Page last updated: 2024-10-29

indomethacin and Leukemia

indomethacin has been researched along with Leukemia in 18 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)

Research Excerpts

ExcerptRelevanceReference
"To investigate the effects of indomethacin on proliferation and senescence of leukemia cells and to analyze whether non-steroidal anti-inflammatory drugs have any adjunctively therapeutic effects on leukemia."7.81[Effects of Indomethacin on Proliferation and Senescence of Leukemia Cells]. ( Jiao, XY; Zhang, Y, 2015)
" We investigated whether indomethacin, which inhibits cyclooxygenases, is able to overcome doxorubicin resistance in K562/ADR leukemia cells."7.75Indomethacin overcomes doxorubicin resistance by decreasing intracellular content of glutathione and its conjugates with decreasing expression of gamma-glutamylcysteine synthetase via promoter activity in doxorubicin-resistant leukemia cells. ( Asano, T; Fukunaga, Y; Tsutsuda-Asano, A, 2009)
"If indomethacin treatment was initiated prior to transplantation of the tumor or 2 weeks post-transplantation, and continued throughout the disease process, there was no effect on either the course of the disease or mortality."5.27Increased sensitivity to indomethacin of mice bearing the BCL1-leukemia. ( Hart, DA, 1984)
"To investigate the effects of indomethacin on proliferation and senescence of leukemia cells and to analyze whether non-steroidal anti-inflammatory drugs have any adjunctively therapeutic effects on leukemia."3.81[Effects of Indomethacin on Proliferation and Senescence of Leukemia Cells]. ( Jiao, XY; Zhang, Y, 2015)
" We investigated whether indomethacin, which inhibits cyclooxygenases, is able to overcome doxorubicin resistance in K562/ADR leukemia cells."3.75Indomethacin overcomes doxorubicin resistance by decreasing intracellular content of glutathione and its conjugates with decreasing expression of gamma-glutamylcysteine synthetase via promoter activity in doxorubicin-resistant leukemia cells. ( Asano, T; Fukunaga, Y; Tsutsuda-Asano, A, 2009)
"If indomethacin treatment was initiated prior to transplantation of the tumor or 2 weeks post-transplantation, and continued throughout the disease process, there was no effect on either the course of the disease or mortality."1.27Increased sensitivity to indomethacin of mice bearing the BCL1-leukemia. ( Hart, DA, 1984)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-199014 (77.78)18.7374
1990's2 (11.11)18.2507
2000's1 (5.56)29.6817
2010's1 (5.56)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Zhang, Y1
Jiao, XY1
Asano, T1
Tsutsuda-Asano, A1
Fukunaga, Y1
O'Keefe, D1
Ashman, L1
Hart, DA1
Greer, KE1
Cooper, PH1
Jakschik, BA1
Falkenhein, S1
Parker, CW1
Mannella, W1
Brodsky, I1
Sufian, S1
Matsumoto, T1
Tanaka, K1
Aikawa, Y1
Kawasaki, H1
Asaoka, K1
Inaba, T1
Yoshida, C1
Teichmann, JV1
Ludwig, WD1
Seibt-Jung, H1
Thiel, E1
Wyckoff, JH1
Shannon, BT1
Petrini, M1
Merler, E1
Kiely, JM1
Calabro, JJ1
Katz, RM1
Maltz, BA1
Banerjee, AK1
Milevskaia, IuL1
Treske, U2
Liotta, S1
Ronchi, F1
Marcolongo, R1
Boggiano, CA1

Reviews

2 reviews available for indomethacin and Leukemia

ArticleYear
Sweet's syndrome (acute febrile neutrophilic dermatosis).
    Clinics in rheumatic diseases, 1982, Volume: 8, Issue:2

    Topics: Adult; Arthritis; Clofazimine; Diagnosis, Differential; Eye Diseases; Female; Fever; Humans; Indomet

1982
A critical reappraisal of juvenile rheumatoid arthritis.
    Clinical orthopaedics and related research, 1971, Volume: 74

    Topics: Agammaglobulinemia; Arthritis, Juvenile; Aspirin; Cardiomegaly; Child; Child, Preschool; Chloroquine

1971

Other Studies

16 other studies available for indomethacin and Leukemia

ArticleYear
[Effects of Indomethacin on Proliferation and Senescence of Leukemia Cells].
    Zhongguo shi yan xue ye xue za zhi, 2015, Volume: 23, Issue:6

    Topics: Apoptosis; Cell Cycle; Cell Proliferation; Cell Survival; Cellular Senescence; Humans; Indomethacin;

2015
Indomethacin overcomes doxorubicin resistance by decreasing intracellular content of glutathione and its conjugates with decreasing expression of gamma-glutamylcysteine synthetase via promoter activity in doxorubicin-resistant leukemia cells.
    Cancer chemotherapy and pharmacology, 2009, Volume: 64, Issue:4

    Topics: Antineoplastic Agents; Base Sequence; DNA Primers; Doxorubicin; Drug Resistance, Neoplasm; Drug Syne

2009
Variation in accessory cell requirements in human mixed lymphocyte response to leukaemic cell lines.
    Immunology, 1982, Volume: 47, Issue:4

    Topics: Adult; Cell Line; Histocompatibility Antigens Class II; HLA-DR Antigens; Humans; Indomethacin; Leuke

1982
Increased sensitivity to indomethacin of mice bearing the BCL1-leukemia.
    Cancer letters, 1984, Volume: 23, Issue:2

    Topics: Animals; Blood Cell Count; Cell Line; Dose-Response Relationship, Drug; Female; Indomethacin; Leukem

1984
Precursor role of arachidonic acid in release of slow reacting substance from rat basophilic leukemia cells.
    Proceedings of the National Academy of Sciences of the United States of America, 1977, Volume: 74, Issue:10

    Topics: Arachidonic Acids; Autacoids; Basophils; Calcimycin; Fatty Acids; Humans; Indomethacin; Leukemia

1977
Postoperative fever in patients with hematologic malignancy.
    International surgery, 1977, Volume: 62, Issue:4

    Topics: Adult; Aged; Colonic Neoplasms; Female; Fever; Humans; Indomethacin; Leukemia; Male; Neoplasms, Mult

1977
Pharmacological studies on 3-formylamino-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-one (T-614), a novel antiinflammatory agent. 4th communication: inhibitory effect on the production of interleukin-1 and interleukin-6.
    Journal of pharmacobio-dynamics, 1992, Volume: 15, Issue:11

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Benzopyrans; Cell Line; Drug Interactions; Humans; Indometh

1992
Lymphokine-activated killer (LAK) cells against human leukemia: augmentation of LAK-cell cytotoxicity by combinations of lymphokines or cytokines.
    Haematology and blood transfusion, 1990, Volume: 33

    Topics: Biological Factors; Cytokines; Cytotoxicity Tests, Immunologic; Drug Synergism; Humans; Indomethacin

1990
Acquired spontaneous cytotoxicity of K562 in a subpopulation of monocytes.
    Immunobiology, 1985, Volume: 169, Issue:2

    Topics: Antigens, Surface; Cell Line; Cytotoxicity, Immunologic; Dinoprostone; Humans; In Vitro Techniques;

1985
Symptomatic control of fever in lymphoma and leukemia.
    Mayo Clinic proceedings, 1969, Volume: 44, Issue:4

    Topics: Adolescent; Adult; Aged; Aminopyrine; Analgesics; Aspirin; Female; Fever; Hodgkin Disease; Humans; I

1969
Use of Indomethacin as an anti-pyretic agent in malignant reticulosis.
    The Medical journal of Malaya, 1972, Volume: 26, Issue:3

    Topics: Adolescent; Adult; Child; Evaluation Studies as Topic; Female; Fever; Hodgkin Disease; Humans; Indom

1972
[Use of indomethacin in internal and hematologic practice].
    Terapevticheskii arkhiv, 1970, Volume: 42, Issue:1

    Topics: Hodgkin Disease; Humans; Indomethacin; Joint Diseases; Leukemia; Lymphoma; Lymphoma, Large B-Cell, D

1970
[Indomethacin in hemoblastosis].
    Arzneimittel-Forschung, 1971, Volume: 21, Issue:11

    Topics: Hodgkin Disease; Humans; Indomethacin; Joint Diseases; Leukemia; Lymphoma; Lymphoma, Large B-Cell, D

1971
[Indomethacin and hematopoiesis. Antipyretic and antiphlogistic effects in hemoblastoses and various uncommon diseases].
    Medizinische Klinik, 1968, Mar-01, Volume: 63, Issue:9

    Topics: Arthritis, Infectious; Arthritis, Rheumatoid; Dermatomyositis; Female; Hematologic Diseases; Hematop

1968
[Antipyretic activity of indomethacin in histiocytic sarcomatosis of a systemic type].
    La Clinica terapeutica, 1967, Aug-31, Volume: 42, Issue:4

    Topics: Adolescent; Adult; Aged; Female; Histiocytes; Hodgkin Disease; Humans; Indomethacin; Leukemia; Male;

1967
[On the antipyretic action of indomethacin in Hodgkin's lymphogranuloma and in neoplasms].
    Minerva medica, 1966, Sep-05, Volume: 57, Issue:71

    Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Antineoplastic Agents; Fever; Hodgkin Disease; Human

1966