indomethacin has been researched along with Malaria, Falciparum in 4 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Malaria, Falciparum: Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Indomethacin was significantly quicker at clearing fever than acetaminophen (P < 0." | 2.67 | Antipyretic efficacy of indomethacin and acetaminophen in uncomplicated falciparum malaria. ( Looareesuwan, S; Wilairatana, P, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (75.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Miller, ME | 1 |
| Parrott, EE | 1 |
| Singh, R | 1 |
| Nelson, SW | 1 |
| Wilairatana, P | 1 |
| Looareesuwan, S | 1 |
| Dekker, E | 1 |
| Romijn, JA | 1 |
| Ackermans, MT | 1 |
| Endert, E | 1 |
| Kager, PA | 1 |
| Thuy, LT | 1 |
| Sauerwein, HP | 1 |
| Alves, MF | 1 |
| Santos-Neto, LL | 1 |
| Junqueira, MI | 1 |
| Tosta, CE | 1 |
| Costa, CE | 1 |
2 trials available for indomethacin and Malaria, Falciparum
| Article | Year |
|---|---|
Antipyretic efficacy of indomethacin and acetaminophen in uncomplicated falciparum malaria.
Topics: Acetaminophen; Administration, Oral; Adolescent; Adult; Female; Fever; Humans; Indomethacin; Malaria | 1994 |
Indomethacin stimulates glucose production in adults with uncomplicated falciparum malaria.
Topics: Adult; Cyclooxygenase Inhibitors; Cytokines; Female; Glucose; Humans; Indomethacin; Insulin; Malaria | 1998 |
2 other studies available for indomethacin and Malaria, Falciparum
| Article | Year |
|---|---|
A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum.
Topics: Antimalarials; Apicoplasts; Chloroplasts; DNA; DNA-Directed DNA Polymerase; Drug Discovery; Exonucle | 2014 |
Cytokines and dysregulation of the immune response in human malaria.
Topics: Dinoprostone; Humans; Indomethacin; Interleukin-1; Leukocytes, Mononuclear; Lymphocyte Activation; M | 1992 |