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indomethacin and Malaria

indomethacin has been researched along with Malaria in 5 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Malaria: A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.

Research Excerpts

ExcerptRelevanceReference
"The effects of p-chlorophenylalanine, an inhibitor of serotonin synthesis, indomethacin, an inhibitor of prostaglandin synthesis, cyproheptadine, a serotonin, bradykinin and histamine antagonist, were assessed separately and in combination with chloroquine (CQ) in Vom strains of Swiss albino mice (18-22 g) of either sex infected intraperitoneally with 1 x 10(7) Plasmodium yoelii nigeriensis-induced malaria."3.72Effects of autacoid inhibitors and of an antagonist on malaria infection in mice. ( Agbani, EO; Iwalewa, EO, 2004)
" Since these T-cell responses are depressed during malaria infection, the capacity of macrophages to produce I1-1 following lipopolysaccharide (LPS) stimulation and that of lymphocytes to release I1-2 upon stimulation with concanavalin A (Con-A) in mice infected with either nonlethal Plasmodium yoelii (NLPY) or lethal Plasmodium berghei (PB) malaria parasites was analyzed."3.67Changes in the capacity of macrophages and T cells to produce interleukins during murine malaria infection. ( Lelchuk, R; Playfair, JH; Rose, G, 1984)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19903 (60.00)18.7374
1990's0 (0.00)18.2507
2000's2 (40.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Deharo, E1
Barkan, D1
Krugliak, M1
Golenser, J1
Ginsburg, H1
Iwalewa, EO1
Agbani, EO1
Lelchuk, R1
Rose, G1
Playfair, JH1
Riley, EM1
MacLennan, C1
Wiatkowski, DK1
Greenwood, BM1
Clarkson, AR1
Robson, JS1

Reviews

1 review available for indomethacin and Malaria

ArticleYear
The effect of drugs on immunological renal disease.
    Progress in biochemical pharmacology, 1972, Volume: 7

    Topics: Adrenal Cortex Hormones; Antilymphocyte Serum; Azathioprine; Chlorambucil; Cyclophosphamide; Glomeru

1972

Other Studies

4 other studies available for indomethacin and Malaria

ArticleYear
Potentiation of the antimalarial action of chloroquine in rodent malaria by drugs known to reduce cellular glutathione levels.
    Biochemical pharmacology, 2003, Sep-01, Volume: 66, Issue:5

    Topics: Acetaminophen; Acetylcysteine; Aminoquinolines; Animals; Antimalarials; Chloroquine; Disulfiram; Dru

2003
Effects of autacoid inhibitors and of an antagonist on malaria infection in mice.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2004, Volume: 37, Issue:8

    Topics: Animals; Antimalarials; Autacoids; Chloroquine; Cyproheptadine; Drug Combinations; Fenclonine; Hista

2004
Changes in the capacity of macrophages and T cells to produce interleukins during murine malaria infection.
    Cellular immunology, 1984, Apr-01, Volume: 84, Issue:2

    Topics: Animals; Concanavalin A; Female; Indomethacin; Interleukin-1; Interleukin-2; Kinetics; Lymphocyte Ac

1984
Suppression of in-vitro lymphoproliferative responses in acute malaria patients can be partially reversed by indomethacin.
    Parasite immunology, 1989, Volume: 11, Issue:5

    Topics: Animals; Antigens, Protozoan; Child; Child, Preschool; Female; Humans; Immune Tolerance; Indomethaci

1989