indomethacin has been researched along with Myocardial Ischemia in 33 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Myocardial ischemia is a complex process leading to the simultaneous release of a number of mediators, including thromboxane A(2) (TxA(2)) and bradykinin (BK), that activate cardiac spinal afferents." | 7.76 | Bradykinin and thromboxane A2 reciprocally interact to synergistically stimulate cardiac spinal afferents during myocardial ischemia. ( Fu, LW; Longhurst, JC, 2010) |
| "The effects of aspirin and indomethacin on the ventricular arrhythmias produced by ligation (ischaemia) and unligation (reperfusion) of the circumflex branch of the left coronary vessel were evaluated in fifty male rabbits weighing 1." | 7.69 | Effects of aspirin and indomethacin on ventricular arrhythmias--comparative study. ( Bhatti, AS; Khan, HH, 1994) |
| "Myocardial ischemia is a complex process leading to the simultaneous release of a number of mediators, including thromboxane A(2) (TxA(2)) and bradykinin (BK), that activate cardiac spinal afferents." | 3.76 | Bradykinin and thromboxane A2 reciprocally interact to synergistically stimulate cardiac spinal afferents during myocardial ischemia. ( Fu, LW; Longhurst, JC, 2010) |
| "The effects of aspirin and indomethacin on the ventricular arrhythmias produced by ligation (ischaemia) and unligation (reperfusion) of the circumflex branch of the left coronary vessel were evaluated in fifty male rabbits weighing 1." | 3.69 | Effects of aspirin and indomethacin on ventricular arrhythmias--comparative study. ( Bhatti, AS; Khan, HH, 1994) |
| " We tested whether pretreatment with the kinin receptor antagonist Hoe 140, the nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester, or the cyclooxygenase inhibitor indomethacin blocked the effect of ramiprilat on infarct size and reperfusion arrhythmias." | 3.69 | Paracrine systems in the cardioprotective effect of angiotensin-converting enzyme inhibitors on myocardial ischemia/reperfusion injury in rats. ( Carretero, OA; Liu, YH; Sabbath, HN; Sharov, VG; Sigmon, DH; Yang, XP, 1996) |
| " Coronary dilatation by neurotensin was not prevented by alpha- or beta-adrenoceptor blockade but was completely abolished by indomethacin or by lowering coronary perfusion pressure to 35 mmHg when depressed systolic segment shortening indicated myocardial ischemia." | 3.68 | Effects of neurotensin and neuropeptide Y on coronary circulation and myocardial function in dogs. ( Bauer, B; Becker, HH; Ertl, G; Rose, G, 1993) |
| "Adenosine acts as a cardioprotective agent by producing coronary vasodilation, decreasing heart rate and by antagonizing the cardiostimulatory effect of catecholamines; adenosine also exerts a direct negative inotropic effect." | 1.31 | Adenosine induced direct negative inotropic effect is abolished during global ischemia: role of protein kinase C and prostacyclin. ( Oriji, GK, 2000) |
| "Cardiac arrhythmias were defined as the presence of ventricular tachycardia and/or ventricular fibrillation after the ligation of the coronary artery was released." | 1.31 | Angiotensin-(1-7): cardioprotective effect in myocardial ischemia/reperfusion. ( Almeida, AP; Ferreira, AJ; Santos, RA, 2001) |
| "Reactive hyperemia was induced following 30 sec and 300 sec of no-flow ischemia of the heart." | 1.30 | Types of potassium channels involved in coronary reactive hyperemia depend on duration of preceding ischemia in rat hearts. ( Ito, T; Mokuno, S; Murase, K; Okumura, K; Shinoda, M; Toki, Y, 1997) |
| "Indomethacin (5 microM) was used to block production of vasodilator prostaglandins, L-NAME (30 microM) to block production of nitric oxide (NO), and adenosine deaminase (2." | 1.29 | Effects of short term ischemia and reperfusion on coronary vascular reactivity and myocardial function. ( Hasan, A; McDonough, KH, 1995) |
| "1." | 1.29 | Dissociation of the anti-ischaemic effects of cloricromene from its anti-platelet activity. ( Cirillo, R; Lidbury, PS; Vane, JR, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 22 (66.67) | 18.2507 |
| 2000's | 10 (30.30) | 29.6817 |
| 2010's | 1 (3.03) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fu, LW | 1 |
| Longhurst, JC | 1 |
| Nishikawa, Y | 1 |
| Stepp, DW | 1 |
| Merkus, D | 1 |
| Jones, D | 1 |
| Chilian, WM | 1 |
| Wen, Q | 1 |
| Sim, MK | 1 |
| Tang, FR | 1 |
| Rakici, O | 1 |
| Kiziltepe, U | 1 |
| Coskun, B | 1 |
| Aslamaci, S | 1 |
| Akar, F | 1 |
| Birkenmeier, K | 1 |
| Staudt, A | 1 |
| Schunck, WH | 1 |
| Janke, I | 1 |
| Labitzke, C | 1 |
| Prange, T | 1 |
| Trimpert, C | 1 |
| Krieg, T | 1 |
| Landsberger, M | 1 |
| Stangl, V | 2 |
| Felix, SB | 2 |
| Penna, C | 1 |
| Mancardi, D | 1 |
| Tullio, F | 1 |
| Pagliaro, P | 1 |
| Hasan, A | 1 |
| McDonough, KH | 1 |
| Bhatti, AS | 1 |
| Khan, HH | 1 |
| Zhu, P | 1 |
| Zaugg, CE | 1 |
| Simper, D | 1 |
| Hornstein, P | 1 |
| Allegrini, PR | 1 |
| Buser, PT | 1 |
| Chester, AH | 1 |
| Jiang, C | 1 |
| Borland, JA | 1 |
| Yacoub, MH | 1 |
| Collins, P | 1 |
| McGowan, FX | 1 |
| Davis, PJ | 1 |
| del Nido, PJ | 1 |
| Sobek, M | 1 |
| Allen, JW | 1 |
| Downing, SE | 1 |
| Ustinova, EE | 2 |
| Schultz, HD | 3 |
| Lidbury, PS | 1 |
| Cirillo, R | 1 |
| Vane, JR | 1 |
| Sellke, FW | 1 |
| Shafique, T | 1 |
| Schoen, FJ | 1 |
| Weintraub, RM | 1 |
| Hohlfeld, T | 1 |
| Strobach, H | 1 |
| Schrör, K | 2 |
| Ertl, G | 1 |
| Bauer, B | 1 |
| Becker, HH | 1 |
| Rose, G | 1 |
| Liu, YH | 1 |
| Yang, XP | 1 |
| Sharov, VG | 1 |
| Sigmon, DH | 1 |
| Sabbath, HN | 1 |
| Carretero, OA | 1 |
| Altman, JD | 1 |
| Klassen, CL | 1 |
| Bache, RJ | 1 |
| Gryglewski, RJ | 1 |
| Chlopicki, S | 1 |
| Niezabitowski, P | 1 |
| Jakubowski, A | 1 |
| Lomnicka, M | 1 |
| Node, K | 2 |
| Kitakaze, M | 2 |
| Kosaka, H | 2 |
| Minamino, T | 2 |
| Sato, H | 1 |
| Kuzuya, T | 1 |
| Hori, M | 2 |
| Shinoda, M | 1 |
| Toki, Y | 1 |
| Murase, K | 1 |
| Mokuno, S | 1 |
| Okumura, K | 1 |
| Ito, T | 1 |
| Funaya, H | 1 |
| Mathias, RS | 1 |
| Carvalho, JC | 1 |
| Cavalcante, MT | 1 |
| de Moraes, S | 1 |
| Matoba, S | 1 |
| Tatsumi, T | 1 |
| Keira, N | 1 |
| Kawahara, A | 1 |
| Akashi, K | 1 |
| Kobara, M | 1 |
| Asayama, J | 1 |
| Nakagawa, M | 1 |
| Frank, TM | 1 |
| Stangl, K | 1 |
| Baumann, G | 1 |
| Bouchard, JF | 1 |
| Lamontagne, D | 1 |
| Criniti, A | 1 |
| Picard, S | 1 |
| Monti, F | 1 |
| Dawodu, AA | 1 |
| Ruvolo, G | 1 |
| Puddu, PE | 1 |
| Campa, PP | 1 |
| Trevisanuto, D | 1 |
| Zaninotto, M | 1 |
| Lachin, M | 1 |
| Altinier, S | 1 |
| Plebani, M | 1 |
| Ferrarese, P | 1 |
| Zanardo, V | 1 |
| Oriji, GK | 1 |
| Sun, SY | 1 |
| Wang, W | 1 |
| Ferreira, AJ | 1 |
| Santos, RA | 1 |
| Almeida, AP | 1 |
| Song, QJ | 1 |
| Xiao, J | 1 |
| Deng, HW | 1 |
| Li, YJ | 1 |
1 trial available for indomethacin and Myocardial Ischemia
| Article | Year |
|---|---|
Effects of resveratrol on vascular tone and endothelial function of human saphenous vein and internal mammary artery.
Topics: Acetylcholine; Antioxidants; Coronary Artery Bypass; Endothelium, Vascular; Female; Follow-Up Studie | 2005 |
32 other studies available for indomethacin and Myocardial Ischemia
| Article | Year |
|---|---|
Bradykinin and thromboxane A2 reciprocally interact to synergistically stimulate cardiac spinal afferents during myocardial ischemia.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Bradykinin; Cats; Cyclo | 2010 |
In vivo role of heme oxygenase in ischemic coronary vasodilation.
Topics: Animals; Carbon Monoxide; Coronary Circulation; Cyclic GMP; Cyclooxygenase Inhibitors; Dogs; Endothe | 2004 |
Reduction of infarct size by orally administered des-aspartate-angiotensin I in the ischemic reperfused rat heart.
Topics: Administration, Oral; Angiotensin I; Animals; Cardiovascular Agents; Indomethacin; Male; Myocardial | 2004 |
COX-2-dependent and potentially cardioprotective effects of negative inotropic substances released after ischemia.
Topics: Adenosine Triphosphate; Animals; Calcium Signaling; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenas | 2007 |
Postconditioning and intermittent bradykinin induced cardioprotection require cyclooxygenase activation and prostacyclin release during reperfusion.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Bradykinin; Diastole; Epoprostenol; Indomethacin; Male; Myoca | 2008 |
Effects of short term ischemia and reperfusion on coronary vascular reactivity and myocardial function.
Topics: Adenosine Deaminase; Animals; Arginine; Blood Pressure; Coronary Vessels; Dose-Response Relationship | 1995 |
Effects of aspirin and indomethacin on ventricular arrhythmias--comparative study.
Topics: Animals; Arrhythmias, Cardiac; Aspirin; Blood Pressure; Cardiac Complexes, Premature; Cause of Death | 1994 |
Bradykinin improves postischaemic recovery in the rat heart: role of high energy phosphates, nitric oxide, and prostacyclin.
Topics: Adenosine Triphosphate; Animals; Arginine; Bradykinin; Epoprostenol; Heart; Indomethacin; Magnetic R | 1995 |
Oestrogen relaxes human epicardial coronary arteries through non-endothelium-dependent mechanisms.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adolescent; Adult; Arginine; Chi | 1995 |
Endothelium-dependent regulation of coronary tone in the neonatal pig.
Topics: Acetylcholine; Animals; Animals, Newborn; Arginine; Coronary Vessels; Endothelium, Vascular; Indomet | 1994 |
Activation of cardiac vagal afferents in ischemia and reperfusion. Prostaglandins versus oxygen-derived free radicals.
Topics: Afferent Pathways; Animals; Deferoxamine; Female; Heart; Hydrogen Peroxide; Indomethacin; Male; Myoc | 1994 |
Dissociation of the anti-ischaemic effects of cloricromene from its anti-platelet activity.
Topics: Animals; Blood Pressure; Chromonar; Coronary Vessels; Electrocardiography; Heart Rate; Ibuprofen; In | 1993 |
Impaired endothelium-dependent coronary microvascular relaxation after cold potassium cardioplegia and reperfusion.
Topics: Acetylcholine; Aminoquinolines; Animals; Bradykinin; Calcimycin; Coronary Vessels; Disease Models, A | 1993 |
Stimulation of endogenous prostacyclin protects the reperfused pig myocardium from ischemic injury.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Platelets; Cyclooxygenase Inhibitors; Disease Models, A | 1993 |
Effects of neurotensin and neuropeptide Y on coronary circulation and myocardial function in dogs.
Topics: Animals; Coronary Vessels; Dogs; Female; Heart; Hemodynamics; Indomethacin; Male; Myocardial Ischemi | 1993 |
Paracrine systems in the cardioprotective effect of angiotensin-converting enzyme inhibitors on myocardial ischemia/reperfusion injury in rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine | 1996 |
Cyclooxygenase blockade limits blood flow to collateral-dependent myocardium during exercise.
Topics: Animals; Collateral Circulation; Coronary Circulation; Cyclooxygenase Inhibitors; Dogs; Female; Indo | 1995 |
Renal sympathetic nerve activity during cardiac ischemia and reperfusion in rats.
Topics: Administration, Topical; Animals; Blood Pressure; Capsaicin; Deferoxamine; Denervation; Heart Conduc | 1996 |
Ischaemic cardiac hyperaemia: role of nitric oxide and other mediators.
Topics: 6-Ketoprostaglandin F1 alpha; Adenosine; Animals; Coronary Circulation; Cyclic GMP; Cyclooxygenase I | 1996 |
Roles of NO and Ca2+-activated K+ channels in coronary vasodilation induced by 17beta-estradiol in ischemic heart failure.
Topics: Animals; Calcium; Cattle; Coronary Circulation; Coronary Vessels; Enzyme Inhibitors; Estradiol; Indo | 1997 |
Types of potassium channels involved in coronary reactive hyperemia depend on duration of preceding ischemia in rat hearts.
Topics: 4-Aminopyridine; Adenosine Diphosphate; Animals; Apamin; Charybdotoxin; Glyburide; Hyperemia; In Vit | 1997 |
Amelioration of ischemia- and reperfusion-induced myocardial injury by 17beta-estradiol: role of nitric oxide and calcium-activated potassium channels.
Topics: Animals; Anti-Inflammatory Agents; Calcium; Dogs; Enzyme Inhibitors; Estradiol; Heart Ventricles; In | 1997 |
Effects of simulated myocardial ischemic conditions on the responses of isolated human umbilical artery strips to 5-hydroxytryptamine and prostaglandin F2 alpha.
Topics: Culture Media; Cyclooxygenase Inhibitors; Dinoprost; Endothelins; Enzyme Inhibitors; Female; Humans; | 1997 |
Cardioprotective effect of angiotensin-converting enzyme inhibition against hypoxia/reoxygenation injury in cultured rat cardiac myocytes.
Topics: Adrenergic beta-Antagonists; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Anti | 1999 |
Interaction of adenosine and prostacyclin in coronary flow regulation after myocardial ischemia.
Topics: Adenosine; Animals; Cyclooxygenase Inhibitors; Drug Interactions; Epoprostenol; Guinea Pigs; Heart; | 1999 |
Mechanisms of protection afforded by cyclooxygenase inhibitors to endothelial function against ischemic injury in rat isolated hearts.
Topics: Animals; Arachidonic Acid; Cardiotonic Agents; Coronary Circulation; Coronary Vessels; Cyclooxygenas | 1999 |
Cicletanine prevents the excitation-conduction blocks induced by terfenadine in ischemic myocardium.
Topics: Animals; Anti-Arrhythmia Agents; Dimethyl Sulfoxide; Drug Interactions; Epoprostenol; Female; Guinea | 1999 |
Effect of patent ductus arteriosus and indomethacin treatment on serum cardiac troponin T levels in preterm infants with respiratory distress syndrome.
Topics: Cardiovascular Agents; Ductus Arteriosus, Patent; Humans; Indomethacin; Infant, Newborn; Infant, Pre | 2000 |
Adenosine induced direct negative inotropic effect is abolished during global ischemia: role of protein kinase C and prostacyclin.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine; Animals; Depression, Chemical; Drug Intera | 2000 |
Activation of cardiac afferents by arachidonic acid: relative contributions of metabolic pathways.
Topics: Animals; Arachidonic Acid; Axons; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Fat | 2001 |
Angiotensin-(1-7): cardioprotective effect in myocardial ischemia/reperfusion.
Topics: Angiotensin I; Angiotensin II; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bradykinin; He | 2001 |
Role of calcitonin gene-related peptide in prostaglandins-mediated ischemic preconditioning in guinea pig hearts.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Pept | 2001 |