indomethacin has been researched along with Metabolic Acidosis in 19 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Topically applied acetylsalicylic acid (ASA), salicylic acid (SA) and indomethacin were tested in an experimental pain model that provides direct nociceptor excitation through cutaneous tissue acidosis." | 9.08 | Topical acetylsalicylic, salicylic acid and indomethacin suppress pain from experimental tissue acidosis in human skin. ( Kreysel, HW; Reeh, PW; Steen, KH, 1995) |
| " We therefore investigated the effect of indomethacin on the CBF increase caused by acetazolamide (Az), a drug that induces brain extracellular acidosis, which triggers its effect on CBF." | 7.68 | Indomethacin abolishes cerebral blood flow increase in response to acetazolamide-induced extracellular acidosis: a mechanism for its effect on hypercapnia? ( Lassen, NA; Paulson, OB; Wang, Q, 1993) |
| "Topically applied acetylsalicylic acid (ASA), salicylic acid (SA) and indomethacin were tested in an experimental pain model that provides direct nociceptor excitation through cutaneous tissue acidosis." | 5.08 | Topical acetylsalicylic, salicylic acid and indomethacin suppress pain from experimental tissue acidosis in human skin. ( Kreysel, HW; Reeh, PW; Steen, KH, 1995) |
| " We therefore investigated the effect of indomethacin on the CBF increase caused by acetazolamide (Az), a drug that induces brain extracellular acidosis, which triggers its effect on CBF." | 3.68 | Indomethacin abolishes cerebral blood flow increase in response to acetazolamide-induced extracellular acidosis: a mechanism for its effect on hypercapnia? ( Lassen, NA; Paulson, OB; Wang, Q, 1993) |
| "d-Mannitol alone was ineffective." | 1.27 | Inhibition by free radical scavengers and by cyclooxygenase inhibitors of the effect of acidosis on calcium transport by masseter muscle sarcoplasmic reticulum. ( Hess, ML; Ito, H; Kato, Y; Kohno, H; Okabe, E, 1985) |
| "Metabolic acidosis is associated with enhanced renal ammonia-genesis which is regulated, in part, by glucocorticoids." | 1.27 | Metabolic acidosis stimulates protein degradation in rat muscle by a glucocorticoid-dependent mechanism. ( Kelly, RA; May, RC; Mitch, WE, 1986) |
| "Systemic hypotension was not observed and the blood pressure in the indomethacintreated cats 1, 2 and 4 h after endotoxin was 30 mmHg higher than in those cats administered endotoxin alone." | 1.25 | The effect of indomethacin on the cardiovascular and metabolic responses to E. coli endotoxin in the cat. ( Parratt, JR; Sturgess, RM, 1974) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (57.89) | 18.7374 |
| 1990's | 4 (21.05) | 18.2507 |
| 2000's | 3 (15.79) | 29.6817 |
| 2010's | 1 (5.26) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Subramaniam, G | 1 |
| Achike, FI | 2 |
| Mustafa, MR | 1 |
| Yeo, JL | 1 |
| Tan, BT | 1 |
| Frick, KK | 1 |
| Bushinsky, DA | 1 |
| Frazier, LW | 1 |
| Jones, ER | 1 |
| Beck, TR | 1 |
| Kapoor, S | 1 |
| Shay, R | 1 |
| Narins, RG | 1 |
| de Jong, PE | 1 |
| de Jong-van den Berg, LT | 1 |
| Schouten, H | 1 |
| Donker, AJ | 1 |
| Statius van Eps, LW | 1 |
| Dunn, MJ | 1 |
| Zawada, ET | 1 |
| Wang, Q | 1 |
| Paulson, OB | 1 |
| Lassen, NA | 1 |
| Steen, KH | 1 |
| Reeh, PW | 1 |
| Kreysel, HW | 1 |
| Coessens, BC | 1 |
| Miller, VM | 1 |
| Wood, MB | 1 |
| Yamaguchi, K | 1 |
| Suzuki, K | 1 |
| Naoki, K | 1 |
| Nishio, K | 1 |
| Sato, N | 1 |
| Takeshita, K | 1 |
| Kudo, H | 1 |
| Aoki, T | 1 |
| Suzuki, Y | 1 |
| Miyata, A | 1 |
| Tsumura, H | 1 |
| Meghji, S | 1 |
| Morrison, MS | 1 |
| Henderson, B | 1 |
| Arnett, TR | 1 |
| Klaus, D | 1 |
| Okabe, E | 1 |
| Kato, Y | 1 |
| Kohno, H | 1 |
| Hess, ML | 1 |
| Ito, H | 1 |
| Nakamura, J | 1 |
| Zhang, SW | 1 |
| Ishikawa, N | 1 |
| May, RC | 1 |
| Kelly, RA | 1 |
| Mitch, WE | 1 |
| Tsuru, N | 1 |
| Chan, JC | 1 |
| Parratt, JR | 1 |
| Sturgess, RM | 1 |
2 reviews available for indomethacin and Metabolic Acidosis
| Article | Year |
|---|---|
Prostaglandins and Bartter's syndrome.
Topics: Acidosis; Aldosterone; Bartter Syndrome; Chemical Phenomena; Chemistry; Diet; Female; Humans; Hypera | 1981 |
Renal consequences of nonsteroidal antiinflammatory drugs.
Topics: Acidosis; Acute Kidney Injury; Aged; Anti-Inflammatory Agents; Bartter Syndrome; Female; Humans; Hyp | 1982 |
1 trial available for indomethacin and Metabolic Acidosis
| Article | Year |
|---|---|
Topical acetylsalicylic, salicylic acid and indomethacin suppress pain from experimental tissue acidosis in human skin.
Topics: Acidosis; Administration, Topical; Adult; Aspirin; Cross-Over Studies; Double-Blind Method; Female; | 1995 |
16 other studies available for indomethacin and Metabolic Acidosis
| Article | Year |
|---|---|
Effect of acidosis on the mechanism(s) of insulin-induced vasorelaxation in normal Wistar-Kyoto (WKY) rat aorta.
Topics: 4-Aminopyridine; Acidosis; Animals; Aorta; Barium Compounds; Chlorides; Endothelium, Vascular; Glybu | 2009 |
Exploring the mechanism of endothelial involvement in acidosis-induced vasodilatation of aortic tissues from normal and diabetic rats.
Topics: 4-Aminopyridine; Acidosis; Animals; Aorta; Barium Compounds; Chlorides; Diabetes Mellitus; Endotheli | 2010 |
Metabolic acidosis stimulates RANKL RNA expression in bone through a cyclo-oxygenase-dependent mechanism.
Topics: Acidosis; Animals; Bone and Bones; Calcium; Carbon Dioxide; Carrier Proteins; Cyclooxygenase Inhibit | 2003 |
The effect of acid-base changes on vasopressin-stimulated water flow in toad urinary bladder.
Topics: Acid-Base Imbalance; Acidosis; Alkalosis; Animals; Body Water; Bucladesine; Bufo marinus; Drug Inter | 1980 |
Prostaglandins inhibit renal ammoniagenesis in the rat.
Topics: Acidosis; Alkalosis; Ammonia; Animals; Hydrogen-Ion Concentration; In Vitro Techniques; Indomethacin | 1984 |
The influence of indomethacin on renal acidification in normal subjects and in patients with sickle cell anemia.
Topics: Acidosis; Adolescent; Adult; Anemia, Sickle Cell; Female; Humans; Indomethacin; Kidney Diseases; Kid | 1983 |
Indomethacin abolishes cerebral blood flow increase in response to acetazolamide-induced extracellular acidosis: a mechanism for its effect on hypercapnia?
Topics: Acetazolamide; Acidosis; Animals; Carbon Dioxide; Cerebrovascular Circulation; Diclofenac; Extracell | 1993 |
Endothelin-A receptors mediate vascular smooth-muscle response to moderate acidosis in the canine tibial nutrient artery.
Topics: Acidosis; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dogs; Dose-Response Relationship, Drug; | 1996 |
Response of intra-acinar pulmonary microvessels to hypoxia, hypercapnic acidosis, and isocapnic acidosis.
Topics: 6-Ketoprostaglandin F1 alpha; Acidosis; Animals; Arterioles; Capillaries; Carbon Dioxide; Epoprosten | 1998 |
pH dependence of bone resorption: mouse calvarial osteoclasts are activated by acidosis.
Topics: Acid-Base Equilibrium; Acidosis; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bicarbonates; Cal | 2001 |
[Conservative therapy of chronic glomerulonephritis].
Topics: Acidosis; Azathioprine; Chlorambucil; Chronic Disease; Chronic Kidney Disease-Mineral and Bone Disor | 1978 |
Inhibition by free radical scavengers and by cyclooxygenase inhibitors of the effect of acidosis on calcium transport by masseter muscle sarcoplasmic reticulum.
Topics: Acidosis; Animals; Arachidonic Acid; Arachidonic Acids; Biological Transport; Calcium; Cyclooxygenas | 1985 |
Inhalation of carbon dioxide enhances the coronary vasodilating action of isosorbide dinitrate in the dog.
Topics: Acidosis; Administration, Inhalation; Animals; Carbon Dioxide; Coronary Vessels; Dogs; Hemodynamics; | 1987 |
Metabolic acidosis stimulates protein degradation in rat muscle by a glucocorticoid-dependent mechanism.
Topics: Acidosis; Adrenalectomy; Ammonium Chloride; Animals; Body Weight; Dexamethasone; Hydrogen-Ion Concen | 1986 |
Growth failure in children with metabolic alkalosis and with metabolic acidosis.
Topics: Acidosis; Alkalosis; Bartter Syndrome; Child; Child, Preschool; Growth Disorders; Humans; Indomethac | 1987 |
The effect of indomethacin on the cardiovascular and metabolic responses to E. coli endotoxin in the cat.
Topics: Acidosis; Animals; Arteries; Blood; Blood Glucose; Cardiac Output; Cats; Central Venous Pressure; En | 1974 |