indomethacin has been researched along with Leukemia, Myeloid, Acute in 14 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Leukemia, Myeloid, Acute: Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chronic exposure of humans to benzene (BZ), a Class I carcinogen, causes acute myelogenous leukemia, possibly via its bone marrow metabolite, hydroquinone (HQ)." | 3.69 | Induction of granulocytic differentiation in myeloblasts by hydroquinone, a metabolite of benzene, involves the leukotriene D4 receptor. ( Hazel, BA; Kalf, GF, 1996) |
| "We studied LSCs in mouse models of acute myelogenous leukemia (AML) induced either by coexpression of the Hoxa9 and Meis1a oncogenes or by the fusion oncoprotein MLL-AF9." | 1.36 | The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML. ( Armstrong, SA; Feng, Z; Goessling, W; Krivtsov, AV; North, TE; Sinha, AU; Wang, Y; Zon, LI, 2010) |
| "Treatment with indomethacin alone induced growth arrest, but not the death of AML-2/IDAC cells." | 1.35 | Alleviation of the drug-resistant phenotype in idarubicin and cytosine arabinoside double-resistant acute myeloid leukemia cells by indomethacin. ( Hwang, SY; Kim, HJ; Kim, SH; Kim, TS; Song, JH, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (64.29) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 2 (14.29) | 29.6817 |
| 2010's | 2 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, Y | 1 |
| Krivtsov, AV | 1 |
| Sinha, AU | 1 |
| North, TE | 1 |
| Goessling, W | 1 |
| Feng, Z | 1 |
| Zon, LI | 1 |
| Armstrong, SA | 1 |
| Lodi, A | 1 |
| Tiziani, S | 1 |
| Khanim, FL | 1 |
| Drayson, MT | 1 |
| Günther, UL | 1 |
| Bunce, CM | 2 |
| Viant, MR | 1 |
| Torii, I | 1 |
| Morikawa, S | 1 |
| Nakano, A | 1 |
| Morikawa, K | 1 |
| Song, JH | 1 |
| Kim, SH | 1 |
| Kim, HJ | 1 |
| Hwang, SY | 1 |
| Kim, TS | 1 |
| Bonser, RW | 1 |
| Siegel, MI | 1 |
| McConnell, RT | 1 |
| Cuatrecasas, P | 1 |
| Seaman, WE | 1 |
| Woodcock, J | 1 |
| Spitzer, G | 2 |
| Verma, DS | 2 |
| Beran, M | 2 |
| Zander, AR | 2 |
| Dicke, KA | 2 |
| McCredie, KB | 2 |
| Siegel, S | 1 |
| Tindle, S | 1 |
| Hazel, BA | 1 |
| Kalf, GF | 1 |
| Carcassonne, Y | 1 |
| Gastaut, JA | 1 |
| Blanc, AP | 1 |
| Pullen, GR | 1 |
| Hosking, CS | 1 |
| Burnett, D | 1 |
| Crocker, J | 1 |
| Afford, SC | 1 |
| Brown, G | 1 |
| Stockley, RA | 1 |
| Lusch, CJ | 1 |
| Serpick, AA | 1 |
| Slater, L | 1 |
| Treske, U | 1 |
14 other studies available for indomethacin and Leukemia, Myeloid, Acute
| Article | Year |
|---|---|
The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML.
Topics: Animals; beta Catenin; Cell Proliferation; Cell Transformation, Neoplastic; Genes, Homeobox; Granulo | 2010 |
Hypoxia triggers major metabolic changes in AML cells without altering indomethacin-induced TCA cycle deregulation.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Hypoxia; Cell Line, Tumor; Citric Acid Cycle; Glycolys | 2011 |
Establishment of a human preadipose cell line, HPB-AML-I: refractory to PPARgamma-mediated adipogenic stimulation.
Topics: Adipocytes; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antigens, CD; Antineo | 2003 |
Alleviation of the drug-resistant phenotype in idarubicin and cytosine arabinoside double-resistant acute myeloid leukemia cells by indomethacin.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; ATP-Binding Cassette Tran | 2008 |
The appearance of phospholipase and cyclo-oxygenase activities in the human promyelocytic leukemia cell line HL60 during dimethyl sulfoxide-induced differentiation.
Topics: Animals; Arachidonic Acids; Cell Differentiation; Cell Line; Dimethyl Sulfoxide; Humans; Indomethaci | 1981 |
Human and murine natural killer cell activity may require lipoxygenation of arachidonic acid.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Anti-Inflammatory Agents; Antibody-Dep | 1984 |
Adherent cell inhibition of human leukemic in vitro agar clonal growth by short-term cell-to-cell contact.
Topics: Agar; Cell Adhesion; Cell Communication; Clone Cells; Culture Media; Cytotoxicity, Immunologic; Grow | 1981 |
Human myeloid leukaemic cell interactions in vitro with normal myeloid colonies.
Topics: Cell Count; Cell Division; Cells, Cultured; Colony-Forming Units Assay; Colony-Stimulating Factors; | 1981 |
Induction of granulocytic differentiation in myeloblasts by hydroquinone, a metabolite of benzene, involves the leukotriene D4 receptor.
Topics: Animals; Benzene; Cell Differentiation; Cell Line; Granulocyte Colony-Stimulating Factor; Granulocyt | 1996 |
Acute leukemia after prolonged immunosuppressive therapy for glomerulonephritis.
Topics: Adolescent; Alkylating Agents; Chlorambucil; Dipyridamole; Glomerulonephritis; Humans; Indomethacin; | 1978 |
Differentiated HL60 promyelocytic leukaemia cells have a deficient myeloperoxidase/halide killing system.
Topics: Candida albicans; Cell Differentiation; Cell Line; Chemotaxis; Cytoplasmic Granules; Dimethyl Sulfox | 1985 |
Cathepsin B synthesis by the HL60 promyelocytic cell line: effects of stimulating agents and anti-inflammatory compounds.
Topics: Anti-Inflammatory Agents; Butanones; Carboxylesterase; Carboxylic Ester Hydrolases; Carrageenan; Cat | 1986 |
Antipyretic effect of indomethacin in patients with malignancy.
Topics: Anti-Bacterial Agents; Body Temperature; Female; Fever; Hodgkin Disease; Humans; Indomethacin; Leuke | 1968 |
[Indomethacin and hematopoiesis. Antipyretic and antiphlogistic effects in hemoblastoses and various uncommon diseases].
Topics: Arthritis, Infectious; Arthritis, Rheumatoid; Dermatomyositis; Female; Hematologic Diseases; Hematop | 1968 |