Page last updated: 2024-10-29

indomethacin and Leprosy

indomethacin has been researched along with Leprosy in 11 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Leprosy: A chronic granulomatous infection caused by MYCOBACTERIUM LEPRAE. The granulomatous lesions are manifested in the skin, the mucous membranes, and the peripheral nerves. Two polar or principal types are lepromatous and tuberculoid.

Research Excerpts

ExcerptRelevanceReference
"The response to soluble mycobacterial antigens of peripheral blood mononuclear cells, from most normal donors, tuberculosis patients or cases of tuberculoid leprosy (TT/BT) was enhanced by the addition of indomethacin."3.66Prostaglandin-dependent regulation of the in vitro proliferative response to mycobacterial antigens of peripheral blood lymphocytes from normal donors and from patients with tuberculosis or leprosy. ( Bahr, GM; Rook, GA; Stanford, JL, 1981)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-199011 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Thiers, H1
Rousset, J1
Coudert, J1
Battesti, MR1
Than, LH1
Fleming, B1
Rook, GA2
Bahr, GM1
Stanford, JL1
Sibley, LD1
Krahenbuhl, JL1
Ridel, PR1
Jamet, P1
Robin, Y1
Bach, MA1
Singh, I1
Srivastava, MC1
Anand, LC1
Thomas, G2
Karat, AB2
Karat, S1
Rao, PS2
Parikh, AC1
Ganapati, R1
Ing, TH1

Trials

4 trials available for indomethacin and Leprosy

ArticleYear
The anti-inflammatory effect of Indomethacin in lepromatous leprosy.
    Leprosy review, 1968, Volume: 39, Issue:3

    Topics: Adult; Clinical Trials as Topic; Humans; Indomethacin; Leprosy; Male; Middle Aged

1968
An open trial of indomethacin therapy in exacerbated phases of lepromatous leprosy.
    Indian journal of medical sciences, 1969, Volume: 23, Issue:2

    Topics: Adolescent; Adult; Clinical Trials as Topic; Humans; Indomethacin; Leprosy

1969
Indomethacin in the management of erythema nodosum leprosum--a double-blind controlled trial.
    Leprosy review, 1969, Volume: 40, Issue:3

    Topics: Adolescent; Adult; Aspirin; Chloroquine; Clinical Trials as Topic; Erythema Nodosum; Humans; Indomet

1969
Indomethacin in the treatment of erythema nodosum leprosum, in comparison with prednisolone.
    Singapore medical journal, 1969, Volume: 10, Issue:1

    Topics: Erythema Nodosum; Humans; Indomethacin; Leprosy; Prednisolone

1969

Other Studies

7 other studies available for indomethacin and Leprosy

ArticleYear
[Indomethacin in reactional states of leprosy].
    Lyon medical, 1967, Mar-09, Volume: 217, Issue:12

    Topics: Adult; Humans; Indomethacin; Leprosy; Middle Aged

1967
T-cell-dependent polyclonal activation by soluble mycobacterial extracts of B cells in peripheral blood mononuclear cell populations from leprosy patients and normal donors.
    Immunology, 1982, Volume: 47, Issue:4

    Topics: Adult; Antigens, Bacterial; B-Lymphocytes; Dose-Response Relationship, Immunologic; Epitopes; Female

1982
Prostaglandin-dependent regulation of the in vitro proliferative response to mycobacterial antigens of peripheral blood lymphocytes from normal donors and from patients with tuberculosis or leprosy.
    Clinical and experimental immunology, 1981, Volume: 45, Issue:3

    Topics: Antigens, Bacterial; Antigens, Fungal; Candida albicans; Cell Division; Cells, Cultured; Dinoproston

1981
Induction of unresponsiveness to gamma interferon in macrophages infected with Mycobacterium leprae.
    Infection and immunity, 1988, Volume: 56, Issue:8

    Topics: Animals; Cells, Cultured; Dinoprostone; Histocompatibility Antigens Class II; Immunity, Cellular; In

1988
Interleukin-1 released by blood-monocyte-derived macrophages from patients with leprosy.
    Infection and immunity, 1986, Volume: 52, Issue:1

    Topics: Adolescent; Adult; Dinoprostone; Female; Humans; Indomethacin; Interleukin-1; Leprosy; Lymphocyte Ac

1986
Treatment of acute exacerbations in leprosy with idomethacin.
    Leprosy review, 1968, Volume: 39, Issue:4

    Topics: Acute Disease; Adolescent; Adult; Child; Female; Humans; Indomethacin; Leprosy; Male

1968
[Treatment of the leprous reaction].
    Alergia, 1965, Volume: 13, Issue:2

    Topics: Adolescent; Adult; Female; Humans; In Vitro Techniques; Indomethacin; Leprosy; Male; Middle Aged

1965