indomethacin has been researched along with Meconium Aspiration Syndrome in 2 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Meconium Aspiration Syndrome: A condition caused by inhalation of MECONIUM into the LUNG of FETUS or NEWBORN, usually due to vigorous respiratory movements during difficult PARTURITION or respiratory system abnormalities. Meconium aspirate may block small airways leading to difficulties in PULMONARY GAS EXCHANGE and ASPIRATION PNEUMONIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Indomethacin pretreatment did not affect the enzyme expressions, whereas dexamethasone administration significantly inhibited the meconium-induced COX-2 and NOS-2 up-regulation." | 1.32 | Meconium aspiration stimulates cyclooxygenase-2 and nitric oxide synthase-2 expression in rat lungs. ( Kääpä, P; Kytölä, J; Uotila, P, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kytölä, J | 1 |
| Kääpä, P | 1 |
| Uotila, P | 1 |
| Khan, AM | 1 |
| Lally, KP | 1 |
| Elidemir, O | 1 |
| Colasurdo, GN | 1 |
2 other studies available for indomethacin and Meconium Aspiration Syndrome
| Article | Year |
|---|---|
Meconium aspiration stimulates cyclooxygenase-2 and nitric oxide synthase-2 expression in rat lungs.
Topics: Age Factors; Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenas | 2003 |
Meconium enhances the release of nitric oxide in human airway epithelial cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Line, Transformed; Dexamethasone; Enzyme Inhibitors; E | 2002 |