indomethacin has been researched along with Leukemia, Myelogenous, Chronic, BCR-ABL Positive in 12 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive: Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A patient with chronic myelogenous leukemia who developed arthritis secondary to IFN therapy is presented." | 2.40 | Alpha-interferon-induced arthritis: clinical presentation treatment, and prevention. ( Nesher, G; Ruchlemer, R, 1998) |
| "Indomethacin (IN) can inhibit cyclooxygenase activity and is considered to exert antitumor action in a variety of cancer cells." | 1.33 | Antiproliferative effect of indomethacin on CML cells is related to the suppression of STATs/Bcl-XL signal pathway. ( Fu, Y; Zhang, G, 2006) |
| " 0 approximately 400 micromol/L of IN could down-regulate the expression of p-STAT1 or p-STAT5 in a dose-response manner, p-STATs were distributed mainly in the nucleus as scattering spots." | 1.32 | [Proliferation inhibition effect of indomethacin on CML cells associated with down-regulation of phosphorylated STAT1/STAT5 and inhibition of COX-2 expression]. ( Fu, YB; Xia, M; Zhang, GS, 2004) |
| "The hallmark of chronic myeloid leukemia (CML) is the presence of the bcr-abl oncogene, which is associated with transforming ability and an intrinsic resistance to induction of apoptosis by genotoxic agents." | 1.30 | Induction of apoptosis by arachidonic acid in chronic myeloid leukemia cells. ( Akard, L; Boswell, HS; Carlo-Stella, C; Dugan, M; Garau, D; Regazzi, E; Rizzo, MT; Rizzoli, V, 1999) |
| "Treatment with indomethacin briefly improved the symptoms, but within 72 hours the patient developed a fulminant illness with high fever and clinical as well as biochemical signs of a severe consumption coagulopathy." | 1.28 | [Atypical joint symptoms as initial symptoms of varicella infection in chronic myeloid leukemia]. ( Arning, M; Aul, C; Bürrig, KF; Reinecke, P; Schneider, W, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (41.67) | 18.2507 |
| 2000's | 5 (41.67) | 29.6817 |
| 2010's | 2 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Heidel, FH | 1 |
| Bullinger, L | 1 |
| Feng, Z | 1 |
| Wang, Z | 1 |
| Neff, TA | 1 |
| Stein, L | 1 |
| Kalaitzidis, D | 1 |
| Lane, SW | 1 |
| Armstrong, SA | 1 |
| Cipák, L | 1 |
| Paulíková, H | 1 |
| Novotný, L | 1 |
| Jarosová, M | 1 |
| Rauko, P | 1 |
| Fu, YB | 2 |
| Zhang, GS | 2 |
| Xia, M | 1 |
| Zhang, G | 4 |
| Fu, Y | 1 |
| Nesher, G | 1 |
| Ruchlemer, R | 1 |
| Rizzo, MT | 1 |
| Regazzi, E | 1 |
| Garau, D | 1 |
| Akard, L | 1 |
| Dugan, M | 1 |
| Boswell, HS | 1 |
| Rizzoli, V | 1 |
| Carlo-Stella, C | 1 |
| Tu, C | 2 |
| Zhou, G | 1 |
| Zheng, W | 1 |
| Lu, H | 1 |
| Maca, RD | 1 |
| Arning, M | 1 |
| Aul, C | 1 |
| Reinecke, P | 1 |
| Bürrig, KF | 1 |
| Schneider, W | 1 |
1 review available for indomethacin and Leukemia, Myelogenous, Chronic, BCR-ABL Positive
| Article | Year |
|---|---|
Alpha-interferon-induced arthritis: clinical presentation treatment, and prevention.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Antinuclear; Antineop | 1998 |
11 other studies available for indomethacin and Leukemia, Myelogenous, Chronic, BCR-ABL Positive
| Article | Year |
|---|---|
Genetic and pharmacologic inhibition of β-catenin targets imatinib-resistant leukemia stem cells in CML.
Topics: Animals; Antineoplastic Agents; Benzamides; beta Catenin; Cyclooxygenase Inhibitors; Drug Resistance | 2012 |
β-catenin inhibition synergizes with imatinib to delay CML recurrence.
Topics: Animals; Antineoplastic Agents; beta Catenin; Cyclooxygenase Inhibitors; Drug Resistance, Neoplasm; | 2012 |
Potentiation of doxorubicin-induced apoptosis and differentiation by indomethacin in K-562 leukemia cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibiotics, Antineoplastic; Apoptosis; Cell Differentiatio | 2004 |
[Proliferation-inhibiting effect of indomethacin on chronic myeliod leukemia cells is related to the supression of STAT signal transduction pathway].
Topics: Antineoplastic Agents; Blotting, Western; Cell Proliferation; Dose-Response Relationship, Drug; Fluo | 2004 |
[Proliferation inhibition effect of indomethacin on CML cells associated with down-regulation of phosphorylated STAT1/STAT5 and inhibition of COX-2 expression].
Topics: bcl-X Protein; Blotting, Western; Cell Proliferation; Cyclooxygenase 2; Cyclooxygenase Inhibitors; D | 2004 |
Antiproliferative effect of indomethacin on CML cells is related to the suppression of STATs/Bcl-XL signal pathway.
Topics: bcl-X Protein; Cell Division; Humans; Indomethacin; K562 Cells; Leukemia, Myelogenous, Chronic, BCR- | 2006 |
Induction of apoptosis by arachidonic acid in chronic myeloid leukemia cells.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Adult; Animals; Antioxidants; Apoptosis; Arachidonic Acid; Bone Mar | 1999 |
Indomethacin induces apoptosis and inhibits proliferation in chronic myeloid leukemia cells.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; bcl-2-Associated X Protein; Cell Division | 2000 |
[Study of apoptosis induced by indomethacin in chronic myeloid leukemia].
Topics: Apoptosis; Down-Regulation; Humans; Indomethacin; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-AB | 1999 |
Enhancement of etoposide and methotrexate sensitivity by indomethacin in vitro.
Topics: Animals; Bleomycin; Drug Synergism; Etoposide; Humans; Indomethacin; Leukemia, Myelogenous, Chronic, | 1991 |
[Atypical joint symptoms as initial symptoms of varicella infection in chronic myeloid leukemia].
Topics: Adult; Chickenpox; Female; Hip Joint; Humans; Indomethacin; Joint Diseases; Leukemia, Myelogenous, C | 1990 |