indomethacin has been researched along with Leucocythaemia in 18 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the effects of indomethacin on proliferation and senescence of leukemia cells and to analyze whether non-steroidal anti-inflammatory drugs have any adjunctively therapeutic effects on leukemia." | 7.81 | [Effects of Indomethacin on Proliferation and Senescence of Leukemia Cells]. ( Jiao, XY; Zhang, Y, 2015) |
| " We investigated whether indomethacin, which inhibits cyclooxygenases, is able to overcome doxorubicin resistance in K562/ADR leukemia cells." | 7.75 | Indomethacin overcomes doxorubicin resistance by decreasing intracellular content of glutathione and its conjugates with decreasing expression of gamma-glutamylcysteine synthetase via promoter activity in doxorubicin-resistant leukemia cells. ( Asano, T; Fukunaga, Y; Tsutsuda-Asano, A, 2009) |
| "If indomethacin treatment was initiated prior to transplantation of the tumor or 2 weeks post-transplantation, and continued throughout the disease process, there was no effect on either the course of the disease or mortality." | 5.27 | Increased sensitivity to indomethacin of mice bearing the BCL1-leukemia. ( Hart, DA, 1984) |
| "To investigate the effects of indomethacin on proliferation and senescence of leukemia cells and to analyze whether non-steroidal anti-inflammatory drugs have any adjunctively therapeutic effects on leukemia." | 3.81 | [Effects of Indomethacin on Proliferation and Senescence of Leukemia Cells]. ( Jiao, XY; Zhang, Y, 2015) |
| " We investigated whether indomethacin, which inhibits cyclooxygenases, is able to overcome doxorubicin resistance in K562/ADR leukemia cells." | 3.75 | Indomethacin overcomes doxorubicin resistance by decreasing intracellular content of glutathione and its conjugates with decreasing expression of gamma-glutamylcysteine synthetase via promoter activity in doxorubicin-resistant leukemia cells. ( Asano, T; Fukunaga, Y; Tsutsuda-Asano, A, 2009) |
| "If indomethacin treatment was initiated prior to transplantation of the tumor or 2 weeks post-transplantation, and continued throughout the disease process, there was no effect on either the course of the disease or mortality." | 1.27 | Increased sensitivity to indomethacin of mice bearing the BCL1-leukemia. ( Hart, DA, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (77.78) | 18.7374 |
| 1990's | 2 (11.11) | 18.2507 |
| 2000's | 1 (5.56) | 29.6817 |
| 2010's | 1 (5.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, Y | 1 |
| Jiao, XY | 1 |
| Asano, T | 1 |
| Tsutsuda-Asano, A | 1 |
| Fukunaga, Y | 1 |
| O'Keefe, D | 1 |
| Ashman, L | 1 |
| Hart, DA | 1 |
| Greer, KE | 1 |
| Cooper, PH | 1 |
| Jakschik, BA | 1 |
| Falkenhein, S | 1 |
| Parker, CW | 1 |
| Mannella, W | 1 |
| Brodsky, I | 1 |
| Sufian, S | 1 |
| Matsumoto, T | 1 |
| Tanaka, K | 1 |
| Aikawa, Y | 1 |
| Kawasaki, H | 1 |
| Asaoka, K | 1 |
| Inaba, T | 1 |
| Yoshida, C | 1 |
| Teichmann, JV | 1 |
| Ludwig, WD | 1 |
| Seibt-Jung, H | 1 |
| Thiel, E | 1 |
| Wyckoff, JH | 1 |
| Shannon, BT | 1 |
| Petrini, M | 1 |
| Merler, E | 1 |
| Kiely, JM | 1 |
| Calabro, JJ | 1 |
| Katz, RM | 1 |
| Maltz, BA | 1 |
| Banerjee, AK | 1 |
| Milevskaia, IuL | 1 |
| Treske, U | 2 |
| Liotta, S | 1 |
| Ronchi, F | 1 |
| Marcolongo, R | 1 |
| Boggiano, CA | 1 |
2 reviews available for indomethacin and Leucocythaemia
| Article | Year |
|---|---|
Sweet's syndrome (acute febrile neutrophilic dermatosis).
Topics: Adult; Arthritis; Clofazimine; Diagnosis, Differential; Eye Diseases; Female; Fever; Humans; Indomet | 1982 |
A critical reappraisal of juvenile rheumatoid arthritis.
Topics: Agammaglobulinemia; Arthritis, Juvenile; Aspirin; Cardiomegaly; Child; Child, Preschool; Chloroquine | 1971 |
16 other studies available for indomethacin and Leucocythaemia
| Article | Year |
|---|---|
[Effects of Indomethacin on Proliferation and Senescence of Leukemia Cells].
Topics: Apoptosis; Cell Cycle; Cell Proliferation; Cell Survival; Cellular Senescence; Humans; Indomethacin; | 2015 |
Indomethacin overcomes doxorubicin resistance by decreasing intracellular content of glutathione and its conjugates with decreasing expression of gamma-glutamylcysteine synthetase via promoter activity in doxorubicin-resistant leukemia cells.
Topics: Antineoplastic Agents; Base Sequence; DNA Primers; Doxorubicin; Drug Resistance, Neoplasm; Drug Syne | 2009 |
Variation in accessory cell requirements in human mixed lymphocyte response to leukaemic cell lines.
Topics: Adult; Cell Line; Histocompatibility Antigens Class II; HLA-DR Antigens; Humans; Indomethacin; Leuke | 1982 |
Increased sensitivity to indomethacin of mice bearing the BCL1-leukemia.
Topics: Animals; Blood Cell Count; Cell Line; Dose-Response Relationship, Drug; Female; Indomethacin; Leukem | 1984 |
Precursor role of arachidonic acid in release of slow reacting substance from rat basophilic leukemia cells.
Topics: Arachidonic Acids; Autacoids; Basophils; Calcimycin; Fatty Acids; Humans; Indomethacin; Leukemia | 1977 |
Postoperative fever in patients with hematologic malignancy.
Topics: Adult; Aged; Colonic Neoplasms; Female; Fever; Humans; Indomethacin; Leukemia; Male; Neoplasms, Mult | 1977 |
Pharmacological studies on 3-formylamino-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-one (T-614), a novel antiinflammatory agent. 4th communication: inhibitory effect on the production of interleukin-1 and interleukin-6.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Benzopyrans; Cell Line; Drug Interactions; Humans; Indometh | 1992 |
Lymphokine-activated killer (LAK) cells against human leukemia: augmentation of LAK-cell cytotoxicity by combinations of lymphokines or cytokines.
Topics: Biological Factors; Cytokines; Cytotoxicity Tests, Immunologic; Drug Synergism; Humans; Indomethacin | 1990 |
Acquired spontaneous cytotoxicity of K562 in a subpopulation of monocytes.
Topics: Antigens, Surface; Cell Line; Cytotoxicity, Immunologic; Dinoprostone; Humans; In Vitro Techniques; | 1985 |
Symptomatic control of fever in lymphoma and leukemia.
Topics: Adolescent; Adult; Aged; Aminopyrine; Analgesics; Aspirin; Female; Fever; Hodgkin Disease; Humans; I | 1969 |
Use of Indomethacin as an anti-pyretic agent in malignant reticulosis.
Topics: Adolescent; Adult; Child; Evaluation Studies as Topic; Female; Fever; Hodgkin Disease; Humans; Indom | 1972 |
[Use of indomethacin in internal and hematologic practice].
Topics: Hodgkin Disease; Humans; Indomethacin; Joint Diseases; Leukemia; Lymphoma; Lymphoma, Large B-Cell, D | 1970 |
[Indomethacin in hemoblastosis].
Topics: Hodgkin Disease; Humans; Indomethacin; Joint Diseases; Leukemia; Lymphoma; Lymphoma, Large B-Cell, D | 1971 |
[Indomethacin and hematopoiesis. Antipyretic and antiphlogistic effects in hemoblastoses and various uncommon diseases].
Topics: Arthritis, Infectious; Arthritis, Rheumatoid; Dermatomyositis; Female; Hematologic Diseases; Hematop | 1968 |
[Antipyretic activity of indomethacin in histiocytic sarcomatosis of a systemic type].
Topics: Adolescent; Adult; Aged; Female; Histiocytes; Hodgkin Disease; Humans; Indomethacin; Leukemia; Male; | 1967 |
[On the antipyretic action of indomethacin in Hodgkin's lymphogranuloma and in neoplasms].
Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Antineoplastic Agents; Fever; Hodgkin Disease; Human | 1966 |