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indomethacin and Leukemia, Myeloid, Acute

indomethacin has been researched along with Leukemia, Myeloid, Acute in 14 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Leukemia, Myeloid, Acute: Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.

Research Excerpts

ExcerptRelevanceReference
"Chronic exposure of humans to benzene (BZ), a Class I carcinogen, causes acute myelogenous leukemia, possibly via its bone marrow metabolite, hydroquinone (HQ)."3.69Induction of granulocytic differentiation in myeloblasts by hydroquinone, a metabolite of benzene, involves the leukotriene D4 receptor. ( Hazel, BA; Kalf, GF, 1996)
"We studied LSCs in mouse models of acute myelogenous leukemia (AML) induced either by coexpression of the Hoxa9 and Meis1a oncogenes or by the fusion oncoprotein MLL-AF9."1.36The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML. ( Armstrong, SA; Feng, Z; Goessling, W; Krivtsov, AV; North, TE; Sinha, AU; Wang, Y; Zon, LI, 2010)
"Treatment with indomethacin alone induced growth arrest, but not the death of AML-2/IDAC cells."1.35Alleviation of the drug-resistant phenotype in idarubicin and cytosine arabinoside double-resistant acute myeloid leukemia cells by indomethacin. ( Hwang, SY; Kim, HJ; Kim, SH; Kim, TS; Song, JH, 2008)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19909 (64.29)18.7374
1990's1 (7.14)18.2507
2000's2 (14.29)29.6817
2010's2 (14.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Wang, Y1
Krivtsov, AV1
Sinha, AU1
North, TE1
Goessling, W1
Feng, Z1
Zon, LI1
Armstrong, SA1
Lodi, A1
Tiziani, S1
Khanim, FL1
Drayson, MT1
Günther, UL1
Bunce, CM2
Viant, MR1
Torii, I1
Morikawa, S1
Nakano, A1
Morikawa, K1
Song, JH1
Kim, SH1
Kim, HJ1
Hwang, SY1
Kim, TS1
Bonser, RW1
Siegel, MI1
McConnell, RT1
Cuatrecasas, P1
Seaman, WE1
Woodcock, J1
Spitzer, G2
Verma, DS2
Beran, M2
Zander, AR2
Dicke, KA2
McCredie, KB2
Siegel, S1
Tindle, S1
Hazel, BA1
Kalf, GF1
Carcassonne, Y1
Gastaut, JA1
Blanc, AP1
Pullen, GR1
Hosking, CS1
Burnett, D1
Crocker, J1
Afford, SC1
Brown, G1
Stockley, RA1
Lusch, CJ1
Serpick, AA1
Slater, L1
Treske, U1

Other Studies

14 other studies available for indomethacin and Leukemia, Myeloid, Acute

ArticleYear
The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML.
    Science (New York, N.Y.), 2010, Mar-26, Volume: 327, Issue:5973

    Topics: Animals; beta Catenin; Cell Proliferation; Cell Transformation, Neoplastic; Genes, Homeobox; Granulo

2010
Hypoxia triggers major metabolic changes in AML cells without altering indomethacin-induced TCA cycle deregulation.
    ACS chemical biology, 2011, Feb-18, Volume: 6, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Hypoxia; Cell Line, Tumor; Citric Acid Cycle; Glycolys

2011
Establishment of a human preadipose cell line, HPB-AML-I: refractory to PPARgamma-mediated adipogenic stimulation.
    Journal of cellular physiology, 2003, Volume: 197, Issue:1

    Topics: Adipocytes; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antigens, CD; Antineo

2003
Alleviation of the drug-resistant phenotype in idarubicin and cytosine arabinoside double-resistant acute myeloid leukemia cells by indomethacin.
    International journal of oncology, 2008, Volume: 32, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; ATP-Binding Cassette Tran

2008
The appearance of phospholipase and cyclo-oxygenase activities in the human promyelocytic leukemia cell line HL60 during dimethyl sulfoxide-induced differentiation.
    Biochemical and biophysical research communications, 1981, Feb-12, Volume: 98, Issue:3

    Topics: Animals; Arachidonic Acids; Cell Differentiation; Cell Line; Dimethyl Sulfoxide; Humans; Indomethaci

1981
Human and murine natural killer cell activity may require lipoxygenation of arachidonic acid.
    The Journal of allergy and clinical immunology, 1984, Volume: 74, Issue:3 Pt 2

    Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Anti-Inflammatory Agents; Antibody-Dep

1984
Adherent cell inhibition of human leukemic in vitro agar clonal growth by short-term cell-to-cell contact.
    Blood, 1981, Volume: 57, Issue:1

    Topics: Agar; Cell Adhesion; Cell Communication; Clone Cells; Culture Media; Cytotoxicity, Immunologic; Grow

1981
Human myeloid leukaemic cell interactions in vitro with normal myeloid colonies.
    British journal of cancer, 1981, Volume: 43, Issue:2

    Topics: Cell Count; Cell Division; Cells, Cultured; Colony-Forming Units Assay; Colony-Stimulating Factors;

1981
Induction of granulocytic differentiation in myeloblasts by hydroquinone, a metabolite of benzene, involves the leukotriene D4 receptor.
    Receptors & signal transduction, 1996, Volume: 6, Issue:1

    Topics: Animals; Benzene; Cell Differentiation; Cell Line; Granulocyte Colony-Stimulating Factor; Granulocyt

1996
Acute leukemia after prolonged immunosuppressive therapy for glomerulonephritis.
    Cancer treatment reports, 1978, Volume: 62, Issue:7

    Topics: Adolescent; Alkylating Agents; Chlorambucil; Dipyridamole; Glomerulonephritis; Humans; Indomethacin;

1978
Differentiated HL60 promyelocytic leukaemia cells have a deficient myeloperoxidase/halide killing system.
    Clinical and experimental immunology, 1985, Volume: 62, Issue:2

    Topics: Candida albicans; Cell Differentiation; Cell Line; Chemotaxis; Cytoplasmic Granules; Dimethyl Sulfox

1985
Cathepsin B synthesis by the HL60 promyelocytic cell line: effects of stimulating agents and anti-inflammatory compounds.
    Biochimica et biophysica acta, 1986, Aug-01, Volume: 887, Issue:3

    Topics: Anti-Inflammatory Agents; Butanones; Carboxylesterase; Carboxylic Ester Hydrolases; Carrageenan; Cat

1986
Antipyretic effect of indomethacin in patients with malignancy.
    Cancer, 1968, Volume: 21, Issue:4

    Topics: Anti-Bacterial Agents; Body Temperature; Female; Fever; Hodgkin Disease; Humans; Indomethacin; Leuke

1968
[Indomethacin and hematopoiesis. Antipyretic and antiphlogistic effects in hemoblastoses and various uncommon diseases].
    Medizinische Klinik, 1968, Mar-01, Volume: 63, Issue:9

    Topics: Arthritis, Infectious; Arthritis, Rheumatoid; Dermatomyositis; Female; Hematologic Diseases; Hematop

1968