indomethacin has been researched along with Leukopenia in 19 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Leukopenia: A decrease in the number of LEUKOCYTES in a blood sample below the normal range (LEUKOCYTE COUNT less than 4000).
| Excerpt | Relevance | Reference |
|---|---|---|
| "During a double-blind, randomized study on 30 patients affected with classic or definite rheumatoid arthritis, the efficacy and safety of treatment with diftalone in a per oral dosage of 500 mg/day were compared with those of indomethacin given orally at doses of 50-75 mg/day initially and 100 mg/day subsequently, for a treatment period of 24 months." | 9.04 | Comparative clinical trial with a new substance, Diftalone, versus indomethacin in 30 patients affected with rheumatoid arthritis. ( Bröll, H; Dunky, A; Eberl, R; Tausch, G, 1976) |
| "During a double-blind, randomized study on 30 patients affected with classic or definite rheumatoid arthritis, the efficacy and safety of treatment with diftalone in a per oral dosage of 500 mg/day were compared with those of indomethacin given orally at doses of 50-75 mg/day initially and 100 mg/day subsequently, for a treatment period of 24 months." | 5.04 | Comparative clinical trial with a new substance, Diftalone, versus indomethacin in 30 patients affected with rheumatoid arthritis. ( Bröll, H; Dunky, A; Eberl, R; Tausch, G, 1976) |
| " WIR-induced mucosal lesion formation was significantly inhibited in animals given iloprost, a stable analog of PGI2, and in those with nitrogen mustard-induced leukocytopenia." | 3.69 | Novel role of prostacyclin in stress-induced gastric mucosal lesion formation in rats. ( Harada, N; Murakami, K; Okabe, H; Okajima, K; Takatsuki, K; Tanaka, K; Uchiba, M, 1997) |
| "The xanthine derivative pentoxifylline (POF, Trental) and its metabolically more stable structural analogues, HWA 138 and HWA 448, were compared for their capacity to prevent leukopenia provoked in mice by injection of bacterial lipopolysaccharide (LPS)." | 3.67 | The role of prostacyclin in the protective effects of pentoxifylline and other xanthine derivatives in endotoxin action in mice. ( Schade, UF, 1989) |
| "The interactions between leukopenia induced by vinblastine and the cyclooxygenase inhibitor indomethacin on the toxicity of tumor necrosis factor (TNF) were studied." | 3.67 | Prevention of the toxic action of tumor necrosis factor by cyclooxygenase inhibitor and leukopenia. ( Fujita, T; Goto, F; Maruyama, N; Watanabe, E, 1989) |
| "Treatment with indomethacin before stress inhibited the increase in 6-keto-PGF1alpha levels and markedly reduced mucosal blood flow." | 1.30 | Gastric prostacyclin (PGI2) prevents stress-induced gastric mucosal injury in rats primarily by inhibiting leukocyte activation. ( Harada, N; Isobe, H; Liu, W; Murakami, K; Okajima, K, 1999) |
| "Hypotension was presumably caused by two factors: an early decrease in systemic vascular resistance and the large reduction in cardiac output due to reduced ventricular filling." | 1.29 | Haemodynamic and haematologic effects of Acanthaster planci venom in dogs. ( Hirayama, K; Matsuzaki, T; Noguchi, K; Ojiri, Y; Sakanashi, M; Shiroma, N, 1994) |
| "Pretreatment with indomethacin also prevented the O3 effects, as reflected by the decreased protein and albumin flux in BAL and 99mTc-DTPA transport from trachea to blood." | 1.28 | Attenuation of ozone-induced airway permeability in rats by pretreatment with cyclophosphamide, FPL 55712, and indomethacin. ( Bhalla, DK; Daniels, DS; Luu, NT, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (68.42) | 18.7374 |
| 1990's | 6 (31.58) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Caldwell, CW | 1 |
| Yesus, YW | 1 |
| Sprouse, RF | 1 |
| Shiroma, N | 1 |
| Noguchi, K | 1 |
| Matsuzaki, T | 1 |
| Ojiri, Y | 1 |
| Hirayama, K | 1 |
| Sakanashi, M | 1 |
| Zabel, P | 1 |
| Schade, FU | 1 |
| Schlaak, M | 1 |
| Bamforth, SD | 1 |
| Lightman, SL | 1 |
| Greenwood, J | 1 |
| Harada, N | 2 |
| Okajima, K | 2 |
| Murakami, K | 2 |
| Uchiba, M | 1 |
| Tanaka, K | 1 |
| Okabe, H | 1 |
| Takatsuki, K | 1 |
| Isobe, H | 1 |
| Liu, W | 1 |
| Tausch, G | 1 |
| Bröll, H | 1 |
| Dunky, A | 1 |
| Eberl, R | 1 |
| Grayson, MF | 1 |
| Martin, VM | 1 |
| Markham, RL | 1 |
| Bhalla, DK | 1 |
| Daniels, DS | 1 |
| Luu, NT | 1 |
| Schade, UF | 2 |
| von der Bosch, J | 1 |
| Schönharting, M | 1 |
| Goto, F | 1 |
| Watanabe, E | 1 |
| Maruyama, N | 1 |
| Fujita, T | 1 |
| Kontos, GJ | 1 |
| Borkon, AM | 1 |
| Baumgartner, WA | 1 |
| Hutchins, GM | 1 |
| Peeler, M | 1 |
| Brawn, J | 1 |
| Reitz, BA | 1 |
| Mårtensson, L | 1 |
| Davoust, N | 1 |
| Walker, JF | 1 |
| Lindsay, RM | 1 |
| Sibbald, WJ | 1 |
| Linton, AL | 1 |
| Hovig, T | 1 |
| Jeremic, M | 1 |
| Stavem, P | 1 |
| Wagner, H | 1 |
| Junge-Hülsing, G | 1 |
| Müller, US | 1 |
| Hrubesch, M | 1 |
| Büchner, T | 1 |
| Wirth, W | 1 |
| Hauss, WH | 1 |
| Nyfos, L | 1 |
| Millington, D | 1 |
1 review available for indomethacin and Leukopenia
| Article | Year |
|---|---|
Inhibition of endogenous TNF formation by pentoxifylline.
Topics: Animals; Cells, Cultured; Cytokines; Humans; Indomethacin; Kidney Transplantation; Leukopenia; Lipop | 1993 |
2 trials available for indomethacin and Leukopenia
| Article | Year |
|---|---|
Comparative clinical trial with a new substance, Diftalone, versus indomethacin in 30 patients affected with rheumatoid arthritis.
Topics: Administration, Oral; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Evaluation; Female; Gast | 1976 |
Controlled clinical trial of 1-(2'-methyl-2'-dimethyl amino-ethyl)-3-phenyl indole HCl (A28A) in rheumatoid arthritis compared with indomethacin (Confortid).
Topics: Adult; Aged; Alanine Transaminase; Arthritis, Rheumatoid; Clinical Trials as Topic; Female; Gait; Hu | 1971 |
16 other studies available for indomethacin and Leukopenia
| Article | Year |
|---|---|
In vitro suppression of myelopoiesis by adherent murine splenocytes in experimental disseminated histoplasmosis.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Cell Adhesion; Hematopoiesis; Histoplasmosis; Indomethacin; | 1983 |
Haemodynamic and haematologic effects of Acanthaster planci venom in dogs.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Cells; Blood Pressure; Cardiac Output; Cyclooxygenase I | 1994 |
Interleukin-1 beta-induced disruption of the retinal vascular barrier of the central nervous system is mediated through leukocyte recruitment and histamine.
Topics: Animals; Blood-Retinal Barrier; Cell Membrane Permeability; Cell Movement; Histamine; Indomethacin; | 1997 |
Novel role of prostacyclin in stress-induced gastric mucosal lesion formation in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase | 1997 |
Gastric prostacyclin (PGI2) prevents stress-induced gastric mucosal injury in rats primarily by inhibiting leukocyte activation.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents, Non-Steroidal; Epoprostenol; Gastri | 1999 |
Antinative DNA antibodies as a reaction to pyrazole drugs.
Topics: Antibodies; Antibodies, Antinuclear; Antistreptolysin; Binding Sites; Binding Sites, Antibody; Human | 1975 |
Attenuation of ozone-induced airway permeability in rats by pretreatment with cyclophosphamide, FPL 55712, and indomethacin.
Topics: Albumins; Animals; Blood Proteins; Bronchoalveolar Lavage Fluid; Chromones; Cyclophosphamide; Indome | 1992 |
Pentoxifylline increases survival of mice in endotoxic shock.
Topics: Animals; Epoprostenol; Female; Indomethacin; Leukopenia; Lipopolysaccharides; Mice; Pentoxifylline; | 1989 |
The role of prostacyclin in the protective effects of pentoxifylline and other xanthine derivatives in endotoxin action in mice.
Topics: Animals; Endotoxins; Epoprostenol; Female; Indomethacin; Leukopenia; Lipopolysaccharides; Mice; Pent | 1989 |
Prevention of the toxic action of tumor necrosis factor by cyclooxygenase inhibitor and leukopenia.
Topics: Animals; Enzyme Inhibitors; Indomethacin; Leukopenia; Male; Rats; Rats, Inbred Strains; Tumor Necros | 1989 |
Neurohumoral modulation of the pulmonary vasoconstrictor response in the autoperfused working heart-lung preparation during cardiopulmonary preservation.
Topics: Animals; Blood Gas Analysis; Cattle; Heart; Heart Transplantation; Heart-Lung Transplantation; Indom | 1988 |
Effects of indomethacin or verapamil on dialysis induced leucopenia and hypoxia in the unstressed sheep.
Topics: Animals; Extracorporeal Circulation; Hypoxia; Indomethacin; Leukopenia; Renal Dialysis; Sheep; Verap | 1987 |
Acute pulmonary hypertension, leucopenia and hypoxia in early haemodialysis.
Topics: Animals; Disease Models, Animal; Female; Humans; Hypertension, Pulmonary; Hypoxia; Indomethacin; Leu | 1985 |
A new type of inclusion bodies in lymphocytes.
Topics: Aged; Arthritis, Rheumatoid; Chronic Disease; Cytoplasmic Granules; Female; Humans; In Vitro Techniq | 1968 |
[Experimental findings on the site of action and on pharmacodynamics of cytostatic and antiphlogistic drugs in inflammation].
Topics: Animals; Azathioprine; Cyclophosphamide; Glycosaminoglycans; Granulation Tissue; Hematopoietic Syste | 1972 |
Leucopenia and indomethacin.
Topics: Arthritis, Rheumatoid; Female; Humans; Indomethacin; Leukopenia; Middle Aged | 1966 |