indomethacin has been researched along with Local Neoplasm Recurrence in 12 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The anti-tumor activity of indomethacin was investigated in CDF1 mice (BALB/c X DBA/2) implanted intraperitoneally with mouse colon adenocarcinoma 26 (5 X 10(5) or 2 X 10(5) cells) in a model study to prevent peritoneal recurrence after surgery for gastrointestinal cancers." | 7.67 | [Prevention of peritoneal carcinomatosis recurrence with a prostaglandin synthesis inhibitor, indomethacin]. ( Koyama, H; Masuda, T; Nagasawa, O; Narisawa, T; Takahashi, M, 1987) |
| " The anti-tumor activity of indomethacin was investigated in CDF1 mice (BALB/c X DBA/2) implanted intraperitoneally with mouse colon adenocarcinoma 26 (5 X 10(5) or 2 X 10(5) cells) in a model study to prevent peritoneal recurrence after surgery for gastrointestinal cancers." | 3.67 | [Prevention of peritoneal carcinomatosis recurrence with a prostaglandin synthesis inhibitor, indomethacin]. ( Koyama, H; Masuda, T; Nagasawa, O; Narisawa, T; Takahashi, M, 1987) |
| "We have shown that prostaglandin E2-(PGE2) mediated inactivation of all killer lineage cells is a common event in the tumor-bearing host, so that chronic indomethacin therapy (CIT) combined with multiple rounds of IL-2 cures spontaneous and experimental metastases of a variety of murine tumors by activating killer cells in situ." | 1.28 | Cure of murine Ehrlich ascites tumors with chronic oral indomethacin therapy combined with intraperitoneal administration of LAK cells and IL-2. ( Lala, PK; Parhar, RS; Singh, P, 1990) |
| "In a prospective study of squamous head and neck cancer, the pretreatment peripheral blood of 125 patients was examined for lymphocyte subclass and in vitro immunologic function." | 1.27 | A prospective study of squamous head and neck carcinoma. Immunologic aberrations in patients who develop recurrent disease. ( Brantley, BA; Cole, TB; Crocker, IR; Fisher, SR; Huang, AT; Mold, NG; Wallman, MJ, 1987) |
| " Flurbiprofen did not seem to alter the bioavailability of the chemotherapeutic agents." | 1.26 | Increased survival of cancer-bearing mice treated with inhibitors of prostaglandin synthesis alone or with chemotherapy. ( Bennett, A; Berstock, DA; Carroll, MA, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (33.33) | 18.7374 |
| 1990's | 3 (25.00) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 1 (8.33) | 24.3611 |
| 2020's | 2 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, F | 1 |
| Wu, Q | 1 |
| Han, W | 1 |
| Laster, K | 1 |
| Hu, Y | 1 |
| Ma, F | 1 |
| Chen, H | 1 |
| Tian, X | 1 |
| Qiao, Y | 1 |
| Liu, H | 1 |
| Kim, DJ | 1 |
| Dong, Z | 1 |
| Liu, K | 1 |
| Aboelella, NS | 1 |
| Brandle, C | 1 |
| Okoko, O | 1 |
| Gazi, MY | 1 |
| Ding, ZC | 1 |
| Xu, H | 1 |
| Gorman, G | 1 |
| Bollag, R | 1 |
| Davila, ML | 1 |
| Bryan, LJ | 1 |
| Munn, DH | 1 |
| Piazza, GA | 1 |
| Zhou, G | 1 |
| Ogura, K | 1 |
| Shinoda, Y | 1 |
| Okuma, T | 1 |
| Ushiku, T | 1 |
| Motoi, T | 1 |
| Kawano, H | 1 |
| Roh, JL | 1 |
| Sung, MW | 1 |
| Kim, KH | 1 |
| Bennett, A | 1 |
| Berstock, DA | 1 |
| Carroll, MA | 1 |
| Hirota, C | 1 |
| Iida, M | 1 |
| Aoyagi, K | 1 |
| Matsumoto, T | 1 |
| Tada, S | 1 |
| Yao, T | 1 |
| Fujishima, M | 1 |
| Onur, O | 1 |
| Celiker, R | 1 |
| Huang, Y | 1 |
| Horvath, CM | 1 |
| Waxman, S | 1 |
| Lala, PK | 2 |
| Parhar, RS | 1 |
| Singh, P | 1 |
| Huang, AT | 1 |
| Mold, NG | 1 |
| Fisher, SR | 1 |
| Brantley, BA | 1 |
| Cole, TB | 1 |
| Wallman, MJ | 1 |
| Crocker, IR | 1 |
| Narisawa, T | 1 |
| Takahashi, M | 1 |
| Masuda, T | 1 |
| Nagasawa, O | 1 |
| Koyama, H | 1 |
| Simon, S | 1 |
| Azevedo, SJ | 1 |
| Byrnes, JJ | 1 |
1 trial available for indomethacin and Local Neoplasm Recurrence
| Article | Year |
|---|---|
Effect of indomethacin suppositories on rectal polyposis in patients with familial adenomatous polyposis.
Topics: Adenomatous Polyposis Coli; Adult; Anti-Inflammatory Agents, Non-Steroidal; Colectomy; Dose-Response | 1996 |
11 other studies available for indomethacin and Local Neoplasm Recurrence
| Article | Year |
|---|---|
Targeting integrin αvβ3 with indomethacin inhibits patient-derived xenograft tumour growth and recurrence in oesophageal squamous cell carcinoma.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line, Tumor; Cell Proliferation; Cell Surviva | 2021 |
Indomethacin-induced oxidative stress enhances death receptor 5 signaling and sensitizes tumor cells to adoptive T-cell therapy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell- and Tissue-Based Therapy; Humans; Indomethac | 2022 |
Recurrent epithelioid hemangioma: therapeutic potential of tranilast and indomethacin.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Diagnosis, Differential; Dose-Response Relat | 2012 |
Suppression of accelerated tumor growth in surgical wounds by celecoxib and indomethacin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carcinoma; Carcinoma, Squamous Cell; Celecoxib; Ce | 2005 |
Increased survival of cancer-bearing mice treated with inhibitors of prostaglandin synthesis alone or with chemotherapy.
Topics: Adenocarcinoma; Animals; Biological Availability; Body Weight; Drug Therapy, Combination; Female; Fl | 1982 |
Polyarthritis as a complication of intravesical bacillus Calmette-Guerin immunotherapy for bladder cancer.
Topics: Administration, Intravesical; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; A | 1999 |
Regrowth of 5-fluorouracil-treated human colon cancer cells is prevented by the combination of interferon gamma, indomethacin, and phenylbutyrate.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting | 2000 |
Cure of murine Ehrlich ascites tumors with chronic oral indomethacin therapy combined with intraperitoneal administration of LAK cells and IL-2.
Topics: Animals; Blood Transfusion; Carcinoma, Ehrlich Tumor; Cell Line; Combined Modality Therapy; Indometh | 1990 |
A prospective study of squamous head and neck carcinoma. Immunologic aberrations in patients who develop recurrent disease.
Topics: Carcinoma, Squamous Cell; Head and Neck Neoplasms; Humans; Indomethacin; Interleukin-2; Lymphocyte A | 1987 |
[Prevention of peritoneal carcinomatosis recurrence with a prostaglandin synthesis inhibitor, indomethacin].
Topics: Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colonic Neoplasms; Dinoprostone; D | 1987 |
Erythema nodosum heralding recurrent Hodgkin's disease.
Topics: Adolescent; Adult; Erythema Nodosum; Hodgkin Disease; Humans; Indomethacin; Male; Neoplasm Recurrenc | 1985 |