indomethacin has been researched along with Mast-Cell Sarcoma in 13 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Mast-Cell Sarcoma: A unifocal malignant tumor that consists of atypical pathological MAST CELLS without systemic involvement. It causes local destructive growth in organs other than in skin or bone marrow.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Indomethacin has little effect on the development of this suppressor cell activity." | 1.27 | Modification by biological products of the generation of suppressor cells in culture. ( Ehrke, MJ; Leung, KH; Mihich, E, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (76.92) | 18.7374 |
| 1990's | 3 (23.08) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Leung, KH | 2 |
| Ehrke, MJ | 2 |
| Mihich, E | 2 |
| Ngo, JL | 1 |
| Orlando, RA | 1 |
| Ibsen, KH | 1 |
| Drysdale, BE | 1 |
| Shin, HS | 1 |
| Rojo, JM | 1 |
| Barasoain, I | 1 |
| Portolés, A | 1 |
| Teshigawara, H | 1 |
| Moriya, Y | 1 |
| De Krey, GK | 1 |
| Baecher-Steppan, L | 1 |
| Fowles, JR | 1 |
| Kerkvliet, NI | 1 |
| Ralph, RK | 1 |
| Wojcik, S | 1 |
| Rakhmilevich, AL | 1 |
| Rakhimova, MS | 1 |
| Lazarus, SC | 1 |
| McCabe, LJ | 1 |
| Nadel, JA | 1 |
| Gold, WM | 1 |
| Leikauf, GD | 1 |
| Kalbhen, DA | 2 |
| Wisgens, D | 1 |
| Domenjoz, R | 1 |
| Lynen, J | 1 |
| Petillo, JJ | 1 |
| Gulbenkian, A | 1 |
| Tabachnick, II | 1 |
13 other studies available for indomethacin and Mast-Cell Sarcoma
| Article | Year |
|---|---|
Modification by biological products of the generation of suppressor cells in culture.
Topics: Animals; Antigens; Cells, Cultured; Culture Media; Dinoprostone; Female; Indomethacin; Mast-Cell Sar | 1983 |
Regulation of pyruvate kinase expression and growth in P-815 mastocytoma cells. II. Potential role of prostaglandins.
Topics: Animals; Bucladesine; Butyrates; Butyric Acid; Dinoprost; Dinoprostone; Drug Synergism; Indomethacin | 1984 |
Activation of macrophages for tumor cell cytotoxicity: identification of indomethacin sensitive and insensitive pathways.
Topics: Animals; Antibody-Dependent Cell Cytotoxicity; Aspirin; Cattle; Cell Adhesion; Cytotoxicity, Immunol | 1981 |
Variable effects of indomethacin and four related compounds on lymphocyte blastogenesis and cell-mediated cytotoxicity.
Topics: Animals; B-Lymphocytes; Concanavalin A; Cytotoxicity, Immunologic; Esters; In Vitro Techniques; Indo | 1981 |
Modulation of the development of cell-mediated immunity: possible role of the products of the cyclo-oxygenase and the lipoxygenase pathways of arachidonic acid metabolism.
Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Female; Immunity, Cellular; | 1982 |
The role of leukotriene C4 in biphasic release of histamine from mouse mastocytoma cell line (P-815).
Topics: Animals; Benzoquinones; Dose-Response Relationship, Drug; Histamine Release; Indomethacin; Leukotrie | 1994 |
Polychlorinated biphenyl-induced suppression of cytotoxic T lymphocyte activity: role of prostaglandin-E2.
Topics: Animals; Ascitic Fluid; Cells, Cultured; Dinoprostone; Immunosuppression Therapy; Indomethacin; Inje | 1994 |
Inhibitors of lipoxygenase have antiproliferative effects on P815 murine mastocytoma cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cell Division; Indomethacin; Leukotrienes; Lipoxygenas | 1990 |
[The synergistic action of lipopolysaccharide and muramyl dipeptide in the immunotherapy of DBA/2 mice with mastocytoma P815].
Topics: Acetylmuramyl-Alanyl-Isoglutamine; Animals; Cyclophosphamide; Drug Evaluation, Preclinical; Drug Syn | 1989 |
Effects of mast cell-derived mediators on epithelial cells in canine trachea.
Topics: Animals; Biological Transport; Calcimycin; Dogs; Electric Conductivity; Electrophysiology; Epitheliu | 1986 |
[Effect of small doses of anti-inflammatory agents on sulfate-S35 incorporation and cell proliferation of neoplastic mast cells in vitro].
Topics: Amides; Anti-Inflammatory Agents; Butyrates; Cell Division; Chloroquine; Culture Techniques; Dinitro | 1970 |
[Effect of some anti-inflammatory drugs on the ATP-content and cell proliferation of neoplastic mast cells in vitro].
Topics: Adenosine Triphosphate; Amides; Aminopyrine; Anti-Inflammatory Agents; Aspirin; Benzimidazoles; Benz | 1968 |
Effects in vivo and in vitro of nonsteroidal anti-inflammatory drugs on (rat stomach) histidine decarboxylase.
Topics: Adrenal Glands; Adrenalectomy; Animals; Anti-Inflammatory Agents; Aspirin; Carboxy-Lyases; Fasting; | 1969 |