indomethacin and Labor, Premature studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Research Excerpts

Excerpt	Relevance	Reference
"A case of severe fetal congestive heart failure due to occlusion of the ductus arteriosus in a mother treated with indomethacin for polyhydramnios and premature contractions is described."	7.69	In utero congestive heart failure due to maternal indomethacin treatment for polyhydramnios and premature labour in a fetus with antenatal closure of the foramen ovale. ( Achiron, R; Berant, M; Hegesh, J; Kidron, D; Lipitz, S; Rotstein, Z, 1996)
"To investigate the effects of indomethacin on the human fetal renal blood flow velocity waveform, 17 fetuses whose mothers were treated for preterm labor (N = 8) or polyhydramnios (N = 9) were studied."	7.68	Doppler assessment of the renal blood flow velocity waveform during indomethacin therapy for preterm labor and polyhydramnios. ( Carpenter, RJ; Deter, RL; Kirshon, B; Mari, G; Moise, KJ, 1990)
"Eighteen pregnant women were given indomethacin during the year 1989 for treatment of premature labor (n = 16) or polyhydramnios (n = 2)."	7.68	[Maternal and neonatal effects of indomethacin administrated during pregnancy. Apropos of 18 cases]. ( Bavoux, F; Blot, P; Boissinot, C; Guillonneau, M; Hartmann, JF; Jacqz-Aigrain, E, 1993)
"A case is reported in which exposure to cocaine and indomethacin was associated with development of fetal anuria, anasarca, and neonatal gastrointestinal hemorrhage."	7.68	Cocaine and indomethacin: fetal anuria, neonatal edema, and gastrointestinal bleeding. ( Angel, JL; Carlan, SJ; Harris, M; O'Brien, WF; Stromquist, C, 1991)
" We took advantage of the treatment of pregnant women with indomethacin, because of premature labor or hydramnios, to investigate the role of prostaglandins in the activation of T suppressor (TS) activity."	7.67	The effects of indomethacin administration during pregnancy on women's and newborns' T-suppressor lymphocyte activity and on HLA class II expression by newborns' leukocytes. ( Brami, C; Durandy, A; Griscelli, C, 1985)
"Indomethacin was administered to suppress premature uterine contractions in a twin pregnancy from the 27th until the 32nd week of pregnancy."	7.67	Patent ductus arteriosus after prolonged treatment with indomethacin during pregnancy: case report. ( Abramovici, H; Atad, J; Lissak, A; Rofe, A, 1987)
"A pregnancy during which both beta-adrenergics and indomethacin were administered in order to stop preterm uterine contractions is reported."	7.66	Indomethacin and the fetal renal nonfunction syndrome. ( de Jong, PA; van Wijck, JA; Veersema, D, 1983)
"Eighty pregnant women threatened with preterm labor between 24 and 34 weeks of gestation were enrolled in the study."	6.67	Increased incidence of bronchopulmonary dysplasia after antenatal administration of indomethacin to prevent preterm labor. ( Eronen, M; Hallman, M; Kurki, T; Pesonen, E; Teramo, K; Ylikorkala, O, 1994)
"Indomethacin has been also used in women with short cervices as well as in those with idiopathic polyhydramnios."	5.38	Indomethacin in pregnancy: applications and safety. ( Abou-Ghannam, G; Nassar, AH; Usta, IM, 2012)
"Indomethacin was discontinued beyond the 33rd week of gestational age."	5.29	[Has the use of indomethacin during pregnancy consequences in newborn infants? Prospective study of 83 pregnant women and 115 newborn infants]. ( Blot, P; Boissinot, C; Carbillon, L; de Gayffier, A; Germain, JF; Jacqz-Aigrain, E; Oury, JF; Sibony, O, 1994)
"Indomethacin is a potent tocolytic agent used in premature labor."	5.28	Oligohydramnios induced by maternal indomethacin therapy. ( Aydin, C; Ozcan, FS; Uslu, T, 1992)
"Among the difficulties encountered, premature labor and polyhydramnios are common."	5.28	Indomethacin therapy and chronic hemodialysis during pregnancy. A case report. ( Dolkart, LA; Eshwar, KP; Reimers, FT, 1992)
"Two women with preeclampsia treated with pindolol and propranolol became profoundly hypertensive when indomethacin was added because of premature contractions."	5.28	Antagonism of antihypertensive drug therapy in pregnancy by indomethacin? ( Freedman, S; Hod, M; Ovadia, Y; Schoenfeld, A, 1989)
"Indomethacin was used for tocolysis and to maintain mild oligohydraminios (amniotic fluid index 5-7 cm)."	5.28	Intraoperative amniocentesis and indomethacin treatment in the management of an immature pregnancy with completely dilated cervix. ( Evans, DJ; King, K; Kofinas, AD, 1992)
"A case of polyhydramnios associated with a ring chromosome is described."	5.27	Polyhydramnios associated with a ring chromosome and low maternal serum alpha-fetoprotein levels managed with indomethacin. ( Cotton, DB; Kirshon, B, 1988)
"Indomethacin purportedly arrests premature labor by inhibiting the production of prostaglandins."	5.26	Possible association between maternal indomethacin therapy and primary pulmonary hypertension of the newborn. ( Manchester, D; Margolis, HS; Sheldon, RE, 1976)
"Treatment with indomethacin significantly prolonged the length of gestation (P smaller than 0-01) compared iwth control, untreated animals."	5.25	The effects of dexamethasone and indomethacin on the outcome of pregnancy in the rabbit. ( Challis, JR; Davies, IJ; Ryan, KJ, 1975)
"Nifedipine may be better for delayed delivery and less likely to produce adverse pregnancy outcomes, followed by indomethacin."	5.22	Four kinds of tocolytic therapy for preterm delivery: Systematic review and network meta-analysis. ( Pei, S; Xiong, Z; Zhu, Z, 2022)
"Clinical trials have demonstrated that most tocolytic agents such as beta mimetics, atosiban and indometacine -exception made for magnesium sulfate- extend the duration of pregnancy, when compared to placebo."	4.81	[Tocolysis: indications and contraindications. When to start and when to stop]. ( Boubli, L; Bretelle, F; D'ercole, C; Desbriere, R; Shojai, R, 2002)
"The purpose of this study was to describe the fetal and newborn safety profile of prolonged indomethacin treatment during pregnancy."	3.74	The safety of prolonged indomethacin therapy. ( Anderson, BL; Savage, AH; Simhan, HN, 2007)
"Three cases of neonatal renal insufficiency in very low birthweight (VLBW) infants following repeated antenatal administration of indomethacin to prevent premature labor are reported."	3.69	Renal impairment in very low birthweight infants following antenatal indomethacin administration. ( Ichijo, M; Kawaguchi, C; Nakagawa, Y; Nakajima, M; Nishikubo, T; Takahashi, Y; Yoshioka, A, 1994)
"A case of severe fetal congestive heart failure due to occlusion of the ductus arteriosus in a mother treated with indomethacin for polyhydramnios and premature contractions is described."	3.69	In utero congestive heart failure due to maternal indomethacin treatment for polyhydramnios and premature labour in a fetus with antenatal closure of the foramen ovale. ( Achiron, R; Berant, M; Hegesh, J; Kidron, D; Lipitz, S; Rotstein, Z, 1996)
"To determine the effect of indomethacin on the amniotic fluid index of individual fetuses in multiple gestations, we evaluated seven sets of twins and two sets of triplets in preterm labor (eight cases) or with polyhydramnios (one case)."	3.69	Effect of indomethacin on individual amniotic fluid indices in multiple gestations. ( Hill, LM; Lazebnik, N; Many, A, 1996)
"Continuous-wave Doppler ultrasound was used to assess blood flow velocities and determine the pulsatility index of the uterine arteries in ten pregnant women at 23-33 weeks' gestation during indomethacin therapy for preterm labor or polyhydramnios."	3.68	Uterine blood flow velocity waveforms in pregnant women during indomethacin therapy. ( Deter, RL; Kirshon, B; Mari, G; Moise, KJ; Wasserstrum, N, 1990)
"Indomethacin was given for the treatment of preterm labor in a twin pregnancy at a dosage of 200 mg/day for 7 days beginning at 34 weeks and 5 days' gestation."	3.68	Indomethacin for preterm labor: fetal toxicity in a dizygotic twin gestation. ( Ayres, NA; Hallak, M; Moise, KJ; Reiter, AA, 1991)
"A case is reported in which exposure to cocaine and indomethacin was associated with development of fetal anuria, anasarca, and neonatal gastrointestinal hemorrhage."	3.68	Cocaine and indomethacin: fetal anuria, neonatal edema, and gastrointestinal bleeding. ( Angel, JL; Carlan, SJ; Harris, M; O'Brien, WF; Stromquist, C, 1991)
"Eighteen pregnant women were given indomethacin during the year 1989 for treatment of premature labor (n = 16) or polyhydramnios (n = 2)."	3.68	[Maternal and neonatal effects of indomethacin administrated during pregnancy. Apropos of 18 cases]. ( Bavoux, F; Blot, P; Boissinot, C; Guillonneau, M; Hartmann, JF; Jacqz-Aigrain, E, 1993)
"To investigate the effects of indomethacin on the human fetal renal blood flow velocity waveform, 17 fetuses whose mothers were treated for preterm labor (N = 8) or polyhydramnios (N = 9) were studied."	3.68	Doppler assessment of the renal blood flow velocity waveform during indomethacin therapy for preterm labor and polyhydramnios. ( Carpenter, RJ; Deter, RL; Kirshon, B; Mari, G; Moise, KJ, 1990)
"We report oligohydramnios and renal dysgenesis in one of identical twins, which might have resulted from in utero exposure to early, prolonged high-dose indomethacin."	3.68	Renal dysgenesis in a monozygotic twin: association with in utero exposure to indomethacin. ( Kaplan, BS; Kaplan, P; Restaino, I; Roberts, N; Rosenberg, HK; Witzleben, C, 1991)
" We took advantage of the treatment of pregnant women with indomethacin, because of premature labor or hydramnios, to investigate the role of prostaglandins in the activation of T suppressor (TS) activity."	3.67	The effects of indomethacin administration during pregnancy on women's and newborns' T-suppressor lymphocyte activity and on HLA class II expression by newborns' leukocytes. ( Brami, C; Durandy, A; Griscelli, C, 1985)
"Indomethacin was administered to suppress premature uterine contractions in a twin pregnancy from the 27th until the 32nd week of pregnancy."	3.67	Patent ductus arteriosus after prolonged treatment with indomethacin during pregnancy: case report. ( Abramovici, H; Atad, J; Lissak, A; Rofe, A, 1987)
"Six twin pregnancies complicated by hydramnios and premature labor were prospectively studied to determine whether indomethacin reduces amniotic fluid."	3.67	Twin with hydramnios: treating premature labor at source. ( Ash, KM; Harman, CR; Lange, IR; Manning, FA; Menticoglou, S, 1989)
"The premature closure of the ductus arteriosus (pcDA) due to maternal tocolysis with indomethacin in the 34th week of gestation was diagnosed in a twin pregnancy."	3.67	[Prenatal diagnosis of premature closure of the ductus arteriosus with subsequent development of a non-immunologic hydrops fetalis]. ( Bollmann, R; Chaoui, R; Hoffmann, H; Wauer, R, 1989)
"A pregnancy during which both beta-adrenergics and indomethacin were administered in order to stop preterm uterine contractions is reported."	3.66	Indomethacin and the fetal renal nonfunction syndrome. ( de Jong, PA; van Wijck, JA; Veersema, D, 1983)
"Women in acute preterm labor with cervical dilatation 1-6 cm were randomized to receive one of three first-line tocolytic drugs."	2.77	Effect of antenatal tocolysis on neonatal outcomes. ( Briery, CM; Keiser, SD; Klauser, CK; Kosek, MA; Martin, RW; Morrison, JC, 2012)
"Indomethacin was less effective than nifedipine for the fast treatment of preterm labor."	2.76	Comparison of the efficacy and adverse effects of nifedipine and indomethacin for the treatment of preterm labor. ( Bahasadri, S; Kashanian, M; Zolali, B, 2011)
" There were no significant maternal or neonatal adverse events."	2.70	A prospective randomized safety trial of celecoxib for treatment of preterm labor. ( Bernhard, LM; Gerber, S; Gross, GA; Leguizamon, G; Levy, R; Mathur, A; Nelson, DM; Sadovsky, Y; Stika, CS, 2002)
"Indomethacin has a significant reversible constrictive effect on the fetal ductus arteriosus that is associated with secondary changes, especially in the right ventricle."	2.68	Fetal cardiac function and ductus arteriosus during indomethacin and sulindac therapy for threatened preterm labor: a randomized study. ( Jouppila, P; Räsänen, J, 1995)
"Tocolysis in advanced preterm labor delays delivery by more than 48 hours in 50% of patients."	2.68	Tocolysis in advanced preterm labor: impact on neonatal outcome. ( Barke, JI; de Veciana, M; Major, CA; Porto, M, 1995)
"If recurrent preterm labor occurred despite maximization of therapy, the treatment arm was determined and therapy was changed; saline pump and oral terbutaline were switched to terbutaline pump, terbutaline pump was switched to oral terbutaline."	2.68	A placebo-controlled randomized trial of the terbutaline pump for prevention of preterm delivery. ( Merrill, D; Niebyl, J; Weiner, CP; Wenstrom, KD, 1997)
"Indomethacin treatment was accompanied by maternal side effects 20% of the time, significantly less commonly (P less than ."	2.67	A randomized double-dummy comparison between indomethacin and nylidrin in threatened preterm labor. ( Eronen, M; Kurki, T; Lumme, R; Ylikorkala, O, 1991)
"Nylidrin treatment was accompanied by a 35% rise in COMT activity 3 h later, whereas indomethacin caused no significant change."	2.67	Catechol-O-methyltransferase activity in red blood cells in threatened preterm labor; effect of indomethacin and nylidrin. ( Kurki, T; Lindén, IB; Schultz, E; Ylikorkala, O, 1991)
"Eighty pregnant women threatened with preterm labor between 24 and 34 weeks of gestation were enrolled in the study."	2.67	Increased incidence of bronchopulmonary dysplasia after antenatal administration of indomethacin to prevent preterm labor. ( Eronen, M; Hallman, M; Kurki, T; Pesonen, E; Teramo, K; Ylikorkala, O, 1994)
"Forty patients with intact membranes in preterm labor at 23 to 34 weeks' gestation were randomized to receive either intravenous ritodrine or oral indomethacin as the first-line tocolytic agent."	2.67	Randomized comparative trial of indomethacin and ritodrine for the long-term treatment of preterm labor. ( Besinger, RE; Johnson, TR; Keyes, WG; Niebyl, JR, 1991)
"Indomethacin was as effective as magnesium sulfate in delaying delivery > 48 hours, 90% versus 85%, and together with oral terbutaline in extending the gestation, 22."	2.67	Efficacy and safety of indomethacin compared with magnesium sulfate in the management of preterm labor: a randomized study. ( Madhav, H; Morales, WJ, 1993)
"Thirty-six women in preterm labor who had failed initial attempts at tocolysis with magnesium sulfate were randomized to receive either oral indomethacin or oral sulindac for 48 hours."	2.67	Randomized comparative trial of indomethacin and sulindac for the treatment of refractory preterm labor. ( Carlan, SJ; Mastrogiannis, D; O'Brien, WF; O'Leary, TD, 1992)
" Tocolysis with indomethacin was associated with no maternal side effects, whereas tocolysis with ritodrine hydrochloride was associated with a 24% incidence of serious cardiovascular and metabolic adverse effects prompting discontinuation of the drug."	2.66	Efficacy and safety of indomethacin versus ritodrine in the management of preterm labor: a randomized study. ( Angel, JL; Knuppel, RA; Morales, WJ; O'Brien, WF; Smith, SG, 1989)
" 200-300 mg of indomethacin was the total dosage in a 24 hours period."	2.65	Further study of the inhibition of premature labor by indomethacin. Part II double-blind study. ( Gilad, G; Katzuni, E; Shalev, E; Zuckerman, H, 1984)
"Indomethacin was significantly more effective than placebo in inhibition of premature labor during a 24-hour course of therapy, with treatment failure during therapy occurring in only one of 15 indomethacin-treated patients compared to nine of 15 placebo-treated patients (p less than 0."	2.65	The inhibition of premature labor with indomethacin. ( Blake, DA; Dubin, NH; Egner, PG; Kumor, KM; Niebyl, JR; Robinson, JC; White, RD, 1980)
" The first treatment consisted of the administration of ritodrine and a placebo; in the second, ritodrine was combined with indomethacin."	2.64	A study of indomethacin combined with ritodrine in threatened preterm labor. ( Cañas, E; Cararach, V; Edo, A; Gamissans, O; Puerto, B; Ribas, J, 1978)
"The pathophysiology leading to preterm labor is not well understood and often multifactorial; initiating factors include intrauterine infection, inflammation, ischemia, overdistension, and hemorrhage."	2.48	Tocolytic therapy for acute preterm labor. ( Abramovici, A; Cantu, J; Jenkins, SM, 2012)
"Although our pooled results did not identify significantly increased risks of adverse effects, the limited statistical power of published randomized trials does not allow us to exclude the possibility that indomethacin tocolysis increases the risk of adverse neonatal outcomes."	2.43	Assessing the neonatal safety of indomethacin tocolysis: a systematic review with meta-analysis. ( Kaunitz, AM; Loe, SM; Sanchez-Ramos, L, 2005)
"Indomethacin is a prostaglandin synthetase inhibitor sometimes used for tocolysis."	2.41	The controversy surrounding indomethacin for tocolysis. ( Clothier, B; Macones, GA; Marder, SJ; Stamilio, DM, 2001)
"In all six cases, severe hydramnios occurred during pregnancy between the 26th and 28th week after the last menstrual period."	2.38	[Antenatal form of Bartter's syndrome]. ( Broyer, M; Burguet, A; Dechaux, M; Deschenes, G; Garabedian, M; Guyot, C; Hubert, P; Loirat, C, 1993)
"Polyhydramnios is an uncommon cause of premature labor and delivery."	2.38	Polyhydramnios: does reducing the amniotic fluid volume decrease the incidence of prematurity? ( Rodriguez, MH, 1992)
"Effective inhibition of premature labor depends on prompt initiation of treatment."	2.36	Drugs for inhibition of premature labor. ( Niebyl, JR, 1979)
"Indomethacin has been also used in women with short cervices as well as in those with idiopathic polyhydramnios."	1.38	Indomethacin in pregnancy: applications and safety. ( Abou-Ghannam, G; Nassar, AH; Usta, IM, 2012)
"Indomethacin was not related to increased risk for periventricular-intraventricular hemorrhage or periventricular hemorrhagic infarction."	1.33	Indomethacin tocolysis and white matter injury in preterm infants. ( Flidel-Rimon, O; Friedman, S; Shinwell, ES; Steinberg, M, 2005)
"Aggressive tocolytic therapy for preterm labor with advanced cervical dilatation is efficacious, allows for steroid therapy, and allows delivery of more mature neonates."	1.33	Efficacy of aggressive tocolysis for preterm labor with advanced cervical dilatation. ( Goldkrand, J; Psomiadis, N, 2005)
"Nimesulide therapy was continued for eight days (5-16) and was associated with a prolongation of pregnancy of 27 days (6-69)."	1.31	Can a cyclo-oxygenase type-2 selective tocolytic agent avoid the fetal side effects of indomethacin? ( Bellini, P; Ghidini, A; Locatelli, A; Strobelt, N; Vergani, P, 2001)
"Indomethacin tocolysis has been reported to increase the incidence of persistent PDA in premature infants."	1.30	Indomethacin tocolysis increases postnatal patent ductus arteriosus severity. ( Eidelman, AI; Ferber, B; Glaser, J; Hammerman, C; Kaplan, M; Schimmel, MS, 1998)
"Since toxic epidermal necrolysis is a potentially fatal disease, awareness of a possible association is warranted."	1.30	Toxic epidermal necrolysis associated with treatment for preterm labor. ( Claessens, N; Delbeke, L; Lafaire, C; Lambert, J; Matthieu, L; Van Marck, E, 1998)
"Another therapy involves the treatment for premature labor, which is the most common cause of pregnancy loss in dialysis patients."	1.29	Pregnancy in women with end-stage renal disease: treatment of anemia and premature labor. ( Ambrose, S; Hou, S; Hussey, M; Orlowski, J; Pahl, M; Wong, D, 1993)
"Drug-induced immune system mediated agranulocytosis is a rare but potentially life-threatening condition."	1.29	Effective treatment of drug-induced agranulocytosis using recombinant human granulocyte colony stimulating factor in pregnancy. ( Fujiwaki, R; Furuya, H; Hata, K; Hata, T; Katoh, Y; Kitao, M, 1995)
"Indomethacin is a non steroidal anti-inflammatory agent widely employed in the treatment of premature contractions."	1.29	Good fetal outcome following prolonged indomethacin induced anhydramnios. Case report. ( Aboulafia, Y; Diamant, YZ; Lavie, O; Rabinowitz, R; Shen, O, 1995)
"Delayed birth intervals of triplets in preterm labor should be considered to improve perinatal salvage of immature triplets, although a successful outcome is rare and unexpected."	1.29	Delayed birth intervals of immature fraternal triplets in preterm labor. A case report. ( Daikoku, NH; Frattarrola, IG; Gopal, JJ; Graham, D; Rock, JA, 1993)
"Three cases of acute renal insufficiency in pregnant women who were treated with indomethacin for premature labor are reported."	1.29	Acute maternal renal insufficiency in premature labor treated with indomethacin. ( Boyd, EL; Nageotte, MP; Powers, DR; Steiger, RM; Towers, CV, 1993)
"Indomethacin was discontinued beyond the 33rd week of gestational age."	1.29	[Has the use of indomethacin during pregnancy consequences in newborn infants? Prospective study of 83 pregnant women and 115 newborn infants]. ( Blot, P; Boissinot, C; Carbillon, L; de Gayffier, A; Germain, JF; Jacqz-Aigrain, E; Oury, JF; Sibony, O, 1994)
"Trivial tricuspid valve regurgitation was detected at a mean of 26."	1.29	Fetal echocardiography during indomethacin treatment. ( Huhta, JC; Respondek, M; Weil, SR, 1995)
"No such convulsion has been described to date in pregnancy."	1.29	Indomethacin-induced maternal convulsion in the treatment of preterm labour. ( DeChazal, R; Halligan, A; Nan, A; Taylor, D, 1993)
"Oral indomethacin treatment for tocolysis has no impact on PT and aPTT; however, profound acute changes in maternal bleeding time occur."	1.29	The effect of indomethacin tocolysis on maternal coagulation status. ( Barth, WH; Hankins, GD; Lunt, CC; Satin, AJ, 1994)
"9 percent, P = 0."	1.29	Neonatal complications after the administration of indomethacin for preterm labor. ( Clyman, RI; Cooper, BA; Kuller, JA; Merrill, J; Norton, ME, 1993)
"Indomethacin was given as part of tocolytic management to mothers with a high incidence of early rupture of membranes and preterm labour; and 76 fetuses were exposed to the drug as a result."	1.28	Cerebral lesions in preterm infants after tocolytic indomethacin. ( Baerts, W; Fetter, WP; Hop, WC; Sauer, PJ; Spritzer, R; Wallenburg, HC, 1990)
"Indomethacin was utilized in 24 pregnancies (31 exposed fetuses) in preterm labor who labored despite intravenous tocolysis."	1.28	Safety and efficacy of long-term tocolysis with indomethacin. ( Abbasi, S; Ashmead, G; Bolognese, R; Gerson, A; Johnson, A; Kalchbrenner, M, 1990)
"Thirty-three women in preterm labor between 25 and 34 weeks of gestation were studied before, during, and after treatment with indomethacin (n = 16) or nylidrin (n = 17)."	1.28	Urinary excretion of prostacyclin and thromboxane metabolites in threatened preterm labor: effect of indomethacin and nylidrin. ( Kurki, T; Viinikka, L; Ylikorkala, O, 1992)
"Indomethacin is a potent tocolytic agent used in premature labor."	1.28	Oligohydramnios induced by maternal indomethacin therapy. ( Aydin, C; Ozcan, FS; Uslu, T, 1992)
"Among the difficulties encountered, premature labor and polyhydramnios are common."	1.28	Indomethacin therapy and chronic hemodialysis during pregnancy. A case report. ( Dolkart, LA; Eshwar, KP; Reimers, FT, 1992)
"Indomethacin was used for tocolysis and to maintain mild oligohydraminios (amniotic fluid index 5-7 cm)."	1.28	Intraoperative amniocentesis and indomethacin treatment in the management of an immature pregnancy with completely dilated cervix. ( Evans, DJ; King, K; Kofinas, AD, 1992)
"Two women with preeclampsia treated with pindolol and propranolol became profoundly hypertensive when indomethacin was added because of premature contractions."	1.28	Antagonism of antihypertensive drug therapy in pregnancy by indomethacin? ( Freedman, S; Hod, M; Ovadia, Y; Schoenfeld, A, 1989)
"A case of hydrops fetalis with intra-uterine death after premature closure of the ductus arteriosus because of inhibition of premature labour by the administration of indomethacin is presented."	1.27	Premature closure of the ductus arteriosus causing intra-uterine death. A case report. ( Coetzee, MJ; Franszen, S; Truter, PJ; van der Merwe, JV, 1986)
"A case of polyhydramnios associated with a ring chromosome is described."	1.27	Polyhydramnios associated with a ring chromosome and low maternal serum alpha-fetoprotein levels managed with indomethacin. ( Cotton, DB; Kirshon, B, 1988)
"The delay of premature labor for 2 to 7 days allowed the administration of betamethasone in an attempt to improve fetal lung maturity."	1.27	Further study of the inhibition of premature labor by indomethacin. Part I. ( Gilad, G; Katzuni, E; Shalev, E; Zuckerman, H, 1984)
"A total of 43 procedures was performed."	1.27	Fetal surgery in the primate II. Uterine electromyographic response to operative procedures and pharmacologic agents. ( Harrison, MR; Nakayama, DK; Seron-Ferre, M; Villa, RL, 1984)
"Appropriate management of preterm labor mandates early recognition of subtle signs and symptoms; successful therapy is dependent on this issue."	1.27	Preterm labor: its diagnosis and management. ( Creasy, RK; Gonik, B, 1986)
" The dosage regimen was 25 mg every four hours in four patients and 25 mg every six hours in the other four patients."	1.27	Influence of short-term indomethacin therapy on fetal urine output. ( Huhta, JC; Kirshon, B; Moise, KJ; Ou, CN; Wasserstrum, N, 1988)
"Indomethacin is a potent agent in the treatment of premature labor, but its use has been limited because of concern about its constrictive effects on the fetal ductus arteriosus."	1.27	Indomethacin in the treatment of premature labor. Effects on the fetal ductus arteriosus. ( Cano, L; Huhta, JC; Kirshon, B; Moise, KJ; Ou, CN; Sharif, DS; Wasserstrum, N, 1988)
"Indomethacin has been tested, in addition to betasympathicomimetic therapy, in cases with an insufficient inhibition of premature labour."	1.27	Inhibition of premature labour with indomethacin. ( Halle, H, 1987)
"Issues of the pharmacologic therapy of preterm labor, enhancement of lung maturity, and management of labor and delivery are discussed."	1.27	Obstetric management of the very low birth weight fetus. ( Hayashi, RH; Marshall, CL, 1986)
"Indomethacin was administered from the 20th to the 34th week of gestation to 51 women (59 fetuses) in whom bed rest and a beta-mimetic compound (ritodrine) had failed to stop preterm labor."	1.26	Perinatal hazards of chronic antenatal tocolysis with indomethacin. ( Baele, G; Derom, R; Thiery, M; Van Egmond, H; Van Kets, H, 1979)
"Indomethacin purportedly arrests premature labor by inhibiting the production of prostaglandins."	1.26	Possible association between maternal indomethacin therapy and primary pulmonary hypertension of the newborn. ( Manchester, D; Margolis, HS; Sheldon, RE, 1976)
"3) Analysis of 263 cases of threatened premature labor treated in our department in the past 5 years demonstrated that there are 2 phases of contraction during premature labor."	1.26	The treatment of threatened premature labor by drugs. ( Chimura, T, 1980)
"Indomethacin has been most effective but not free of significant complications."	1.26	Premature onset of labor, neonatal patent ductus arteriosus, and prostaglandin synthetase antagonists--a rat model of a human problem. ( Altmiller, DH; Altshuler, G; Krous, HF; Sharpe, GL, 1979)
"Indomethacin treatment was effective in all the 68 patients."	1.26	Classification of threatened premature labor related to treatment with a prostaglandin inhibitor: indomethacin. ( Abramovici, H; Atad, J; David, A; Moise, J, 1980)
"Treatment with indomethacin significantly prolonged the length of gestation (P smaller than 0-01) compared iwth control, untreated animals."	1.25	The effects of dexamethasone and indomethacin on the outcome of pregnancy in the rabbit. ( Challis, JR; Davies, IJ; Ryan, KJ, 1975)
"Prevention of premature labor is of considerable interest in research and clinics."	1.25	The treatment of threatened premature labor by tocolytics, Ca++-Antagonists and anti-inflammatory drugs. ( Mosler, KH, 1975)

Research

Studies (222)

Authors

Clinical Trials (10)

Trial Overview

Trial Outcomes

Birthweight

Gestational Age at Delivery

Gestational Latency Achieved Between Cerclage Placement and Time of Delivery

Timeframe	Studies, this research(%)	All Research%
pre-1990	90 (40.54)	18.7374
1990's	77 (34.68)	18.2507
2000's	32 (14.41)	29.6817
2010's	19 (8.56)	24.3611
2020's	4 (1.80)	2.80

Authors	Studies
Xiong, Z	1
Pei, S	1
Zhu, Z	1
Premkumar, A	1
Sinha, N	1
Miller, ES	3
Peaceman, AM	1
Novoa Y Novoa, V	1
Shazly, S	1
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Trial	Phase	Enrollment	Study Type	Start Date	Status
Vaginal Indomethacin Versus Oral Nifedipine for Preterm Labor; a Randomized Controlled Trial[NCT04404686]	Phase 2/Phase 3	300 participants (Anticipated)	Interventional	2020-10-31	Not yet recruiting
Comparison of the Efficacy of Emergency Double-level and Single Cervical Cerclage in Cervical Insufficiency in the Second Trimester of Pregnancy - Multicenter Prospective Randomized Trial[NCT05268640]		78 participants (Anticipated)	Interventional	2022-03-11	Recruiting
Role in Emergent Cerclage of Indomethacin and Antibiotics[NCT01114516]		53 participants (Actual)	Interventional	2010-03-31	Completed
Prevention of Preterm Delivery With Vaginal Progesterone in Women With Preterm Labor[NCT00536003]	Phase 3	384 participants (Actual)	Interventional	2006-07-31	Terminated
Vaginal Progesterone Supplementation in the Management of Preterm Labor: A Randomized, Double Blind, Controlled Trial[NCT03202836]		90 participants (Actual)	Interventional	2017-06-29	Completed
Randomized, Placebo Controlled Trial of Indomethacin for Tocolysis[NCT01869361]	Early Phase 1	0 participants (Actual)	Interventional	2020-08-01	Withdrawn (stopped due to Due to much lower than expected numbers of eligible patients and lack of PI time, the study was not started.)
Aspirin Supplementation for Pregnancy Indicated Risk Reduction In Nulliparas (ASPIRIN)[NCT02409680]		11,976 participants (Actual)	Interventional	2016-03-23	Completed
Randomized Double-Blinded Trial of Magnesium Sulfate Tocolysis Versus Nifedipine Tocolysis in Women With Preterm Labor Between 24 to 32 6/7 Weeks' Gestation[NCT00306462]		33 participants (Actual)	Interventional	2006-03-31	Terminated (stopped due to No enrollment in past year, lack of interest)
Effect of Non-steroidal Anti-inflammatory Use on Blood Pressure in Women With Hypertensive Disorders of Pregnancy: A Randomized Open Label Trial[NCT03824119]	Phase 4	200 participants (Anticipated)	Interventional	2018-12-11	Recruiting
Liberal Versus Restrictive Platelet Transfusion for Treatment of Hemodynamically Significant Patent Ductus Arteriosus in Thrombocytopenic Preterm Neonates- A Randomized Open Label, Controlled Trial[NCT03022253]	Phase 3	44 participants (Anticipated)	Interventional	2016-03-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Intervention	grams (Median)
Control	2488
Indomethacin and Antibiotics	2850

Intervention	weeks (Median)
Control	31.1
Indomethacin and Antibiotics	34.8

Median gestational latency achieved Between Cerclage Placement and Time of Delivery (NCT01114516)
Timeframe: 24 weeks

Gestational Latency of More Than 28 Days

Intervention	days (Median)
Control	80
Indomethacin and Antibiotics	97

The frequency of achieving a gestational latency of more than 28 days (NCT01114516)
Timeframe: 28 days postpartum

Neonatal Morbidity and Mortality

Fetal Outcome 1 - Incidence of Early Preterm Delivery (<34 Weeks)

Fetal Outcome 2 - Incidence of Actual Birth Weight <2500g

Fetal Outcome 3 - Incidence of Actual Birth Weight <1500g

Fetal Outcome 4 - Incidence of Fetal Loss

Fetal Outcome 5 - Incidence of Spontaneous Abortion

Fetal Outcome 6 - Incidence of All Stillbirth

Fetal Outcome 7 - Incidence of Medical Termination of Pregnancy

Intervention	percentage of participants (Number)
Control	62.5
Indomethacin and Antibiotics	92.3

Intervention	days (Median)
Control	95
Indomethacin and Antibiotics	43

Intervention	Participants (Count of Participants)
Intervention Arm	189
Placebo Arm	230

Intervention	Participants (Count of Participants)
Intervention Arm	1078
Placebo Arm	1153

Intervention	Participants (Count of Participants)
Intervention Arm	78
Placebo Arm	101

Intervention	Participants (Count of Participants)
Intervention Arm	303
Placebo Arm	353

Intervention	Participants (Count of Participants)
Intervention Arm	134
Placebo Arm	152

Intervention	Participants (Count of Participants)
Intervention Arm	141
Placebo Arm	166

- Incidence of Medical Termination of Pregnancy (NCT02409680)
Timeframe: At delivery

Incidence of Hypertensive Disorders of Pregnancy

Intervention	Participants (Count of Participants)
Intervention Arm	42
Placebo Arm	30

- Hypertensive disorders of pregnancy is defined by the characterization of evidence of a hypertensive disorder, including either preeclampsia or eclampsia occurring during the pregnancy. (NCT02409680)
Timeframe: Evidence of hypertensive disorder during the pregnancy (prior to delivery/birth)

Incidence of Perinatal Mortality

Intervention	Participants (Count of Participants)
Intervention Arm	352
Placebo Arm	325

- Incidence of Perinatal Mortality (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

Incidence of Preterm Birth

Intervention	Participants (Count of Participants)
Intervention Arm	264
Placebo Arm	309

The primary outcome of this study is incidence of preterm birth, which will be defined as delivery at or after 20 0/7 weeks and prior to 37 0/7 weeks. This will be determined based on actual date of delivery in comparison to the projected estimated due date (EDD), independent of whether or not the preterm delivery is indicated or spontaneous. (NCT02409680)
Timeframe: At delivery

Incidence of Small for Gestational Age (SGA)

Intervention	Participants (Count of Participants)
Intervention Arm	668
Placebo Arm	754

- Small for gestational age (SGA) as defined by the INTERGROWTH-21st standard (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

Maternal Outcome 1 - Incidence of Vaginal Bleeding

Intervention	Participants (Count of Participants)
Intervention Arm	1506
Placebo Arm	1564

- Vaginal bleeding (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

Maternal Outcome 2 - Incidence of Antepartum Hemorrhage

Intervention	Participants (Count of Participants)
Intervention Arm	214
Placebo Arm	246

- Antepartum hemorrhage (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

Maternal Outcome 3 - Incidence of Postpartum Hemorrhage

Intervention	Participants (Count of Participants)
Intervention Arm	26
Placebo Arm	25

- Postpartum hemorrhage (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

Maternal Outcome 4 - Incidence of Maternal Mortality

Intervention	Participants (Count of Participants)
Intervention Arm	54
Placebo Arm	43

- Incidence of Maternal Mortality (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

Maternal Outcome 5 - Incidence of Late Abortion

Intervention	Participants (Count of Participants)
Intervention Arm	9
Placebo Arm	12

- Incidence of Late Abortion (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

Maternal Outcome 6 - Change in Maternal Hemoglobin

Intervention	Participants (Count of Participants)
Intervention Arm	23
Placebo Arm	30

Hemoglobin < 7.0 gm/dl at 26-30 weeks gestation or a drop of 3.5+ gm/dl from screening to 26-30 weeks gestation (NCT02409680)
Timeframe: At enrollment, 4 weeks post enrollment, and 26-30 weeks GA.

Maternal Outcome 7 - Incidence of Preterm, Preeclampsia

Intervention	Participants (Count of Participants)
Intervention Arm	290
Placebo Arm	333

Early preterm delivery (<34 weeks) and hypertensive disorders (i.e.: preeclampsia) (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

Article	Year
Four kinds of tocolytic therapy for preterm delivery: Systematic review and network meta-analysis. Journal of clinical pharmacy and therapeutics, 2022, Volume: 47, Issue:7 Topics: Female; Humans; Indomethacin; Infant; Infant, Newborn; Network Meta-Analysis; Nifedipine; Obstetric	2022
Tocolysis for open prenatal repair of myelomeningocele: systematic review. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2020, Volume: 33, Issue:10 Topics: Female; Fetoscopy; Gestational Age; Humans; Indomethacin; Meningomyelocele; Obstetric Labor, Prematu	2020
A short cervical length in pregnancy: management options. American journal of perinatology, 2009, Volume: 26, Issue:10 Topics: Cerclage, Cervical; Cervix Uteri; Cohort Studies; Combined Modality Therapy; Female; Humans; Indomet	2009
Tocolytic therapy for acute preterm labor. Obstetrics and gynecology clinics of North America, 2012, Volume: 39, Issue:1 Topics: Calcium Channel Blockers; Drug Administration Schedule; Female; Gestational Age; Humans; Indomethaci	2012
Tocolytic therapy for acute preterm labor. Obstetrics and gynecology clinics of North America, 2012, Volume: 39, Issue:1 Topics: Calcium Channel Blockers; Drug Administration Schedule; Female; Gestational Age; Humans; Indomethaci	2012
Tocolytic therapy for acute preterm labor. Obstetrics and gynecology clinics of North America, 2012, Volume: 39, Issue:1 Topics: Calcium Channel Blockers; Drug Administration Schedule; Female; Gestational Age; Humans; Indomethaci	2012
Tocolytic therapy for acute preterm labor. Obstetrics and gynecology clinics of North America, 2012, Volume: 39, Issue:1 Topics: Calcium Channel Blockers; Drug Administration Schedule; Female; Gestational Age; Humans; Indomethaci	2012
Oral betamimetics for maintenance therapy after threatened preterm labour. The Cochrane database of systematic reviews, 2012, Dec-12, Volume: 12 Topics: Administration, Oral; Adrenergic beta-2 Receptor Agonists; Female; Humans; Indomethacin; Magnesium C	2012
[Tocolysis: indications and contraindications. When to start and when to stop]. Journal de gynecologie, obstetrique et biologie de la reproduction, 2002, Volume: 31, Issue:7 Suppl Topics: Clinical Trials as Topic; Contraindications; Female; France; Gestational Age; Humans; Indomethacin;	2002
Prostaglandin inhibitors in preterm labour. Best practice & research. Clinical obstetrics & gynaecology, 2003, Volume: 17, Issue:5 Topics: Anti-Inflammatory Agents, Non-Steroidal; Cervix Uteri; Cyclooxygenase 2; Ductus Arteriosus; Enzyme I	2003
Assessing the neonatal safety of indomethacin tocolysis: a systematic review with meta-analysis. Obstetrics and gynecology, 2005, Volume: 106, Issue:1 Topics: Adult; Confidence Intervals; Dose-Response Relationship, Drug; Drug Administration Schedule; Female;	2005
Assessing the neonatal safety of indomethacin tocolysis: a systematic review with meta-analysis. Obstetrics and gynecology, 2005, Volume: 106, Issue:1 Topics: Adult; Confidence Intervals; Dose-Response Relationship, Drug; Drug Administration Schedule; Female;	2005
Assessing the neonatal safety of indomethacin tocolysis: a systematic review with meta-analysis. Obstetrics and gynecology, 2005, Volume: 106, Issue:1 Topics: Adult; Confidence Intervals; Dose-Response Relationship, Drug; Drug Administration Schedule; Female;	2005
Assessing the neonatal safety of indomethacin tocolysis: a systematic review with meta-analysis. Obstetrics and gynecology, 2005, Volume: 106, Issue:1 Topics: Adult; Confidence Intervals; Dose-Response Relationship, Drug; Drug Administration Schedule; Female;	2005
Antiprostaglandin drugs. Obstetrics and gynecology clinics of North America, 2005, Volume: 32, Issue:3 Topics: Cyclooxygenase Inhibitors; Female; Fetal Monitoring; Humans; Indomethacin; Obstetric Labor, Prematur	2005
Oral betamimetics for maintenance therapy after threatened preterm labour. The Cochrane database of systematic reviews, 2006, Jan-25, Issue:1 Topics: Administration, Oral; Adrenergic beta-Agonists; Female; Humans; Indomethacin; Obstetric Labor, Prema	2006
Preterm labour. The present and future of tocolysis. Best practice & research. Clinical obstetrics & gynaecology, 2007, Volume: 21, Issue:5 Topics: Adrenergic beta-Agonists; Female; Humans; Indomethacin; Magnesium Sulfate; Nifedipine; Obstetric Lab	2007
Prevention of premature birth. Clinics in perinatology, 1980, Volume: 7, Issue:1 Topics: Adrenergic beta-Agonists; Calcium; Chemical Phenomena; Chemistry; Cyclooxygenase Inhibitors; Depress	1980
Preterm parturition. Prostaglandin synthetase inhibitors. Seminars in perinatology, 1981, Volume: 5, Issue:3 Topics: Amniotic Fluid; Animals; Aspirin; Cyclooxygenase Inhibitors; Ductus Arteriosus; Ductus Arteriosus, P	1981
Prostaglandin synthetase inhibitors in pregnancy. Obstetrical & gynecological survey, 1993, Volume: 48, Issue:7 Topics: Animals; Contraindications; Cyclooxygenase Inhibitors; Female; Fetal Diseases; Forecasting; Humans;	1993
[Antenatal form of Bartter's syndrome]. Annales de pediatrie, 1993, Volume: 40, Issue:2 Topics: Aldosterone; Bartter Syndrome; Calcium; Female; Fetal Diseases; Gestational Age; Humans; Indomethaci	1993
Indomethacin. Clinical obstetrics and gynecology, 1995, Volume: 38, Issue:4 Topics: Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Female; Humans; Indomethacin; Obs	1995
Risks and complications of tocolysis. Clinical obstetrics and gynecology, 1995, Volume: 38, Issue:4 Topics: Calcium Channel Blockers; Drug Therapy, Combination; Female; Fetus; Humans; Indomethacin; Magnesium	1995
[Prematurity: current role of prostaglandin synthesis inhibitors]. Revue medicale de Liege, 1998, Volume: 53, Issue:3 Topics: Cyclooxygenase Inhibitors; Female; Humans; Indomethacin; Obstetric Labor, Premature; Pregnancy; Preg	1998
The great tocolytic debate: some pitfalls in the study of safety. American journal of obstetrics and gynecology, 2001, Volume: 184, Issue:2 Topics: Cerebral Hemorrhage; Female; Humans; Indomethacin; MEDLINE; Obstetric Labor, Premature; Pregnancy; R	2001
The controversy surrounding indomethacin for tocolysis. American journal of obstetrics and gynecology, 2001, Volume: 184, Issue:3 Topics: Adult; Clinical Trials as Topic; Female; Humans; Indomethacin; Infant, Newborn; Obstetric Labor, Pre	2001
Prostaglandin inhibitors as tocolytic agents. Seminars in perinatology, 2001, Volume: 25, Issue:4 Topics: Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Female;	2001
Tocolysis: an update for the practitioner. Obstetrical & gynecological survey, 2002, Volume: 57, Issue:5 Suppl 2 Topics: Adrenergic beta-Agonists; Algorithms; Calcium Channel Blockers; Cyclooxygenase 1; Cyclooxygenase 2;	2002
Drugs for inhibition of premature labor. Clinics in perinatology, 1979, Volume: 6, Issue:1 Topics: Adrenergic beta-Agonists; Animals; Ethanol; Female; Humans; Indomethacin; Labor, Obstetric; Magnesiu	1979
[Clinical pharmacology in obstetrics: regulation of the uterus]. Medizinische Klinik, 1975, May-02, Volume: 70, Issue:18 Topics: Adrenergic beta-Agonists; Aspirin; Ergotamine; Female; Humans; Indomethacin; Methylergonovine; Obste	1975
On the use of blockers of prostaglandin synthesis in the control of labor. Advances in prostaglandin and thromboxane research, 1978, Volume: 4 Topics: Animals; Aspirin; Clinical Trials as Topic; Female; Fetal Death; Fetus; Hemodynamics; Humans; Indome	1978
[Fetal toxicity of non-steroidal anti-inflammatory agents]. Presse medicale (Paris, France : 1983), 1992, Nov-28, Volume: 21, Issue:40 Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Fetal Diseases; Heart Failure; Humans; Indomethacin	1992
Polyhydramnios: does reducing the amniotic fluid volume decrease the incidence of prematurity? Clinics in perinatology, 1992, Volume: 19, Issue:2 Topics: Amniocentesis; Clinical Trials as Topic; Combined Modality Therapy; Female; Humans; Incidence; Indom	1992
Maternal, fetal, and neonatal physiology in pregnancy. Current opinion in obstetrics & gynecology, 1990, Volume: 2, Issue:1 Topics: Clinical Trials as Topic; Ductus Arteriosus, Patent; Female; Humans; Indomethacin; Obstetric Labor,	1990
[Indomethacin and a tocolytic agent: fetal and neonatal outcome]. Harefuah, 1990, Dec-02, Volume: 119, Issue:11 Topics: Female; Humans; Indomethacin; Infant, Newborn; Male; Obstetric Labor, Premature; Pregnancy; Prenatal	1990
Arachidonic acid derivatives in the perinatal period. Advances in pediatrics, 1989, Volume: 36 Topics: Animals; Arachidonic Acid; Arachidonic Acids; Female; Heart Defects, Congenital; Humans; Indomethaci	1989
Prostaglandins and leukotrienes in the perinatal period. Clinics in perinatology, 1987, Volume: 14, Issue:4 Topics: Ductus Arteriosus; Female; Heart Defects, Congenital; Humans; Indomethacin; Infant, Newborn; Leukotr	1987
[At what point is premature labor to be arrested?]. Duodecim; laaketieteellinen aikakauskirja, 1987, Volume: 103, Issue:20 Topics: Adrenergic beta-Agonists; Female; Humans; Indomethacin; Magnesium Sulfate; Obstetric Labor, Prematur	1987

Article	Year
A comparative study on the efficacy of nifedipine and indomethacin for prevention of preterm birth as monotherapy and combination therapy: a randomized clinical trial. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2020, Volume: 33, Issue:19 Topics: Female; Humans; Indomethacin; Infant; Infant, Newborn; Nifedipine; Obstetric Labor, Premature; Pregn	2020
A comparison of three tocolytics for preterm labor: a randomized clinical trial. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2014, Volume: 27, Issue:8 Topics: Adolescent; Adult; Drug Administration Routes; Female; Gestational Age; Humans; Indomethacin; Magnes	2014
Indomethacin and antibiotics in examination-indicated cerclage: a randomized controlled trial. Obstetrics and gynecology, 2014, Volume: 123, Issue:6 Topics: Adult; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antibiotic Prophylaxis; Cefaz	2014
Indomethacin and antibiotics in examination-indicated cerclage: a randomized controlled trial. Obstetrics and gynecology, 2014, Volume: 123, Issue:6 Topics: Adult; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antibiotic Prophylaxis; Cefaz	2014
Indomethacin and antibiotics in examination-indicated cerclage: a randomized controlled trial. Obstetrics and gynecology, 2014, Volume: 123, Issue:6 Topics: Adult; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antibiotic Prophylaxis; Cefaz	2014
Indomethacin and antibiotics in examination-indicated cerclage: a randomized controlled trial. Obstetrics and gynecology, 2014, Volume: 123, Issue:6 Topics: Adult; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antibiotic Prophylaxis; Cefaz	2014
Prevention of preterm delivery with vaginal progesterone in women with preterm labour (4P): randomised double-blind placebo-controlled trial. BJOG : an international journal of obstetrics and gynaecology, 2015, Volume: 122, Issue:1 Topics: Administration, Intravaginal; Adult; Apgar Score; Birth Weight; Double-Blind Method; Female; Humans;	2015
Prevention of preterm delivery with vaginal progesterone in women with preterm labour (4P): randomised double-blind placebo-controlled trial. BJOG : an international journal of obstetrics and gynaecology, 2015, Volume: 122, Issue:1 Topics: Administration, Intravaginal; Adult; Apgar Score; Birth Weight; Double-Blind Method; Female; Humans;	2015
Prevention of preterm delivery with vaginal progesterone in women with preterm labour (4P): randomised double-blind placebo-controlled trial. BJOG : an international journal of obstetrics and gynaecology, 2015, Volume: 122, Issue:1 Topics: Administration, Intravaginal; Adult; Apgar Score; Birth Weight; Double-Blind Method; Female; Humans;	2015
Prevention of preterm delivery with vaginal progesterone in women with preterm labour (4P): randomised double-blind placebo-controlled trial. BJOG : an international journal of obstetrics and gynaecology, 2015, Volume: 122, Issue:1 Topics: Administration, Intravaginal; Adult; Apgar Score; Birth Weight; Double-Blind Method; Female; Humans;	2015
Tocolysis in women with advanced preterm labor: a secondary analysis of a randomized clinical trial. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2016, Volume: 29, Issue:5 Topics: Administration, Intravenous; Administration, Oral; Administration, Rectal; Adolescent; Adult; Female	2016
Comparison of the efficacy and adverse effects of nifedipine and indomethacin for the treatment of preterm labor. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2011, Volume: 113, Issue:3 Topics: Adult; Drug Administration Schedule; Female; Humans; Indomethacin; Nifedipine; Obstetric Labor, Prem	2011
Effect of antenatal tocolysis on neonatal outcomes. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2012, Volume: 25, Issue:12 Topics: Female; Gestational Age; Humans; Indomethacin; Infant, Newborn; Infant, Newborn, Diseases; Magnesium	2012
A prospective randomized safety trial of celecoxib for treatment of preterm labor. American journal of obstetrics and gynecology, 2002, Volume: 187, Issue:3 Topics: Adolescent; Adult; Celecoxib; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Humans; Indome	2002
A double-blind randomized study of fetal side effects during and after the short-term maternal administration of indomethacin, sulindac, and nimesulide for the treatment of preterm labor. American journal of obstetrics and gynecology, 2003, Volume: 188, Issue:4 Topics: Adult; Amniotic Fluid; Diuresis; Double-Blind Method; Drug Administration Schedule; Ductus Arteriosu	2003
The effect of short-term indomethacin therapy on amniotic fluid volume. American journal of obstetrics and gynecology, 2005, Volume: 192, Issue:5 Topics: Amniotic Fluid; Drug Administration Schedule; Female; Humans; Incidence; Indomethacin; Obstetric Lab	2005
Further study of the inhibition of premature labor by indomethacin. Part II double-blind study. Journal of perinatal medicine, 1984, Volume: 12, Issue:1 Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Female; Gestational Age; Humans; Indomethacin;	1984
Further study of the inhibition of premature labor by indomethacin. Part II double-blind study. Journal of perinatal medicine, 1984, Volume: 12, Issue:1 Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Female; Gestational Age; Humans; Indomethacin;	1984
Further study of the inhibition of premature labor by indomethacin. Part II double-blind study. Journal of perinatal medicine, 1984, Volume: 12, Issue:1 Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Female; Gestational Age; Humans; Indomethacin;	1984
Further study of the inhibition of premature labor by indomethacin. Part II double-blind study. Journal of perinatal medicine, 1984, Volume: 12, Issue:1 Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Female; Gestational Age; Humans; Indomethacin;	1984
Treatment of premature labor with indomethacin. Advances in prostaglandin and thromboxane research, 1980, Volume: 8 Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Indomethacin; Infant, Newborn;	1980
The inhibition of premature labor with indomethacin. American journal of obstetrics and gynecology, 1980, Apr-15, Volume: 136, Issue:8 Topics: Dinoprost; Double-Blind Method; Drug Evaluation; Estradiol; Female; Fetal Blood; Fetal Death; Humans	1980
The inhibition of premature labor with indomethacin. American journal of obstetrics and gynecology, 1980, Apr-15, Volume: 136, Issue:8 Topics: Dinoprost; Double-Blind Method; Drug Evaluation; Estradiol; Female; Fetal Blood; Fetal Death; Humans	1980
The inhibition of premature labor with indomethacin. American journal of obstetrics and gynecology, 1980, Apr-15, Volume: 136, Issue:8 Topics: Dinoprost; Double-Blind Method; Drug Evaluation; Estradiol; Female; Fetal Blood; Fetal Death; Humans	1980
The inhibition of premature labor with indomethacin. American journal of obstetrics and gynecology, 1980, Apr-15, Volume: 136, Issue:8 Topics: Dinoprost; Double-Blind Method; Drug Evaluation; Estradiol; Female; Fetal Blood; Fetal Death; Humans	1980
Tocolysis in advanced preterm labor: impact on neonatal outcome. American journal of perinatology, 1995, Volume: 12, Issue:4 Topics: Cohort Studies; Female; Humans; Indomethacin; Infant, Newborn; Infant, Premature, Diseases; Magnesiu	1995
A comparison of magnesium sulfate and indomethacin to magnesium sulfate only for tocolysis in preterm labor with advanced cervical dilation. Southern medical journal, 1995, Volume: 88, Issue:7 Topics: Adult; Cervix Uteri; Dilatation, Pathologic; Drug Therapy, Combination; Female; Humans; Indomethacin	1995
Fetal cardiac function and ductus arteriosus during indomethacin and sulindac therapy for threatened preterm labor: a randomized study. American journal of obstetrics and gynecology, 1995, Volume: 173, Issue:1 Topics: Ductus Arteriosus; Echocardiography; Female; Fetal Heart; Humans; Indomethacin; Obstetric Labor, Pre	1995
Increased incidence of bronchopulmonary dysplasia after antenatal administration of indomethacin to prevent preterm labor. The Journal of pediatrics, 1994, Volume: 124, Issue:5 Pt 1 Topics: Adult; Bronchopulmonary Dysplasia; Female; Humans; Indomethacin; Infant, Newborn; Infant, Premature;	1994
Randomized trial of oral indomethacin and terbutaline sulfate for the long-term suppression of preterm labor. American journal of obstetrics and gynecology, 1993, Volume: 169, Issue:4 Topics: Adult; Chi-Square Distribution; Ductus Arteriosus; Female; Humans; Indomethacin; Obstetric Labor, Pr	1993
Efficacy and safety of indomethacin compared with magnesium sulfate in the management of preterm labor: a randomized study. American journal of obstetrics and gynecology, 1993, Volume: 169, Issue:1 Topics: Adult; Female; Humans; Indomethacin; Magnesium Sulfate; Obstetric Labor, Premature; Pregnancy; Prosp	1993
A placebo-controlled randomized trial of the terbutaline pump for prevention of preterm delivery. American journal of perinatology, 1997, Volume: 14, Issue:2 Topics: Administration, Oral; Adrenergic beta-Agonists; Adult; Cervix Uteri; Drug Combinations; Female; Gest	1997
The effect of indomethacin tocolysis in preterm labour on perinatal outcome: a randomised placebo-controlled trial. British journal of obstetrics and gynaecology, 1999, Volume: 106, Issue:5 Topics: Adult; Double-Blind Method; Female; Gestational Age; Humans; Indomethacin; Infant Mortality; Infant,	1999
Indomethacin for preterm labor: a randomized comparison of vaginal and rectal-oral routes. Obstetrics and gynecology, 2000, Volume: 95, Issue:4 Topics: Administration, Intravaginal; Administration, Oral; Administration, Rectal; Adult; Female; Humans; I	2000
Indomethacin and corticosteroids: an additive constrictive effect on the fetal ductus arteriosus. American journal of perinatology, 1999, Volume: 16, Issue:8 Topics: Adrenal Cortex Hormones; Analysis of Variance; Blood Flow Velocity; Child, Preschool; Constriction,	1999
[Additional tocolysis via inhibition of prostaglandin synthetase with indometacin (author's transl)]. Zeitschrift fur Geburtshilfe und Perinatologie, 1978, Volume: 182, Issue:5 Topics: Clinical Trials as Topic; Cyclooxygenase Inhibitors; Drug Evaluation; Female; Humans; Indomethacin;	1978
On the use of blockers of prostaglandin synthesis in the control of labor. Advances in prostaglandin and thromboxane research, 1978, Volume: 4 Topics: Animals; Aspirin; Clinical Trials as Topic; Female; Fetal Death; Fetus; Hemodynamics; Humans; Indome	1978
Premature labor and indomethacin. Prostaglandins, 1978, Volume: 16, Issue:6 Topics: Apgar Score; Clinical Trials as Topic; Drug Evaluation; Estriol; Female; Humans; Indomethacin; Infan	1978
A study of indomethacin combined with ritodrine in threatened preterm labor. European journal of obstetrics, gynecology, and reproductive biology, 1978, Volume: 8, Issue:3 Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Female; Fetal Death	1978
Randomized comparative trial of indomethacin and sulindac for the treatment of refractory preterm labor. Obstetrics and gynecology, 1992, Volume: 79, Issue:2 Topics: Adult; Female; Humans; Indomethacin; Obstetric Labor, Premature; Pregnancy; Sulindac; Tocolytic Agen	1992
Combination antibiotics and indomethacin in idiopathic preterm labor: a randomized double-blind clinical trial. American journal of obstetrics and gynecology, 1991, Volume: 165, Issue:6 Pt 1 Topics: Ampicillin; Bacterial Infections; Double-Blind Method; Drug Therapy, Combination; Female; Humans; In	1991
Catechol-O-methyltransferase activity in red blood cells in threatened preterm labor; effect of indomethacin and nylidrin. Acta obstetricia et gynecologica Scandinavica, 1991, Volume: 70, Issue:3 Topics: Adult; Catechol O-Methyltransferase; Double-Blind Method; Erythrocytes; Female; Humans; Indomethacin	1991
A randomized double-dummy comparison between indomethacin and nylidrin in threatened preterm labor. Obstetrics and gynecology, 1991, Volume: 78, Issue:6 Topics: Adult; Double-Blind Method; Female; Humans; Indomethacin; Nylidrin; Obstetric Labor, Premature; Preg	1991
The effects of indomethacin and a beta-sympathomimetic agent on the fetal ductus arteriosus during treatment of premature labor: a randomized double-blind study. American journal of obstetrics and gynecology, 1991, Volume: 164, Issue:1 Pt 1 Topics: Blood Flow Velocity; Cardiac Output, Low; Delivery, Obstetric; Double-Blind Method; Ductus Arteriosu	1991
Randomized comparative trial of indomethacin and ritodrine for the long-term treatment of preterm labor. American journal of obstetrics and gynecology, 1991, Volume: 164, Issue:4 Topics: Amniotic Fluid; Diseases in Twins; Female; Fetal Diseases; Humans; Hypertension, Pulmonary; Indometh	1991
Efficacy and safety of indomethacin versus ritodrine in the management of preterm labor: a randomized study. Obstetrics and gynecology, 1989, Volume: 74, Issue:4 Topics: Adult; Amniotic Fluid; Female; Humans; Indomethacin; Infant Mortality; Infant, Newborn; Obstetric La	1989
Inhibition of arachidonic acid metabolism in the perinatal period: pharmacology, clinical application, and potential adverse effects. Seminars in perinatology, 1986, Volume: 10, Issue:4 Topics: Administration, Oral; Arachidonic Acid; Arachidonic Acids; Aspirin; Clinical Trials as Topic; Cycloo	1986

Article	Year
Perioperative Use of Cefazolin and Indomethacin for Physical Examination-Indicated Cerclages to Improve Gestational Latency. Obstetrics and gynecology, 2020, Volume: 135, Issue:6 Topics: Adult; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antibiotic Prophylaxis; Cefaz	2020
Effect of betamethasone, indomethacin and fenoterol on neonatal and maternal mononuclear cells stimulated with Escherichia coli. Cytokine, 2019, Volume: 116 Topics: Adult; Anti-Inflammatory Agents; Betamethasone; Cytokines; Escherichia coli; Female; Fenoterol; Huma	2019
Indomethacin and antibiotics in examination-indicated cerclage: a randomized controlled trial. Obstetrics and gynecology, 2014, Volume: 124, Issue:3 Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Cefazolin; Cerclage, Cervical; Femal	2014
In Reply: Dr. Burwick. Obstetrics and gynecology, 2014, Volume: 124, Issue:3 Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Cefazolin; Cerclage, Cervical; Femal	2014
Uterus-targeted liposomes for preterm labor management: studies in pregnant mice. Scientific reports, 2016, 10-11, Volume: 6 Topics: Animals; Disease Models, Animal; Drug Compounding; Female; Gene Expression; Hormone Antagonists; Hum	2016
Outcomes With Cerclage Alone Compared With Cerclage Plus 17α-Hydroxyprogesterone Caproate. Obstetrics and gynecology, 2016, Volume: 128, Issue:5 Topics: 17 alpha-Hydroxyprogesterone Caproate; Adult; Cerclage, Cervical; Cohort Studies; Female; Humans; Hy	2016
Successful management of intraoperative haemorrhage during emergency cervical cerclage using balloon tamponade. Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, 2017, Volume: 37, Issue:4 Topics: Adult; Balloon Occlusion; Blood Loss, Surgical; Cerclage, Cervical; Extraembryonic Membranes; Female	2017
Pregnancy outcome after placement of 'rescue' Shirodkar cerclage. Journal of perinatology : official journal of the California Perinatal Association, 2009, Volume: 29, Issue:4 Topics: Adolescent; Adult; Bed Rest; Cerclage, Cervical; Cohort Studies; Combined Modality Therapy; Female;	2009
Indomethacin as a diagnostic and therapeutic tool in the management of progressive cervical shortening diagnosed by trans-vaginal sonography. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2011, Volume: 24, Issue:1 Topics: Cerclage, Cervical; Cervical Length Measurement; Female; Humans; Indomethacin; Obstetric Labor, Prem	2011
Nifedipine for the treatment of preterm labor in twin and singleton pregnancies. Archives of gynecology and obstetrics, 2011, Volume: 284, Issue:4 Topics: Adult; Databases, Factual; Female; Gestational Age; Hospitals, University; Humans; Indomethacin; Inf	2011
Indomethacin in pregnancy: applications and safety. American journal of perinatology, 2012, Volume: 29, Issue:3 Topics: Cerclage, Cervical; Cerebral Hemorrhage; Ductus Arteriosus; Enterocolitis, Necrotizing; Female; Fetu	2012
Inhibition of uterine contractility with various tocolytics with and without progesterone: in vitro studies. American journal of obstetrics and gynecology, 2012, Volume: 206, Issue:3 Topics: Adult; Female; Humans; Indomethacin; Magnesium Sulfate; Myometrium; Nifedipine; Obstetric Labor, Pre	2012
[Treatment of preterm delivery--therapeutic algorithm]. Akusherstvo i ginekologiia, 2011, Volume: 50 Suppl 2 Topics: Ambroxol; Anti-Inflammatory Agents, Non-Steroidal; Calcium Channel Blockers; Expectorants; Female; G	2011
Therapeutic effect of cyclo-oxygenase inhibitors with different isoform selectivity in lipopolysaccharide-induced preterm birth in mice. American journal of obstetrics and gynecology, 2003, Volume: 189, Issue:1 Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Femal	2003
In situ inhibition of uterine activity by indomethacin: possible relevance to preterm labor prevention after fetal surgery. Journal of pediatric surgery, 2004, Volume: 39, Issue:8 Topics: Animals; Depression, Chemical; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Femal	2004
Efficacy of aggressive tocolysis for preterm labor with advanced cervical dilatation. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2005, Volume: 18, Issue:1 Topics: Adrenal Cortex Hormones; Adult; Delivery, Obstetric; Female; Gestational Age; Humans; Indomethacin;	2005
Indomethacin tocolysis and white matter injury in preterm infants. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2005, Volume: 18, Issue:2 Topics: Cerebral Hemorrhage; Female; Humans; Indomethacin; Infant; Infant, Newborn; Infant, Premature; Israe	2005
Kinetics and secretion of placental growth hormone around parturition. European journal of endocrinology, 2006, Volume: 154, Issue:3 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Betamethasone; Carrier Proteins; Cesarean Section; C	2006
The safety of prolonged indomethacin therapy. American journal of perinatology, 2007, Volume: 24, Issue:4 Topics: Adolescent; Adult; Cohort Studies; Drug-Related Side Effects and Adverse Reactions; Ductus Arteriosu	2007
A cost decision analysis of 4 tocolytic drugs. American journal of obstetrics and gynecology, 2007, Volume: 197, Issue:4 Topics: Decision Trees; Drug Costs; Female; Humans; Indomethacin; Magnesium Sulfate; Nifedipine; Obstetric L	2007
Immunomodulators plus antibiotics delay preterm delivery after experimental intraamniotic infection in a nonhuman primate model. American journal of obstetrics and gynecology, 2007, Volume: 197, Issue:5 Topics: Amnion; Amniotic Fluid; Ampicillin; Animals; Anti-Bacterial Agents; Cesarean Section; Chorioamnionit	2007
Prostaglandin synthase inhibitors in preterm labour. Lancet (London, England), 1980, Sep-27, Volume: 2, Issue:8196 Topics: Ductus Arteriosus; Female; Humans; Indomethacin; Obstetric Labor, Premature; Pregnancy	1980
On reducing prematurity: the hospital's role. Hospital practice (Hospital ed.), 1982, Volume: 17, Issue:6 Topics: 17 alpha-Hydroxyprogesterone Caproate; Adrenergic beta-Agonists; Female; Hospital Departments; Human	1982
Tocolytics. European journal of obstetrics, gynecology, and reproductive biology, 1983, Volume: 15, Issue:4-6 Topics: Adrenergic beta-Agonists; Blood Glucose; Female; Fetal Distress; Humans; Indomethacin; Infant, Newbo	1983
Treatment of premature labor contractions with combined ritodrine and indomethacine. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 1983, Volume: 21, Issue:4 Topics: Adolescent; Adult; Apgar Score; Birth Weight; Drug Therapy, Combination; Female; Humans; Indomethaci	1983
A survey of tocolytic drug treatment in preterm labour. British journal of obstetrics and gynaecology, 1984, Volume: 91, Issue:5 Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Attitude of Health Personnel; Belgium; Cervix Ute	1984
The treatment of threatened premature labor by drugs. Nihon Sanka Fujinka Gakkai zasshi, 1980, Volume: 32, Issue:10 Topics: Bucladesine; Cyclic AMP; Female; Humans; Indomethacin; Obstetric Labor, Premature; Pregnancy; Prosta	1980
Fetal surgery in the primate II. Uterine electromyographic response to operative procedures and pharmacologic agents. Journal of pediatric surgery, 1984, Volume: 19, Issue:4 Topics: Amniocentesis; Anesthesia, Obstetrical; Animals; Catheterization; Electrodes, Implanted; Electromyog	1984
RDS prophylaxis in preterm labor: corticosteroids and beta-mimetics association-indications and limits. Biological research in pregnancy and perinatology, 1984, Volume: 5, Issue:4 Topics: 1,2-Dipalmitoylphosphatidylcholine; Adrenal Cortex Hormones; Drug Therapy, Combination; Female; Huma	1984
Indomethacin and the fetal renal nonfunction syndrome. European journal of obstetrics, gynecology, and reproductive biology, 1983, Volume: 16, Issue:2 Topics: Abnormalities, Drug-Induced; Adult; Face; Female; Humans; Indomethacin; Infant, Newborn; Kidney; Mat	1983
Unexpected cardiac pathology in pregnant women treated with beta-adrenergic agents (ritodrine). Obstetrics and gynecology, 1983, Volume: 61, Issue:3 Suppl Topics: Adult; Cardiomyopathies; Cesarean Section; Dyspnea; Female; Heart Septal Defects, Atrial; Humans; In	1983
Further study of the inhibition of premature labor by indomethacin. Part I. Journal of perinatal medicine, 1984, Volume: 12, Issue:1 Topics: Adolescent; Adult; Female; Gestational Age; Humans; Indomethacin; Obstetric Labor, Premature; Pregna	1984
[Fetal hydrops following indomethacin administration during pregnancy]. Nederlands tijdschrift voor geneeskunde, 1983, Jan-01, Volume: 127, Issue:1 Topics: Adult; Edema; Female; Humans; Indomethacin; Infant, Newborn; Infant, Premature, Diseases; Male; Mate	1983
[Treatment of premature labor with indomethacin and its effect on the fetus]. Ceskoslovenska gynekologie, 1982, Volume: 47, Issue:10 Topics: Ductus Arteriosus, Patent; Female; Humans; Indomethacin; Infant, Newborn; Obstetric Labor, Premature	1982
[Premature labor]. Revista chilena de obstetricia y ginecologia, 1982, Volume: 47, Issue:3 Topics: Child, Preschool; Chile; Female; Humans; Indomethacin; Infant, Low Birth Weight; Infant, Newborn; Ob	1982
[Combined indomethacin and ritodrine treatment in the prevention of pre-term labor. Preventive note]. Minerva ginecologica, 1980, Volume: 32, Issue:12 Topics: Adult; Drug Therapy, Combination; Female; Humans; Indomethacin; Obstetric Labor, Premature; Pregnanc	1980
[Indomethacin in the prevention of pre-term labor]. Minerva ginecologica, 1980, Volume: 32, Issue:12 Topics: Adult; Female; Humans; Indomethacin; Obstetric Labor, Premature; Pregnancy	1980
[Maternal treatment with indomethacin and severe neonatal pulmonary hypertension (author's transl)]. Archives francaises de pediatrie, 1981, Volume: 38, Issue:4 Topics: Female; Humans; Hypertension, Pulmonary; Indomethacin; Infant, Newborn; Infant, Premature, Diseases;	1981
Oligohydramnion, meconium and perinatal death concurrent with indomethacin treatment in human pregnancy. The Journal of reproductive medicine, 1980, Volume: 24, Issue:3 Topics: Adult; Amniotic Fluid; Female; Fetal Death; Humans; Indomethacin; Infant Mortality; Infant, Newborn;	1980
Classification of threatened premature labor related to treatment with a prostaglandin inhibitor: indomethacin. Biology of the neonate, 1980, Volume: 37, Issue:5-6 Topics: Female; Humans; Indomethacin; Infant, Newborn; Obstetric Labor, Premature; Pregnancy; Uterine Contra	1980
[Indomethacin for prevention of premature labor]. Ginekologia polska, 1980, Volume: 51, Issue:4 Topics: Female; Humans; Indomethacin; Obstetric Labor, Premature; Pregnancy; Uterine Contraction	1980
[Persistent pulmonary hypertension in the newborn caused by prenatal use of prostaglandin inhibitors, (indomethacin). Report of a case]. Ginecologia y obstetricia de Mexico, 1980, Volume: 48, Issue:286 Topics: Abortion, Threatened; Adult; Female; Humans; Hypertension, Pulmonary; Indomethacin; Infant, Newborn;	1980
[Prostaglandin and threat of premature labour inhibitors. 1. The possibilities and consequences (as given in the literature) (author's transl)]. Journal de gynecologie, obstetrique et biologie de la reproduction, 1980, Volume: 9, Issue:6 Topics: Anti-Inflammatory Agents; Female; Humans; Indomethacin; Infant, Newborn; Labor, Obstetric; Maternal-	1980
Fetal echocardiography during indomethacin treatment. Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology, 1995, Volume: 5, Issue:2 Topics: Arterial Occlusive Diseases; Blood Flow Velocity; Constriction, Pathologic; Ductus Arteriosus; Echoc	1995
Quadruplet pregnancy--successful outcome using indomethacin. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 1994, Volume: 46, Issue:3 Topics: Female; Humans; Indomethacin; Obstetric Labor, Premature; Pregnancy; Pregnancy Outcome; Pregnancy, M	1994
[Has the use of indomethacin during pregnancy consequences in newborn infants? Prospective study of 83 pregnant women and 115 newborn infants]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 1994, Volume: 1, Issue:8 Topics: Female; Humans; Indomethacin; Infant, Newborn; Infant, Newborn, Diseases; Obstetric Labor, Premature	1994
The contemporary use of beta-agonists. British journal of obstetrics and gynaecology, 1994, Volume: 101, Issue:5 Topics: Adrenergic beta-Agonists; Female; Humans; Indomethacin; Obstetric Labor, Premature; Pregnancy; Tocol	1994
The effect of indomethacin tocolysis on maternal coagulation status. Obstetrics and gynecology, 1994, Volume: 84, Issue:5 Topics: Administration, Oral; Adult; Bleeding Time; Blood Coagulation; Female; Humans; Indomethacin; Obstetr	1994
Successful pregnancy outcome in uterus didelphys with leiomyoma uteri. Acta obstetricia et gynecologica Scandinavica, 1994, Volume: 73, Issue:2 Topics: Adult; Bed Rest; Cesarean Section; Female; Humans; Indomethacin; Leiomyoma; Obstetric Labor, Prematu	1994
Indomethacin-induced maternal convulsion in the treatment of preterm labour. European journal of obstetrics, gynecology, and reproductive biology, 1993, Volume: 52, Issue:1 Topics: Adult; Female; Humans; Indomethacin; Obstetric Labor, Premature; Pregnancy; Pregnancy Complications;	1993
Indomethacin as a tocolytic agent: the controversy continues. The Journal of pediatrics, 1994, Volume: 124, Issue:5 Pt 1 Topics: Female; Humans; Indomethacin; Infant, Newborn; Infant, Premature, Diseases; Obstetric Labor, Prematu	1994
Effect of interleukin 2 on the production of progesterone and prostaglandin E2 in human fetal membranes and its consequences for preterm uterine contractions. European journal of endocrinology, 1994, Volume: 130, Issue:5 Topics: Amniotic Fluid; Bacterial Infections; Chorioamnionitis; Culture Techniques; Dinoprostone; Extraembry	1994
Renal impairment in very low birthweight infants following antenatal indomethacin administration. Acta paediatrica Japonica : Overseas edition, 1994, Volume: 36, Issue:2 Topics: Adult; Female; Humans; Indomethacin; Infant, Low Birth Weight; Infant, Newborn; Male; Maternal-Fetal	1994
Neonatal complications after the administration of indomethacin for preterm labor. The New England journal of medicine, 1993, Nov-25, Volume: 329, Issue:22 Topics: Cerebral Hemorrhage; Ductus Arteriosus, Patent; Enterocolitis, Pseudomembranous; Female; Fetus; Huma	1993
Acute maternal renal insufficiency in premature labor treated with indomethacin. American journal of perinatology, 1993, Volume: 10, Issue:5 Topics: Acute Kidney Injury; Administration, Oral; Adult; Dyspnea; Female; Fetofetal Transfusion; Humans; Hy	1993
Delayed birth intervals of immature fraternal triplets in preterm labor. A case report. The Journal of reproductive medicine, 1993, Volume: 38, Issue:9 Topics: Adult; Anti-Bacterial Agents; Birth Intervals; Birth Weight; Female; Gamete Intrafallopian Transfer;	1993
Tocolysis with indomethacin increases the incidence of necrotizing enterocolitis in the low-birth-weight neonate. American journal of obstetrics and gynecology, 1994, Volume: 170, Issue:1 Pt 1 Topics: Birth Weight; Chi-Square Distribution; Cohort Studies; Enterocolitis, Pseudomembranous; Female; Gest	1994
[Maternal and neonatal effects of indomethacin administrated during pregnancy. Apropos of 18 cases]. Archives francaises de pediatrie, 1993, Volume: 50, Issue:4 Topics: Adult; Female; Humans; Indomethacin; Infant, Newborn; Male; Obstetric Labor, Premature; Polyhydramni	1993
Pregnancy in women with end-stage renal disease: treatment of anemia and premature labor. American journal of kidney diseases : the official journal of the National Kidney Foundation, 1993, Volume: 21, Issue:1 Topics: Abnormalities, Drug-Induced; Adult; Anemia; Erythropoietin; Female; Hematocrit; Humans; Hypertension	1993
Good fetal outcome following prolonged indomethacin induced anhydramnios. Case report. Journal of perinatal medicine, 1995, Volume: 23, Issue:3 Topics: Adult; Female; Humans; Indomethacin; Infant, Newborn; Obstetric Labor, Premature; Oligohydramnios; P	1995
Effective treatment of drug-induced agranulocytosis using recombinant human granulocyte colony stimulating factor in pregnancy. Gynecologic and obstetric investigation, 1995, Volume: 40, Issue:4 Topics: Adult; Agranulocytosis; Drug Therapy, Combination; Female; Granulocyte Colony-Stimulating Factor; Hu	1995
Repeated administration of low-dose lipopolysaccharide induces preterm delivery in mice: a model for human preterm parturition and for assessment of the therapeutic ability of drugs against preterm delivery. American journal of obstetrics and gynecology, 1996, Volume: 174, Issue:2 Topics: Animals; Disease Models, Animal; Escherichia coli; Female; Gabexate; Glycoproteins; Humans; Indometh	1996
Acute renal failure in the neonate induced by the administration of indomethacin as a tocolytic agent. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1996, Volume: 11, Issue:6 Topics: Acute Kidney Injury; Adult; Ductus Arteriosus, Patent; Female; Humans; Indomethacin; Infant, Newborn	1996
Effect of indomethacin on individual amniotic fluid indices in multiple gestations. Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine, 1996, Volume: 15, Issue:5 Topics: Amniotic Fluid; Cyclooxygenase Inhibitors; Female; Humans; Indomethacin; Obstetric Labor, Premature;	1996
Preterm labour and delivery. European journal of pediatrics, 1996, Volume: 155 Suppl 2 Topics: Adrenergic beta-Agonists; Biomarkers; Female; Humans; Indomethacin; Magnesium; Nitroglycerin; Obstet	1996
In utero congestive heart failure due to maternal indomethacin treatment for polyhydramnios and premature labour in a fetus with antenatal closure of the foramen ovale. Prenatal diagnosis, 1996, Volume: 16, Issue:7 Topics: Adult; Autopsy; Female; Fetal Death; Heart Failure; Heart Septum; Humans; Indomethacin; Obstetric La	1996
Preterm delivery after indomethacin. A risk factor for neonatal complications? The Journal of reproductive medicine, 1996, Volume: 41, Issue:12 Topics: Cohort Studies; Ductus Arteriosus, Patent; Enterocolitis, Pseudomembranous; Female; Hemorrhage; Huma	1996
Progesterone levels in preterm labor are not affected by ritodrin treatment. Gynecologic and obstetric investigation, 1997, Volume: 43, Issue:1 Topics: Administration, Rectal; Female; Humans; Indomethacin; Infusion Pumps; Obstetric Labor, Premature; Pr	1997
The effect of indomethacin tocolysis on fetal ductus arteriosus constriction with advancing gestational age. American journal of obstetrics and gynecology, 1997, Volume: 177, Issue:2 Topics: Ductus Arteriosus; Echocardiography; Female; Gestational Age; Humans; Indomethacin; Obstetric Labor,	1997
[Indomethacin in obstetrics: benefits and risks]. Ceska gynekologie, 1997, Volume: 62, Issue:3 Topics: Female; Humans; Indomethacin; Obstetric Labor, Premature; Pregnancy; Tocolytic Agents	1997
Is there justification for using indomethacin in preterm labor? An analysis of neonatal risks and benefits. American journal of obstetrics and gynecology, 1997, Volume: 177, Issue:4 Topics: Cerebral Hemorrhage; Decision Support Techniques; Enterocolitis, Pseudomembranous; Female; Gestation	1997
Indomethacin tocolysis. American journal of obstetrics and gynecology, 1998, Volume: 178, Issue:1 Pt 1 Topics: Contraindications; Ductus Arteriosus, Patent; Echocardiography; Female; Gestational Age; Humans; Ind	1998
Safety of antenatal indomethacin. American journal of obstetrics and gynecology, 1998, Volume: 178, Issue:4 Topics: Female; Humans; Indomethacin; Obstetric Labor, Premature; Pregnancy; Risk Factors; Tocolysis	1998
Toxic epidermal necrolysis associated with treatment for preterm labor. Dermatology (Basel, Switzerland), 1998, Volume: 196, Issue:4 Topics: Adult; Betamethasone; Female; Gestational Age; Glucocorticoids; Humans; Indomethacin; Obstetric Labo	1998
Indomethacin tocolysis increases postnatal patent ductus arteriosus severity. Pediatrics, 1998, Volume: 102, Issue:5 Topics: Ductus Arteriosus, Patent; Female; Humans; Indomethacin; Infant, Newborn; Infant, Premature; Infant,	1998
ECT-induced premature labor: a case report. The Journal of clinical psychiatry, 1999, Volume: 60, Issue:1 Topics: Adult; Depressive Disorder; Electroconvulsive Therapy; Female; Humans; Indomethacin; Mental Disorder	1999
Recent indomethacin tocolysis is not associated with neonatal complications in preterm infants. American journal of obstetrics and gynecology, 1999, Volume: 181, Issue:5 Pt 1 Topics: Birth Weight; Case-Control Studies; Delivery, Obstetric; Drug Administration Schedule; Female; Gesta	1999
Inhibition of cyclooxygenase-2 prevents inflammation-mediated preterm labor in the mouse. American journal of physiology. Regulatory, integrative and comparative physiology, 2000, Volume: 278, Issue:6 Topics: Animals; Blotting, Northern; Calcium; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitor	2000
Search for best tocolytic for preterm labour. Lancet (London, England), 2000, Aug-26, Volume: 356, Issue:9231 Topics: Female; Humans; Indomethacin; Nifedipine; Obstetric Labor, Premature; Pregnancy; Randomized Controll	2000
Vascular reactivity to angiotensin II and eicosanoid production in the human placenta from term and preterm pregnancy. Gynecologic and obstetric investigation, 2000, Volume: 50, Issue:4 Topics: 6-Ketoprostaglandin F1 alpha; Analysis of Variance; Angiotensin II; Culture Techniques; Enzyme-Linke	2000
Enhancement of amniotic cyclooxygenase type 2 activity in women with preterm delivery associated with twins or polyhydramnios. American journal of obstetrics and gynecology, 2001, Volume: 184, Issue:2 Topics: Amnion; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors;	2001
Can a cyclo-oxygenase type-2 selective tocolytic agent avoid the fetal side effects of indomethacin? BJOG : an international journal of obstetrics and gynaecology, 2001, Volume: 108, Issue:3 Topics: Administration, Oral; Adult; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitor	2001
Indomethacin tocolysis and intraventricular hemorrhage. Obstetrics and gynecology, 2001, Volume: 97, Issue:6 Topics: Adult; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Confiden	2001
Severe heart failure due to ductal constriction caused by maternal indomethacin. Pediatrics international : official journal of the Japan Pediatric Society, 2002, Volume: 44, Issue:2 Topics: Adult; Constriction, Pathologic; Ductus Arteriosus; Female; Heart Failure; Humans; Indomethacin; Inf	2002
[Tocolysis and its place in premature labor]. Akusherstvo i ginekologiia, 1999, Volume: 38, Issue:1 Topics: Adrenergic Agents; Anti-Inflammatory Agents, Non-Steroidal; Bulgaria; Drug Interactions; Female; Hum	1999
Indomethacin-induced rectovaginal fistula in a postpartum patient. Diseases of the colon and rectum, 2002, Volume: 45, Issue:6 Topics: Adult; Colostomy; Escherichia coli Infections; Fecal Incontinence; Female; Humans; Indomethacin; Obs	2002
[Prevention of premature labor]. Gynakologische Rundschau, 1975, Volume: 15 suppl 1 Topics: Adrenergic beta-Agonists; Aspirin; Female; Humans; Indomethacin; Obstetric Labor, Premature; Pregnan	1975
Perinatal use of indomethacin. Lancet (London, England), 1977, Jul-09, Volume: 2, Issue:8028 Topics: Animals; Female; Fetal Death; Humans; Indomethacin; Obstetric Labor, Premature; Pregnancy; Rats	1977
Post-partum pulmonary oedema associated with preventive therapy for premature labour. Lancet (London, England), 1979, May-12, Volume: 1, Issue:8124 Topics: Adult; Betamethasone; Drug Therapy, Combination; Female; Humans; Indomethacin; Obstetric Labor, Prem	1979
Effect on the fetus of indomethacin given to suppress labour. Lancet (London, England), 1979, Dec-01, Volume: 2, Issue:8153 Topics: Animals; Female; Fetal Heart; Humans; Indomethacin; Infant, Newborn; Male; Maternal-Fetal Exchange;	1979
Treatment of premature labor by prostaglandin synthetase inhibitors. Acta biologica et medica Germanica, 1978, Volume: 37, Issue:5-6 Topics: Adult; Animals; Anti-Inflammatory Agents; Birth Weight; Cyclooxygenase Inhibitors; Female; Gestation	1978
Premature onset of labor, neonatal patent ductus arteriosus, and prostaglandin synthetase antagonists--a rat model of a human problem. American journal of obstetrics and gynecology, 1979, Sep-15, Volume: 135, Issue:2 Topics: Animals; Brain Diseases; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Ductus Arterio	1979
The treatment of threatened premature labor by tocolytics, Ca++-Antagonists and anti-inflammatory drugs. Arzneimittel-Forschung, 1975, Volume: 25, Issue:2 Topics: Adrenergic beta-Agonists; Animals; Anti-Inflammatory Agents; Aspirin; Calcium; Drug Therapy, Combina	1975
Alcohol, indomethacin, and salbutamol. A comparative trial of their use in preterm labor. Obstetrics and gynecology, 1979, Volume: 53, Issue:2 Topics: Albuterol; Birth Weight; Drug Therapy, Combination; Ethanol; Female; Fetal Membranes, Premature Rupt	1979
Perinatal hazards of chronic antenatal tocolysis with indomethacin. Prostaglandins, 1979, Volume: 18, Issue:6 Topics: Adult; Female; Humans; Indomethacin; Infant, Newborn; Infant, Premature, Diseases; Obstetric Labor,	1979
Relationship of maternal treatment with indomethacin to persistence of fetal circulation syndrome. The Journal of pediatrics, 1978, Volume: 92, Issue:3 Topics: Ductus Arteriosus, Patent; Female; Fetus; Humans; Indomethacin; Infant, Newborn; Obstetric Labor Com	1978
Pregnant mare's serum gonadotropin. IV. Induction of premature labor by pregnant mare's serum gonadotropin and its prevention by using clomiphene or indomethacin. Fertility and sterility, 1978, Volume: 29, Issue:6 Topics: Abortifacient Agents; Animals; Clomiphene; Female; Gonadotropins, Equine; Indomethacin; Labor, Induc	1978
Management of premature labor. Clinical obstetrics and gynecology, 1978, Volume: 21, Issue:2 Topics: Aspirin; Bed Rest; Betamethasone; Estrogens; Ethanol; Female; Fetal Membranes, Premature Rupture; Gl	1978
The effects of combined dexamethasone and indomethacin treatment on the outcome of pregnancy in the rabbit. Biology of reproduction, 1976, Volume: 15, Issue:4 Topics: Animals; Dexamethasone; Female; Indomethacin; Obstetric Labor, Premature; Pregnancy; Pregnancy, Anim	1976
[Inhibition of endogenous prostaglandin synthesis by indomethacin in the treatment of premature labor]. Ceskoslovenska gynekologie, 1976, Volume: 41, Issue:7 Topics: Female; Humans; Indomethacin; Infant, Newborn; Obstetric Labor, Premature; Pregnancy; Prostaglandin	1976
Indomethacin to stop premature labor. American journal of obstetrics and gynecology, 1976, Jun-15, Volume: 125, Issue:4 Topics: Animals; Female; Indomethacin; Obstetric Labor, Premature; Pregnancy; Rats	1976
Possible association between maternal indomethacin therapy and primary pulmonary hypertension of the newborn. American journal of obstetrics and gynecology, 1976, Oct-15, Volume: 126, Issue:4 Topics: Adolescent; Female; Humans; Hypertension, Pulmonary; Indomethacin; Infant, Newborn; Infant, Newborn,	1976
The effects of dexamethasone and indomethacin on the outcome of pregnancy in the rabbit. The Journal of endocrinology, 1975, Volume: 64, Issue:2 Topics: Administration, Oral; Animals; Dexamethasone; Female; Hematocrit; Indomethacin; Injections, Subcutan	1975
On the role of prostaglandins in parturition in the rat. Endocrinology, 1975, Volume: 96, Issue:4 Topics: Animals; Female; Gestational Age; Hypophysectomy; Indomethacin; Labor, Obstetric; Medroxyprogesteron	1975
[Indomethacin as an inhibitor of premature labor]. Harefuah, 1975, Sep-01, Volume: 89, Issue:5 Topics: Adult; Female; Humans; Indomethacin; Obstetric Labor, Premature; Pregnancy	1975
Premature labor and indomethacin. Prostaglandins, 1975, Volume: 10, Issue:3 Topics: Adult; Female; Humans; Indomethacin; Obstetric Labor, Premature; Pregnancy; Prostaglandins F; Time F	1975
Letter: Indomethacin. Obstetrics and gynecology, 1976, Volume: 47, Issue:1 Topics: Animals; Female; Humans; Indomethacin; Obstetric Labor, Premature; Pregnancy	1976
[Indomethacin in threatening premature labor. Fetal and neonatal cardiovascular effects]. Ginecologia y obstetricia de Mexico, 1992, Volume: 60 Topics: Cardiovascular Diseases; Female; Fetal Diseases; Humans; Hypertension, Pulmonary; Indomethacin; Infa	1992
Oligohydramnios induced by maternal indomethacin therapy. International journal of clinical pharmacology, therapy, and toxicology, 1992, Volume: 30, Issue:7 Topics: Female; Humans; Indomethacin; Maternal-Fetal Exchange; Obstetric Labor, Premature; Oligohydramnios;	1992
Indomethacin therapy and chronic hemodialysis during pregnancy. A case report. The Journal of reproductive medicine, 1992, Volume: 37, Issue:2 Topics: Adult; Female; Glomerulosclerosis, Focal Segmental; Humans; Indomethacin; Infant, Newborn; Obstetric	1992
Intraoperative amniocentesis and indomethacin treatment in the management of an immature pregnancy with completely dilated cervix. Obstetrics and gynecology, 1992, Volume: 79, Issue:5 ( Pt 2) Topics: Adult; Amniocentesis; Cervix Uteri; Female; Humans; Indomethacin; Infant, Newborn; Intraoperative Pe	1992
Randomized comparative trial of indomethacin and sulindac for the treatment of refractory preterm labor. Obstetrics and gynecology, 1992, Volume: 79, Issue:6 Topics: Female; Humans; Indomethacin; Obstetric Labor, Premature; Pregnancy; Randomized Controlled Trials as	1992
Urinary excretion of prostacyclin and thromboxane metabolites in threatened preterm labor: effect of indomethacin and nylidrin. American journal of obstetrics and gynecology, 1992, Volume: 166, Issue:1 Pt 1 Topics: 6-Ketoprostaglandin F1 alpha; Adult; Epoprostenol; Female; Humans; Indomethacin; Kinetics; Nylidrin;	1992
Renal dysgenesis in a monozygotic twin: association with in utero exposure to indomethacin. American journal of medical genetics, 1991, Jun-01, Volume: 39, Issue:3 Topics: Adult; Diseases in Twins; Female; Humans; Indomethacin; Infant, Newborn; Kidney; Maternal-Fetal Exch	1991
Cocaine and indomethacin: fetal anuria, neonatal edema, and gastrointestinal bleeding. Obstetrics and gynecology, 1991, Volume: 78, Issue:3 Pt 2 Topics: Adult; Anuria; Cocaine; Drug Synergism; Female; Fetal Diseases; Gastrointestinal Hemorrhage; Humans;	1991
A product of activated human granulocytes stimulates prostaglandin E2 synthesis in human amnion cells. Prostaglandins, leukotrienes, and essential fatty acids, 1991, Volume: 43, Issue:1 Topics: Amnion; Cells, Cultured; Chorioamnionitis; Cytochalasin B; Dinoprostone; Epidermal Growth Factor; Fe	1991
Maternal plasma corticotrophin-releasing hormone--elevated in preterm labour but unaffected by indomethacin or nylidrin. British journal of obstetrics and gynaecology, 1991, Volume: 98, Issue:7 Topics: Adult; Corticotropin-Releasing Hormone; Female; Humans; Hydrocortisone; Indomethacin; Nylidrin; Obst	1991
Indomethacin for preterm labor: fetal toxicity in a dizygotic twin gestation. Obstetrics and gynecology, 1991, Volume: 78, Issue:5 Pt 2 Topics: Abnormalities, Drug-Induced; Adult; Diseases in Twins; Drug Monitoring; Ductus Arteriosus; Female; F	1991
Long-term indomethacin therapy decreases fetal urine output and results in oligohydramnios. American journal of perinatology, 1991, Volume: 8, Issue:2 Topics: Adult; Amniotic Fluid; Female; Fetus; Humans; Indomethacin; Obstetric Labor, Premature; Oligohydramn	1991
Uterine blood flow velocity waveforms in pregnant women during indomethacin therapy. Obstetrics and gynecology, 1990, Volume: 76, Issue:1 Topics: Blood Flow Velocity; Female; Humans; Indomethacin; Obstetric Labor, Premature; Polyhydramnios; Pregn	1990
Cerebral lesions in preterm infants after tocolytic indomethacin. Developmental medicine and child neurology, 1990, Volume: 32, Issue:10 Topics: Administration, Rectal; Brain; Brain Damage, Chronic; Cerebral Hemorrhage; Dose-Response Relationshi	1990
Safety and efficacy of long-term tocolysis with indomethacin. American journal of perinatology, 1990, Volume: 7, Issue:1 Topics: Apgar Score; Birth Weight; Female; Humans; Indomethacin; Infant, Newborn; Obstetric Labor, Premature	1990
Oligohydramnios in each sac of a triplet gestation caused by Motrin--fulfilling Kock's postulates. American journal of obstetrics and gynecology, 1990, Volume: 162, Issue:2 Topics: Adult; Amniotic Fluid; Female; Humans; Ibuprofen; Indomethacin; Obstetric Labor, Premature; Pregnanc	1990
Oligohydramnios associated with prostaglandin synthetase inhibitors in preterm labour. British journal of obstetrics and gynaecology, 1990, Volume: 97, Issue:4 Topics: Adult; Amniotic Fluid; Birth Weight; Female; Gestational Age; Humans; Ibuprofen; Indomethacin; Infan	1990
Doppler assessment of the renal blood flow velocity waveform during indomethacin therapy for preterm labor and polyhydramnios. Obstetrics and gynecology, 1990, Volume: 75, Issue:2 Topics: Ductus Arteriosus; Female; Fetal Monitoring; Gestational Age; Humans; Indomethacin; Kidney; Maternal	1990
Polyhydramnios associated with a ring chromosome and low maternal serum alpha-fetoprotein levels managed with indomethacin. American journal of obstetrics and gynecology, 1988, Volume: 158, Issue:5 Topics: alpha-Fetoproteins; Chromosome Aberrations; Female; Fetus; Humans; Indomethacin; Infant, Newborn; Ob	1988
Neonatal renal dysfunction and intrauterine exposure to prostaglandin synthesis inhibitors. European journal of pediatrics, 1989, Volume: 148, Issue:4 Topics: Acute Kidney Injury; Anti-Inflammatory Agents, Non-Steroidal; Betamethasone; Cesarean Section; Cyclo	1989
[Prescribing indomethacin to prevent premature labor. Risk of cardiomyopathy]. Presse medicale (Paris, France : 1983), 1989, Jun-03, Volume: 18, Issue:22 Topics: Cardiomyopathy, Dilated; Female; Humans; Indomethacin; Infant, Newborn; Male; Obstetric Labor, Prema	1989
Antagonism of antihypertensive drug therapy in pregnancy by indomethacin? American journal of obstetrics and gynecology, 1989, Volume: 161, Issue:5 Topics: Adult; Antihypertensive Agents; Blood Pressure; Female; Humans; Indomethacin; Obstetric Labor, Prema	1989
Twin with hydramnios: treating premature labor at source. American journal of obstetrics and gynecology, 1989, Volume: 160, Issue:3 Topics: Delivery, Obstetric; Female; Humans; Indomethacin; Obstetric Labor, Premature; Polyhydramnios; Pregn	1989
Indomethacin-induced oligohydramnios. American journal of obstetrics and gynecology, 1989, Volume: 160, Issue:5 Pt 1 Topics: Adult; Amniotic Fluid; Dose-Response Relationship, Drug; Female; Humans; Indomethacin; Obstetric Lab	1989
Doppler assessment of the pulsatility index of the middle cerebral artery during constriction of the fetal ductus arteriosus after indomethacin therapy. American journal of obstetrics and gynecology, 1989, Volume: 161, Issue:6 Pt 1 Topics: Blood Circulation; Cerebral Arteries; Ductus Arteriosus; Female; Fetus; Hemodynamics; Humans; Indome	1989
[Prenatal diagnosis of premature closure of the ductus arteriosus with subsequent development of a non-immunologic hydrops fetalis]. Geburtshilfe und Frauenheilkunde, 1989, Volume: 49, Issue:12 Topics: Adult; Cesarean Section; Constriction, Pathologic; Ductus Arteriosus; Female; Humans; Hydrops Fetali	1989
Preterm labor: its diagnosis and management. American journal of obstetrics and gynecology, 1986, Volume: 154, Issue:1 Topics: Adolescent; Adrenergic beta-Agonists; Adult; Female; Fluid Therapy; Humans; Indomethacin; Infant, Ne	1986
Patent ductus arteriosus after prolonged treatment with indomethacin during pregnancy: case report. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 1987, Volume: 25, Issue:1 Topics: Adult; Diseases in Twins; Ductus Arteriosus, Patent; Female; Humans; Indomethacin; Infant, Newborn;	1987
The effects of indomethacin administration during pregnancy on women's and newborns' T-suppressor lymphocyte activity and on HLA class II expression by newborns' leukocytes. American journal of reproductive immunology and microbiology : AJRIM, 1985, Volume: 8, Issue:3 Topics: B-Lymphocytes; Female; Histocompatibility Antigens Class II; HLA-DR Antigens; Humans; Indomethacin;	1985
Effects of indomethacin on the fetus. The New England journal of medicine, 1988, Dec-01, Volume: 319, Issue:22 Topics: Ductus Arteriosus; Female; Humans; Indomethacin; Obstetric Labor, Premature; Pregnancy; Tocolytic Ag	1988
Indomethacin as an inhibitor of preterm labor. Effect on postnatal renal function. Contributions to nephrology, 1988, Volume: 67 Topics: Female; Gestational Age; Glomerular Filtration Rate; Humans; Indomethacin; Infant, Newborn; Kidney;	1988
[The uterine inhibition in the management of premature labor. Comparing the efficiency of various methods]. Revista chilena de obstetricia y ginecologia, 1987, Volume: 52, Issue:6 Topics: Analysis of Variance; Betamethasone; Female; Fenoterol; Humans; Indomethacin; Obstetric Labor, Prema	1987
Influence of short-term indomethacin therapy on fetal urine output. Obstetrics and gynecology, 1988, Volume: 72, Issue:1 Topics: Constriction, Pathologic; Diuresis; Ductus Arteriosus; Female; Fetus; Humans; Indomethacin; Obstetri	1988
Prolonged maternal indomethacin therapy associated with oligohydramnios. Case reports. British journal of obstetrics and gynaecology, 1988, Volume: 95, Issue:3 Topics: Adult; Amniotic Fluid; Female; Humans; Indomethacin; Obstetric Labor, Premature; Pregnancy; Pregnanc	1988
Indomethacin in the treatment of premature labor. Effects on the fetal ductus arteriosus. The New England journal of medicine, 1988, Aug-11, Volume: 319, Issue:6 Topics: Adolescent; Adult; Constriction, Pathologic; Dose-Response Relationship, Drug; Ductus Arteriosus; Ec	1988
Safety of indomethacin tocolysis. American journal of obstetrics and gynecology, 1987, Volume: 156, Issue:5 Topics: Female; Humans; Indomethacin; Obstetric Labor, Premature; Pregnancy	1987
[Maternal administration of indomethacin and neonatal tricuspid insufficiency]. Archives francaises de pediatrie, 1987, Volume: 44, Issue:3 Topics: Female; Humans; Indomethacin; Infant, Newborn; Male; Obstetric Labor, Premature; Pregnancy; Tricuspi	1987
Inhibition of premature labour with indomethacin. Acta chirurgica Hungarica, 1987, Volume: 28, Issue:1 Topics: Female; Fetal Membranes, Premature Rupture; Humans; Indomethacin; Infant, Low Birth Weight; Infant,	1987
Management of preterm labor and delivery. Clinical obstetrics and gynecology, 1986, Volume: 29, Issue:2 Topics: Adrenal Cortex Hormones; Anesthesia, Conduction; Calcium Channel Blockers; Cesarean Section; Deliver	1986
Obstetric management of the very low birth weight fetus. Clinics in perinatology, 1986, Volume: 13, Issue:2 Topics: Adrenal Cortex Hormones; Extraction, Obstetrical; Female; Fetal Distress; Fetal Monitoring; Fetal Or	1986
Neonatal outcome after indomethacin treatment for preterm labor. American journal of obstetrics and gynecology, 1986, Volume: 155, Issue:4 Topics: Apgar Score; Birth Weight; Female; Gestational Age; Humans; Indomethacin; Infant, Newborn, Diseases;	1986
Premature closure of the ductus arteriosus causing intra-uterine death. A case report. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1986, Oct-25, Volume: 70, Issue:9 Topics: Adult; Ductus Arteriosus; Edema; Female; Fetal Death; Humans; Indomethacin; Obstetric Labor, Prematu	1986
Detection and quantitation of constriction of the fetal ductus arteriosus by Doppler echocardiography. Circulation, 1987, Volume: 75, Issue:2 Topics: Animals; Constriction, Pathologic; Ductus Arteriosus; Echocardiography; Female; Fetal Diseases; Huma	1987
Fetal and neonatal effects of indomethacin used as a tocolytic agent. American journal of obstetrics and gynecology, 1985, Jan-15, Volume: 151, Issue:2 Topics: Birth Weight; Female; Fetus; Humans; Indomethacin; Infant Mortality; Infant, Newborn; Infant, Newbor	1985
Side effects of indomethacin. Journal of perinatal medicine, 1985, Volume: 13, Issue:2 Topics: Animals; Female; Fetus; Humans; Indomethacin; Infant, Newborn; Obstetric Labor, Premature; Pregnancy	1985
Fetal and neonatal effects of indomethacin used as a tocolytic agent. American journal of obstetrics and gynecology, 1985, Nov-15, Volume: 153, Issue:6 Topics: Female; Fetus; Humans; Indomethacin; Infant, Newborn; Obstetric Labor, Premature; Pregnancy	1985
Fetal and neonatal effects of indomethacin used as a tocolytic agent. American journal of obstetrics and gynecology, 1985, Dec-15, Volume: 153, Issue:8 Topics: Female; Fetus; Humans; Indomethacin; Infant, Newborn; Obstetric Labor, Premature; Pregnancy	1985
Inhibition of human premature labor by indomethacin. Obstetrics and gynecology, 1974, Volume: 44, Issue:6 Topics: Adolescent; Adult; Blood Pressure; Depression, Chemical; Extraembryonic Membranes; Female; Fetal Hea	1974
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indomethacin and Labor, Premature