indomethacin has been researched along with Leishmaniasis, Cutaneous in 6 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Leishmaniasis, Cutaneous: An endemic disease that is characterized by the development of single or multiple localized lesions on exposed areas of skin that typically ulcerate. The disease has been divided into Old and New World forms. Old World leishmaniasis is separated into three distinct types according to epidemiology and clinical manifestations and is caused by species of the L. tropica and L. aethiopica complexes as well as by species of the L. major genus. New World leishmaniasis, also called American leishmaniasis, occurs in South and Central America and is caused by species of the L. mexicana or L. braziliensis complexes.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cutaneous leishmaniasis is still one of the health problems in Iran and in the region." | 1.35 | Evaluation of anti-leishmanial activity by induction of nitric oxide and inhibition of prostaglandin in Balb/c mice infected with Leishmania major. ( Arjmand, M; Farahmand, M; Ghasemi, F; Hajihosseini, R; Nahrevanian, H, 2009) |
| "Mice treated with indomethacin are responsive to treatment with exogenous IL-12 through at least the first 2 weeks of infection and, unlike control mice treated with IL-12, develop an enhanced Th1-type response associated with increased enhanced resistance to infection." | 1.31 | Combined treatment with interleukin-12 and indomethacin promotes increased resistance in BALB/c mice with established Leishmania major infections. ( Farrell, JP; Li, J; Padigel, UM; Scott, P, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 4 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nahrevanian, H | 1 |
| Hajihosseini, R | 1 |
| Arjmand, M | 1 |
| Farahmand, M | 1 |
| Ghasemi, F | 1 |
| Li, J | 1 |
| Padigel, UM | 1 |
| Scott, P | 1 |
| Farrell, JP | 1 |
| Guimarães, ET | 1 |
| Santos, LA | 1 |
| Ribeiro dos Santos, R | 1 |
| Teixeira, MM | 1 |
| dos Santos, WL | 1 |
| Soares, MB | 1 |
| Ajdary, S | 1 |
| Hosseini, MH | 1 |
| Alimohammadian, MH | 1 |
| De Freitas, LA | 1 |
| Mbow, LM | 1 |
| Estay, M | 1 |
| Bleyenberg, JA | 1 |
| Titus, RG | 1 |
| Pérez-Santos, JL | 1 |
| Talamás-Rohana, P | 1 |
6 other studies available for indomethacin and Leishmaniasis, Cutaneous
| Article | Year |
|---|---|
Evaluation of anti-leishmanial activity by induction of nitric oxide and inhibition of prostaglandin in Balb/c mice infected with Leishmania major.
Topics: Analysis of Variance; Animals; Arginine; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; | 2009 |
Combined treatment with interleukin-12 and indomethacin promotes increased resistance in BALB/c mice with established Leishmania major infections.
Topics: Animals; Female; In Vitro Techniques; Indomethacin; Interferon-gamma; Interleukin-12; Leishmania maj | 2002 |
Role of interleukin-4 and prostaglandin E2 in Leishmania amazonensis infection of BALB/c mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Disease Susceptibility; Female; Huma | 2006 |
Recombinant interleukin-1 promotes leishmaniasis in susceptible mice.
Topics: Animals; Disease Progression; Indomethacin; Interleukin-1; Leishmaniasis, Cutaneous; Mice; Mice, Inb | 1997 |
Indomethacin treatment slows disease progression and enhances a Th1 response in susceptible BALB/c mice infected with Leishmania major.
Topics: Animals; Antiprotozoal Agents; Cyclooxygenase Inhibitors; Disease Progression; Female; Immunity, Cel | 1999 |
In vitro indomethacin administration upregulates interleukin-12 production and polarizes the immune response towards a Th1 type in susceptible BALB/c mice infected with Leishmania mexicana.
Topics: Animals; Blotting, Western; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Enzyme- | 2001 |