indomethacin has been researched along with Mitochondrial Diseases in 4 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Mitochondrial Diseases: Diseases caused by abnormal function of the MITOCHONDRIA. They may be caused by mutations, acquired or inherited, in mitochondrial DNA or in nuclear genes that code for mitochondrial components. They may also be the result of acquired mitochondria dysfunction due to adverse effects of drugs, infections, or other environmental causes.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study, PVR was induced in pups in utero by exposure of pregnant dams to indomethacin and hypoxia and cardiac lipids, echocardiographic function and cardiomyocyte mitochondrial function were subsequently examined." | 4.12 | Altered cardiolipin metabolism is associated with cardiac mitochondrial dysfunction in pulmonary vascular remodeled perinatal rat pups. ( Cole, LK; Dolinsky, VW; Hatch, GM; Sparagna, GC, 2022) |
| "Quercetin was the most efficient in protecting against mitochondrial dysfunction; this could be due to its ability to enter cells and accumulate in mitochondria." | 1.38 | Differential protective effects of quercetin, resveratrol, rutin and epigallocatechin gallate against mitochondrial dysfunction induced by indomethacin in Caco-2 cells. ( Carrasco-Pozo, C; Gotteland, M; Mizgier, ML; Speisky, H, 2012) |
| "Pre-treatment with curcumin was found to ameliorate these drug-induced changes." | 1.35 | Curcumin attenuates indomethacin-induced oxidative stress and mitochondrial dysfunction. ( Balasubramanian, KA; Basivireddy, J; Jacob, M; Sivalingam, N, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cole, LK | 1 |
| Sparagna, GC | 1 |
| Dolinsky, VW | 1 |
| Hatch, GM | 1 |
| Carrasco-Pozo, C | 2 |
| Gotteland, M | 2 |
| Speisky, H | 2 |
| Mizgier, ML | 1 |
| Sivalingam, N | 1 |
| Basivireddy, J | 1 |
| Balasubramanian, KA | 1 |
| Jacob, M | 1 |
4 other studies available for indomethacin and Mitochondrial Diseases
| Article | Year |
|---|---|
Altered cardiolipin metabolism is associated with cardiac mitochondrial dysfunction in pulmonary vascular remodeled perinatal rat pups.
Topics: Animals; Animals, Newborn; Cardiolipins; Disease Models, Animal; Female; Hypoxia; Indomethacin; Mito | 2022 |
Protection by apple peel polyphenols against indometacin-induced oxidative stress, mitochondrial damage and cytotoxicity in Caco-2 cells.
Topics: Adenosine Triphosphate; Antioxidants; Caco-2 Cells; Cell Line, Tumor; Cell Survival; Dose-Response R | 2010 |
Differential protective effects of quercetin, resveratrol, rutin and epigallocatechin gallate against mitochondrial dysfunction induced by indomethacin in Caco-2 cells.
Topics: Adenosine Triphosphate; Caco-2 Cells; Catechin; Drug Interactions; Electron Transport Complex I; Gas | 2012 |
Curcumin attenuates indomethacin-induced oxidative stress and mitochondrial dysfunction.
Topics: Alkaline Phosphatase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Curcumin; Indomethacin; Inte | 2008 |