indomethacin has been researched along with Local Neoplasm Recurrence in 12 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Excerpt | Relevance | Reference |
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" The anti-tumor activity of indomethacin was investigated in CDF1 mice (BALB/c X DBA/2) implanted intraperitoneally with mouse colon adenocarcinoma 26 (5 X 10(5) or 2 X 10(5) cells) in a model study to prevent peritoneal recurrence after surgery for gastrointestinal cancers." | 7.67 | [Prevention of peritoneal carcinomatosis recurrence with a prostaglandin synthesis inhibitor, indomethacin]. ( Koyama, H; Masuda, T; Nagasawa, O; Narisawa, T; Takahashi, M, 1987) |
" The anti-tumor activity of indomethacin was investigated in CDF1 mice (BALB/c X DBA/2) implanted intraperitoneally with mouse colon adenocarcinoma 26 (5 X 10(5) or 2 X 10(5) cells) in a model study to prevent peritoneal recurrence after surgery for gastrointestinal cancers." | 3.67 | [Prevention of peritoneal carcinomatosis recurrence with a prostaglandin synthesis inhibitor, indomethacin]. ( Koyama, H; Masuda, T; Nagasawa, O; Narisawa, T; Takahashi, M, 1987) |
"We have shown that prostaglandin E2-(PGE2) mediated inactivation of all killer lineage cells is a common event in the tumor-bearing host, so that chronic indomethacin therapy (CIT) combined with multiple rounds of IL-2 cures spontaneous and experimental metastases of a variety of murine tumors by activating killer cells in situ." | 1.28 | Cure of murine Ehrlich ascites tumors with chronic oral indomethacin therapy combined with intraperitoneal administration of LAK cells and IL-2. ( Lala, PK; Parhar, RS; Singh, P, 1990) |
"In a prospective study of squamous head and neck cancer, the pretreatment peripheral blood of 125 patients was examined for lymphocyte subclass and in vitro immunologic function." | 1.27 | A prospective study of squamous head and neck carcinoma. Immunologic aberrations in patients who develop recurrent disease. ( Brantley, BA; Cole, TB; Crocker, IR; Fisher, SR; Huang, AT; Mold, NG; Wallman, MJ, 1987) |
" Flurbiprofen did not seem to alter the bioavailability of the chemotherapeutic agents." | 1.26 | Increased survival of cancer-bearing mice treated with inhibitors of prostaglandin synthesis alone or with chemotherapy. ( Bennett, A; Berstock, DA; Carroll, MA, 1982) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 4 (33.33) | 18.7374 |
1990's | 3 (25.00) | 18.2507 |
2000's | 2 (16.67) | 29.6817 |
2010's | 1 (8.33) | 24.3611 |
2020's | 2 (16.67) | 2.80 |
Authors | Studies |
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Liu, F | 1 |
Wu, Q | 1 |
Han, W | 1 |
Laster, K | 1 |
Hu, Y | 1 |
Ma, F | 1 |
Chen, H | 1 |
Tian, X | 1 |
Qiao, Y | 1 |
Liu, H | 1 |
Kim, DJ | 1 |
Dong, Z | 1 |
Liu, K | 1 |
Aboelella, NS | 1 |
Brandle, C | 1 |
Okoko, O | 1 |
Gazi, MY | 1 |
Ding, ZC | 1 |
Xu, H | 1 |
Gorman, G | 1 |
Bollag, R | 1 |
Davila, ML | 1 |
Bryan, LJ | 1 |
Munn, DH | 1 |
Piazza, GA | 1 |
Zhou, G | 1 |
Ogura, K | 1 |
Shinoda, Y | 1 |
Okuma, T | 1 |
Ushiku, T | 1 |
Motoi, T | 1 |
Kawano, H | 1 |
Roh, JL | 1 |
Sung, MW | 1 |
Kim, KH | 1 |
Bennett, A | 1 |
Berstock, DA | 1 |
Carroll, MA | 1 |
Hirota, C | 1 |
Iida, M | 1 |
Aoyagi, K | 1 |
Matsumoto, T | 1 |
Tada, S | 1 |
Yao, T | 1 |
Fujishima, M | 1 |
Onur, O | 1 |
Celiker, R | 1 |
Huang, Y | 1 |
Horvath, CM | 1 |
Waxman, S | 1 |
Lala, PK | 2 |
Parhar, RS | 1 |
Singh, P | 1 |
Huang, AT | 1 |
Mold, NG | 1 |
Fisher, SR | 1 |
Brantley, BA | 1 |
Cole, TB | 1 |
Wallman, MJ | 1 |
Crocker, IR | 1 |
Narisawa, T | 1 |
Takahashi, M | 1 |
Masuda, T | 1 |
Nagasawa, O | 1 |
Koyama, H | 1 |
Simon, S | 1 |
Azevedo, SJ | 1 |
Byrnes, JJ | 1 |
1 trial available for indomethacin and Local Neoplasm Recurrence
Article | Year |
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Effect of indomethacin suppositories on rectal polyposis in patients with familial adenomatous polyposis.
Topics: Adenomatous Polyposis Coli; Adult; Anti-Inflammatory Agents, Non-Steroidal; Colectomy; Dose-Response | 1996 |
11 other studies available for indomethacin and Local Neoplasm Recurrence
Article | Year |
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Targeting integrin αvβ3 with indomethacin inhibits patient-derived xenograft tumour growth and recurrence in oesophageal squamous cell carcinoma.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line, Tumor; Cell Proliferation; Cell Surviva | 2021 |
Indomethacin-induced oxidative stress enhances death receptor 5 signaling and sensitizes tumor cells to adoptive T-cell therapy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell- and Tissue-Based Therapy; Humans; Indomethac | 2022 |
Recurrent epithelioid hemangioma: therapeutic potential of tranilast and indomethacin.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Diagnosis, Differential; Dose-Response Relat | 2012 |
Suppression of accelerated tumor growth in surgical wounds by celecoxib and indomethacin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carcinoma; Carcinoma, Squamous Cell; Celecoxib; Ce | 2005 |
Increased survival of cancer-bearing mice treated with inhibitors of prostaglandin synthesis alone or with chemotherapy.
Topics: Adenocarcinoma; Animals; Biological Availability; Body Weight; Drug Therapy, Combination; Female; Fl | 1982 |
Polyarthritis as a complication of intravesical bacillus Calmette-Guerin immunotherapy for bladder cancer.
Topics: Administration, Intravesical; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; A | 1999 |
Regrowth of 5-fluorouracil-treated human colon cancer cells is prevented by the combination of interferon gamma, indomethacin, and phenylbutyrate.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting | 2000 |
Cure of murine Ehrlich ascites tumors with chronic oral indomethacin therapy combined with intraperitoneal administration of LAK cells and IL-2.
Topics: Animals; Blood Transfusion; Carcinoma, Ehrlich Tumor; Cell Line; Combined Modality Therapy; Indometh | 1990 |
A prospective study of squamous head and neck carcinoma. Immunologic aberrations in patients who develop recurrent disease.
Topics: Carcinoma, Squamous Cell; Head and Neck Neoplasms; Humans; Indomethacin; Interleukin-2; Lymphocyte A | 1987 |
[Prevention of peritoneal carcinomatosis recurrence with a prostaglandin synthesis inhibitor, indomethacin].
Topics: Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colonic Neoplasms; Dinoprostone; D | 1987 |
Erythema nodosum heralding recurrent Hodgkin's disease.
Topics: Adolescent; Adult; Erythema Nodosum; Hodgkin Disease; Humans; Indomethacin; Male; Neoplasm Recurrenc | 1985 |