indomethacin has been researched along with Multiple Sclerosis in 9 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Multiple Sclerosis: An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The addition of indomethacin to concanavalin A (Con A)-induced cultures of human peripheral blood leukocytes (PBL) caused an increase in interferon response, regardless of whether the PBLs were derived from multiple sclerosis (MS) patients or from control donors." | 7.67 | Influence of prostaglandin E2 and indomethacin on interferon-gamma production by cultured peripheral blood leukocytes of multiple sclerosis patients and healthy donors. ( Billiau, A; Carton, H; Deckmyn, H; Vervliet, G, 1985) |
| "The addition of indomethacin to concanavalin A (Con A)-induced cultures of human peripheral blood leukocytes (PBL) caused an increase in interferon response, regardless of whether the PBLs were derived from multiple sclerosis (MS) patients or from control donors." | 3.67 | Influence of prostaglandin E2 and indomethacin on interferon-gamma production by cultured peripheral blood leukocytes of multiple sclerosis patients and healthy donors. ( Billiau, A; Carton, H; Deckmyn, H; Vervliet, G, 1985) |
| " The number of treatments was fewer and the dosage of interferon beta administered was less in the present study than in the preliminary one." | 2.66 | Intrathecally administered natural human fibroblast interferon reduces exacerbations of multiple sclerosis. Results of a multicenter, double-blind study. ( Cuetter, A; Ekes, R; Freeman, A; Herndon, R; Husain, F; Jacobs, L; Jozefowicz, R; Reese, PA; Salazar, AM; Smith, WA, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (88.89) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Merrill, JE | 2 |
| Myers, LW | 2 |
| Ellison, GW | 2 |
| Jondal, M | 1 |
| Merrill, J | 1 |
| Ullberg, M | 1 |
| Porrini, AM | 1 |
| Reder, AT | 1 |
| Panitch, HS | 1 |
| Berenbaum, MC | 1 |
| Jacobs, L | 1 |
| Salazar, AM | 1 |
| Herndon, R | 1 |
| Reese, PA | 1 |
| Freeman, A | 1 |
| Jozefowicz, R | 1 |
| Cuetter, A | 1 |
| Husain, F | 1 |
| Smith, WA | 1 |
| Ekes, R | 1 |
| Vervliet, G | 1 |
| Deckmyn, H | 1 |
| Carton, H | 1 |
| Billiau, A | 1 |
| Khan, SN | 1 |
| Belin, J | 1 |
| Smith, AD | 1 |
| Sidey, M | 1 |
| Zilkha, KJ | 1 |
1 trial available for indomethacin and Multiple Sclerosis
| Article | Year |
|---|---|
Intrathecally administered natural human fibroblast interferon reduces exacerbations of multiple sclerosis. Results of a multicenter, double-blind study.
Topics: Adult; Double-Blind Method; Humans; Indomethacin; Injections, Spinal; Interferon Type I; Multiple Sc | 1987 |
8 other studies available for indomethacin and Multiple Sclerosis
| Article | Year |
|---|---|
Regulation of natural killer cell cytotoxicity by prostaglandin E in the peripheral blood and cerebrospinal fluid of patients with multiple sclerosis and other neurological diseases. Part 2. Effect of exogenous PGE1 on spontaneous and interferon-induced n
Topics: Alprostadil; Cytotoxicity, Immunologic; Dose-Response Relationship, Drug; Humans; Indomethacin; Inte | 1983 |
Cytotoxic cells in peripheral blood and cerebrospinal fluid of multiple sclerosis patients.
Topics: Alprostadil; Antibody-Dependent Cell Cytotoxicity; Bipolar Disorder; Cerebrospinal Fluid; Cytotoxici | 1984 |
Monocyte-induced human natural killer cell suppression followed by increased cytotoxic activity during short-term in vitro culture in autologous serum.
Topics: Cell Communication; Cells, Cultured; Depression, Chemical; Hodgkin Disease; Humans; Immunosuppressio | 1981 |
IFN-gamma, IFN-beta, and PGE1 affect monokine secretion: relevance to monocyte activation in multiple sclerosis.
Topics: Alprostadil; Humans; In Vitro Techniques; Indomethacin; Interferon-beta; Interferon-gamma; Interleuk | 1994 |
Indomethacin, interferons, and multiple sclerosis.
Topics: Humans; Indomethacin; Interferons; Multiple Sclerosis | 1987 |
Intrathecal interferon, indomethacin, and multiple sclerosis.
Topics: Humans; Indomethacin; Injections, Spinal; Interferon Type I; Multiple Sclerosis | 1987 |
Influence of prostaglandin E2 and indomethacin on interferon-gamma production by cultured peripheral blood leukocytes of multiple sclerosis patients and healthy donors.
Topics: Adult; Dinoprostone; Humans; Indomethacin; Inflammation; Interferon-gamma; Leukocytes; Macrophages; | 1985 |
Response to platelet-activating factor of platelets from patients with multiple sclerosis.
Topics: Acetophenones; Blood Platelets; Calcium; Humans; Indomethacin; Multiple Sclerosis; Platelet Activati | 1985 |