indomethacin has been researched along with Malaria in 5 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Malaria: A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of p-chlorophenylalanine, an inhibitor of serotonin synthesis, indomethacin, an inhibitor of prostaglandin synthesis, cyproheptadine, a serotonin, bradykinin and histamine antagonist, were assessed separately and in combination with chloroquine (CQ) in Vom strains of Swiss albino mice (18-22 g) of either sex infected intraperitoneally with 1 x 10(7) Plasmodium yoelii nigeriensis-induced malaria." | 3.72 | Effects of autacoid inhibitors and of an antagonist on malaria infection in mice. ( Agbani, EO; Iwalewa, EO, 2004) |
| " Since these T-cell responses are depressed during malaria infection, the capacity of macrophages to produce I1-1 following lipopolysaccharide (LPS) stimulation and that of lymphocytes to release I1-2 upon stimulation with concanavalin A (Con-A) in mice infected with either nonlethal Plasmodium yoelii (NLPY) or lethal Plasmodium berghei (PB) malaria parasites was analyzed." | 3.67 | Changes in the capacity of macrophages and T cells to produce interleukins during murine malaria infection. ( Lelchuk, R; Playfair, JH; Rose, G, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (60.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Deharo, E | 1 |
| Barkan, D | 1 |
| Krugliak, M | 1 |
| Golenser, J | 1 |
| Ginsburg, H | 1 |
| Iwalewa, EO | 1 |
| Agbani, EO | 1 |
| Lelchuk, R | 1 |
| Rose, G | 1 |
| Playfair, JH | 1 |
| Riley, EM | 1 |
| MacLennan, C | 1 |
| Wiatkowski, DK | 1 |
| Greenwood, BM | 1 |
| Clarkson, AR | 1 |
| Robson, JS | 1 |
1 review available for indomethacin and Malaria
| Article | Year |
|---|---|
The effect of drugs on immunological renal disease.
Topics: Adrenal Cortex Hormones; Antilymphocyte Serum; Azathioprine; Chlorambucil; Cyclophosphamide; Glomeru | 1972 |
4 other studies available for indomethacin and Malaria
| Article | Year |
|---|---|
Potentiation of the antimalarial action of chloroquine in rodent malaria by drugs known to reduce cellular glutathione levels.
Topics: Acetaminophen; Acetylcysteine; Aminoquinolines; Animals; Antimalarials; Chloroquine; Disulfiram; Dru | 2003 |
Effects of autacoid inhibitors and of an antagonist on malaria infection in mice.
Topics: Animals; Antimalarials; Autacoids; Chloroquine; Cyproheptadine; Drug Combinations; Fenclonine; Hista | 2004 |
Changes in the capacity of macrophages and T cells to produce interleukins during murine malaria infection.
Topics: Animals; Concanavalin A; Female; Indomethacin; Interleukin-1; Interleukin-2; Kinetics; Lymphocyte Ac | 1984 |
Suppression of in-vitro lymphoproliferative responses in acute malaria patients can be partially reversed by indomethacin.
Topics: Animals; Antigens, Protozoan; Child; Child, Preschool; Female; Humans; Immune Tolerance; Indomethaci | 1989 |