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indomethacin and Local Neoplasm Recurrence

indomethacin has been researched along with Local Neoplasm Recurrence in 12 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Research Excerpts

ExcerptRelevanceReference
" The anti-tumor activity of indomethacin was investigated in CDF1 mice (BALB/c X DBA/2) implanted intraperitoneally with mouse colon adenocarcinoma 26 (5 X 10(5) or 2 X 10(5) cells) in a model study to prevent peritoneal recurrence after surgery for gastrointestinal cancers."7.67[Prevention of peritoneal carcinomatosis recurrence with a prostaglandin synthesis inhibitor, indomethacin]. ( Koyama, H; Masuda, T; Nagasawa, O; Narisawa, T; Takahashi, M, 1987)
" The anti-tumor activity of indomethacin was investigated in CDF1 mice (BALB/c X DBA/2) implanted intraperitoneally with mouse colon adenocarcinoma 26 (5 X 10(5) or 2 X 10(5) cells) in a model study to prevent peritoneal recurrence after surgery for gastrointestinal cancers."3.67[Prevention of peritoneal carcinomatosis recurrence with a prostaglandin synthesis inhibitor, indomethacin]. ( Koyama, H; Masuda, T; Nagasawa, O; Narisawa, T; Takahashi, M, 1987)
"We have shown that prostaglandin E2-(PGE2) mediated inactivation of all killer lineage cells is a common event in the tumor-bearing host, so that chronic indomethacin therapy (CIT) combined with multiple rounds of IL-2 cures spontaneous and experimental metastases of a variety of murine tumors by activating killer cells in situ."1.28Cure of murine Ehrlich ascites tumors with chronic oral indomethacin therapy combined with intraperitoneal administration of LAK cells and IL-2. ( Lala, PK; Parhar, RS; Singh, P, 1990)
"In a prospective study of squamous head and neck cancer, the pretreatment peripheral blood of 125 patients was examined for lymphocyte subclass and in vitro immunologic function."1.27A prospective study of squamous head and neck carcinoma. Immunologic aberrations in patients who develop recurrent disease. ( Brantley, BA; Cole, TB; Crocker, IR; Fisher, SR; Huang, AT; Mold, NG; Wallman, MJ, 1987)
" Flurbiprofen did not seem to alter the bioavailability of the chemotherapeutic agents."1.26Increased survival of cancer-bearing mice treated with inhibitors of prostaglandin synthesis alone or with chemotherapy. ( Bennett, A; Berstock, DA; Carroll, MA, 1982)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19904 (33.33)18.7374
1990's3 (25.00)18.2507
2000's2 (16.67)29.6817
2010's1 (8.33)24.3611
2020's2 (16.67)2.80

Authors

AuthorsStudies
Liu, F1
Wu, Q1
Han, W1
Laster, K1
Hu, Y1
Ma, F1
Chen, H1
Tian, X1
Qiao, Y1
Liu, H1
Kim, DJ1
Dong, Z1
Liu, K1
Aboelella, NS1
Brandle, C1
Okoko, O1
Gazi, MY1
Ding, ZC1
Xu, H1
Gorman, G1
Bollag, R1
Davila, ML1
Bryan, LJ1
Munn, DH1
Piazza, GA1
Zhou, G1
Ogura, K1
Shinoda, Y1
Okuma, T1
Ushiku, T1
Motoi, T1
Kawano, H1
Roh, JL1
Sung, MW1
Kim, KH1
Bennett, A1
Berstock, DA1
Carroll, MA1
Hirota, C1
Iida, M1
Aoyagi, K1
Matsumoto, T1
Tada, S1
Yao, T1
Fujishima, M1
Onur, O1
Celiker, R1
Huang, Y1
Horvath, CM1
Waxman, S1
Lala, PK2
Parhar, RS1
Singh, P1
Huang, AT1
Mold, NG1
Fisher, SR1
Brantley, BA1
Cole, TB1
Wallman, MJ1
Crocker, IR1
Narisawa, T1
Takahashi, M1
Masuda, T1
Nagasawa, O1
Koyama, H1
Simon, S1
Azevedo, SJ1
Byrnes, JJ1

Trials

1 trial available for indomethacin and Local Neoplasm Recurrence

ArticleYear
Effect of indomethacin suppositories on rectal polyposis in patients with familial adenomatous polyposis.
    Cancer, 1996, Oct-15, Volume: 78, Issue:8

    Topics: Adenomatous Polyposis Coli; Adult; Anti-Inflammatory Agents, Non-Steroidal; Colectomy; Dose-Response

1996

Other Studies

11 other studies available for indomethacin and Local Neoplasm Recurrence

ArticleYear
Targeting integrin αvβ3 with indomethacin inhibits patient-derived xenograft tumour growth and recurrence in oesophageal squamous cell carcinoma.
    Clinical and translational medicine, 2021, Volume: 11, Issue:10

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line, Tumor; Cell Proliferation; Cell Surviva

2021
Indomethacin-induced oxidative stress enhances death receptor 5 signaling and sensitizes tumor cells to adoptive T-cell therapy.
    Journal for immunotherapy of cancer, 2022, Volume: 10, Issue:7

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell- and Tissue-Based Therapy; Humans; Indomethac

2022
Recurrent epithelioid hemangioma: therapeutic potential of tranilast and indomethacin.
    Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 2012, Volume: 17, Issue:2

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Diagnosis, Differential; Dose-Response Relat

2012
Suppression of accelerated tumor growth in surgical wounds by celecoxib and indomethacin.
    Head & neck, 2005, Volume: 27, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carcinoma; Carcinoma, Squamous Cell; Celecoxib; Ce

2005
Increased survival of cancer-bearing mice treated with inhibitors of prostaglandin synthesis alone or with chemotherapy.
    British journal of cancer, 1982, Volume: 45, Issue:5

    Topics: Adenocarcinoma; Animals; Biological Availability; Body Weight; Drug Therapy, Combination; Female; Fl

1982
Polyarthritis as a complication of intravesical bacillus Calmette-Guerin immunotherapy for bladder cancer.
    Clinical rheumatology, 1999, Volume: 18, Issue:1

    Topics: Administration, Intravesical; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; A

1999
Regrowth of 5-fluorouracil-treated human colon cancer cells is prevented by the combination of interferon gamma, indomethacin, and phenylbutyrate.
    Cancer research, 2000, Jun-15, Volume: 60, Issue:12

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting

2000
Cure of murine Ehrlich ascites tumors with chronic oral indomethacin therapy combined with intraperitoneal administration of LAK cells and IL-2.
    Cancer letters, 1990, May-15, Volume: 51, Issue:1

    Topics: Animals; Blood Transfusion; Carcinoma, Ehrlich Tumor; Cell Line; Combined Modality Therapy; Indometh

1990
A prospective study of squamous head and neck carcinoma. Immunologic aberrations in patients who develop recurrent disease.
    Cancer, 1987, May-15, Volume: 59, Issue:10

    Topics: Carcinoma, Squamous Cell; Head and Neck Neoplasms; Humans; Indomethacin; Interleukin-2; Lymphocyte A

1987
[Prevention of peritoneal carcinomatosis recurrence with a prostaglandin synthesis inhibitor, indomethacin].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:8

    Topics: Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colonic Neoplasms; Dinoprostone; D

1987
Erythema nodosum heralding recurrent Hodgkin's disease.
    Cancer, 1985, Sep-15, Volume: 56, Issue:6

    Topics: Adolescent; Adult; Erythema Nodosum; Hodgkin Disease; Humans; Indomethacin; Male; Neoplasm Recurrenc

1985