indomethacin has been researched along with Leukemia in 18 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the effects of indomethacin on proliferation and senescence of leukemia cells and to analyze whether non-steroidal anti-inflammatory drugs have any adjunctively therapeutic effects on leukemia." | 7.81 | [Effects of Indomethacin on Proliferation and Senescence of Leukemia Cells]. ( Jiao, XY; Zhang, Y, 2015) |
| " We investigated whether indomethacin, which inhibits cyclooxygenases, is able to overcome doxorubicin resistance in K562/ADR leukemia cells." | 7.75 | Indomethacin overcomes doxorubicin resistance by decreasing intracellular content of glutathione and its conjugates with decreasing expression of gamma-glutamylcysteine synthetase via promoter activity in doxorubicin-resistant leukemia cells. ( Asano, T; Fukunaga, Y; Tsutsuda-Asano, A, 2009) |
| "If indomethacin treatment was initiated prior to transplantation of the tumor or 2 weeks post-transplantation, and continued throughout the disease process, there was no effect on either the course of the disease or mortality." | 5.27 | Increased sensitivity to indomethacin of mice bearing the BCL1-leukemia. ( Hart, DA, 1984) |
| "To investigate the effects of indomethacin on proliferation and senescence of leukemia cells and to analyze whether non-steroidal anti-inflammatory drugs have any adjunctively therapeutic effects on leukemia." | 3.81 | [Effects of Indomethacin on Proliferation and Senescence of Leukemia Cells]. ( Jiao, XY; Zhang, Y, 2015) |
| " We investigated whether indomethacin, which inhibits cyclooxygenases, is able to overcome doxorubicin resistance in K562/ADR leukemia cells." | 3.75 | Indomethacin overcomes doxorubicin resistance by decreasing intracellular content of glutathione and its conjugates with decreasing expression of gamma-glutamylcysteine synthetase via promoter activity in doxorubicin-resistant leukemia cells. ( Asano, T; Fukunaga, Y; Tsutsuda-Asano, A, 2009) |
| "If indomethacin treatment was initiated prior to transplantation of the tumor or 2 weeks post-transplantation, and continued throughout the disease process, there was no effect on either the course of the disease or mortality." | 1.27 | Increased sensitivity to indomethacin of mice bearing the BCL1-leukemia. ( Hart, DA, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (77.78) | 18.7374 |
| 1990's | 2 (11.11) | 18.2507 |
| 2000's | 1 (5.56) | 29.6817 |
| 2010's | 1 (5.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, Y | 1 |
| Jiao, XY | 1 |
| Asano, T | 1 |
| Tsutsuda-Asano, A | 1 |
| Fukunaga, Y | 1 |
| O'Keefe, D | 1 |
| Ashman, L | 1 |
| Hart, DA | 1 |
| Greer, KE | 1 |
| Cooper, PH | 1 |
| Jakschik, BA | 1 |
| Falkenhein, S | 1 |
| Parker, CW | 1 |
| Mannella, W | 1 |
| Brodsky, I | 1 |
| Sufian, S | 1 |
| Matsumoto, T | 1 |
| Tanaka, K | 1 |
| Aikawa, Y | 1 |
| Kawasaki, H | 1 |
| Asaoka, K | 1 |
| Inaba, T | 1 |
| Yoshida, C | 1 |
| Teichmann, JV | 1 |
| Ludwig, WD | 1 |
| Seibt-Jung, H | 1 |
| Thiel, E | 1 |
| Wyckoff, JH | 1 |
| Shannon, BT | 1 |
| Petrini, M | 1 |
| Merler, E | 1 |
| Kiely, JM | 1 |
| Calabro, JJ | 1 |
| Katz, RM | 1 |
| Maltz, BA | 1 |
| Banerjee, AK | 1 |
| Milevskaia, IuL | 1 |
| Treske, U | 2 |
| Liotta, S | 1 |
| Ronchi, F | 1 |
| Marcolongo, R | 1 |
| Boggiano, CA | 1 |
2 reviews available for indomethacin and Leukemia
| Article | Year |
|---|---|
Sweet's syndrome (acute febrile neutrophilic dermatosis).
Topics: Adult; Arthritis; Clofazimine; Diagnosis, Differential; Eye Diseases; Female; Fever; Humans; Indomet | 1982 |
A critical reappraisal of juvenile rheumatoid arthritis.
Topics: Agammaglobulinemia; Arthritis, Juvenile; Aspirin; Cardiomegaly; Child; Child, Preschool; Chloroquine | 1971 |
16 other studies available for indomethacin and Leukemia
| Article | Year |
|---|---|
[Effects of Indomethacin on Proliferation and Senescence of Leukemia Cells].
Topics: Apoptosis; Cell Cycle; Cell Proliferation; Cell Survival; Cellular Senescence; Humans; Indomethacin; | 2015 |
Indomethacin overcomes doxorubicin resistance by decreasing intracellular content of glutathione and its conjugates with decreasing expression of gamma-glutamylcysteine synthetase via promoter activity in doxorubicin-resistant leukemia cells.
Topics: Antineoplastic Agents; Base Sequence; DNA Primers; Doxorubicin; Drug Resistance, Neoplasm; Drug Syne | 2009 |
Variation in accessory cell requirements in human mixed lymphocyte response to leukaemic cell lines.
Topics: Adult; Cell Line; Histocompatibility Antigens Class II; HLA-DR Antigens; Humans; Indomethacin; Leuke | 1982 |
Increased sensitivity to indomethacin of mice bearing the BCL1-leukemia.
Topics: Animals; Blood Cell Count; Cell Line; Dose-Response Relationship, Drug; Female; Indomethacin; Leukem | 1984 |
Precursor role of arachidonic acid in release of slow reacting substance from rat basophilic leukemia cells.
Topics: Arachidonic Acids; Autacoids; Basophils; Calcimycin; Fatty Acids; Humans; Indomethacin; Leukemia | 1977 |
Postoperative fever in patients with hematologic malignancy.
Topics: Adult; Aged; Colonic Neoplasms; Female; Fever; Humans; Indomethacin; Leukemia; Male; Neoplasms, Mult | 1977 |
Pharmacological studies on 3-formylamino-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-one (T-614), a novel antiinflammatory agent. 4th communication: inhibitory effect on the production of interleukin-1 and interleukin-6.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Benzopyrans; Cell Line; Drug Interactions; Humans; Indometh | 1992 |
Lymphokine-activated killer (LAK) cells against human leukemia: augmentation of LAK-cell cytotoxicity by combinations of lymphokines or cytokines.
Topics: Biological Factors; Cytokines; Cytotoxicity Tests, Immunologic; Drug Synergism; Humans; Indomethacin | 1990 |
Acquired spontaneous cytotoxicity of K562 in a subpopulation of monocytes.
Topics: Antigens, Surface; Cell Line; Cytotoxicity, Immunologic; Dinoprostone; Humans; In Vitro Techniques; | 1985 |
Symptomatic control of fever in lymphoma and leukemia.
Topics: Adolescent; Adult; Aged; Aminopyrine; Analgesics; Aspirin; Female; Fever; Hodgkin Disease; Humans; I | 1969 |
Use of Indomethacin as an anti-pyretic agent in malignant reticulosis.
Topics: Adolescent; Adult; Child; Evaluation Studies as Topic; Female; Fever; Hodgkin Disease; Humans; Indom | 1972 |
[Use of indomethacin in internal and hematologic practice].
Topics: Hodgkin Disease; Humans; Indomethacin; Joint Diseases; Leukemia; Lymphoma; Lymphoma, Large B-Cell, D | 1970 |
[Indomethacin in hemoblastosis].
Topics: Hodgkin Disease; Humans; Indomethacin; Joint Diseases; Leukemia; Lymphoma; Lymphoma, Large B-Cell, D | 1971 |
[Indomethacin and hematopoiesis. Antipyretic and antiphlogistic effects in hemoblastoses and various uncommon diseases].
Topics: Arthritis, Infectious; Arthritis, Rheumatoid; Dermatomyositis; Female; Hematologic Diseases; Hematop | 1968 |
[Antipyretic activity of indomethacin in histiocytic sarcomatosis of a systemic type].
Topics: Adolescent; Adult; Aged; Female; Histiocytes; Hodgkin Disease; Humans; Indomethacin; Leukemia; Male; | 1967 |
[On the antipyretic action of indomethacin in Hodgkin's lymphogranuloma and in neoplasms].
Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Antineoplastic Agents; Fever; Hodgkin Disease; Human | 1966 |