indomethacin has been researched along with Kidney Neoplasms in 26 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Kidney Neoplasms: Tumors or cancers of the KIDNEY.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Most of the tested compounds showed significant anti-inflammatory activity using carrageenan-induced rat paw edema method compared to indomethacin." | 7.79 | New nitric oxide donating 1,2,4-triazole/oxime hybrids: synthesis, investigation of anti-inflammatory, ulceroginic liability and antiproliferative activities. ( Abdel-Aziz, M; Abuo-Rahma, Gel-D; Ali, TF; Beshr, EA, 2013) |
| "An infant presented with a non-metastatic renal spindle cell sarcoma and hypercalcaemia, which resolved after treatment with indomethacin." | 7.68 | Indomethacin responsive hypercalcaemia associated with a renal sarcoma. ( Dillon, MJ; Gibbs, J; Lang, S; Meghji, S; Pritchard, J, 1990) |
| "The hypercalcemia was unresponsive to hydration and oral phosphate." | 5.25 | Indomethacin-responsive hypercalcemia in a patient with renal-cell adenocarcinoma. ( Alexander, RW; Brereton, HD; DeVita, VT; Halushka, PV; Keiser, HR; Mason, DM, 1974) |
| " Most of the tested compounds showed significant anti-inflammatory activity using carrageenan-induced rat paw edema method compared to indomethacin." | 3.79 | New nitric oxide donating 1,2,4-triazole/oxime hybrids: synthesis, investigation of anti-inflammatory, ulceroginic liability and antiproliferative activities. ( Abdel-Aziz, M; Abuo-Rahma, Gel-D; Ali, TF; Beshr, EA, 2013) |
| "An infant presented with a non-metastatic renal spindle cell sarcoma and hypercalcaemia, which resolved after treatment with indomethacin." | 3.68 | Indomethacin responsive hypercalcaemia associated with a renal sarcoma. ( Dillon, MJ; Gibbs, J; Lang, S; Meghji, S; Pritchard, J, 1990) |
| "Indomethacin treatment was associated with increased expression of glucose-regulated protein 78 (GRP78) and C/EBP homologus protein (CHOP) and activation of ATF-6, characteristics of endoplasmic reticulum stress." | 1.34 | Indomethacin induces apoptosis in 786-O renal cell carcinoma cells by activating mitogen-activated protein kinases and AKT. ( Chen, CJ; Cheng, CL; Hung, YY; Ou, YC; Raung, SL; Yang, CR, 2007) |
| "Pretreatment with indomethacin had no effect on tumor take or initial growth." | 1.30 | The influence of zymosan and indomethacin on liver and kidney tumor growth. An experimental study in rats. ( Blind, PJ; Hafström, LR; Holmberg, SB; Lindnér, PG; Naredi, PL; Ohman, MG, 1997) |
| "The bone-resorbing capacity of human renal cell carcinomas in vitro has been examined." | 1.28 | Renal cell carcinoma in tissue culture secretes nondialyzable product that stimulates bone resorption in organ-cultured mouse calvaria. ( Lerner, UH; Ljungberg, B, 1989) |
| "Indomethacin was given orally to 40 of the rats." | 1.28 | Effect of indomethacin in autotransplanted colonic tumors. ( Duvander, A; Rubio, CA; Sveander, M; Wallin, B; Ware, J, 1989) |
| "Osteolysis is estimated by the amount of 45Ca released from bone to medium, the mice being given injections of 45Ca on their day of birth." | 1.26 | Inhibition by two diphosphonates of bone lysis in tumor-conditioned media. ( Barras, C; Baud, M; Courvoisier, B; Jung, A; Mermillod, B, 1981) |
| "Tumours associated with bone resorption had higher concentrations of prostaglandin E in culture media at the end of incubation than did non-resorbers." | 1.26 | Prostaglandins as mediators of bone resorption in renal and breast tumours. ( Atkins, D; Greaves, M; Ibbotson, KJ; Martin, TJ, 1980) |
| "In 9/13 cases significant bone resorption occurred whilst in no case did control kidney cause significant resorption." | 1.26 | Secretion of prostaglandins as bone-resorbing agents by renal cortical carcinoma in culture. ( Atkins, D; Hammonds, JC; Hillier, K; Hunt, NH; Ibbotson, KJ; Martin, TJ, 1977) |
| "The hypercalcemia was unresponsive to hydration and oral phosphate." | 1.25 | Indomethacin-responsive hypercalcemia in a patient with renal-cell adenocarcinoma. ( Alexander, RW; Brereton, HD; DeVita, VT; Halushka, PV; Keiser, HR; Mason, DM, 1974) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (53.85) | 18.7374 |
| 1990's | 9 (34.62) | 18.2507 |
| 2000's | 2 (7.69) | 29.6817 |
| 2010's | 1 (3.85) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Abdel-Aziz, M | 1 |
| Abuo-Rahma, Gel-D | 1 |
| Beshr, EA | 1 |
| Ali, TF | 1 |
| Zaki, M | 1 |
| Schöneberg, T | 1 |
| Al Ajrawi, T | 1 |
| Al Said, AN | 1 |
| Sangkuhl, K | 1 |
| Römpler, H | 1 |
| Ou, YC | 1 |
| Yang, CR | 1 |
| Cheng, CL | 1 |
| Raung, SL | 1 |
| Hung, YY | 1 |
| Chen, CJ | 1 |
| Braun, DP | 1 |
| Harris, ZL | 1 |
| Harris, JE | 1 |
| Sandler, S | 1 |
| Khandekar, J | 1 |
| Locker, G | 1 |
| Haid, M | 1 |
| Gordon, L | 1 |
| Shaw, J | 1 |
| Cobleigh, M | 1 |
| Hagiwara, M | 1 |
| McNamara, DB | 1 |
| Chen, IL | 1 |
| Fisher, JW | 1 |
| Jung, A | 1 |
| Mermillod, B | 1 |
| Barras, C | 1 |
| Baud, M | 1 |
| Courvoisier, B | 1 |
| Greaves, M | 1 |
| Ibbotson, KJ | 2 |
| Atkins, D | 2 |
| Martin, TJ | 2 |
| Mertens, WC | 1 |
| Bramwell, VH | 1 |
| Banerjee, D | 1 |
| Gwadry-Sridhar, F | 1 |
| al-Mutter, N | 1 |
| Parhar, RS | 1 |
| Lala, PK | 1 |
| Ben-Efraim, S | 1 |
| Tak, C | 1 |
| Fieren, MJ | 1 |
| Romijn, JC | 1 |
| Beckmann, I | 1 |
| Bonta, IL | 1 |
| Yanaihara, H | 1 |
| Nakazono, M | 1 |
| Tsunoda, S | 1 |
| Alexandrov, VA | 1 |
| Bespalov, VG | 1 |
| Petrov, AS | 1 |
| Troyan, DN | 1 |
| Obrecht-Pflumio, S | 1 |
| Grosse, Y | 1 |
| Pfohl-Leszkowicz, A | 1 |
| Dirheimer, G | 1 |
| Ohman, MG | 1 |
| Blind, PJ | 1 |
| Holmberg, SB | 1 |
| Naredi, PL | 1 |
| Lindnér, PG | 1 |
| Hafström, LR | 1 |
| Dindogru, A | 1 |
| Gailani, S | 1 |
| Henderson, ES | 1 |
| Wallace, HJ | 1 |
| Fitzpatrick, J | 1 |
| Hillier, K | 1 |
| Hunt, NH | 1 |
| Hammonds, JC | 1 |
| Seyberth, HW | 1 |
| Raisz, LG | 1 |
| Oates, JA | 1 |
| Ito, H | 1 |
| Sanada, T | 1 |
| Katayama, T | 1 |
| Shimazaki, J | 1 |
| Hamblin, TJ | 1 |
| Gregorian, SK | 1 |
| Battisto, JR | 1 |
| Gibbs, J | 1 |
| Dillon, MJ | 1 |
| Lang, S | 1 |
| Meghji, S | 1 |
| Pritchard, J | 1 |
| Lerner, UH | 1 |
| Ljungberg, B | 1 |
| Chasan, SA | 1 |
| Pothel, LR | 1 |
| Huben, RP | 1 |
| Rubio, CA | 1 |
| Wallin, B | 1 |
| Ware, J | 1 |
| Sveander, M | 1 |
| Duvander, A | 1 |
| Kanar, MC | 1 |
| Thiele, DL | 1 |
| Ostensen, M | 1 |
| Lipsky, PE | 1 |
| Sosman, JA | 1 |
| Kohler, PC | 1 |
| Hank, JA | 1 |
| Moore, KH | 1 |
| Bechhofer, R | 1 |
| Storer, B | 1 |
| Sondel, PM | 1 |
| Brereton, HD | 1 |
| Halushka, PV | 1 |
| Alexander, RW | 1 |
| Mason, DM | 1 |
| Keiser, HR | 1 |
| DeVita, VT | 1 |
1 review available for indomethacin and Kidney Neoplasms
| Article | Year |
|---|---|
Prostaglandins and hypercalcemic states.
Topics: Adenocarcinoma; Animals; Bone and Bones; Bone Resorption; Humans; Hypercalcemia; Indomethacin; Kidne | 1978 |
3 trials available for indomethacin and Kidney Neoplasms
| Article | Year |
|---|---|
Sustained oral indomethacin and ranitidine with intermittent continuous infusion interleukin-2 in advanced renal cell carcinoma.
Topics: Carcinoma, Renal Cell; Female; Humans; Indomethacin; Interleukin-2; Kidney Neoplasms; Male; Middle A | 1993 |
Indomethacin, ranitidine, and interleukin-2 in melanoma.
Topics: Colorectal Neoplasms; Drug Therapy, Combination; Humans; Indomethacin; Interleukin-2; Kidney Neoplas | 1992 |
Repetitive weekly cycles of interleukin-2. II. Clinical and immunologic effects of dose, schedule, and addition of indomethacin.
Topics: Adult; Aged; Cytotoxicity, Immunologic; Drug Administration Schedule; Female; Fever; Humans; Hypoten | 1988 |
22 other studies available for indomethacin and Kidney Neoplasms
| Article | Year |
|---|---|
New nitric oxide donating 1,2,4-triazole/oxime hybrids: synthesis, investigation of anti-inflammatory, ulceroginic liability and antiproliferative activities.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Cell Line, Tumor; Edema; Hu | 2013 |
Nephrogenic diabetes insipidus, thiazide treatment and renal cell carcinoma.
Topics: Amino Acid Sequence; Aquaporin 2; Carcinoma, Renal Cell; Cardiovascular Agents; Diabetes Insipidus, | 2006 |
Indomethacin induces apoptosis in 786-O renal cell carcinoma cells by activating mitogen-activated protein kinases and AKT.
Topics: Activating Transcription Factor 6; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; A | 2007 |
Effect of interferon therapy on indomethacin-sensitive immunoregulation in the peripheral blood mononuclear cells of renal cell carcinoma patients.
Topics: Adenocarcinoma; Adult; Aged; Antibodies, Monoclonal; Cell Adhesion; Cell Division; Female; Humans; I | 1983 |
Role of endogenous prostaglandin E2 in erythropoietin production and dome formation by human renal carcinoma cells in culture.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Carcinoma; Cell Transformation, Neoplastic; Cells, Cul | 1984 |
Inhibition by two diphosphonates of bone lysis in tumor-conditioned media.
Topics: Animals; Bone Resorption; Clodronic Acid; Culture Media; Diphosphonates; Etidronic Acid; Indomethaci | 1981 |
Prostaglandins as mediators of bone resorption in renal and breast tumours.
Topics: Animals; Biological Assay; Bone Resorption; Breast Neoplasms; Culture Techniques; Female; Humans; In | 1980 |
Activity of human peritoneal macrophages against a human tumor: role of tumor necrosis factor-alpha, PGE2 and nitrite, in vitro studies.
Topics: Animals; Carcinoma, Renal Cell; Culture Media; Cytotoxicity, Immunologic; Dinoprostone; Humans; Indo | 1993 |
[A case of drug-induced immune hemolytic anemia during alpha-interferon therapy for renal cell carcinoma].
Topics: Anemia, Hemolytic, Autoimmune; Carcinoma, Renal Cell; Diclofenac; Female; Humans; Indomethacin; Inte | 1996 |
Study of post-natal effect of chemopreventive agents on ethylnitrosourea-induced transplacental carcinogenesis in rats. III. Inhibitory action of indomethacin, voltaren, theophylline and epsilon-aminocaproic acid.
Topics: Aminocaproic Acid; Animals; Anticarcinogenic Agents; Brain Neoplasms; Carcinogens; Central Nervous S | 1996 |
Protection by indomethacin and aspirin against genotoxicity of ochratoxin A, particularly in the urinary bladder and kidney.
Topics: Animals; Anticarcinogenic Agents; Aspirin; DNA Adducts; DNA Damage; Indomethacin; Kidney; Kidney Neo | 1996 |
The influence of zymosan and indomethacin on liver and kidney tumor growth. An experimental study in rats.
Topics: Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Antineoplas | 1997 |
Letter: Indomethacin in hypercalcaemia.
Topics: Adenocarcinoma; Calcium; Humans; Hypercalcemia; Indomethacin; Kidney Neoplasms; Multiple Myeloma | 1975 |
Secretion of prostaglandins as bone-resorbing agents by renal cortical carcinoma in culture.
Topics: Animals; Bone Resorption; Cyclic AMP; Humans; In Vitro Techniques; Indomethacin; Kidney Cortex; Kidn | 1977 |
Letter: Indomethacin-responsive hypercalcemia.
Topics: Adenocarcinoma; Humans; Hypercalcemia; Indomethacin; Kidney Neoplasms; Male; Middle Aged | 1975 |
Immunosuppression in murine renal cell carcinoma. II. Identification of responsible lymphoid cell phenotypes and examination of elimination of suppression.
Topics: Animals; Antigens, Surface; Carcinoma, Renal Cell; Dinoprostone; Female; Immune Tolerance; Indometha | 1990 |
Indomethacin responsive hypercalcaemia associated with a renal sarcoma.
Topics: Combined Modality Therapy; Dinoprostone; Humans; Hypercalcemia; Indomethacin; Infant; Kidney Neoplas | 1990 |
Renal cell carcinoma in tissue culture secretes nondialyzable product that stimulates bone resorption in organ-cultured mouse calvaria.
Topics: Animals; Bone Matrix; Bone Resorption; Carcinoma, Renal Cell; Culture Media; Cyclooxygenase Inhibito | 1989 |
Management and prognostic significance of hypercalcemia in renal cell carcinoma.
Topics: Calcitonin; Calcium; Carcinoma, Renal Cell; Furosemide; Humans; Hypercalcemia; Indomethacin; Kidney | 1989 |
Effect of indomethacin in autotransplanted colonic tumors.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; | 1989 |
Regulation of human natural killer (NK) cell function: induction of killing of an NK-resistant renal carcinoma cell line.
Topics: Cell Line; Cytotoxicity, Immunologic; Dinoprostone; Humans; In Vitro Techniques; Indomethacin; Inter | 1988 |
Indomethacin-responsive hypercalcemia in a patient with renal-cell adenocarcinoma.
Topics: Adenocarcinoma; Administration, Oral; Calcium; Humans; Hypercalcemia; Indomethacin; Kidney Neoplasms | 1974 |