indomethacin has been researched along with Leprosy in 11 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Leprosy: A chronic granulomatous infection caused by MYCOBACTERIUM LEPRAE. The granulomatous lesions are manifested in the skin, the mucous membranes, and the peripheral nerves. Two polar or principal types are lepromatous and tuberculoid.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The response to soluble mycobacterial antigens of peripheral blood mononuclear cells, from most normal donors, tuberculosis patients or cases of tuberculoid leprosy (TT/BT) was enhanced by the addition of indomethacin." | 3.66 | Prostaglandin-dependent regulation of the in vitro proliferative response to mycobacterial antigens of peripheral blood lymphocytes from normal donors and from patients with tuberculosis or leprosy. ( Bahr, GM; Rook, GA; Stanford, JL, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Thiers, H | 1 |
| Rousset, J | 1 |
| Coudert, J | 1 |
| Battesti, MR | 1 |
| Than, LH | 1 |
| Fleming, B | 1 |
| Rook, GA | 2 |
| Bahr, GM | 1 |
| Stanford, JL | 1 |
| Sibley, LD | 1 |
| Krahenbuhl, JL | 1 |
| Ridel, PR | 1 |
| Jamet, P | 1 |
| Robin, Y | 1 |
| Bach, MA | 1 |
| Singh, I | 1 |
| Srivastava, MC | 1 |
| Anand, LC | 1 |
| Thomas, G | 2 |
| Karat, AB | 2 |
| Karat, S | 1 |
| Rao, PS | 2 |
| Parikh, AC | 1 |
| Ganapati, R | 1 |
| Ing, TH | 1 |
4 trials available for indomethacin and Leprosy
| Article | Year |
|---|---|
The anti-inflammatory effect of Indomethacin in lepromatous leprosy.
Topics: Adult; Clinical Trials as Topic; Humans; Indomethacin; Leprosy; Male; Middle Aged | 1968 |
An open trial of indomethacin therapy in exacerbated phases of lepromatous leprosy.
Topics: Adolescent; Adult; Clinical Trials as Topic; Humans; Indomethacin; Leprosy | 1969 |
Indomethacin in the management of erythema nodosum leprosum--a double-blind controlled trial.
Topics: Adolescent; Adult; Aspirin; Chloroquine; Clinical Trials as Topic; Erythema Nodosum; Humans; Indomet | 1969 |
Indomethacin in the treatment of erythema nodosum leprosum, in comparison with prednisolone.
Topics: Erythema Nodosum; Humans; Indomethacin; Leprosy; Prednisolone | 1969 |
7 other studies available for indomethacin and Leprosy
| Article | Year |
|---|---|
[Indomethacin in reactional states of leprosy].
Topics: Adult; Humans; Indomethacin; Leprosy; Middle Aged | 1967 |
T-cell-dependent polyclonal activation by soluble mycobacterial extracts of B cells in peripheral blood mononuclear cell populations from leprosy patients and normal donors.
Topics: Adult; Antigens, Bacterial; B-Lymphocytes; Dose-Response Relationship, Immunologic; Epitopes; Female | 1982 |
Prostaglandin-dependent regulation of the in vitro proliferative response to mycobacterial antigens of peripheral blood lymphocytes from normal donors and from patients with tuberculosis or leprosy.
Topics: Antigens, Bacterial; Antigens, Fungal; Candida albicans; Cell Division; Cells, Cultured; Dinoproston | 1981 |
Induction of unresponsiveness to gamma interferon in macrophages infected with Mycobacterium leprae.
Topics: Animals; Cells, Cultured; Dinoprostone; Histocompatibility Antigens Class II; Immunity, Cellular; In | 1988 |
Interleukin-1 released by blood-monocyte-derived macrophages from patients with leprosy.
Topics: Adolescent; Adult; Dinoprostone; Female; Humans; Indomethacin; Interleukin-1; Leprosy; Lymphocyte Ac | 1986 |
Treatment of acute exacerbations in leprosy with idomethacin.
Topics: Acute Disease; Adolescent; Adult; Child; Female; Humans; Indomethacin; Leprosy; Male | 1968 |
[Treatment of the leprous reaction].
Topics: Adolescent; Adult; Female; Humans; In Vitro Techniques; Indomethacin; Leprosy; Male; Middle Aged | 1965 |