Page last updated: 2024-10-29

indomethacin and Meconium Aspiration Syndrome

indomethacin has been researched along with Meconium Aspiration Syndrome in 2 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Meconium Aspiration Syndrome: A condition caused by inhalation of MECONIUM into the LUNG of FETUS or NEWBORN, usually due to vigorous respiratory movements during difficult PARTURITION or respiratory system abnormalities. Meconium aspirate may block small airways leading to difficulties in PULMONARY GAS EXCHANGE and ASPIRATION PNEUMONIA.

Research Excerpts

ExcerptRelevanceReference
"Indomethacin pretreatment did not affect the enzyme expressions, whereas dexamethasone administration significantly inhibited the meconium-induced COX-2 and NOS-2 up-regulation."1.32Meconium aspiration stimulates cyclooxygenase-2 and nitric oxide synthase-2 expression in rat lungs. ( Kääpä, P; Kytölä, J; Uotila, P, 2003)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kytölä, J1
Kääpä, P1
Uotila, P1
Khan, AM1
Lally, KP1
Elidemir, O1
Colasurdo, GN1

Other Studies

2 other studies available for indomethacin and Meconium Aspiration Syndrome

ArticleYear
Meconium aspiration stimulates cyclooxygenase-2 and nitric oxide synthase-2 expression in rat lungs.
    Pediatric research, 2003, Volume: 53, Issue:5

    Topics: Age Factors; Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenas

2003
Meconium enhances the release of nitric oxide in human airway epithelial cells.
    Biology of the neonate, 2002, Volume: 81, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Line, Transformed; Dexamethasone; Enzyme Inhibitors; E

2002