indomethacin has been researched along with Liver Failure, Acute in 3 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Liver Failure, Acute: A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of HEPATOCYTES. It is characterized by sudden development of liver dysfunction and JAUNDICE. Acute liver failure may progress to exhibit cerebral dysfunction even HEPATIC COMA depending on the etiology that includes hepatic ISCHEMIA, drug toxicity, malignant infiltration, and viral hepatitis such as post-transfusion HEPATITIS B and HEPATITIS C.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 42-year-old woman receiving intensive care for fulminant hepatic failure secondary to acetaminophen toxicity developed cerebral edema and intracranial hypertension refractory to standard pharmacotherapy and respiratory support measures." | 7.81 | Indomethacin for treatment of refractory intracranial hypertension secondary to acute liver failure. ( Abdelhak, TM; Jones, MC; Lasak-Myall, T; Varelas, PN, 2015) |
| "A 42-year-old woman receiving intensive care for fulminant hepatic failure secondary to acetaminophen toxicity developed cerebral edema and intracranial hypertension refractory to standard pharmacotherapy and respiratory support measures." | 3.81 | Indomethacin for treatment of refractory intracranial hypertension secondary to acute liver failure. ( Abdelhak, TM; Jones, MC; Lasak-Myall, T; Varelas, PN, 2015) |
| "Rats treated with indomethacin had significant higher plasma levels of TNF-alpha (indomethacin vs N/S: 22+/-5 vs 10+/-1 pg/mL, P<0." | 1.33 | Prostacyclin inhibition by indomethacin aggravates hepatic damage and encephalopathy in rats with thioacetamide-induced fulminant hepatic failure. ( Chan, CY; Chang, FY; Chen, YC; Chu, CJ; Hsiao, CC; Huang, HC; Lee, FY; Lee, SD; Wang, SS; Wang, TF, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jones, MC | 1 |
| Lasak-Myall, T | 1 |
| Abdelhak, TM | 1 |
| Varelas, PN | 1 |
| Chu, CJ | 1 |
| Hsiao, CC | 1 |
| Wang, TF | 1 |
| Chan, CY | 1 |
| Lee, FY | 1 |
| Chang, FY | 1 |
| Chen, YC | 1 |
| Huang, HC | 1 |
| Wang, SS | 1 |
| Lee, SD | 1 |
| Raghavan, M | 1 |
| Marik, PE | 1 |
1 review available for indomethacin and Liver Failure, Acute
| Article | Year |
|---|---|
Therapy of intracranial hypertension in patients with fulminant hepatic failure.
Topics: Ammonia; Anesthetics, Intravenous; Brain; Cardiovascular Agents; Cerebrovascular Circulation; Electr | 2006 |
2 other studies available for indomethacin and Liver Failure, Acute
| Article | Year |
|---|---|
Indomethacin for treatment of refractory intracranial hypertension secondary to acute liver failure.
Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injur | 2015 |
Prostacyclin inhibition by indomethacin aggravates hepatic damage and encephalopathy in rats with thioacetamide-induced fulminant hepatic failure.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Bilirubin; Creatinine; Disease Models, Animal; Indomethacin; | 2005 |