indomethacin has been researched along with Multiple Organ Failure in 3 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Multiple Organ Failure: A progressive condition usually characterized by combined failure of several organs such as the lungs, liver, kidney, along with some clotting mechanisms, usually postinjury or postoperative.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The aim of the study is to verify the efficacy of the pharmacological blockade of the systemic inflammatory response syndrome (SIRS) in serious blunt chest injuries, and to identify whether the administration of indomethacin as a cyclooxygenase inhibitor could prevent a multiorgan dysfunction (MODS) and a multiorgan failure (MOF)." | 5.11 | Systemic inflammatory response syndrome (SIRS) in serious chest injuries: is a pharmacological blockade effective? ( Cervinka, V; Havlícek, K; Motycka, V; Siller, J, 2005) |
| " The aim is also to find out if the administration of indomethacin as a cyclooxygenase inhibitor could prevent multiorgan dysfunction (MODS) and multiorgan failure (MOF)." | 5.10 | [Pharmacologic prevention of SIRS (systemic inflammatory response syndrome) in severe thoracic injuries]. ( Fortová, M; Grofová, Z; Havlícek, K; Motycka, V; Siller, J; Vanác, J, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Evans, SM | 1 |
| Whittle, BJ | 1 |
| Motycka, V | 2 |
| Havlícek, K | 2 |
| Siller, J | 2 |
| Grofová, Z | 1 |
| Vanác, J | 1 |
| Fortová, M | 1 |
| Cervinka, V | 1 |
2 trials available for indomethacin and Multiple Organ Failure
| Article | Year |
|---|---|
[Pharmacologic prevention of SIRS (systemic inflammatory response syndrome) in severe thoracic injuries].
Topics: Cyclooxygenase Inhibitors; Humans; Indomethacin; Multiple Organ Failure; Premedication; Systemic Inf | 2003 |
Systemic inflammatory response syndrome (SIRS) in serious chest injuries: is a pharmacological blockade effective?
Topics: Adult; Aged; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studi | 2005 |
1 other study available for indomethacin and Multiple Organ Failure
| Article | Year |
|---|---|
Role of bacteria and inducible nitric oxide synthase activity in the systemic inflammatory microvascular response provoked by indomethacin in the rat.
Topics: Ampicillin; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non- | 2003 |