indomethacin has been researched along with Mucositis, Oral in 19 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The efficacy and safety of indomethacin (IM) oral spray (OS) as a pain control therapy for oropharyngeal mucositis due to anticancer chemo- and radiotherapy were assessed in patients with head and neck carcinomas and haematological tumours." | 9.24 | Assessment of indomethacin oral spray for the treatment of oropharyngeal mucositis-induced pain during anticancer therapy. ( Bukawa, H; Chiba, S; Homma, M; Kizawa, Y; Kohda, Y; Momo, K; Nagaoka, H, 2017) |
| "The preparation and clinical applications of indomethacin (IM) gel were investigated in the treatment of stomatitis resulting from chemotherapy and radiotherapy for cancer." | 9.11 | Preparation and clinical application of indomethacin gel for medical treatment of stomatitis. ( Hashizaki, K; Makimura, M; Momo, K; Ogawa, N; Saito, Y; Shiratsuchi, T; Taguchi, H, 2005) |
| "25% indomethacin (IM) spray as an in-hospital preparation on the pain of stomatitis after hematopoietic stem cell transplantation in 9 patients with various types of leukemia by measuring the change in pain and the decrease in morphine dose." | 9.10 | [The effects of indomethacin spray on the pain of stomatitis in the patients for hematopoietic stem cell transplantation]. ( Aoyama, T; Furukawa, T; Hirai, H; Iga, T; Kanda, Y; Miyoshi, A; Nakamura, T; Yamada, Y; Yanagihara, Y, 2003) |
| "IMS effectively relieved anticancer drug-induced OM pain and may be useful for immediate self-medication." | 7.01 | Analgesic effects of indomethacin spray on drug-induced oral mucositis pain in patients with cancer: A single-arm cross-sectional study. ( Edo, M; Fujikawa, K; Hata, H; Imamachi, K; Kitagawa, Y; Matsuzaka, M; Sagawa, T; Sato, J; Takada, S; Ueda, M; Yoshikawa, K, 2021) |
| "The efficacy and safety of indomethacin (IM) oral spray (OS) as a pain control therapy for oropharyngeal mucositis due to anticancer chemo- and radiotherapy were assessed in patients with head and neck carcinomas and haematological tumours." | 5.24 | Assessment of indomethacin oral spray for the treatment of oropharyngeal mucositis-induced pain during anticancer therapy. ( Bukawa, H; Chiba, S; Homma, M; Kizawa, Y; Kohda, Y; Momo, K; Nagaoka, H, 2017) |
| "The preparation and clinical applications of indomethacin (IM) gel were investigated in the treatment of stomatitis resulting from chemotherapy and radiotherapy for cancer." | 5.11 | Preparation and clinical application of indomethacin gel for medical treatment of stomatitis. ( Hashizaki, K; Makimura, M; Momo, K; Ogawa, N; Saito, Y; Shiratsuchi, T; Taguchi, H, 2005) |
| "25% indomethacin (IM) spray as an in-hospital preparation on the pain of stomatitis after hematopoietic stem cell transplantation in 9 patients with various types of leukemia by measuring the change in pain and the decrease in morphine dose." | 5.10 | [The effects of indomethacin spray on the pain of stomatitis in the patients for hematopoietic stem cell transplantation]. ( Aoyama, T; Furukawa, T; Hirai, H; Iga, T; Kanda, Y; Miyoshi, A; Nakamura, T; Yamada, Y; Yanagihara, Y, 2003) |
| " In this study, we investigated the development of an indomethacin mouth wash(IM-MW)as a novel approach to treat pain due to oral mucositis." | 3.96 | [Optimization of Preparation, and Stability of Indomethacin Mouth Wash for Oral Mucositis Caused by Cancer Therapy]. ( Kiyomi, A; Kuroda, S; Momo, K; Ono, K; Sugiura, M; Yasu, T, 2020) |
| "The analgesic effects on pain-related behaviors following the topical application of hangeshashinto were evaluated in an oral ulcer rat model treated with acetic acid using recently developed methods." | 3.83 | The traditional Japanese medicine hangeshashinto alleviates oral ulcer-induced pain in a rat model. ( Hattori, T; Hitomi, S; Imai, R; Inenaga, K; Kase, Y; Kubota, K; Omiya, Y; Ono, K; Terawaki, K; Yamaguchi, K, 2016) |
| "IMS effectively relieved anticancer drug-induced OM pain and may be useful for immediate self-medication." | 3.01 | Analgesic effects of indomethacin spray on drug-induced oral mucositis pain in patients with cancer: A single-arm cross-sectional study. ( Edo, M; Fujikawa, K; Hata, H; Imamachi, K; Kitagawa, Y; Matsuzaka, M; Sagawa, T; Sato, J; Takada, S; Ueda, M; Yoshikawa, K, 2021) |
| " The local therapy of alveolitis, is free of risk with solution out of Metindol--vials under dosage up to 6 milligram indomethacin substance." | 2.67 | [Etiology of alveolitis and its therapy with indomethacin]. ( Fischer, R; Schroeder, H, 1990) |
| "Upper gastrointestinal haemorrhage and pseudomembranous colitis are potentially fatal manifestations of drug therapy." | 2.36 | Drug-induced gastrointestinal disease. ( Bramble, MG; Record, CO, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (42.11) | 18.7374 |
| 1990's | 1 (5.26) | 18.2507 |
| 2000's | 2 (10.53) | 29.6817 |
| 2010's | 4 (21.05) | 24.3611 |
| 2020's | 4 (21.05) | 2.80 |
| Authors | Studies |
|---|---|
| Yasu, T | 2 |
| Momo, K | 6 |
| Horii, M | 1 |
| Yokoyama, K | 1 |
| Ono, K | 3 |
| Kiyomi, A | 2 |
| Sugiura, M | 2 |
| Kuroda, S | 2 |
| Nagaoka, H | 2 |
| Hamano, J | 1 |
| Miyaji, T | 1 |
| Oyamada, S | 1 |
| Kawaguchi, T | 1 |
| Homma, M | 2 |
| Yamaguchi, T | 1 |
| Morita, T | 1 |
| Kizawa, Y | 2 |
| Hata, H | 1 |
| Takada, S | 1 |
| Sato, J | 1 |
| Yoshikawa, K | 1 |
| Imamachi, K | 1 |
| Edo, M | 1 |
| Sagawa, T | 1 |
| Fujikawa, K | 1 |
| Ueda, M | 1 |
| Matsuzaka, M | 1 |
| Kitagawa, Y | 1 |
| Bukawa, H | 1 |
| Chiba, S | 1 |
| Kohda, Y | 1 |
| Sugiyama, I | 1 |
| Kudo, K | 1 |
| Sadzuka, Y | 1 |
| Hitomi, S | 1 |
| Yamaguchi, K | 1 |
| Terawaki, K | 1 |
| Imai, R | 1 |
| Kubota, K | 1 |
| Omiya, Y | 1 |
| Hattori, T | 1 |
| Kase, Y | 1 |
| Inenaga, K | 1 |
| Nakamura, T | 1 |
| Aoyama, T | 1 |
| Yanagihara, Y | 1 |
| Yamada, Y | 1 |
| Miyoshi, A | 1 |
| Kanda, Y | 1 |
| Hirai, H | 1 |
| Furukawa, T | 1 |
| Iga, T | 1 |
| Shiratsuchi, T | 1 |
| Taguchi, H | 1 |
| Hashizaki, K | 1 |
| Saito, Y | 1 |
| Makimura, M | 1 |
| Ogawa, N | 2 |
| Ohnishi, M | 1 |
| Kawai, T | 1 |
| Knychalska-Karwan, Z | 1 |
| Krówczyński, L | 1 |
| Krasowska, H | 1 |
| Kosowska, K | 1 |
| Lejman, L | 1 |
| Tompson, HM | 1 |
| Bramble, MG | 1 |
| Record, CO | 1 |
| Schroeder, H | 1 |
| Fischer, R | 1 |
| Pillsbury, HC | 1 |
| Webster, WP | 1 |
| Rosenman, J | 1 |
| Almeyda, J | 1 |
| Baker, H | 1 |
| Lazar, M | 1 |
| Weiner, MJ | 1 |
| Leopold, IH | 1 |
| Culand, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Radiosensitization With a COX-2 Inhibitor (Celecoxib), With Chemoradiation for Cancer of the Head and Neck[NCT00581971] | Phase 1/Phase 2 | 30 participants (Actual) | Interventional | 2002-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Evaluate the response to concurrent celecoxib, carboplatin, paclitaxel, and radiotherapy in the treatment of locally advanced SSC of the head and neck. Response is determined by local control only, local and distant metastasis, distant metastasis only, second primary, and surgical salvage. (NCT00581971)
Timeframe: 2 years from end of treatment (Radiation therapy)
| Intervention | Participants (Number) | ||||
|---|---|---|---|---|---|
| Local Control Only | Local Control and Distant Metastasis | Distant Metastatsis Only | Secondary Primary - Site Unknown | Surgical Salvage | |
| Recurrence | 6 | 2 | 1 | 2 | 3 |
Particpants experiencing Acute Toxicities > Grade 3 (NCT00581971)
Timeframe: 2 years from radiation therapy
| Intervention | participants (Number) | ||
|---|---|---|---|
| Hematologic | Dermatitis | Mucositis/Dysphagia | |
| Acute Toxicity | 12 | 7 | 16 |
4 reviews available for indomethacin and Mucositis, Oral
| Article | Year |
|---|---|
[The Collaboration between Clinical Therapy and Academic Study to Benefit Patients].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Drug Compounding; Drug Packaging; Fe | 2018 |
[Indomethacin Spray Preparation for the Control of Pain Associated with Stomatitis Caused by Chemotherapy and Radiotherapy in Cancer Patients].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Drug Stability; Drug Storage; Humans | 2015 |
Drug-induced gastrointestinal disease.
Topics: Adrenal Cortex Hormones; Cathartics; Colon; Constipation; Diarrhea; Enterocolitis, Pseudomembranous; | 1978 |
Drug reactions. XII. Cutaneous reactions to anti-rheumatic drugs.
Topics: Adult; Anti-Inflammatory Agents; Drug Eruptions; Edema; Female; Gold; Humans; Indomethacin; Lymphade | 1970 |
8 trials available for indomethacin and Mucositis, Oral
| Article | Year |
|---|---|
Effects of an Indomethacin Oral Spray on Pain Due to Oral Mucositis in Cancer Patients Treated With Radiotherapy and Chemotherapy: A Double-Blind, Randomized, Placebo-Controlled Trial (JORTC-PAL04).
Topics: Adult; Double-Blind Method; Head and Neck Neoplasms; Humans; Indomethacin; Oral Sprays; Pain; Qualit | 2021 |
Analgesic effects of indomethacin spray on drug-induced oral mucositis pain in patients with cancer: A single-arm cross-sectional study.
Topics: Analgesics; Cross-Sectional Studies; Humans; Indomethacin; Japan; Middle Aged; Neoplasms; Pain; Phar | 2021 |
Assessment of indomethacin oral spray for the treatment of oropharyngeal mucositis-induced pain during anticancer therapy.
Topics: Adult; Aged; Antineoplastic Agents; Drug-Related Side Effects and Adverse Reactions; Female; Head an | 2017 |
[The effects of indomethacin spray on the pain of stomatitis in the patients for hematopoietic stem cell transplantation].
Topics: Administration, Buccal; Adult; Female; Hematopoietic Stem Cell Transplantation; Humans; Indomethacin | 2003 |
Preparation and clinical application of indomethacin gel for medical treatment of stomatitis.
Topics: Administration, Topical; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Cellulose; Chemical P | 2005 |
Double-blind evaluation of piroxicam and indomethacin in the treatment of inflammation following oral surgery.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Double-B | 1983 |
[Etiology of alveolitis and its therapy with indomethacin].
Topics: Adult; Alveolar Process; Humans; Indomethacin; Stomatitis | 1990 |
Prostaglandin inhibitor and radiotherapy in advanced head and neck cancers.
Topics: Clinical Trials as Topic; Combined Modality Therapy; Double-Blind Method; Head and Neck Neoplasms; H | 1986 |
7 other studies available for indomethacin and Mucositis, Oral
| Article | Year |
|---|---|
Effect of Indomethacin Mouthwash on Pain Due to Chemotherapy-Induced Oral Mucositis.
Topics: Antineoplastic Agents; Humans; Indomethacin; Mouthwashes; Pain; Stomatitis | 2020 |
[Optimization of Preparation, and Stability of Indomethacin Mouth Wash for Oral Mucositis Caused by Cancer Therapy].
Topics: Humans; Indomethacin; Mouthwashes; Neoplasms; Pain; Stomatitis | 2020 |
The traditional Japanese medicine hangeshashinto alleviates oral ulcer-induced pain in a rat model.
Topics: Acetic Acid; Administration, Topical; Analgesics; Animals; Disease Models, Animal; Drugs, Chinese He | 2016 |
[Indomethacin in the treatment of stomatitis and periodontitis].
Topics: Adult; Female; Humans; Indomethacin; Male; Periodontitis; Stomatitis; Stomatitis, Aphthous | 1980 |
Allergic reaction?
Topics: Dimethoate; Drug Hypersensitivity; Humans; Indomethacin; Insecticides; Male; Stomatitis | 1981 |
Treatment of uveitis with methotrexate.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Alopecia; Anti-Bacterial Agents; Child; | 1969 |
[Anti-inflammatory drugs].
Topics: Adrenocorticotropic Hormone; Aminobenzoates; Anti-Inflammatory Agents; Dental Pulp Capping; Edema; E | 1971 |