indomethacin has been researched along with Labor, Premature in 222 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
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"A case of severe fetal congestive heart failure due to occlusion of the ductus arteriosus in a mother treated with indomethacin for polyhydramnios and premature contractions is described." | 7.69 | In utero congestive heart failure due to maternal indomethacin treatment for polyhydramnios and premature labour in a fetus with antenatal closure of the foramen ovale. ( Achiron, R; Berant, M; Hegesh, J; Kidron, D; Lipitz, S; Rotstein, Z, 1996) |
"To investigate the effects of indomethacin on the human fetal renal blood flow velocity waveform, 17 fetuses whose mothers were treated for preterm labor (N = 8) or polyhydramnios (N = 9) were studied." | 7.68 | Doppler assessment of the renal blood flow velocity waveform during indomethacin therapy for preterm labor and polyhydramnios. ( Carpenter, RJ; Deter, RL; Kirshon, B; Mari, G; Moise, KJ, 1990) |
"Eighteen pregnant women were given indomethacin during the year 1989 for treatment of premature labor (n = 16) or polyhydramnios (n = 2)." | 7.68 | [Maternal and neonatal effects of indomethacin administrated during pregnancy. Apropos of 18 cases]. ( Bavoux, F; Blot, P; Boissinot, C; Guillonneau, M; Hartmann, JF; Jacqz-Aigrain, E, 1993) |
"A case is reported in which exposure to cocaine and indomethacin was associated with development of fetal anuria, anasarca, and neonatal gastrointestinal hemorrhage." | 7.68 | Cocaine and indomethacin: fetal anuria, neonatal edema, and gastrointestinal bleeding. ( Angel, JL; Carlan, SJ; Harris, M; O'Brien, WF; Stromquist, C, 1991) |
" We took advantage of the treatment of pregnant women with indomethacin, because of premature labor or hydramnios, to investigate the role of prostaglandins in the activation of T suppressor (TS) activity." | 7.67 | The effects of indomethacin administration during pregnancy on women's and newborns' T-suppressor lymphocyte activity and on HLA class II expression by newborns' leukocytes. ( Brami, C; Durandy, A; Griscelli, C, 1985) |
"Indomethacin was administered to suppress premature uterine contractions in a twin pregnancy from the 27th until the 32nd week of pregnancy." | 7.67 | Patent ductus arteriosus after prolonged treatment with indomethacin during pregnancy: case report. ( Abramovici, H; Atad, J; Lissak, A; Rofe, A, 1987) |
"A pregnancy during which both beta-adrenergics and indomethacin were administered in order to stop preterm uterine contractions is reported." | 7.66 | Indomethacin and the fetal renal nonfunction syndrome. ( de Jong, PA; van Wijck, JA; Veersema, D, 1983) |
"Eighty pregnant women threatened with preterm labor between 24 and 34 weeks of gestation were enrolled in the study." | 6.67 | Increased incidence of bronchopulmonary dysplasia after antenatal administration of indomethacin to prevent preterm labor. ( Eronen, M; Hallman, M; Kurki, T; Pesonen, E; Teramo, K; Ylikorkala, O, 1994) |
"Indomethacin has been also used in women with short cervices as well as in those with idiopathic polyhydramnios." | 5.38 | Indomethacin in pregnancy: applications and safety. ( Abou-Ghannam, G; Nassar, AH; Usta, IM, 2012) |
"Indomethacin was discontinued beyond the 33rd week of gestational age." | 5.29 | [Has the use of indomethacin during pregnancy consequences in newborn infants? Prospective study of 83 pregnant women and 115 newborn infants]. ( Blot, P; Boissinot, C; Carbillon, L; de Gayffier, A; Germain, JF; Jacqz-Aigrain, E; Oury, JF; Sibony, O, 1994) |
"Indomethacin is a potent tocolytic agent used in premature labor." | 5.28 | Oligohydramnios induced by maternal indomethacin therapy. ( Aydin, C; Ozcan, FS; Uslu, T, 1992) |
"Among the difficulties encountered, premature labor and polyhydramnios are common." | 5.28 | Indomethacin therapy and chronic hemodialysis during pregnancy. A case report. ( Dolkart, LA; Eshwar, KP; Reimers, FT, 1992) |
"Two women with preeclampsia treated with pindolol and propranolol became profoundly hypertensive when indomethacin was added because of premature contractions." | 5.28 | Antagonism of antihypertensive drug therapy in pregnancy by indomethacin? ( Freedman, S; Hod, M; Ovadia, Y; Schoenfeld, A, 1989) |
"Indomethacin was used for tocolysis and to maintain mild oligohydraminios (amniotic fluid index 5-7 cm)." | 5.28 | Intraoperative amniocentesis and indomethacin treatment in the management of an immature pregnancy with completely dilated cervix. ( Evans, DJ; King, K; Kofinas, AD, 1992) |
"A case of polyhydramnios associated with a ring chromosome is described." | 5.27 | Polyhydramnios associated with a ring chromosome and low maternal serum alpha-fetoprotein levels managed with indomethacin. ( Cotton, DB; Kirshon, B, 1988) |
"Indomethacin purportedly arrests premature labor by inhibiting the production of prostaglandins." | 5.26 | Possible association between maternal indomethacin therapy and primary pulmonary hypertension of the newborn. ( Manchester, D; Margolis, HS; Sheldon, RE, 1976) |
"Treatment with indomethacin significantly prolonged the length of gestation (P smaller than 0-01) compared iwth control, untreated animals." | 5.25 | The effects of dexamethasone and indomethacin on the outcome of pregnancy in the rabbit. ( Challis, JR; Davies, IJ; Ryan, KJ, 1975) |
"Nifedipine may be better for delayed delivery and less likely to produce adverse pregnancy outcomes, followed by indomethacin." | 5.22 | Four kinds of tocolytic therapy for preterm delivery: Systematic review and network meta-analysis. ( Pei, S; Xiong, Z; Zhu, Z, 2022) |
"Clinical trials have demonstrated that most tocolytic agents such as beta mimetics, atosiban and indometacine -exception made for magnesium sulfate- extend the duration of pregnancy, when compared to placebo." | 4.81 | [Tocolysis: indications and contraindications. When to start and when to stop]. ( Boubli, L; Bretelle, F; D'ercole, C; Desbriere, R; Shojai, R, 2002) |
"The purpose of this study was to describe the fetal and newborn safety profile of prolonged indomethacin treatment during pregnancy." | 3.74 | The safety of prolonged indomethacin therapy. ( Anderson, BL; Savage, AH; Simhan, HN, 2007) |
"Three cases of neonatal renal insufficiency in very low birthweight (VLBW) infants following repeated antenatal administration of indomethacin to prevent premature labor are reported." | 3.69 | Renal impairment in very low birthweight infants following antenatal indomethacin administration. ( Ichijo, M; Kawaguchi, C; Nakagawa, Y; Nakajima, M; Nishikubo, T; Takahashi, Y; Yoshioka, A, 1994) |
"A case of severe fetal congestive heart failure due to occlusion of the ductus arteriosus in a mother treated with indomethacin for polyhydramnios and premature contractions is described." | 3.69 | In utero congestive heart failure due to maternal indomethacin treatment for polyhydramnios and premature labour in a fetus with antenatal closure of the foramen ovale. ( Achiron, R; Berant, M; Hegesh, J; Kidron, D; Lipitz, S; Rotstein, Z, 1996) |
"To determine the effect of indomethacin on the amniotic fluid index of individual fetuses in multiple gestations, we evaluated seven sets of twins and two sets of triplets in preterm labor (eight cases) or with polyhydramnios (one case)." | 3.69 | Effect of indomethacin on individual amniotic fluid indices in multiple gestations. ( Hill, LM; Lazebnik, N; Many, A, 1996) |
"Continuous-wave Doppler ultrasound was used to assess blood flow velocities and determine the pulsatility index of the uterine arteries in ten pregnant women at 23-33 weeks' gestation during indomethacin therapy for preterm labor or polyhydramnios." | 3.68 | Uterine blood flow velocity waveforms in pregnant women during indomethacin therapy. ( Deter, RL; Kirshon, B; Mari, G; Moise, KJ; Wasserstrum, N, 1990) |
"Indomethacin was given for the treatment of preterm labor in a twin pregnancy at a dosage of 200 mg/day for 7 days beginning at 34 weeks and 5 days' gestation." | 3.68 | Indomethacin for preterm labor: fetal toxicity in a dizygotic twin gestation. ( Ayres, NA; Hallak, M; Moise, KJ; Reiter, AA, 1991) |
"A case is reported in which exposure to cocaine and indomethacin was associated with development of fetal anuria, anasarca, and neonatal gastrointestinal hemorrhage." | 3.68 | Cocaine and indomethacin: fetal anuria, neonatal edema, and gastrointestinal bleeding. ( Angel, JL; Carlan, SJ; Harris, M; O'Brien, WF; Stromquist, C, 1991) |
"Eighteen pregnant women were given indomethacin during the year 1989 for treatment of premature labor (n = 16) or polyhydramnios (n = 2)." | 3.68 | [Maternal and neonatal effects of indomethacin administrated during pregnancy. Apropos of 18 cases]. ( Bavoux, F; Blot, P; Boissinot, C; Guillonneau, M; Hartmann, JF; Jacqz-Aigrain, E, 1993) |
"To investigate the effects of indomethacin on the human fetal renal blood flow velocity waveform, 17 fetuses whose mothers were treated for preterm labor (N = 8) or polyhydramnios (N = 9) were studied." | 3.68 | Doppler assessment of the renal blood flow velocity waveform during indomethacin therapy for preterm labor and polyhydramnios. ( Carpenter, RJ; Deter, RL; Kirshon, B; Mari, G; Moise, KJ, 1990) |
"We report oligohydramnios and renal dysgenesis in one of identical twins, which might have resulted from in utero exposure to early, prolonged high-dose indomethacin." | 3.68 | Renal dysgenesis in a monozygotic twin: association with in utero exposure to indomethacin. ( Kaplan, BS; Kaplan, P; Restaino, I; Roberts, N; Rosenberg, HK; Witzleben, C, 1991) |
" We took advantage of the treatment of pregnant women with indomethacin, because of premature labor or hydramnios, to investigate the role of prostaglandins in the activation of T suppressor (TS) activity." | 3.67 | The effects of indomethacin administration during pregnancy on women's and newborns' T-suppressor lymphocyte activity and on HLA class II expression by newborns' leukocytes. ( Brami, C; Durandy, A; Griscelli, C, 1985) |
"Indomethacin was administered to suppress premature uterine contractions in a twin pregnancy from the 27th until the 32nd week of pregnancy." | 3.67 | Patent ductus arteriosus after prolonged treatment with indomethacin during pregnancy: case report. ( Abramovici, H; Atad, J; Lissak, A; Rofe, A, 1987) |
"Six twin pregnancies complicated by hydramnios and premature labor were prospectively studied to determine whether indomethacin reduces amniotic fluid." | 3.67 | Twin with hydramnios: treating premature labor at source. ( Ash, KM; Harman, CR; Lange, IR; Manning, FA; Menticoglou, S, 1989) |
"The premature closure of the ductus arteriosus (pcDA) due to maternal tocolysis with indomethacin in the 34th week of gestation was diagnosed in a twin pregnancy." | 3.67 | [Prenatal diagnosis of premature closure of the ductus arteriosus with subsequent development of a non-immunologic hydrops fetalis]. ( Bollmann, R; Chaoui, R; Hoffmann, H; Wauer, R, 1989) |
"A pregnancy during which both beta-adrenergics and indomethacin were administered in order to stop preterm uterine contractions is reported." | 3.66 | Indomethacin and the fetal renal nonfunction syndrome. ( de Jong, PA; van Wijck, JA; Veersema, D, 1983) |
"Women in acute preterm labor with cervical dilatation 1-6 cm were randomized to receive one of three first-line tocolytic drugs." | 2.77 | Effect of antenatal tocolysis on neonatal outcomes. ( Briery, CM; Keiser, SD; Klauser, CK; Kosek, MA; Martin, RW; Morrison, JC, 2012) |
"Indomethacin was less effective than nifedipine for the fast treatment of preterm labor." | 2.76 | Comparison of the efficacy and adverse effects of nifedipine and indomethacin for the treatment of preterm labor. ( Bahasadri, S; Kashanian, M; Zolali, B, 2011) |
" There were no significant maternal or neonatal adverse events." | 2.70 | A prospective randomized safety trial of celecoxib for treatment of preterm labor. ( Bernhard, LM; Gerber, S; Gross, GA; Leguizamon, G; Levy, R; Mathur, A; Nelson, DM; Sadovsky, Y; Stika, CS, 2002) |
"Indomethacin has a significant reversible constrictive effect on the fetal ductus arteriosus that is associated with secondary changes, especially in the right ventricle." | 2.68 | Fetal cardiac function and ductus arteriosus during indomethacin and sulindac therapy for threatened preterm labor: a randomized study. ( Jouppila, P; Räsänen, J, 1995) |
"Tocolysis in advanced preterm labor delays delivery by more than 48 hours in 50% of patients." | 2.68 | Tocolysis in advanced preterm labor: impact on neonatal outcome. ( Barke, JI; de Veciana, M; Major, CA; Porto, M, 1995) |
"If recurrent preterm labor occurred despite maximization of therapy, the treatment arm was determined and therapy was changed; saline pump and oral terbutaline were switched to terbutaline pump, terbutaline pump was switched to oral terbutaline." | 2.68 | A placebo-controlled randomized trial of the terbutaline pump for prevention of preterm delivery. ( Merrill, D; Niebyl, J; Weiner, CP; Wenstrom, KD, 1997) |
"Indomethacin treatment was accompanied by maternal side effects 20% of the time, significantly less commonly (P less than ." | 2.67 | A randomized double-dummy comparison between indomethacin and nylidrin in threatened preterm labor. ( Eronen, M; Kurki, T; Lumme, R; Ylikorkala, O, 1991) |
"Nylidrin treatment was accompanied by a 35% rise in COMT activity 3 h later, whereas indomethacin caused no significant change." | 2.67 | Catechol-O-methyltransferase activity in red blood cells in threatened preterm labor; effect of indomethacin and nylidrin. ( Kurki, T; Lindén, IB; Schultz, E; Ylikorkala, O, 1991) |
"Eighty pregnant women threatened with preterm labor between 24 and 34 weeks of gestation were enrolled in the study." | 2.67 | Increased incidence of bronchopulmonary dysplasia after antenatal administration of indomethacin to prevent preterm labor. ( Eronen, M; Hallman, M; Kurki, T; Pesonen, E; Teramo, K; Ylikorkala, O, 1994) |
"Forty patients with intact membranes in preterm labor at 23 to 34 weeks' gestation were randomized to receive either intravenous ritodrine or oral indomethacin as the first-line tocolytic agent." | 2.67 | Randomized comparative trial of indomethacin and ritodrine for the long-term treatment of preterm labor. ( Besinger, RE; Johnson, TR; Keyes, WG; Niebyl, JR, 1991) |
"Indomethacin was as effective as magnesium sulfate in delaying delivery > 48 hours, 90% versus 85%, and together with oral terbutaline in extending the gestation, 22." | 2.67 | Efficacy and safety of indomethacin compared with magnesium sulfate in the management of preterm labor: a randomized study. ( Madhav, H; Morales, WJ, 1993) |
"Thirty-six women in preterm labor who had failed initial attempts at tocolysis with magnesium sulfate were randomized to receive either oral indomethacin or oral sulindac for 48 hours." | 2.67 | Randomized comparative trial of indomethacin and sulindac for the treatment of refractory preterm labor. ( Carlan, SJ; Mastrogiannis, D; O'Brien, WF; O'Leary, TD, 1992) |
" Tocolysis with indomethacin was associated with no maternal side effects, whereas tocolysis with ritodrine hydrochloride was associated with a 24% incidence of serious cardiovascular and metabolic adverse effects prompting discontinuation of the drug." | 2.66 | Efficacy and safety of indomethacin versus ritodrine in the management of preterm labor: a randomized study. ( Angel, JL; Knuppel, RA; Morales, WJ; O'Brien, WF; Smith, SG, 1989) |
" 200-300 mg of indomethacin was the total dosage in a 24 hours period." | 2.65 | Further study of the inhibition of premature labor by indomethacin. Part II double-blind study. ( Gilad, G; Katzuni, E; Shalev, E; Zuckerman, H, 1984) |
"Indomethacin was significantly more effective than placebo in inhibition of premature labor during a 24-hour course of therapy, with treatment failure during therapy occurring in only one of 15 indomethacin-treated patients compared to nine of 15 placebo-treated patients (p less than 0." | 2.65 | The inhibition of premature labor with indomethacin. ( Blake, DA; Dubin, NH; Egner, PG; Kumor, KM; Niebyl, JR; Robinson, JC; White, RD, 1980) |
" The first treatment consisted of the administration of ritodrine and a placebo; in the second, ritodrine was combined with indomethacin." | 2.64 | A study of indomethacin combined with ritodrine in threatened preterm labor. ( Cañas, E; Cararach, V; Edo, A; Gamissans, O; Puerto, B; Ribas, J, 1978) |
"The pathophysiology leading to preterm labor is not well understood and often multifactorial; initiating factors include intrauterine infection, inflammation, ischemia, overdistension, and hemorrhage." | 2.48 | Tocolytic therapy for acute preterm labor. ( Abramovici, A; Cantu, J; Jenkins, SM, 2012) |
"Although our pooled results did not identify significantly increased risks of adverse effects, the limited statistical power of published randomized trials does not allow us to exclude the possibility that indomethacin tocolysis increases the risk of adverse neonatal outcomes." | 2.43 | Assessing the neonatal safety of indomethacin tocolysis: a systematic review with meta-analysis. ( Kaunitz, AM; Loe, SM; Sanchez-Ramos, L, 2005) |
"Indomethacin is a prostaglandin synthetase inhibitor sometimes used for tocolysis." | 2.41 | The controversy surrounding indomethacin for tocolysis. ( Clothier, B; Macones, GA; Marder, SJ; Stamilio, DM, 2001) |
"In all six cases, severe hydramnios occurred during pregnancy between the 26th and 28th week after the last menstrual period." | 2.38 | [Antenatal form of Bartter's syndrome]. ( Broyer, M; Burguet, A; Dechaux, M; Deschenes, G; Garabedian, M; Guyot, C; Hubert, P; Loirat, C, 1993) |
"Polyhydramnios is an uncommon cause of premature labor and delivery." | 2.38 | Polyhydramnios: does reducing the amniotic fluid volume decrease the incidence of prematurity? ( Rodriguez, MH, 1992) |
"Effective inhibition of premature labor depends on prompt initiation of treatment." | 2.36 | Drugs for inhibition of premature labor. ( Niebyl, JR, 1979) |
"Indomethacin has been also used in women with short cervices as well as in those with idiopathic polyhydramnios." | 1.38 | Indomethacin in pregnancy: applications and safety. ( Abou-Ghannam, G; Nassar, AH; Usta, IM, 2012) |
"Indomethacin was not related to increased risk for periventricular-intraventricular hemorrhage or periventricular hemorrhagic infarction." | 1.33 | Indomethacin tocolysis and white matter injury in preterm infants. ( Flidel-Rimon, O; Friedman, S; Shinwell, ES; Steinberg, M, 2005) |
"Aggressive tocolytic therapy for preterm labor with advanced cervical dilatation is efficacious, allows for steroid therapy, and allows delivery of more mature neonates." | 1.33 | Efficacy of aggressive tocolysis for preterm labor with advanced cervical dilatation. ( Goldkrand, J; Psomiadis, N, 2005) |
"Nimesulide therapy was continued for eight days (5-16) and was associated with a prolongation of pregnancy of 27 days (6-69)." | 1.31 | Can a cyclo-oxygenase type-2 selective tocolytic agent avoid the fetal side effects of indomethacin? ( Bellini, P; Ghidini, A; Locatelli, A; Strobelt, N; Vergani, P, 2001) |
"Indomethacin tocolysis has been reported to increase the incidence of persistent PDA in premature infants." | 1.30 | Indomethacin tocolysis increases postnatal patent ductus arteriosus severity. ( Eidelman, AI; Ferber, B; Glaser, J; Hammerman, C; Kaplan, M; Schimmel, MS, 1998) |
"Since toxic epidermal necrolysis is a potentially fatal disease, awareness of a possible association is warranted." | 1.30 | Toxic epidermal necrolysis associated with treatment for preterm labor. ( Claessens, N; Delbeke, L; Lafaire, C; Lambert, J; Matthieu, L; Van Marck, E, 1998) |
"Another therapy involves the treatment for premature labor, which is the most common cause of pregnancy loss in dialysis patients." | 1.29 | Pregnancy in women with end-stage renal disease: treatment of anemia and premature labor. ( Ambrose, S; Hou, S; Hussey, M; Orlowski, J; Pahl, M; Wong, D, 1993) |
"Drug-induced immune system mediated agranulocytosis is a rare but potentially life-threatening condition." | 1.29 | Effective treatment of drug-induced agranulocytosis using recombinant human granulocyte colony stimulating factor in pregnancy. ( Fujiwaki, R; Furuya, H; Hata, K; Hata, T; Katoh, Y; Kitao, M, 1995) |
"Indomethacin is a non steroidal anti-inflammatory agent widely employed in the treatment of premature contractions." | 1.29 | Good fetal outcome following prolonged indomethacin induced anhydramnios. Case report. ( Aboulafia, Y; Diamant, YZ; Lavie, O; Rabinowitz, R; Shen, O, 1995) |
"Delayed birth intervals of triplets in preterm labor should be considered to improve perinatal salvage of immature triplets, although a successful outcome is rare and unexpected." | 1.29 | Delayed birth intervals of immature fraternal triplets in preterm labor. A case report. ( Daikoku, NH; Frattarrola, IG; Gopal, JJ; Graham, D; Rock, JA, 1993) |
"Three cases of acute renal insufficiency in pregnant women who were treated with indomethacin for premature labor are reported." | 1.29 | Acute maternal renal insufficiency in premature labor treated with indomethacin. ( Boyd, EL; Nageotte, MP; Powers, DR; Steiger, RM; Towers, CV, 1993) |
"Indomethacin was discontinued beyond the 33rd week of gestational age." | 1.29 | [Has the use of indomethacin during pregnancy consequences in newborn infants? Prospective study of 83 pregnant women and 115 newborn infants]. ( Blot, P; Boissinot, C; Carbillon, L; de Gayffier, A; Germain, JF; Jacqz-Aigrain, E; Oury, JF; Sibony, O, 1994) |
"Trivial tricuspid valve regurgitation was detected at a mean of 26." | 1.29 | Fetal echocardiography during indomethacin treatment. ( Huhta, JC; Respondek, M; Weil, SR, 1995) |
"No such convulsion has been described to date in pregnancy." | 1.29 | Indomethacin-induced maternal convulsion in the treatment of preterm labour. ( DeChazal, R; Halligan, A; Nan, A; Taylor, D, 1993) |
"Oral indomethacin treatment for tocolysis has no impact on PT and aPTT; however, profound acute changes in maternal bleeding time occur." | 1.29 | The effect of indomethacin tocolysis on maternal coagulation status. ( Barth, WH; Hankins, GD; Lunt, CC; Satin, AJ, 1994) |
"9 percent, P = 0." | 1.29 | Neonatal complications after the administration of indomethacin for preterm labor. ( Clyman, RI; Cooper, BA; Kuller, JA; Merrill, J; Norton, ME, 1993) |
"Indomethacin was given as part of tocolytic management to mothers with a high incidence of early rupture of membranes and preterm labour; and 76 fetuses were exposed to the drug as a result." | 1.28 | Cerebral lesions in preterm infants after tocolytic indomethacin. ( Baerts, W; Fetter, WP; Hop, WC; Sauer, PJ; Spritzer, R; Wallenburg, HC, 1990) |
"Indomethacin was utilized in 24 pregnancies (31 exposed fetuses) in preterm labor who labored despite intravenous tocolysis." | 1.28 | Safety and efficacy of long-term tocolysis with indomethacin. ( Abbasi, S; Ashmead, G; Bolognese, R; Gerson, A; Johnson, A; Kalchbrenner, M, 1990) |
"Thirty-three women in preterm labor between 25 and 34 weeks of gestation were studied before, during, and after treatment with indomethacin (n = 16) or nylidrin (n = 17)." | 1.28 | Urinary excretion of prostacyclin and thromboxane metabolites in threatened preterm labor: effect of indomethacin and nylidrin. ( Kurki, T; Viinikka, L; Ylikorkala, O, 1992) |
"Indomethacin is a potent tocolytic agent used in premature labor." | 1.28 | Oligohydramnios induced by maternal indomethacin therapy. ( Aydin, C; Ozcan, FS; Uslu, T, 1992) |
"Among the difficulties encountered, premature labor and polyhydramnios are common." | 1.28 | Indomethacin therapy and chronic hemodialysis during pregnancy. A case report. ( Dolkart, LA; Eshwar, KP; Reimers, FT, 1992) |
"Indomethacin was used for tocolysis and to maintain mild oligohydraminios (amniotic fluid index 5-7 cm)." | 1.28 | Intraoperative amniocentesis and indomethacin treatment in the management of an immature pregnancy with completely dilated cervix. ( Evans, DJ; King, K; Kofinas, AD, 1992) |
"Two women with preeclampsia treated with pindolol and propranolol became profoundly hypertensive when indomethacin was added because of premature contractions." | 1.28 | Antagonism of antihypertensive drug therapy in pregnancy by indomethacin? ( Freedman, S; Hod, M; Ovadia, Y; Schoenfeld, A, 1989) |
"A case of hydrops fetalis with intra-uterine death after premature closure of the ductus arteriosus because of inhibition of premature labour by the administration of indomethacin is presented." | 1.27 | Premature closure of the ductus arteriosus causing intra-uterine death. A case report. ( Coetzee, MJ; Franszen, S; Truter, PJ; van der Merwe, JV, 1986) |
"A case of polyhydramnios associated with a ring chromosome is described." | 1.27 | Polyhydramnios associated with a ring chromosome and low maternal serum alpha-fetoprotein levels managed with indomethacin. ( Cotton, DB; Kirshon, B, 1988) |
"The delay of premature labor for 2 to 7 days allowed the administration of betamethasone in an attempt to improve fetal lung maturity." | 1.27 | Further study of the inhibition of premature labor by indomethacin. Part I. ( Gilad, G; Katzuni, E; Shalev, E; Zuckerman, H, 1984) |
"A total of 43 procedures was performed." | 1.27 | Fetal surgery in the primate II. Uterine electromyographic response to operative procedures and pharmacologic agents. ( Harrison, MR; Nakayama, DK; Seron-Ferre, M; Villa, RL, 1984) |
"Appropriate management of preterm labor mandates early recognition of subtle signs and symptoms; successful therapy is dependent on this issue." | 1.27 | Preterm labor: its diagnosis and management. ( Creasy, RK; Gonik, B, 1986) |
" The dosage regimen was 25 mg every four hours in four patients and 25 mg every six hours in the other four patients." | 1.27 | Influence of short-term indomethacin therapy on fetal urine output. ( Huhta, JC; Kirshon, B; Moise, KJ; Ou, CN; Wasserstrum, N, 1988) |
"Indomethacin is a potent agent in the treatment of premature labor, but its use has been limited because of concern about its constrictive effects on the fetal ductus arteriosus." | 1.27 | Indomethacin in the treatment of premature labor. Effects on the fetal ductus arteriosus. ( Cano, L; Huhta, JC; Kirshon, B; Moise, KJ; Ou, CN; Sharif, DS; Wasserstrum, N, 1988) |
"Indomethacin has been tested, in addition to betasympathicomimetic therapy, in cases with an insufficient inhibition of premature labour." | 1.27 | Inhibition of premature labour with indomethacin. ( Halle, H, 1987) |
"Issues of the pharmacologic therapy of preterm labor, enhancement of lung maturity, and management of labor and delivery are discussed." | 1.27 | Obstetric management of the very low birth weight fetus. ( Hayashi, RH; Marshall, CL, 1986) |
"Indomethacin was administered from the 20th to the 34th week of gestation to 51 women (59 fetuses) in whom bed rest and a beta-mimetic compound (ritodrine) had failed to stop preterm labor." | 1.26 | Perinatal hazards of chronic antenatal tocolysis with indomethacin. ( Baele, G; Derom, R; Thiery, M; Van Egmond, H; Van Kets, H, 1979) |
"Indomethacin purportedly arrests premature labor by inhibiting the production of prostaglandins." | 1.26 | Possible association between maternal indomethacin therapy and primary pulmonary hypertension of the newborn. ( Manchester, D; Margolis, HS; Sheldon, RE, 1976) |
"3) Analysis of 263 cases of threatened premature labor treated in our department in the past 5 years demonstrated that there are 2 phases of contraction during premature labor." | 1.26 | The treatment of threatened premature labor by drugs. ( Chimura, T, 1980) |
"Indomethacin has been most effective but not free of significant complications." | 1.26 | Premature onset of labor, neonatal patent ductus arteriosus, and prostaglandin synthetase antagonists--a rat model of a human problem. ( Altmiller, DH; Altshuler, G; Krous, HF; Sharpe, GL, 1979) |
"Indomethacin treatment was effective in all the 68 patients." | 1.26 | Classification of threatened premature labor related to treatment with a prostaglandin inhibitor: indomethacin. ( Abramovici, H; Atad, J; David, A; Moise, J, 1980) |
"Treatment with indomethacin significantly prolonged the length of gestation (P smaller than 0-01) compared iwth control, untreated animals." | 1.25 | The effects of dexamethasone and indomethacin on the outcome of pregnancy in the rabbit. ( Challis, JR; Davies, IJ; Ryan, KJ, 1975) |
"Prevention of premature labor is of considerable interest in research and clinics." | 1.25 | The treatment of threatened premature labor by tocolytics, Ca++-Antagonists and anti-inflammatory drugs. ( Mosler, KH, 1975) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 90 (40.54) | 18.7374 |
1990's | 77 (34.68) | 18.2507 |
2000's | 32 (14.41) | 29.6817 |
2010's | 19 (8.56) | 24.3611 |
2020's | 4 (1.80) | 2.80 |
Authors | Studies |
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Xiong, Z | 1 |
Pei, S | 1 |
Zhu, Z | 1 |
Premkumar, A | 1 |
Sinha, N | 1 |
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Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Vaginal Indomethacin Versus Oral Nifedipine for Preterm Labor; a Randomized Controlled Trial[NCT04404686] | Phase 2/Phase 3 | 300 participants (Anticipated) | Interventional | 2020-10-31 | Not yet recruiting | ||
Comparison of the Efficacy of Emergency Double-level and Single Cervical Cerclage in Cervical Insufficiency in the Second Trimester of Pregnancy - Multicenter Prospective Randomized Trial[NCT05268640] | 78 participants (Anticipated) | Interventional | 2022-03-11 | Recruiting | |||
Role in Emergent Cerclage of Indomethacin and Antibiotics[NCT01114516] | 53 participants (Actual) | Interventional | 2010-03-31 | Completed | |||
Prevention of Preterm Delivery With Vaginal Progesterone in Women With Preterm Labor[NCT00536003] | Phase 3 | 384 participants (Actual) | Interventional | 2006-07-31 | Terminated | ||
Vaginal Progesterone Supplementation in the Management of Preterm Labor: A Randomized, Double Blind, Controlled Trial[NCT03202836] | 90 participants (Actual) | Interventional | 2017-06-29 | Completed | |||
Randomized, Placebo Controlled Trial of Indomethacin for Tocolysis[NCT01869361] | Early Phase 1 | 0 participants (Actual) | Interventional | 2020-08-01 | Withdrawn (stopped due to Due to much lower than expected numbers of eligible patients and lack of PI time, the study was not started.) | ||
Aspirin Supplementation for Pregnancy Indicated Risk Reduction In Nulliparas (ASPIRIN)[NCT02409680] | 11,976 participants (Actual) | Interventional | 2016-03-23 | Completed | |||
Randomized Double-Blinded Trial of Magnesium Sulfate Tocolysis Versus Nifedipine Tocolysis in Women With Preterm Labor Between 24 to 32 6/7 Weeks' Gestation[NCT00306462] | 33 participants (Actual) | Interventional | 2006-03-31 | Terminated (stopped due to No enrollment in past year, lack of interest) | |||
Effect of Non-steroidal Anti-inflammatory Use on Blood Pressure in Women With Hypertensive Disorders of Pregnancy: A Randomized Open Label Trial[NCT03824119] | Phase 4 | 200 participants (Anticipated) | Interventional | 2018-12-11 | Recruiting | ||
Liberal Versus Restrictive Platelet Transfusion for Treatment of Hemodynamically Significant Patent Ductus Arteriosus in Thrombocytopenic Preterm Neonates- A Randomized Open Label, Controlled Trial[NCT03022253] | Phase 3 | 44 participants (Anticipated) | Interventional | 2016-03-31 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Median birthweight (NCT01114516)
Timeframe: 24 weeks
Intervention | grams (Median) |
---|---|
Control | 2488 |
Indomethacin and Antibiotics | 2850 |
Median gestational age at delivery (NCT01114516)
Timeframe: 24 weeks
Intervention | weeks (Median) |
---|---|
Control | 31.1 |
Indomethacin and Antibiotics | 34.8 |
Median gestational latency achieved Between Cerclage Placement and Time of Delivery (NCT01114516)
Timeframe: 24 weeks
Intervention | days (Median) |
---|---|
Control | 80 |
Indomethacin and Antibiotics | 97 |
The frequency of achieving a gestational latency of more than 28 days (NCT01114516)
Timeframe: 28 days postpartum
Intervention | percentage of participants (Number) |
---|---|
Control | 62.5 |
Indomethacin and Antibiotics | 92.3 |
Days spent in the neonatal intensive care unit (NCT01114516)
Timeframe: 1 year
Intervention | days (Median) |
---|---|
Control | 95 |
Indomethacin and Antibiotics | 43 |
- Early preterm delivery (<34 weeks) (NCT02409680)
Timeframe: At delivery
Intervention | Participants (Count of Participants) |
---|---|
Intervention Arm | 189 |
Placebo Arm | 230 |
- Birth weight <2500g (NCT02409680)
Timeframe: At delivery
Intervention | Participants (Count of Participants) |
---|---|
Intervention Arm | 1078 |
Placebo Arm | 1153 |
- Birth weight <1500g (NCT02409680)
Timeframe: At delivery
Intervention | Participants (Count of Participants) |
---|---|
Intervention Arm | 78 |
Placebo Arm | 101 |
- Incidence of Fetal Loss (NCT02409680)
Timeframe: At delivery
Intervention | Participants (Count of Participants) |
---|---|
Intervention Arm | 303 |
Placebo Arm | 353 |
- Incidence of Spontaneous Abortion (NCT02409680)
Timeframe: At delivery
Intervention | Participants (Count of Participants) |
---|---|
Intervention Arm | 134 |
Placebo Arm | 152 |
- Incidence of All stillbirth (NCT02409680)
Timeframe: At delivery
Intervention | Participants (Count of Participants) |
---|---|
Intervention Arm | 141 |
Placebo Arm | 166 |
- Incidence of Medical Termination of Pregnancy (NCT02409680)
Timeframe: At delivery
Intervention | Participants (Count of Participants) |
---|---|
Intervention Arm | 42 |
Placebo Arm | 30 |
- Hypertensive disorders of pregnancy is defined by the characterization of evidence of a hypertensive disorder, including either preeclampsia or eclampsia occurring during the pregnancy. (NCT02409680)
Timeframe: Evidence of hypertensive disorder during the pregnancy (prior to delivery/birth)
Intervention | Participants (Count of Participants) |
---|---|
Intervention Arm | 352 |
Placebo Arm | 325 |
- Incidence of Perinatal Mortality (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
Intervention | Participants (Count of Participants) |
---|---|
Intervention Arm | 264 |
Placebo Arm | 309 |
The primary outcome of this study is incidence of preterm birth, which will be defined as delivery at or after 20 0/7 weeks and prior to 37 0/7 weeks. This will be determined based on actual date of delivery in comparison to the projected estimated due date (EDD), independent of whether or not the preterm delivery is indicated or spontaneous. (NCT02409680)
Timeframe: At delivery
Intervention | Participants (Count of Participants) |
---|---|
Intervention Arm | 668 |
Placebo Arm | 754 |
- Small for gestational age (SGA) as defined by the INTERGROWTH-21st standard (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
Intervention | Participants (Count of Participants) |
---|---|
Intervention Arm | 1506 |
Placebo Arm | 1564 |
- Vaginal bleeding (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
Intervention | Participants (Count of Participants) |
---|---|
Intervention Arm | 214 |
Placebo Arm | 246 |
- Antepartum hemorrhage (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
Intervention | Participants (Count of Participants) |
---|---|
Intervention Arm | 26 |
Placebo Arm | 25 |
- Postpartum hemorrhage (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
Intervention | Participants (Count of Participants) |
---|---|
Intervention Arm | 54 |
Placebo Arm | 43 |
- Incidence of Maternal Mortality (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
Intervention | Participants (Count of Participants) |
---|---|
Intervention Arm | 9 |
Placebo Arm | 12 |
- Incidence of Late Abortion (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
Intervention | Participants (Count of Participants) |
---|---|
Intervention Arm | 23 |
Placebo Arm | 30 |
Hemoglobin < 7.0 gm/dl at 26-30 weeks gestation or a drop of 3.5+ gm/dl from screening to 26-30 weeks gestation (NCT02409680)
Timeframe: At enrollment, 4 weeks post enrollment, and 26-30 weeks GA.
Intervention | Participants (Count of Participants) |
---|---|
Intervention Arm | 290 |
Placebo Arm | 333 |
Early preterm delivery (<34 weeks) and hypertensive disorders (i.e.: preeclampsia) (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
Intervention | Participants (Count of Participants) |
---|---|
Intervention Arm | 8 |
Placebo Arm | 21 |
32 reviews available for indomethacin and Labor, Premature
Article | Year |
---|---|
Four kinds of tocolytic therapy for preterm delivery: Systematic review and network meta-analysis.
Topics: Female; Humans; Indomethacin; Infant; Infant, Newborn; Network Meta-Analysis; Nifedipine; Obstetric | 2022 |
Tocolysis for open prenatal repair of myelomeningocele: systematic review.
Topics: Female; Fetoscopy; Gestational Age; Humans; Indomethacin; Meningomyelocele; Obstetric Labor, Prematu | 2020 |
A short cervical length in pregnancy: management options.
Topics: Cerclage, Cervical; Cervix Uteri; Cohort Studies; Combined Modality Therapy; Female; Humans; Indomet | 2009 |
Tocolytic therapy for acute preterm labor.
Topics: Calcium Channel Blockers; Drug Administration Schedule; Female; Gestational Age; Humans; Indomethaci | 2012 |
Tocolytic therapy for acute preterm labor.
Topics: Calcium Channel Blockers; Drug Administration Schedule; Female; Gestational Age; Humans; Indomethaci | 2012 |
Tocolytic therapy for acute preterm labor.
Topics: Calcium Channel Blockers; Drug Administration Schedule; Female; Gestational Age; Humans; Indomethaci | 2012 |
Tocolytic therapy for acute preterm labor.
Topics: Calcium Channel Blockers; Drug Administration Schedule; Female; Gestational Age; Humans; Indomethaci | 2012 |
Oral betamimetics for maintenance therapy after threatened preterm labour.
Topics: Administration, Oral; Adrenergic beta-2 Receptor Agonists; Female; Humans; Indomethacin; Magnesium C | 2012 |
[Tocolysis: indications and contraindications. When to start and when to stop].
Topics: Clinical Trials as Topic; Contraindications; Female; France; Gestational Age; Humans; Indomethacin; | 2002 |
Prostaglandin inhibitors in preterm labour.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cervix Uteri; Cyclooxygenase 2; Ductus Arteriosus; Enzyme I | 2003 |
Assessing the neonatal safety of indomethacin tocolysis: a systematic review with meta-analysis.
Topics: Adult; Confidence Intervals; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; | 2005 |
Assessing the neonatal safety of indomethacin tocolysis: a systematic review with meta-analysis.
Topics: Adult; Confidence Intervals; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; | 2005 |
Assessing the neonatal safety of indomethacin tocolysis: a systematic review with meta-analysis.
Topics: Adult; Confidence Intervals; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; | 2005 |
Assessing the neonatal safety of indomethacin tocolysis: a systematic review with meta-analysis.
Topics: Adult; Confidence Intervals; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; | 2005 |
Antiprostaglandin drugs.
Topics: Cyclooxygenase Inhibitors; Female; Fetal Monitoring; Humans; Indomethacin; Obstetric Labor, Prematur | 2005 |
Oral betamimetics for maintenance therapy after threatened preterm labour.
Topics: Administration, Oral; Adrenergic beta-Agonists; Female; Humans; Indomethacin; Obstetric Labor, Prema | 2006 |
Preterm labour. The present and future of tocolysis.
Topics: Adrenergic beta-Agonists; Female; Humans; Indomethacin; Magnesium Sulfate; Nifedipine; Obstetric Lab | 2007 |
Prevention of premature birth.
Topics: Adrenergic beta-Agonists; Calcium; Chemical Phenomena; Chemistry; Cyclooxygenase Inhibitors; Depress | 1980 |
Preterm parturition. Prostaglandin synthetase inhibitors.
Topics: Amniotic Fluid; Animals; Aspirin; Cyclooxygenase Inhibitors; Ductus Arteriosus; Ductus Arteriosus, P | 1981 |
Prostaglandin synthetase inhibitors in pregnancy.
Topics: Animals; Contraindications; Cyclooxygenase Inhibitors; Female; Fetal Diseases; Forecasting; Humans; | 1993 |
[Antenatal form of Bartter's syndrome].
Topics: Aldosterone; Bartter Syndrome; Calcium; Female; Fetal Diseases; Gestational Age; Humans; Indomethaci | 1993 |
Indomethacin.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Female; Humans; Indomethacin; Obs | 1995 |
Risks and complications of tocolysis.
Topics: Calcium Channel Blockers; Drug Therapy, Combination; Female; Fetus; Humans; Indomethacin; Magnesium | 1995 |
[Prematurity: current role of prostaglandin synthesis inhibitors].
Topics: Cyclooxygenase Inhibitors; Female; Humans; Indomethacin; Obstetric Labor, Premature; Pregnancy; Preg | 1998 |
The great tocolytic debate: some pitfalls in the study of safety.
Topics: Cerebral Hemorrhage; Female; Humans; Indomethacin; MEDLINE; Obstetric Labor, Premature; Pregnancy; R | 2001 |
The controversy surrounding indomethacin for tocolysis.
Topics: Adult; Clinical Trials as Topic; Female; Humans; Indomethacin; Infant, Newborn; Obstetric Labor, Pre | 2001 |
Prostaglandin inhibitors as tocolytic agents.
Topics: Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Female; | 2001 |
Tocolysis: an update for the practitioner.
Topics: Adrenergic beta-Agonists; Algorithms; Calcium Channel Blockers; Cyclooxygenase 1; Cyclooxygenase 2; | 2002 |
Drugs for inhibition of premature labor.
Topics: Adrenergic beta-Agonists; Animals; Ethanol; Female; Humans; Indomethacin; Labor, Obstetric; Magnesiu | 1979 |
[Clinical pharmacology in obstetrics: regulation of the uterus].
Topics: Adrenergic beta-Agonists; Aspirin; Ergotamine; Female; Humans; Indomethacin; Methylergonovine; Obste | 1975 |
On the use of blockers of prostaglandin synthesis in the control of labor.
Topics: Animals; Aspirin; Clinical Trials as Topic; Female; Fetal Death; Fetus; Hemodynamics; Humans; Indome | 1978 |
[Fetal toxicity of non-steroidal anti-inflammatory agents].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Fetal Diseases; Heart Failure; Humans; Indomethacin | 1992 |
Polyhydramnios: does reducing the amniotic fluid volume decrease the incidence of prematurity?
Topics: Amniocentesis; Clinical Trials as Topic; Combined Modality Therapy; Female; Humans; Incidence; Indom | 1992 |
Maternal, fetal, and neonatal physiology in pregnancy.
Topics: Clinical Trials as Topic; Ductus Arteriosus, Patent; Female; Humans; Indomethacin; Obstetric Labor, | 1990 |
[Indomethacin and a tocolytic agent: fetal and neonatal outcome].
Topics: Female; Humans; Indomethacin; Infant, Newborn; Male; Obstetric Labor, Premature; Pregnancy; Prenatal | 1990 |
Arachidonic acid derivatives in the perinatal period.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Female; Heart Defects, Congenital; Humans; Indomethaci | 1989 |
Prostaglandins and leukotrienes in the perinatal period.
Topics: Ductus Arteriosus; Female; Heart Defects, Congenital; Humans; Indomethacin; Infant, Newborn; Leukotr | 1987 |
[At what point is premature labor to be arrested?].
Topics: Adrenergic beta-Agonists; Female; Humans; Indomethacin; Magnesium Sulfate; Obstetric Labor, Prematur | 1987 |
35 trials available for indomethacin and Labor, Premature
Article | Year |
---|---|
A comparative study on the efficacy of nifedipine and indomethacin for prevention of preterm birth as monotherapy and combination therapy: a randomized clinical trial.
Topics: Female; Humans; Indomethacin; Infant; Infant, Newborn; Nifedipine; Obstetric Labor, Premature; Pregn | 2020 |
A comparison of three tocolytics for preterm labor: a randomized clinical trial.
Topics: Adolescent; Adult; Drug Administration Routes; Female; Gestational Age; Humans; Indomethacin; Magnes | 2014 |
Indomethacin and antibiotics in examination-indicated cerclage: a randomized controlled trial.
Topics: Adult; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antibiotic Prophylaxis; Cefaz | 2014 |
Indomethacin and antibiotics in examination-indicated cerclage: a randomized controlled trial.
Topics: Adult; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antibiotic Prophylaxis; Cefaz | 2014 |
Indomethacin and antibiotics in examination-indicated cerclage: a randomized controlled trial.
Topics: Adult; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antibiotic Prophylaxis; Cefaz | 2014 |
Indomethacin and antibiotics in examination-indicated cerclage: a randomized controlled trial.
Topics: Adult; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antibiotic Prophylaxis; Cefaz | 2014 |
Prevention of preterm delivery with vaginal progesterone in women with preterm labour (4P): randomised double-blind placebo-controlled trial.
Topics: Administration, Intravaginal; Adult; Apgar Score; Birth Weight; Double-Blind Method; Female; Humans; | 2015 |
Prevention of preterm delivery with vaginal progesterone in women with preterm labour (4P): randomised double-blind placebo-controlled trial.
Topics: Administration, Intravaginal; Adult; Apgar Score; Birth Weight; Double-Blind Method; Female; Humans; | 2015 |
Prevention of preterm delivery with vaginal progesterone in women with preterm labour (4P): randomised double-blind placebo-controlled trial.
Topics: Administration, Intravaginal; Adult; Apgar Score; Birth Weight; Double-Blind Method; Female; Humans; | 2015 |
Prevention of preterm delivery with vaginal progesterone in women with preterm labour (4P): randomised double-blind placebo-controlled trial.
Topics: Administration, Intravaginal; Adult; Apgar Score; Birth Weight; Double-Blind Method; Female; Humans; | 2015 |
Tocolysis in women with advanced preterm labor: a secondary analysis of a randomized clinical trial.
Topics: Administration, Intravenous; Administration, Oral; Administration, Rectal; Adolescent; Adult; Female | 2016 |
Comparison of the efficacy and adverse effects of nifedipine and indomethacin for the treatment of preterm labor.
Topics: Adult; Drug Administration Schedule; Female; Humans; Indomethacin; Nifedipine; Obstetric Labor, Prem | 2011 |
Effect of antenatal tocolysis on neonatal outcomes.
Topics: Female; Gestational Age; Humans; Indomethacin; Infant, Newborn; Infant, Newborn, Diseases; Magnesium | 2012 |
A prospective randomized safety trial of celecoxib for treatment of preterm labor.
Topics: Adolescent; Adult; Celecoxib; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Humans; Indome | 2002 |
A double-blind randomized study of fetal side effects during and after the short-term maternal administration of indomethacin, sulindac, and nimesulide for the treatment of preterm labor.
Topics: Adult; Amniotic Fluid; Diuresis; Double-Blind Method; Drug Administration Schedule; Ductus Arteriosu | 2003 |
The effect of short-term indomethacin therapy on amniotic fluid volume.
Topics: Amniotic Fluid; Drug Administration Schedule; Female; Humans; Incidence; Indomethacin; Obstetric Lab | 2005 |
Further study of the inhibition of premature labor by indomethacin. Part II double-blind study.
Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Female; Gestational Age; Humans; Indomethacin; | 1984 |
Further study of the inhibition of premature labor by indomethacin. Part II double-blind study.
Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Female; Gestational Age; Humans; Indomethacin; | 1984 |
Further study of the inhibition of premature labor by indomethacin. Part II double-blind study.
Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Female; Gestational Age; Humans; Indomethacin; | 1984 |
Further study of the inhibition of premature labor by indomethacin. Part II double-blind study.
Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Female; Gestational Age; Humans; Indomethacin; | 1984 |
Treatment of premature labor with indomethacin.
Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Indomethacin; Infant, Newborn; | 1980 |
The inhibition of premature labor with indomethacin.
Topics: Dinoprost; Double-Blind Method; Drug Evaluation; Estradiol; Female; Fetal Blood; Fetal Death; Humans | 1980 |
The inhibition of premature labor with indomethacin.
Topics: Dinoprost; Double-Blind Method; Drug Evaluation; Estradiol; Female; Fetal Blood; Fetal Death; Humans | 1980 |
The inhibition of premature labor with indomethacin.
Topics: Dinoprost; Double-Blind Method; Drug Evaluation; Estradiol; Female; Fetal Blood; Fetal Death; Humans | 1980 |
The inhibition of premature labor with indomethacin.
Topics: Dinoprost; Double-Blind Method; Drug Evaluation; Estradiol; Female; Fetal Blood; Fetal Death; Humans | 1980 |
Tocolysis in advanced preterm labor: impact on neonatal outcome.
Topics: Cohort Studies; Female; Humans; Indomethacin; Infant, Newborn; Infant, Premature, Diseases; Magnesiu | 1995 |
A comparison of magnesium sulfate and indomethacin to magnesium sulfate only for tocolysis in preterm labor with advanced cervical dilation.
Topics: Adult; Cervix Uteri; Dilatation, Pathologic; Drug Therapy, Combination; Female; Humans; Indomethacin | 1995 |
Fetal cardiac function and ductus arteriosus during indomethacin and sulindac therapy for threatened preterm labor: a randomized study.
Topics: Ductus Arteriosus; Echocardiography; Female; Fetal Heart; Humans; Indomethacin; Obstetric Labor, Pre | 1995 |
Increased incidence of bronchopulmonary dysplasia after antenatal administration of indomethacin to prevent preterm labor.
Topics: Adult; Bronchopulmonary Dysplasia; Female; Humans; Indomethacin; Infant, Newborn; Infant, Premature; | 1994 |
Randomized trial of oral indomethacin and terbutaline sulfate for the long-term suppression of preterm labor.
Topics: Adult; Chi-Square Distribution; Ductus Arteriosus; Female; Humans; Indomethacin; Obstetric Labor, Pr | 1993 |
Efficacy and safety of indomethacin compared with magnesium sulfate in the management of preterm labor: a randomized study.
Topics: Adult; Female; Humans; Indomethacin; Magnesium Sulfate; Obstetric Labor, Premature; Pregnancy; Prosp | 1993 |
A placebo-controlled randomized trial of the terbutaline pump for prevention of preterm delivery.
Topics: Administration, Oral; Adrenergic beta-Agonists; Adult; Cervix Uteri; Drug Combinations; Female; Gest | 1997 |
The effect of indomethacin tocolysis in preterm labour on perinatal outcome: a randomised placebo-controlled trial.
Topics: Adult; Double-Blind Method; Female; Gestational Age; Humans; Indomethacin; Infant Mortality; Infant, | 1999 |
Indomethacin for preterm labor: a randomized comparison of vaginal and rectal-oral routes.
Topics: Administration, Intravaginal; Administration, Oral; Administration, Rectal; Adult; Female; Humans; I | 2000 |
Indomethacin and corticosteroids: an additive constrictive effect on the fetal ductus arteriosus.
Topics: Adrenal Cortex Hormones; Analysis of Variance; Blood Flow Velocity; Child, Preschool; Constriction, | 1999 |
[Additional tocolysis via inhibition of prostaglandin synthetase with indometacin (author's transl)].
Topics: Clinical Trials as Topic; Cyclooxygenase Inhibitors; Drug Evaluation; Female; Humans; Indomethacin; | 1978 |
On the use of blockers of prostaglandin synthesis in the control of labor.
Topics: Animals; Aspirin; Clinical Trials as Topic; Female; Fetal Death; Fetus; Hemodynamics; Humans; Indome | 1978 |
Premature labor and indomethacin.
Topics: Apgar Score; Clinical Trials as Topic; Drug Evaluation; Estriol; Female; Humans; Indomethacin; Infan | 1978 |
A study of indomethacin combined with ritodrine in threatened preterm labor.
Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Female; Fetal Death | 1978 |
Randomized comparative trial of indomethacin and sulindac for the treatment of refractory preterm labor.
Topics: Adult; Female; Humans; Indomethacin; Obstetric Labor, Premature; Pregnancy; Sulindac; Tocolytic Agen | 1992 |
Combination antibiotics and indomethacin in idiopathic preterm labor: a randomized double-blind clinical trial.
Topics: Ampicillin; Bacterial Infections; Double-Blind Method; Drug Therapy, Combination; Female; Humans; In | 1991 |
Catechol-O-methyltransferase activity in red blood cells in threatened preterm labor; effect of indomethacin and nylidrin.
Topics: Adult; Catechol O-Methyltransferase; Double-Blind Method; Erythrocytes; Female; Humans; Indomethacin | 1991 |
A randomized double-dummy comparison between indomethacin and nylidrin in threatened preterm labor.
Topics: Adult; Double-Blind Method; Female; Humans; Indomethacin; Nylidrin; Obstetric Labor, Premature; Preg | 1991 |
The effects of indomethacin and a beta-sympathomimetic agent on the fetal ductus arteriosus during treatment of premature labor: a randomized double-blind study.
Topics: Blood Flow Velocity; Cardiac Output, Low; Delivery, Obstetric; Double-Blind Method; Ductus Arteriosu | 1991 |
Randomized comparative trial of indomethacin and ritodrine for the long-term treatment of preterm labor.
Topics: Amniotic Fluid; Diseases in Twins; Female; Fetal Diseases; Humans; Hypertension, Pulmonary; Indometh | 1991 |
Efficacy and safety of indomethacin versus ritodrine in the management of preterm labor: a randomized study.
Topics: Adult; Amniotic Fluid; Female; Humans; Indomethacin; Infant Mortality; Infant, Newborn; Obstetric La | 1989 |
Inhibition of arachidonic acid metabolism in the perinatal period: pharmacology, clinical application, and potential adverse effects.
Topics: Administration, Oral; Arachidonic Acid; Arachidonic Acids; Aspirin; Clinical Trials as Topic; Cycloo | 1986 |
156 other studies available for indomethacin and Labor, Premature
Article | Year |
---|---|
Perioperative Use of Cefazolin and Indomethacin for Physical Examination-Indicated Cerclages to Improve Gestational Latency.
Topics: Adult; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antibiotic Prophylaxis; Cefaz | 2020 |
Effect of betamethasone, indomethacin and fenoterol on neonatal and maternal mononuclear cells stimulated with Escherichia coli.
Topics: Adult; Anti-Inflammatory Agents; Betamethasone; Cytokines; Escherichia coli; Female; Fenoterol; Huma | 2019 |
Indomethacin and antibiotics in examination-indicated cerclage: a randomized controlled trial.
Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Cefazolin; Cerclage, Cervical; Femal | 2014 |
In Reply: Dr. Burwick.
Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Cefazolin; Cerclage, Cervical; Femal | 2014 |
Uterus-targeted liposomes for preterm labor management: studies in pregnant mice.
Topics: Animals; Disease Models, Animal; Drug Compounding; Female; Gene Expression; Hormone Antagonists; Hum | 2016 |
Outcomes With Cerclage Alone Compared With Cerclage Plus 17α-Hydroxyprogesterone Caproate.
Topics: 17 alpha-Hydroxyprogesterone Caproate; Adult; Cerclage, Cervical; Cohort Studies; Female; Humans; Hy | 2016 |
Successful management of intraoperative haemorrhage during emergency cervical cerclage using balloon tamponade.
Topics: Adult; Balloon Occlusion; Blood Loss, Surgical; Cerclage, Cervical; Extraembryonic Membranes; Female | 2017 |
Pregnancy outcome after placement of 'rescue' Shirodkar cerclage.
Topics: Adolescent; Adult; Bed Rest; Cerclage, Cervical; Cohort Studies; Combined Modality Therapy; Female; | 2009 |
Indomethacin as a diagnostic and therapeutic tool in the management of progressive cervical shortening diagnosed by trans-vaginal sonography.
Topics: Cerclage, Cervical; Cervical Length Measurement; Female; Humans; Indomethacin; Obstetric Labor, Prem | 2011 |
Nifedipine for the treatment of preterm labor in twin and singleton pregnancies.
Topics: Adult; Databases, Factual; Female; Gestational Age; Hospitals, University; Humans; Indomethacin; Inf | 2011 |
Indomethacin in pregnancy: applications and safety.
Topics: Cerclage, Cervical; Cerebral Hemorrhage; Ductus Arteriosus; Enterocolitis, Necrotizing; Female; Fetu | 2012 |
Inhibition of uterine contractility with various tocolytics with and without progesterone: in vitro studies.
Topics: Adult; Female; Humans; Indomethacin; Magnesium Sulfate; Myometrium; Nifedipine; Obstetric Labor, Pre | 2012 |
[Treatment of preterm delivery--therapeutic algorithm].
Topics: Ambroxol; Anti-Inflammatory Agents, Non-Steroidal; Calcium Channel Blockers; Expectorants; Female; G | 2011 |
Therapeutic effect of cyclo-oxygenase inhibitors with different isoform selectivity in lipopolysaccharide-induced preterm birth in mice.
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Femal | 2003 |
In situ inhibition of uterine activity by indomethacin: possible relevance to preterm labor prevention after fetal surgery.
Topics: Animals; Depression, Chemical; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Femal | 2004 |
Efficacy of aggressive tocolysis for preterm labor with advanced cervical dilatation.
Topics: Adrenal Cortex Hormones; Adult; Delivery, Obstetric; Female; Gestational Age; Humans; Indomethacin; | 2005 |
Indomethacin tocolysis and white matter injury in preterm infants.
Topics: Cerebral Hemorrhage; Female; Humans; Indomethacin; Infant; Infant, Newborn; Infant, Premature; Israe | 2005 |
Kinetics and secretion of placental growth hormone around parturition.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Betamethasone; Carrier Proteins; Cesarean Section; C | 2006 |
The safety of prolonged indomethacin therapy.
Topics: Adolescent; Adult; Cohort Studies; Drug-Related Side Effects and Adverse Reactions; Ductus Arteriosu | 2007 |
A cost decision analysis of 4 tocolytic drugs.
Topics: Decision Trees; Drug Costs; Female; Humans; Indomethacin; Magnesium Sulfate; Nifedipine; Obstetric L | 2007 |
Immunomodulators plus antibiotics delay preterm delivery after experimental intraamniotic infection in a nonhuman primate model.
Topics: Amnion; Amniotic Fluid; Ampicillin; Animals; Anti-Bacterial Agents; Cesarean Section; Chorioamnionit | 2007 |
Prostaglandin synthase inhibitors in preterm labour.
Topics: Ductus Arteriosus; Female; Humans; Indomethacin; Obstetric Labor, Premature; Pregnancy | 1980 |
On reducing prematurity: the hospital's role.
Topics: 17 alpha-Hydroxyprogesterone Caproate; Adrenergic beta-Agonists; Female; Hospital Departments; Human | 1982 |
Tocolytics.
Topics: Adrenergic beta-Agonists; Blood Glucose; Female; Fetal Distress; Humans; Indomethacin; Infant, Newbo | 1983 |
Treatment of premature labor contractions with combined ritodrine and indomethacine.
Topics: Adolescent; Adult; Apgar Score; Birth Weight; Drug Therapy, Combination; Female; Humans; Indomethaci | 1983 |
A survey of tocolytic drug treatment in preterm labour.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Attitude of Health Personnel; Belgium; Cervix Ute | 1984 |
The treatment of threatened premature labor by drugs.
Topics: Bucladesine; Cyclic AMP; Female; Humans; Indomethacin; Obstetric Labor, Premature; Pregnancy; Prosta | 1980 |
Fetal surgery in the primate II. Uterine electromyographic response to operative procedures and pharmacologic agents.
Topics: Amniocentesis; Anesthesia, Obstetrical; Animals; Catheterization; Electrodes, Implanted; Electromyog | 1984 |
RDS prophylaxis in preterm labor: corticosteroids and beta-mimetics association-indications and limits.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Adrenal Cortex Hormones; Drug Therapy, Combination; Female; Huma | 1984 |
Indomethacin and the fetal renal nonfunction syndrome.
Topics: Abnormalities, Drug-Induced; Adult; Face; Female; Humans; Indomethacin; Infant, Newborn; Kidney; Mat | 1983 |
Unexpected cardiac pathology in pregnant women treated with beta-adrenergic agents (ritodrine).
Topics: Adult; Cardiomyopathies; Cesarean Section; Dyspnea; Female; Heart Septal Defects, Atrial; Humans; In | 1983 |
Further study of the inhibition of premature labor by indomethacin. Part I.
Topics: Adolescent; Adult; Female; Gestational Age; Humans; Indomethacin; Obstetric Labor, Premature; Pregna | 1984 |
[Fetal hydrops following indomethacin administration during pregnancy].
Topics: Adult; Edema; Female; Humans; Indomethacin; Infant, Newborn; Infant, Premature, Diseases; Male; Mate | 1983 |
[Treatment of premature labor with indomethacin and its effect on the fetus].
Topics: Ductus Arteriosus, Patent; Female; Humans; Indomethacin; Infant, Newborn; Obstetric Labor, Premature | 1982 |
[Premature labor].
Topics: Child, Preschool; Chile; Female; Humans; Indomethacin; Infant, Low Birth Weight; Infant, Newborn; Ob | 1982 |
[Combined indomethacin and ritodrine treatment in the prevention of pre-term labor. Preventive note].
Topics: Adult; Drug Therapy, Combination; Female; Humans; Indomethacin; Obstetric Labor, Premature; Pregnanc | 1980 |
[Indomethacin in the prevention of pre-term labor].
Topics: Adult; Female; Humans; Indomethacin; Obstetric Labor, Premature; Pregnancy | 1980 |
[Maternal treatment with indomethacin and severe neonatal pulmonary hypertension (author's transl)].
Topics: Female; Humans; Hypertension, Pulmonary; Indomethacin; Infant, Newborn; Infant, Premature, Diseases; | 1981 |
Oligohydramnion, meconium and perinatal death concurrent with indomethacin treatment in human pregnancy.
Topics: Adult; Amniotic Fluid; Female; Fetal Death; Humans; Indomethacin; Infant Mortality; Infant, Newborn; | 1980 |
Classification of threatened premature labor related to treatment with a prostaglandin inhibitor: indomethacin.
Topics: Female; Humans; Indomethacin; Infant, Newborn; Obstetric Labor, Premature; Pregnancy; Uterine Contra | 1980 |
[Indomethacin for prevention of premature labor].
Topics: Female; Humans; Indomethacin; Obstetric Labor, Premature; Pregnancy; Uterine Contraction | 1980 |
[Persistent pulmonary hypertension in the newborn caused by prenatal use of prostaglandin inhibitors, (indomethacin). Report of a case].
Topics: Abortion, Threatened; Adult; Female; Humans; Hypertension, Pulmonary; Indomethacin; Infant, Newborn; | 1980 |
[Prostaglandin and threat of premature labour inhibitors. 1. The possibilities and consequences (as given in the literature) (author's transl)].
Topics: Anti-Inflammatory Agents; Female; Humans; Indomethacin; Infant, Newborn; Labor, Obstetric; Maternal- | 1980 |
Fetal echocardiography during indomethacin treatment.
Topics: Arterial Occlusive Diseases; Blood Flow Velocity; Constriction, Pathologic; Ductus Arteriosus; Echoc | 1995 |
Quadruplet pregnancy--successful outcome using indomethacin.
Topics: Female; Humans; Indomethacin; Obstetric Labor, Premature; Pregnancy; Pregnancy Outcome; Pregnancy, M | 1994 |
[Has the use of indomethacin during pregnancy consequences in newborn infants? Prospective study of 83 pregnant women and 115 newborn infants].
Topics: Female; Humans; Indomethacin; Infant, Newborn; Infant, Newborn, Diseases; Obstetric Labor, Premature | 1994 |
The contemporary use of beta-agonists.
Topics: Adrenergic beta-Agonists; Female; Humans; Indomethacin; Obstetric Labor, Premature; Pregnancy; Tocol | 1994 |
The effect of indomethacin tocolysis on maternal coagulation status.
Topics: Administration, Oral; Adult; Bleeding Time; Blood Coagulation; Female; Humans; Indomethacin; Obstetr | 1994 |
Successful pregnancy outcome in uterus didelphys with leiomyoma uteri.
Topics: Adult; Bed Rest; Cesarean Section; Female; Humans; Indomethacin; Leiomyoma; Obstetric Labor, Prematu | 1994 |
Indomethacin-induced maternal convulsion in the treatment of preterm labour.
Topics: Adult; Female; Humans; Indomethacin; Obstetric Labor, Premature; Pregnancy; Pregnancy Complications; | 1993 |
Indomethacin as a tocolytic agent: the controversy continues.
Topics: Female; Humans; Indomethacin; Infant, Newborn; Infant, Premature, Diseases; Obstetric Labor, Prematu | 1994 |
Effect of interleukin 2 on the production of progesterone and prostaglandin E2 in human fetal membranes and its consequences for preterm uterine contractions.
Topics: Amniotic Fluid; Bacterial Infections; Chorioamnionitis; Culture Techniques; Dinoprostone; Extraembry | 1994 |
Renal impairment in very low birthweight infants following antenatal indomethacin administration.
Topics: Adult; Female; Humans; Indomethacin; Infant, Low Birth Weight; Infant, Newborn; Male; Maternal-Fetal | 1994 |
Neonatal complications after the administration of indomethacin for preterm labor.
Topics: Cerebral Hemorrhage; Ductus Arteriosus, Patent; Enterocolitis, Pseudomembranous; Female; Fetus; Huma | 1993 |
Acute maternal renal insufficiency in premature labor treated with indomethacin.
Topics: Acute Kidney Injury; Administration, Oral; Adult; Dyspnea; Female; Fetofetal Transfusion; Humans; Hy | 1993 |
Delayed birth intervals of immature fraternal triplets in preterm labor. A case report.
Topics: Adult; Anti-Bacterial Agents; Birth Intervals; Birth Weight; Female; Gamete Intrafallopian Transfer; | 1993 |
Tocolysis with indomethacin increases the incidence of necrotizing enterocolitis in the low-birth-weight neonate.
Topics: Birth Weight; Chi-Square Distribution; Cohort Studies; Enterocolitis, Pseudomembranous; Female; Gest | 1994 |
[Maternal and neonatal effects of indomethacin administrated during pregnancy. Apropos of 18 cases].
Topics: Adult; Female; Humans; Indomethacin; Infant, Newborn; Male; Obstetric Labor, Premature; Polyhydramni | 1993 |
Pregnancy in women with end-stage renal disease: treatment of anemia and premature labor.
Topics: Abnormalities, Drug-Induced; Adult; Anemia; Erythropoietin; Female; Hematocrit; Humans; Hypertension | 1993 |
Good fetal outcome following prolonged indomethacin induced anhydramnios. Case report.
Topics: Adult; Female; Humans; Indomethacin; Infant, Newborn; Obstetric Labor, Premature; Oligohydramnios; P | 1995 |
Effective treatment of drug-induced agranulocytosis using recombinant human granulocyte colony stimulating factor in pregnancy.
Topics: Adult; Agranulocytosis; Drug Therapy, Combination; Female; Granulocyte Colony-Stimulating Factor; Hu | 1995 |
Repeated administration of low-dose lipopolysaccharide induces preterm delivery in mice: a model for human preterm parturition and for assessment of the therapeutic ability of drugs against preterm delivery.
Topics: Animals; Disease Models, Animal; Escherichia coli; Female; Gabexate; Glycoproteins; Humans; Indometh | 1996 |
Acute renal failure in the neonate induced by the administration of indomethacin as a tocolytic agent.
Topics: Acute Kidney Injury; Adult; Ductus Arteriosus, Patent; Female; Humans; Indomethacin; Infant, Newborn | 1996 |
Effect of indomethacin on individual amniotic fluid indices in multiple gestations.
Topics: Amniotic Fluid; Cyclooxygenase Inhibitors; Female; Humans; Indomethacin; Obstetric Labor, Premature; | 1996 |
Preterm labour and delivery.
Topics: Adrenergic beta-Agonists; Biomarkers; Female; Humans; Indomethacin; Magnesium; Nitroglycerin; Obstet | 1996 |
In utero congestive heart failure due to maternal indomethacin treatment for polyhydramnios and premature labour in a fetus with antenatal closure of the foramen ovale.
Topics: Adult; Autopsy; Female; Fetal Death; Heart Failure; Heart Septum; Humans; Indomethacin; Obstetric La | 1996 |
Preterm delivery after indomethacin. A risk factor for neonatal complications?
Topics: Cohort Studies; Ductus Arteriosus, Patent; Enterocolitis, Pseudomembranous; Female; Hemorrhage; Huma | 1996 |
Progesterone levels in preterm labor are not affected by ritodrin treatment.
Topics: Administration, Rectal; Female; Humans; Indomethacin; Infusion Pumps; Obstetric Labor, Premature; Pr | 1997 |
The effect of indomethacin tocolysis on fetal ductus arteriosus constriction with advancing gestational age.
Topics: Ductus Arteriosus; Echocardiography; Female; Gestational Age; Humans; Indomethacin; Obstetric Labor, | 1997 |
[Indomethacin in obstetrics: benefits and risks].
Topics: Female; Humans; Indomethacin; Obstetric Labor, Premature; Pregnancy; Tocolytic Agents | 1997 |
Is there justification for using indomethacin in preterm labor? An analysis of neonatal risks and benefits.
Topics: Cerebral Hemorrhage; Decision Support Techniques; Enterocolitis, Pseudomembranous; Female; Gestation | 1997 |
Indomethacin tocolysis.
Topics: Contraindications; Ductus Arteriosus, Patent; Echocardiography; Female; Gestational Age; Humans; Ind | 1998 |
Safety of antenatal indomethacin.
Topics: Female; Humans; Indomethacin; Obstetric Labor, Premature; Pregnancy; Risk Factors; Tocolysis | 1998 |
Toxic epidermal necrolysis associated with treatment for preterm labor.
Topics: Adult; Betamethasone; Female; Gestational Age; Glucocorticoids; Humans; Indomethacin; Obstetric Labo | 1998 |
Indomethacin tocolysis increases postnatal patent ductus arteriosus severity.
Topics: Ductus Arteriosus, Patent; Female; Humans; Indomethacin; Infant, Newborn; Infant, Premature; Infant, | 1998 |
ECT-induced premature labor: a case report.
Topics: Adult; Depressive Disorder; Electroconvulsive Therapy; Female; Humans; Indomethacin; Mental Disorder | 1999 |
Recent indomethacin tocolysis is not associated with neonatal complications in preterm infants.
Topics: Birth Weight; Case-Control Studies; Delivery, Obstetric; Drug Administration Schedule; Female; Gesta | 1999 |
Inhibition of cyclooxygenase-2 prevents inflammation-mediated preterm labor in the mouse.
Topics: Animals; Blotting, Northern; Calcium; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitor | 2000 |
Search for best tocolytic for preterm labour.
Topics: Female; Humans; Indomethacin; Nifedipine; Obstetric Labor, Premature; Pregnancy; Randomized Controll | 2000 |
Vascular reactivity to angiotensin II and eicosanoid production in the human placenta from term and preterm pregnancy.
Topics: 6-Ketoprostaglandin F1 alpha; Analysis of Variance; Angiotensin II; Culture Techniques; Enzyme-Linke | 2000 |
Enhancement of amniotic cyclooxygenase type 2 activity in women with preterm delivery associated with twins or polyhydramnios.
Topics: Amnion; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; | 2001 |
Can a cyclo-oxygenase type-2 selective tocolytic agent avoid the fetal side effects of indomethacin?
Topics: Administration, Oral; Adult; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitor | 2001 |
Indomethacin tocolysis and intraventricular hemorrhage.
Topics: Adult; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Confiden | 2001 |
Severe heart failure due to ductal constriction caused by maternal indomethacin.
Topics: Adult; Constriction, Pathologic; Ductus Arteriosus; Female; Heart Failure; Humans; Indomethacin; Inf | 2002 |
[Tocolysis and its place in premature labor].
Topics: Adrenergic Agents; Anti-Inflammatory Agents, Non-Steroidal; Bulgaria; Drug Interactions; Female; Hum | 1999 |
Indomethacin-induced rectovaginal fistula in a postpartum patient.
Topics: Adult; Colostomy; Escherichia coli Infections; Fecal Incontinence; Female; Humans; Indomethacin; Obs | 2002 |
[Prevention of premature labor].
Topics: Adrenergic beta-Agonists; Aspirin; Female; Humans; Indomethacin; Obstetric Labor, Premature; Pregnan | 1975 |
Perinatal use of indomethacin.
Topics: Animals; Female; Fetal Death; Humans; Indomethacin; Obstetric Labor, Premature; Pregnancy; Rats | 1977 |
Post-partum pulmonary oedema associated with preventive therapy for premature labour.
Topics: Adult; Betamethasone; Drug Therapy, Combination; Female; Humans; Indomethacin; Obstetric Labor, Prem | 1979 |
Effect on the fetus of indomethacin given to suppress labour.
Topics: Animals; Female; Fetal Heart; Humans; Indomethacin; Infant, Newborn; Male; Maternal-Fetal Exchange; | 1979 |
Treatment of premature labor by prostaglandin synthetase inhibitors.
Topics: Adult; Animals; Anti-Inflammatory Agents; Birth Weight; Cyclooxygenase Inhibitors; Female; Gestation | 1978 |
Premature onset of labor, neonatal patent ductus arteriosus, and prostaglandin synthetase antagonists--a rat model of a human problem.
Topics: Animals; Brain Diseases; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Ductus Arterio | 1979 |
The treatment of threatened premature labor by tocolytics, Ca++-Antagonists and anti-inflammatory drugs.
Topics: Adrenergic beta-Agonists; Animals; Anti-Inflammatory Agents; Aspirin; Calcium; Drug Therapy, Combina | 1975 |
Alcohol, indomethacin, and salbutamol. A comparative trial of their use in preterm labor.
Topics: Albuterol; Birth Weight; Drug Therapy, Combination; Ethanol; Female; Fetal Membranes, Premature Rupt | 1979 |
Perinatal hazards of chronic antenatal tocolysis with indomethacin.
Topics: Adult; Female; Humans; Indomethacin; Infant, Newborn; Infant, Premature, Diseases; Obstetric Labor, | 1979 |
Relationship of maternal treatment with indomethacin to persistence of fetal circulation syndrome.
Topics: Ductus Arteriosus, Patent; Female; Fetus; Humans; Indomethacin; Infant, Newborn; Obstetric Labor Com | 1978 |
Pregnant mare's serum gonadotropin. IV. Induction of premature labor by pregnant mare's serum gonadotropin and its prevention by using clomiphene or indomethacin.
Topics: Abortifacient Agents; Animals; Clomiphene; Female; Gonadotropins, Equine; Indomethacin; Labor, Induc | 1978 |
Management of premature labor.
Topics: Aspirin; Bed Rest; Betamethasone; Estrogens; Ethanol; Female; Fetal Membranes, Premature Rupture; Gl | 1978 |
The effects of combined dexamethasone and indomethacin treatment on the outcome of pregnancy in the rabbit.
Topics: Animals; Dexamethasone; Female; Indomethacin; Obstetric Labor, Premature; Pregnancy; Pregnancy, Anim | 1976 |
[Inhibition of endogenous prostaglandin synthesis by indomethacin in the treatment of premature labor].
Topics: Female; Humans; Indomethacin; Infant, Newborn; Obstetric Labor, Premature; Pregnancy; Prostaglandin | 1976 |
Indomethacin to stop premature labor.
Topics: Animals; Female; Indomethacin; Obstetric Labor, Premature; Pregnancy; Rats | 1976 |
Possible association between maternal indomethacin therapy and primary pulmonary hypertension of the newborn.
Topics: Adolescent; Female; Humans; Hypertension, Pulmonary; Indomethacin; Infant, Newborn; Infant, Newborn, | 1976 |
The effects of dexamethasone and indomethacin on the outcome of pregnancy in the rabbit.
Topics: Administration, Oral; Animals; Dexamethasone; Female; Hematocrit; Indomethacin; Injections, Subcutan | 1975 |
On the role of prostaglandins in parturition in the rat.
Topics: Animals; Female; Gestational Age; Hypophysectomy; Indomethacin; Labor, Obstetric; Medroxyprogesteron | 1975 |
[Indomethacin as an inhibitor of premature labor].
Topics: Adult; Female; Humans; Indomethacin; Obstetric Labor, Premature; Pregnancy | 1975 |
Premature labor and indomethacin.
Topics: Adult; Female; Humans; Indomethacin; Obstetric Labor, Premature; Pregnancy; Prostaglandins F; Time F | 1975 |
Letter: Indomethacin.
Topics: Animals; Female; Humans; Indomethacin; Obstetric Labor, Premature; Pregnancy | 1976 |
[Indomethacin in threatening premature labor. Fetal and neonatal cardiovascular effects].
Topics: Cardiovascular Diseases; Female; Fetal Diseases; Humans; Hypertension, Pulmonary; Indomethacin; Infa | 1992 |
Oligohydramnios induced by maternal indomethacin therapy.
Topics: Female; Humans; Indomethacin; Maternal-Fetal Exchange; Obstetric Labor, Premature; Oligohydramnios; | 1992 |
Indomethacin therapy and chronic hemodialysis during pregnancy. A case report.
Topics: Adult; Female; Glomerulosclerosis, Focal Segmental; Humans; Indomethacin; Infant, Newborn; Obstetric | 1992 |
Intraoperative amniocentesis and indomethacin treatment in the management of an immature pregnancy with completely dilated cervix.
Topics: Adult; Amniocentesis; Cervix Uteri; Female; Humans; Indomethacin; Infant, Newborn; Intraoperative Pe | 1992 |
Randomized comparative trial of indomethacin and sulindac for the treatment of refractory preterm labor.
Topics: Female; Humans; Indomethacin; Obstetric Labor, Premature; Pregnancy; Randomized Controlled Trials as | 1992 |
Urinary excretion of prostacyclin and thromboxane metabolites in threatened preterm labor: effect of indomethacin and nylidrin.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Epoprostenol; Female; Humans; Indomethacin; Kinetics; Nylidrin; | 1992 |
Renal dysgenesis in a monozygotic twin: association with in utero exposure to indomethacin.
Topics: Adult; Diseases in Twins; Female; Humans; Indomethacin; Infant, Newborn; Kidney; Maternal-Fetal Exch | 1991 |
Cocaine and indomethacin: fetal anuria, neonatal edema, and gastrointestinal bleeding.
Topics: Adult; Anuria; Cocaine; Drug Synergism; Female; Fetal Diseases; Gastrointestinal Hemorrhage; Humans; | 1991 |
A product of activated human granulocytes stimulates prostaglandin E2 synthesis in human amnion cells.
Topics: Amnion; Cells, Cultured; Chorioamnionitis; Cytochalasin B; Dinoprostone; Epidermal Growth Factor; Fe | 1991 |
Maternal plasma corticotrophin-releasing hormone--elevated in preterm labour but unaffected by indomethacin or nylidrin.
Topics: Adult; Corticotropin-Releasing Hormone; Female; Humans; Hydrocortisone; Indomethacin; Nylidrin; Obst | 1991 |
Indomethacin for preterm labor: fetal toxicity in a dizygotic twin gestation.
Topics: Abnormalities, Drug-Induced; Adult; Diseases in Twins; Drug Monitoring; Ductus Arteriosus; Female; F | 1991 |
Long-term indomethacin therapy decreases fetal urine output and results in oligohydramnios.
Topics: Adult; Amniotic Fluid; Female; Fetus; Humans; Indomethacin; Obstetric Labor, Premature; Oligohydramn | 1991 |
Uterine blood flow velocity waveforms in pregnant women during indomethacin therapy.
Topics: Blood Flow Velocity; Female; Humans; Indomethacin; Obstetric Labor, Premature; Polyhydramnios; Pregn | 1990 |
Cerebral lesions in preterm infants after tocolytic indomethacin.
Topics: Administration, Rectal; Brain; Brain Damage, Chronic; Cerebral Hemorrhage; Dose-Response Relationshi | 1990 |
Safety and efficacy of long-term tocolysis with indomethacin.
Topics: Apgar Score; Birth Weight; Female; Humans; Indomethacin; Infant, Newborn; Obstetric Labor, Premature | 1990 |
Oligohydramnios in each sac of a triplet gestation caused by Motrin--fulfilling Kock's postulates.
Topics: Adult; Amniotic Fluid; Female; Humans; Ibuprofen; Indomethacin; Obstetric Labor, Premature; Pregnanc | 1990 |
Oligohydramnios associated with prostaglandin synthetase inhibitors in preterm labour.
Topics: Adult; Amniotic Fluid; Birth Weight; Female; Gestational Age; Humans; Ibuprofen; Indomethacin; Infan | 1990 |
Doppler assessment of the renal blood flow velocity waveform during indomethacin therapy for preterm labor and polyhydramnios.
Topics: Ductus Arteriosus; Female; Fetal Monitoring; Gestational Age; Humans; Indomethacin; Kidney; Maternal | 1990 |
Polyhydramnios associated with a ring chromosome and low maternal serum alpha-fetoprotein levels managed with indomethacin.
Topics: alpha-Fetoproteins; Chromosome Aberrations; Female; Fetus; Humans; Indomethacin; Infant, Newborn; Ob | 1988 |
Neonatal renal dysfunction and intrauterine exposure to prostaglandin synthesis inhibitors.
Topics: Acute Kidney Injury; Anti-Inflammatory Agents, Non-Steroidal; Betamethasone; Cesarean Section; Cyclo | 1989 |
[Prescribing indomethacin to prevent premature labor. Risk of cardiomyopathy].
Topics: Cardiomyopathy, Dilated; Female; Humans; Indomethacin; Infant, Newborn; Male; Obstetric Labor, Prema | 1989 |
Antagonism of antihypertensive drug therapy in pregnancy by indomethacin?
Topics: Adult; Antihypertensive Agents; Blood Pressure; Female; Humans; Indomethacin; Obstetric Labor, Prema | 1989 |
Twin with hydramnios: treating premature labor at source.
Topics: Delivery, Obstetric; Female; Humans; Indomethacin; Obstetric Labor, Premature; Polyhydramnios; Pregn | 1989 |
Indomethacin-induced oligohydramnios.
Topics: Adult; Amniotic Fluid; Dose-Response Relationship, Drug; Female; Humans; Indomethacin; Obstetric Lab | 1989 |
Doppler assessment of the pulsatility index of the middle cerebral artery during constriction of the fetal ductus arteriosus after indomethacin therapy.
Topics: Blood Circulation; Cerebral Arteries; Ductus Arteriosus; Female; Fetus; Hemodynamics; Humans; Indome | 1989 |
[Prenatal diagnosis of premature closure of the ductus arteriosus with subsequent development of a non-immunologic hydrops fetalis].
Topics: Adult; Cesarean Section; Constriction, Pathologic; Ductus Arteriosus; Female; Humans; Hydrops Fetali | 1989 |
Preterm labor: its diagnosis and management.
Topics: Adolescent; Adrenergic beta-Agonists; Adult; Female; Fluid Therapy; Humans; Indomethacin; Infant, Ne | 1986 |
Patent ductus arteriosus after prolonged treatment with indomethacin during pregnancy: case report.
Topics: Adult; Diseases in Twins; Ductus Arteriosus, Patent; Female; Humans; Indomethacin; Infant, Newborn; | 1987 |
The effects of indomethacin administration during pregnancy on women's and newborns' T-suppressor lymphocyte activity and on HLA class II expression by newborns' leukocytes.
Topics: B-Lymphocytes; Female; Histocompatibility Antigens Class II; HLA-DR Antigens; Humans; Indomethacin; | 1985 |
Effects of indomethacin on the fetus.
Topics: Ductus Arteriosus; Female; Humans; Indomethacin; Obstetric Labor, Premature; Pregnancy; Tocolytic Ag | 1988 |
Indomethacin as an inhibitor of preterm labor. Effect on postnatal renal function.
Topics: Female; Gestational Age; Glomerular Filtration Rate; Humans; Indomethacin; Infant, Newborn; Kidney; | 1988 |
[The uterine inhibition in the management of premature labor. Comparing the efficiency of various methods].
Topics: Analysis of Variance; Betamethasone; Female; Fenoterol; Humans; Indomethacin; Obstetric Labor, Prema | 1987 |
Influence of short-term indomethacin therapy on fetal urine output.
Topics: Constriction, Pathologic; Diuresis; Ductus Arteriosus; Female; Fetus; Humans; Indomethacin; Obstetri | 1988 |
Prolonged maternal indomethacin therapy associated with oligohydramnios. Case reports.
Topics: Adult; Amniotic Fluid; Female; Humans; Indomethacin; Obstetric Labor, Premature; Pregnancy; Pregnanc | 1988 |
Indomethacin in the treatment of premature labor. Effects on the fetal ductus arteriosus.
Topics: Adolescent; Adult; Constriction, Pathologic; Dose-Response Relationship, Drug; Ductus Arteriosus; Ec | 1988 |
Safety of indomethacin tocolysis.
Topics: Female; Humans; Indomethacin; Obstetric Labor, Premature; Pregnancy | 1987 |
[Maternal administration of indomethacin and neonatal tricuspid insufficiency].
Topics: Female; Humans; Indomethacin; Infant, Newborn; Male; Obstetric Labor, Premature; Pregnancy; Tricuspi | 1987 |
Inhibition of premature labour with indomethacin.
Topics: Female; Fetal Membranes, Premature Rupture; Humans; Indomethacin; Infant, Low Birth Weight; Infant, | 1987 |
Management of preterm labor and delivery.
Topics: Adrenal Cortex Hormones; Anesthesia, Conduction; Calcium Channel Blockers; Cesarean Section; Deliver | 1986 |
Obstetric management of the very low birth weight fetus.
Topics: Adrenal Cortex Hormones; Extraction, Obstetrical; Female; Fetal Distress; Fetal Monitoring; Fetal Or | 1986 |
Neonatal outcome after indomethacin treatment for preterm labor.
Topics: Apgar Score; Birth Weight; Female; Gestational Age; Humans; Indomethacin; Infant, Newborn, Diseases; | 1986 |
Premature closure of the ductus arteriosus causing intra-uterine death. A case report.
Topics: Adult; Ductus Arteriosus; Edema; Female; Fetal Death; Humans; Indomethacin; Obstetric Labor, Prematu | 1986 |
Detection and quantitation of constriction of the fetal ductus arteriosus by Doppler echocardiography.
Topics: Animals; Constriction, Pathologic; Ductus Arteriosus; Echocardiography; Female; Fetal Diseases; Huma | 1987 |
Fetal and neonatal effects of indomethacin used as a tocolytic agent.
Topics: Birth Weight; Female; Fetus; Humans; Indomethacin; Infant Mortality; Infant, Newborn; Infant, Newbor | 1985 |
Side effects of indomethacin.
Topics: Animals; Female; Fetus; Humans; Indomethacin; Infant, Newborn; Obstetric Labor, Premature; Pregnancy | 1985 |
Fetal and neonatal effects of indomethacin used as a tocolytic agent.
Topics: Female; Fetus; Humans; Indomethacin; Infant, Newborn; Obstetric Labor, Premature; Pregnancy | 1985 |
Fetal and neonatal effects of indomethacin used as a tocolytic agent.
Topics: Female; Fetus; Humans; Indomethacin; Infant, Newborn; Obstetric Labor, Premature; Pregnancy | 1985 |
Inhibition of human premature labor by indomethacin.
Topics: Adolescent; Adult; Blood Pressure; Depression, Chemical; Extraembryonic Membranes; Female; Fetal Hea | 1974 |
Delay of parturition in the rat by anti-inflammatory agents which inhibit the biosynthesis of prostaglandins.
Topics: Acetates; Administration, Oral; Animals; Anti-Inflammatory Agents; Aspirin; Cortisone; Depression, C | 1972 |