issue:2

    Topics: Adolescent; Adrenal Cortex Hormones; Adult; Birth Weight; Case-Control Studies; Cerebral Hemorrhage;

2016
The role of ischemia in necrotizing enterocolitis.
    Journal of pediatric surgery, 2016, Volume: 51, Issue:8

    Topics: Age of Onset; Biomarkers; Enterocolitis, Necrotizing; Glucose Transporter Type 1; Humans; Hypoxia; H

2016
Enteral feeding during indomethacin treatment for patent ductus arteriosus: association with gastrointestinal outcomes.
    Journal of perinatology : official journal of the California Perinatal Association, 2016, Volume: 36, Issue:7

    Topics: Birth Weight; Canada; Ductus Arteriosus, Patent; Enteral Nutrition; Enterocolitis, Necrotizing; Fema

2016
Perinatal Outcomes after Short versus Prolonged Indomethacin for Tocolysis in Women with Preterm Labor.
    American journal of perinatology, 2016, Volume: 33, Issue:9

    Topics: Adult; Drug Administration Schedule; Enterocolitis, Necrotizing; Female; Gestational Age; Humans; In

2016
Quality Improvement Initiative to Reduce the Necrotizing Enterocolitis Rate in Premature Infants.
    Pediatrics, 2016, Volume: 137, Issue:5

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Blood Transfusion; Enterocolitis, Necrotizing; Humans; Inci

2016
Antenatal indomethacin is more likely associated with spontaneous intestinal perforation rather than NEC.
    American journal of obstetrics and gynecology, 2008, Volume: 198, Issue:6

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Enterocolitis, Necrotizing; Humans; Indomethacin; Intestina

2008
Prenatal or postnatal indomethacin exposure and neonatal gut injury associated with isolated intestinal perforation and necrotizing enterocolitis.
    Journal of perinatology : official journal of the California Perinatal Association, 2010, Volume: 30, Issue:12

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cerebral Hemorrhage; Cerebral Ventricles; Drug Administrati

2010
The patent ductus arteriosus ligation decision.
    The Journal of pediatrics, 2011, Volume: 158, Issue:6

    Topics: Cardiovascular Agents; Ductus Arteriosus, Patent; Echocardiography; Enterocolitis, Necrotizing; Huma

2011
The risk of necrotizing enterocolitis after indomethacin tocolysis.
    Pediatrics, 2011, Volume: 128, Issue:1

    Topics: Cohort Studies; Enterocolitis, Necrotizing; Female; Humans; Indomethacin; Infant, Newborn; Infant, P

2011
Indomethacin in pregnancy: applications and safety.
    American journal of perinatology, 2012, Volume: 29, Issue:3

    Topics: Cerclage, Cervical; Cerebral Hemorrhage; Ductus Arteriosus; Enterocolitis, Necrotizing; Female; Fetu

2012
Prolonged persistent patent ductus arteriosus: potential perdurable anomalies in premature infants.
    Journal of perinatology : official journal of the California Perinatal Association, 2012, Volume: 32, Issue:12

    Topics: Analysis of Variance; Bronchopulmonary Dysplasia; Cardiac Surgical Procedures; Case-Control Studies;

2012
Treatment of patent ductus arteriosus and neonatal mortality/morbidities: adjustment for treatment selection bias.
    The Journal of pediatrics, 2012, Volume: 161, Issue:4

    Topics: Bronchopulmonary Dysplasia; Cerebral Hemorrhage; Comorbidity; Cyclooxygenase Inhibitors; Ductus Arte

2012
Oral ibuprofen versus intravenous indomethacin for closure of patent ductus arteriosus in very low birth weight infants.
    Pediatrics and neonatology, 2012, Volume: 53, Issue:6

    Topics: Administration, Intravenous; Administration, Oral; Ductus Arteriosus, Patent; Enterocolitis, Necroti

2012
Effectiveness and safety of indomethacin versus ibuprofen for the treatment of patent ductus arteriosus in preterm infants.
    American journal of perinatology, 2013, Volume: 30, Issue:9

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Ductus Arteriosus, Patent; Enterocolitis, Necrotizing; Fema

2013
Are localized intestinal perforations distinct from necrotizing enterocolitis?
    Journal of pediatric surgery, 2003, Volume: 38, Issue:5

    Topics: Adult; Catheterization; Dexamethasone; Diagnosis, Differential; Enterocolitis, Necrotizing; Female;

2003
Necrotizing enterocolitis and gastrointestinal complications after indomethacin therapy and surgical ligation in premature infants with patent ductus arteriosus.
    Journal of perinatology : official journal of the California Perinatal Association, 2003, Volume: 23, Issue:4

    Topics: Birth Weight; Cardiac Surgical Procedures; Cardiovascular Agents; Ductus Arteriosus, Patent; Enteroc

2003
Combining phenobarbital and indomethacin to improve early neonatal outcomes in the extremely low birth weight infant.
    American journal of perinatology, 2005, Volume: 22, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Drug Therapy, Combination; Enterocolitis,

2005
Patent ductus arteriosus, indomethacin and necrotizing enterocolitis in very low birth weight infants: a population-based study.
    Journal of pediatric gastroenterology and nutrition, 2005, Volume: 40, Issue:2

    Topics: Cardiovascular Agents; Ductus Arteriosus, Patent; Enterocolitis, Necrotizing; Female; Humans; Indome

2005
Continuous indomethacin infusion may be less effective than bolus infusions for ductal closure in very low birth weight infants.
    American journal of perinatology, 2005, Volume: 22, Issue:2

    Topics: Cardiovascular Agents; Case-Control Studies; Dose-Response Relationship, Drug; Drug Administration S

2005
Outcome of very low birth weight infants exposed to antenatal indomethacin for tocolysis.
    Journal of perinatology : official journal of the California Perinatal Association, 2005, Volume: 25, Issue:5

    Topics: Cause of Death; Cohort Studies; Critical Care; Ductus Arteriosus, Patent; Enterocolitis, Necrotizing

2005
New insights into spontaneous intestinal perforation using a national data set: (1) SIP is associated with early indomethacin exposure.
    Journal of perinatology : official journal of the California Perinatal Association, 2006, Volume: 26, Issue:2

    Topics: Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Cohort Studies; Databases, Factual; E

2006
Attridge et al. present an analysis of a complex data set, which offers important confirmation of the differences between the clinical presentation of spontaneous intestinal perforations (SIP) and surgical necrotizing enterocolitis (NEC).
    Journal of perinatology : official journal of the California Perinatal Association, 2006, Volume: 26, Issue:6

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Diagnosis, Differential; Enterocolitis, Necrotizing; Humans

2006
Does patent ductus arteriosus affect feed tolerance in preterm neonates?
    Archives of disease in childhood. Fetal and neonatal edition, 2007, Volume: 92, Issue:1

    Topics: Age Factors; Analysis of Variance; Cardiovascular Agents; Ductus Arteriosus, Patent; Enteral Nutriti

2007
Prevention of necrotizing enterocolitis in preterm infants: a 20-year experience.
    Pediatrics, 2007, Volume: 119, Issue:1

    Topics: Dexamethasone; Enterocolitis, Necrotizing; Feeding Methods; Female; Humans; Indomethacin; Infant, Ex

2007
Gastrointestinal perforation in very low-birthweight infants.
    Pediatrics international : official journal of the Japan Pediatric Society, 2006, Volume: 48, Issue:6

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Diagnosis, Differential; Enterocolitis, Necrotizing; Female

2006
Ontogeny of salivary epidermal growth factor and necrotizing enterocolitis.
    The Journal of pediatrics, 2007, Volume: 150, Issue:4

    Topics: Age Factors; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Apgar Score; Cohort Stu

2007
Predictors of ductal closure and intestinal complications in very low birth weight infants treated with indomethacin.
    Neonatology, 2008, Volume: 94, Issue:1

    Topics: Cardiovascular Agents; Ductus Arteriosus, Patent; Enterocolitis, Necrotizing; Female; Humans; Indome

2008
Incidence and outcome of a 10-fold indomethacin overdose in premature infants.
    The Journal of pediatrics, 1999, Volume: 135, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Bronchopulmonary Dysplasia; Cerebral Hemorrhage; Ductus Art

1999
The incidence of necrotizing enterocolitis after introducing standardized feeding schedules for infants between 1250 and 2500 grams and less than 35 weeks of gestation.
    Pediatrics, 2000, Volume: 105, Issue:2

    Topics: Birth Weight; Cohort Studies; Enterocolitis, Necrotizing; Feeding Methods; Female; Humans; Indometha

2000
Perinatal indomethacin treatment and neonatal complications in preterm infants.
    European journal of pediatrics, 2000, Volume: 159, Issue:3

    Topics: Cerebral Hemorrhage; Enterocolitis, Necrotizing; Female; Humans; Indomethacin; Infant, Newborn; Infa

2000
Indomethacin tocolysis and risk of necrotizing enterocolitis.
    Obstetrics and gynecology, 2000, Volume: 96, Issue:1

    Topics: Adult; Case-Control Studies; Enterocolitis, Necrotizing; Female; Humans; Indomethacin; Infant, Newbo

2000