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indomethacin and Leukopenia

indomethacin has been researched along with Leukopenia in 19 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Leukopenia: A decrease in the number of LEUKOCYTES in a blood sample below the normal range (LEUKOCYTE COUNT less than 4000).

Research Excerpts

ExcerptRelevanceReference
"During a double-blind, randomized study on 30 patients affected with classic or definite rheumatoid arthritis, the efficacy and safety of treatment with diftalone in a per oral dosage of 500 mg/day were compared with those of indomethacin given orally at doses of 50-75 mg/day initially and 100 mg/day subsequently, for a treatment period of 24 months."9.04Comparative clinical trial with a new substance, Diftalone, versus indomethacin in 30 patients affected with rheumatoid arthritis. ( Bröll, H; Dunky, A; Eberl, R; Tausch, G, 1976)
"During a double-blind, randomized study on 30 patients affected with classic or definite rheumatoid arthritis, the efficacy and safety of treatment with diftalone in a per oral dosage of 500 mg/day were compared with those of indomethacin given orally at doses of 50-75 mg/day initially and 100 mg/day subsequently, for a treatment period of 24 months."5.04Comparative clinical trial with a new substance, Diftalone, versus indomethacin in 30 patients affected with rheumatoid arthritis. ( Bröll, H; Dunky, A; Eberl, R; Tausch, G, 1976)
" WIR-induced mucosal lesion formation was significantly inhibited in animals given iloprost, a stable analog of PGI2, and in those with nitrogen mustard-induced leukocytopenia."3.69Novel role of prostacyclin in stress-induced gastric mucosal lesion formation in rats. ( Harada, N; Murakami, K; Okabe, H; Okajima, K; Takatsuki, K; Tanaka, K; Uchiba, M, 1997)
"The xanthine derivative pentoxifylline (POF, Trental) and its metabolically more stable structural analogues, HWA 138 and HWA 448, were compared for their capacity to prevent leukopenia provoked in mice by injection of bacterial lipopolysaccharide (LPS)."3.67The role of prostacyclin in the protective effects of pentoxifylline and other xanthine derivatives in endotoxin action in mice. ( Schade, UF, 1989)
"The interactions between leukopenia induced by vinblastine and the cyclooxygenase inhibitor indomethacin on the toxicity of tumor necrosis factor (TNF) were studied."3.67Prevention of the toxic action of tumor necrosis factor by cyclooxygenase inhibitor and leukopenia. ( Fujita, T; Goto, F; Maruyama, N; Watanabe, E, 1989)
"Treatment with indomethacin before stress inhibited the increase in 6-keto-PGF1alpha levels and markedly reduced mucosal blood flow."1.30Gastric prostacyclin (PGI2) prevents stress-induced gastric mucosal injury in rats primarily by inhibiting leukocyte activation. ( Harada, N; Isobe, H; Liu, W; Murakami, K; Okajima, K, 1999)
"Hypotension was presumably caused by two factors: an early decrease in systemic vascular resistance and the large reduction in cardiac output due to reduced ventricular filling."1.29Haemodynamic and haematologic effects of Acanthaster planci venom in dogs. ( Hirayama, K; Matsuzaki, T; Noguchi, K; Ojiri, Y; Sakanashi, M; Shiroma, N, 1994)
"Pretreatment with indomethacin also prevented the O3 effects, as reflected by the decreased protein and albumin flux in BAL and 99mTc-DTPA transport from trachea to blood."1.28Attenuation of ozone-induced airway permeability in rats by pretreatment with cyclophosphamide, FPL 55712, and indomethacin. ( Bhalla, DK; Daniels, DS; Luu, NT, 1992)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-199013 (68.42)18.7374
1990's6 (31.58)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Caldwell, CW1
Yesus, YW1
Sprouse, RF1
Shiroma, N1
Noguchi, K1
Matsuzaki, T1
Ojiri, Y1
Hirayama, K1
Sakanashi, M1
Zabel, P1
Schade, FU1
Schlaak, M1
Bamforth, SD1
Lightman, SL1
Greenwood, J1
Harada, N2
Okajima, K2
Murakami, K2
Uchiba, M1
Tanaka, K1
Okabe, H1
Takatsuki, K1
Isobe, H1
Liu, W1
Tausch, G1
Bröll, H1
Dunky, A1
Eberl, R1
Grayson, MF1
Martin, VM1
Markham, RL1
Bhalla, DK1
Daniels, DS1
Luu, NT1
Schade, UF2
von der Bosch, J1
Schönharting, M1
Goto, F1
Watanabe, E1
Maruyama, N1
Fujita, T1
Kontos, GJ1
Borkon, AM1
Baumgartner, WA1
Hutchins, GM1
Peeler, M1
Brawn, J1
Reitz, BA1
Mårtensson, L1
Davoust, N1
Walker, JF1
Lindsay, RM1
Sibbald, WJ1
Linton, AL1
Hovig, T1
Jeremic, M1
Stavem, P1
Wagner, H1
Junge-Hülsing, G1
Müller, US1
Hrubesch, M1
Büchner, T1
Wirth, W1
Hauss, WH1
Nyfos, L1
Millington, D1

Reviews

1 review available for indomethacin and Leukopenia

ArticleYear
Inhibition of endogenous TNF formation by pentoxifylline.
    Immunobiology, 1993, Volume: 187, Issue:3-5

    Topics: Animals; Cells, Cultured; Cytokines; Humans; Indomethacin; Kidney Transplantation; Leukopenia; Lipop

1993

Trials

2 trials available for indomethacin and Leukopenia

ArticleYear
Comparative clinical trial with a new substance, Diftalone, versus indomethacin in 30 patients affected with rheumatoid arthritis.
    Scandinavian journal of rheumatology, 1976, Volume: 5, Issue:3

    Topics: Administration, Oral; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Evaluation; Female; Gast

1976
Controlled clinical trial of 1-(2'-methyl-2'-dimethyl amino-ethyl)-3-phenyl indole HCl (A28A) in rheumatoid arthritis compared with indomethacin (Confortid).
    Acta rheumatologica Scandinavica, 1971, Volume: 17, Issue:2

    Topics: Adult; Aged; Alanine Transaminase; Arthritis, Rheumatoid; Clinical Trials as Topic; Female; Gait; Hu

1971

Other Studies

16 other studies available for indomethacin and Leukopenia

ArticleYear
In vitro suppression of myelopoiesis by adherent murine splenocytes in experimental disseminated histoplasmosis.
    The American journal of pathology, 1983, Volume: 110, Issue:3

    Topics: Animals; Bone Marrow; Bone Marrow Cells; Cell Adhesion; Hematopoiesis; Histoplasmosis; Indomethacin;

1983
Haemodynamic and haematologic effects of Acanthaster planci venom in dogs.
    Toxicon : official journal of the International Society on Toxinology, 1994, Volume: 32, Issue:10

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Cells; Blood Pressure; Cardiac Output; Cyclooxygenase I

1994
Interleukin-1 beta-induced disruption of the retinal vascular barrier of the central nervous system is mediated through leukocyte recruitment and histamine.
    The American journal of pathology, 1997, Volume: 150, Issue:1

    Topics: Animals; Blood-Retinal Barrier; Cell Membrane Permeability; Cell Movement; Histamine; Indomethacin;

1997
Novel role of prostacyclin in stress-induced gastric mucosal lesion formation in rats.
    The Journal of laboratory and clinical medicine, 1997, Volume: 129, Issue:6

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase

1997
Gastric prostacyclin (PGI2) prevents stress-induced gastric mucosal injury in rats primarily by inhibiting leukocyte activation.
    Prostaglandins & other lipid mediators, 1999, Volume: 57, Issue:5-6

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents, Non-Steroidal; Epoprostenol; Gastri

1999
Antinative DNA antibodies as a reaction to pyrazole drugs.
    Annals of the rheumatic diseases, 1975, Volume: 34, Issue:4

    Topics: Antibodies; Antibodies, Antinuclear; Antistreptolysin; Binding Sites; Binding Sites, Antibody; Human

1975
Attenuation of ozone-induced airway permeability in rats by pretreatment with cyclophosphamide, FPL 55712, and indomethacin.
    American journal of respiratory cell and molecular biology, 1992, Volume: 7, Issue:1

    Topics: Albumins; Animals; Blood Proteins; Bronchoalveolar Lavage Fluid; Chromones; Cyclophosphamide; Indome

1992
Pentoxifylline increases survival of mice in endotoxic shock.
    Progress in clinical and biological research, 1989, Volume: 301

    Topics: Animals; Epoprostenol; Female; Indomethacin; Leukopenia; Lipopolysaccharides; Mice; Pentoxifylline;

1989
The role of prostacyclin in the protective effects of pentoxifylline and other xanthine derivatives in endotoxin action in mice.
    Eicosanoids, 1989, Volume: 2, Issue:3

    Topics: Animals; Endotoxins; Epoprostenol; Female; Indomethacin; Leukopenia; Lipopolysaccharides; Mice; Pent

1989
Prevention of the toxic action of tumor necrosis factor by cyclooxygenase inhibitor and leukopenia.
    Circulatory shock, 1989, Volume: 29, Issue:3

    Topics: Animals; Enzyme Inhibitors; Indomethacin; Leukopenia; Male; Rats; Rats, Inbred Strains; Tumor Necros

1989
Neurohumoral modulation of the pulmonary vasoconstrictor response in the autoperfused working heart-lung preparation during cardiopulmonary preservation.
    Transplantation, 1988, Volume: 45, Issue:2

    Topics: Animals; Blood Gas Analysis; Cattle; Heart; Heart Transplantation; Heart-Lung Transplantation; Indom

1988
Effects of indomethacin or verapamil on dialysis induced leucopenia and hypoxia in the unstressed sheep.
    Progress in clinical and biological research, 1987, Volume: 242

    Topics: Animals; Extracorporeal Circulation; Hypoxia; Indomethacin; Leukopenia; Renal Dialysis; Sheep; Verap

1987
Acute pulmonary hypertension, leucopenia and hypoxia in early haemodialysis.
    Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress, 1985, Volume: 21

    Topics: Animals; Disease Models, Animal; Female; Humans; Hypertension, Pulmonary; Hypoxia; Indomethacin; Leu

1985
A new type of inclusion bodies in lymphocytes.
    Scandinavian journal of haematology, 1968, Volume: 5, Issue:2

    Topics: Aged; Arthritis, Rheumatoid; Chronic Disease; Cytoplasmic Granules; Female; Humans; In Vitro Techniq

1968
[Experimental findings on the site of action and on pharmacodynamics of cytostatic and antiphlogistic drugs in inflammation].
    Verhandlungen der Deutschen Gesellschaft fur Rheumatologie, 1972, Volume: 2

    Topics: Animals; Azathioprine; Cyclophosphamide; Glycosaminoglycans; Granulation Tissue; Hematopoietic Syste

1972
Leucopenia and indomethacin.
    British medical journal, 1966, Jan-01, Volume: 1, Issue:5478

    Topics: Arthritis, Rheumatoid; Female; Humans; Indomethacin; Leukopenia; Middle Aged

1966