indomethacin has been researched along with Morphine Dependence in 7 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Morphine Dependence: Strong dependence, both physiological and emotional, upon morphine.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Indomethacin pretreatment also greatly enhanced the capacity of naloxone to decrease temperature and suppress FR 30 behavior in morphine-treated rats." | 1.27 | Indomethacin facilitates acute tolerance to and dependence upon morphine as measured by changes in fixed-ratio behavior and rectal temperature in rats. ( Nielsen, JA; Sparber, SB, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Beubler, E | 1 |
| Bukhave, K | 1 |
| Rask-Madsen, J | 1 |
| Ramírez-Solares, R | 1 |
| Luján, M | 1 |
| Rodríguez, R | 1 |
| Johnson, MA | 1 |
| Hill, RG | 1 |
| Hughes, J | 1 |
| Parmar, NS | 1 |
| Tariq, M | 1 |
| Ageel, AM | 1 |
| Krakow, MS | 1 |
| Ehrenpreis, ED | 1 |
| Ehrenpreis, S | 1 |
| Nielsen, JA | 1 |
| Sparber, SB | 1 |
| Collier, HO | 1 |
1 review available for indomethacin and Morphine Dependence
| Article | Year |
|---|---|
Drug dependence: a pharmacological analysis.
Topics: Acetylcholine; Animals; Atropine; Brain Chemistry; Catecholamines; Cerebral Cortex; Chemoreceptor Ce | 1972 |
6 other studies available for indomethacin and Morphine Dependence
| Article | Year |
|---|---|
Colonic secretion mediated by prostaglandin E2 and 5-hydroxytryptamine may contribute to diarrhea due to morphine withdrawal in the rat.
Topics: Animals; Atropine; Clonidine; Colon; Cyclic AMP; Diarrhea; Dinoprostone; Female; Humans; Indomethaci | 1984 |
Evidences for involvement of prostaglandins of the E series in morphine physical dependence in the isolated ileum of the guinea-pig.
Topics: Acetylcholine; Animals; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Indomethacin; Male; Morphin | 1983 |
A possible role for prostaglandins in the expression of morphine dependence in guinea-pig isolated ileum.
Topics: Alprostadil; Animals; Cyclooxygenase Inhibitors; Guinea Pigs; Ileum; In Vitro Techniques; Indomethac | 1988 |
Studies on the gastroulcerogenic effects of pylorus ligation, hypothermic restraint stress, aspirin, indomethacin and reserpine in morphine dependent rats.
Topics: Animals; Aspirin; Gastric Acid; Hypothermia; Indomethacin; Ligation; Male; Morphine Dependence; Pylo | 1987 |
Inhibition by indomethacin of naloxone-precipitated opiate withdrawal contraction in isolated guinea pig myenteric plexus-longitudinal muscle preparation.
Topics: Acetylcholine; Animals; Guinea Pigs; Ileum; In Vitro Techniques; Indomethacin; Male; Morphine Depend | 1986 |
Indomethacin facilitates acute tolerance to and dependence upon morphine as measured by changes in fixed-ratio behavior and rectal temperature in rats.
Topics: Animals; Body Temperature; Brain; Conditioning, Operant; Drug Tolerance; Humans; Indomethacin; Male; | 1985 |