indomethacin has been researched along with Lymph Node Metastasis in 5 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "As a result of preclinical data demonstrating the antitumour and antimetastatic efficiency of indomethacin in murine models, and the clinical observation of occasional tumour regression in patients with advanced melanoma treated with indomethacin together with ranitidine, a Phase II study was performed of prolonged administration of these two oral agents in combination." | 9.08 | Oral indomethacin and ranitidine in advanced melanoma: a phase II study. ( Lohmann, RC; Mertens, WC, 1996) |
| "To investigate the combined effects of indomethacin and oxaliplatin on expressions of epidermal growth factor receptor (EGFR), E-cadherin (E-cad), intercellular adhesion molecule-1 (ICAM-1) and CD44v6 related to lymph node metastasis of human lung cancer cell lines." | 7.83 | Combined effects off indomethacin and oxaliplatin on lymph node metastasis related factors in human lung cancerxenografts in nude mice. ( Chen, G; Chen, YQ; Wang, DC; Xing, D; Zhao, YX, 2016) |
| "As a result of preclinical data demonstrating the antitumour and antimetastatic efficiency of indomethacin in murine models, and the clinical observation of occasional tumour regression in patients with advanced melanoma treated with indomethacin together with ranitidine, a Phase II study was performed of prolonged administration of these two oral agents in combination." | 5.08 | Oral indomethacin and ranitidine in advanced melanoma: a phase II study. ( Lohmann, RC; Mertens, WC, 1996) |
| "To investigate the combined effects of indomethacin and oxaliplatin on expressions of epidermal growth factor receptor (EGFR), E-cadherin (E-cad), intercellular adhesion molecule-1 (ICAM-1) and CD44v6 related to lymph node metastasis of human lung cancer cell lines." | 3.83 | Combined effects off indomethacin and oxaliplatin on lymph node metastasis related factors in human lung cancerxenografts in nude mice. ( Chen, G; Chen, YQ; Wang, DC; Xing, D; Zhao, YX, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (40.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xing, D | 1 |
| Chen, YQ | 1 |
| Wang, DC | 1 |
| Zhao, YX | 1 |
| Chen, G | 1 |
| Metzger, U | 1 |
| Meier, J | 1 |
| Uhlschmid, G | 1 |
| Weihe, H | 1 |
| Mertens, WC | 1 |
| Lohmann, RC | 1 |
| Barrera, JL | 1 |
| Verastegui, E | 1 |
| Meneses, A | 1 |
| Zinser, J | 1 |
| de la Garza, J | 1 |
| Hadden, JW | 1 |
| Ishihara, K | 1 |
2 trials available for indomethacin and Lymph Node Metastasis
| Article | Year |
|---|---|
Oral indomethacin and ranitidine in advanced melanoma: a phase II study.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antin | 1996 |
Combination immunotherapy of squamous cell carcinoma of the head and neck: a phase 2 trial.
Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Combined Modality Therapy; Cyclophosphamid | 2000 |
3 other studies available for indomethacin and Lymph Node Metastasis
| Article | Year |
|---|---|
Combined effects off indomethacin and oxaliplatin on lymph node metastasis related factors in human lung cancerxenografts in nude mice.
Topics: A549 Cells; Adenocarcinoma; Adenocarcinoma of Lung; Animals; Antigens, CD; Antineoplastic Combined C | 2016 |
Influence of various prostaglandin synthesis inhibitors on DMH-induced rat colon cancer.
Topics: 1,2-Dimethylhydrazine; Animals; Body Weight; Colonic Neoplasms; Dimethylhydrazines; Drinking; Eating | 1984 |
[Therapeutic response of interferon-beta in malignant melanoma].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Dacarbazine; Female; Humans; | 1986 |